公开(公告)号：US20150368173A1

公开(公告)日：2015-12-24

申请号：US14817286

申请日：2015-08-04

Applicant: NEONC Technologies, Inc.

Inventor： Thomas CHEN ,  DANIEL LEVIN ,  SATISH PUPPALI

IPC: C07C29/88 ,  C07C201/12 ,  C07C67/14 ,  C07C201/16

CPC classification number: C07C29/92 ,  A61K31/045 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07B2200/07 ,  C07C29/78 ,  C07C29/86 ,  C07C29/88 ,  C07C67/14 ,  C07C201/12 ,  C07C201/16 ,  C07C2601/16 ,  C07C33/14 ,  C07C205/57 ,  C07C69/76 ,  C07C69/92

Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

Abstract translation: 本发明提供纯化大于约98.5％（w / w）的单萜或倍半萜的方法。 该方法包括衍生单萜（或倍半萜烯）以产生单萜（或倍半萜烯）衍生物，分离单萜（或倍半萜烯）衍生物和从衍生物中释放单萜（或倍半萜烯）的步骤。 包括本发明范围的药物组合物是包含纯度大于约98.5％（w / w）的单萜（或倍半萜烯）的药物组合物。 纯化的单萜可用于治疗癌症等疾病。 本单萜（或倍半萜烯）可以单独施用，或者可以与辐射或其它治疗剂如化学治疗剂共同施用。

公开(公告)号：US09192877B2

公开(公告)日：2015-11-24

申请号：US13990352

申请日：2011-12-07

Applicant: Mahesh Ratnakar Sawant ,  Daniel M. Trauth ,  John G. Pendergast

Inventor： Mahesh Ratnakar Sawant ,  Daniel M. Trauth ,  John G. Pendergast

IPC: B01D3/34 ,  C07C205/00 ,  B01D3/36 ,  C07C201/08 ,  C07C201/16

CPC classification number: B01D3/36 ,  C07C201/08 ,  C07C201/16 ,  C07C205/02

Abstract: Disclosed are a process and an apparatus for concentrating an organic acid by using a nitroalkane as an entrainer for the azeotropic removal of water from an aqueous organic acid solution. The nitroalkane may be the same as a nitroalkane that is the product of a high pressure nitration process that produces nitroalkanes and aqueous organic acid.

Abstract translation: 公开了一种通过使用硝基烷烃作为夹带剂浓缩有机酸的方法和装置，用于从有机酸水溶液中共沸除去水。 硝基烷烃可以与硝基烷烃相同，硝基烷烃是产生硝基烷烃和含水有机酸的高压硝化方法的产物。

公开(公告)号：US09133094B2

公开(公告)日：2015-09-15

申请号：US14007531

申请日：2012-04-05

Applicant: Mahesh Sawant ,  Daniel M. Trauth ,  John G. Pendergast, Jr.

Inventor： Mahesh Sawant ,  Daniel M. Trauth ,  John G. Pendergast, Jr.

IPC: C07C205/02 ,  C07C201/08 ,  C07C201/16

CPC classification number: C07C205/02 ,  C07C201/08 ,  C07C201/16

Abstract: Disclosed are processes and apparatuses for concentrating at least one organic acid using an alkyl acetate as an entrainer. The processes and apparatuses may use the same alkyl acetate as an entrainer to concentrate a mixture of organic acids.

Abstract translation: 公开了使用乙酸烷基酯作为夹带剂浓缩至少一种有机酸的方法和装置。 方法和装置可以使用相同的乙酸烷基酯作为夹带剂来浓缩有机酸的混合物。

公开(公告)号：US09040758B2

公开(公告)日：2015-05-26

申请号：US13388836

申请日：2009-08-18

Applicant: Sergio Berretta

Inventor： Sergio Berretta

IPC: C07C27/26 ,  C07C201/16 ,  C02F1/04 ,  C02F1/20 ,  C02F101/38

CPC classification number: C07C201/16 ,  C02F1/04 ,  C02F1/20 ,  C02F2101/38 ,  C02F2209/06 ,  C07C205/06

Abstract: A method of removing alkalinity and salt from a nitroaromatic product downstream of water washing to remove mineral acids and alkaline washing to remove salts of organic acids, comprises washing the product stream with an acidic aqueous solution, prior to the step of removing excess organic reactant, by steam stripping or distillation. Acid removed from the stripper or column is recycled back for use in the acidic washing. The acidic washing is done instead of the neutral washing step of the prior art. It removes residual salt and decreases the level of entrained colloidal water in the nitroaromatic product.

Abstract translation: 一种从水洗下游的硝基芳族化合物产物中去除碱度和盐的方法，以除去无机酸和碱洗涤以除去有机酸的盐，包括在除去过量有机反应物的步骤之前用酸性水溶液洗涤产物流， 通过汽提或蒸馏。 从汽提塔或塔中除去的酸被循环使用，用于酸洗。 进行酸性洗涤代替现有技术的中性洗涤步骤。 它去除残留的盐并降低硝基芳族产物中夹带的胶体水的含量。

公开(公告)号：US20150099906A1

公开(公告)日：2015-04-09

申请号：US14046068

申请日：2013-10-04

Applicant: Bayer MaterialScience AG

Inventor： Thomas Knauf ,  Jurgen Munnig ,  Joerg Schmiedler

IPC: C07C201/08

CPC classification number: C07C201/08 ,  C07C201/16 ,  C07C205/06

Abstract: The present invention relates to a method for producing nitrobenzene, in which the waste gas streams accruing in the process and containing benzene and (traces of) nitrobenzene, possibly low- and medium-boiling components, possibly non-condensable gases and possibly water, optionally after removal of nitrogen oxides, are scrubbed in an absorption column with nitrobenzene, which comprises only very small amounts (maximum 50 ppm) of benzene and is distributed by means of a liquid distributor at a rate of 50 to 200 drip points per square metre, preferably 60 to 120 drip points per square metre, wherein (i) a liquid stream containing benzene and nitrobenzene, possibly organic low- and medium-boiling components and additionally containing sulfuric acid if sulfuric acid is used as the scrubbing agent and (ii) waste gas depleted in benzene and possibly in organic low- and medium-boiling components are obtained. A waste gas purified by the method according to the invention is particularly suitable for burning in a thermal exhaust air treatment process.

公开(公告)号：US20140209464A1

公开(公告)日：2014-07-31

申请号：US14229011

申请日：2014-03-28

Applicant: Dynamic Connections, LLC

Inventor： Osman Kibar ,  Mirianas Chachisvilis ,  Eugene Tu ,  Thomas H. Marsilje

IPC: C07C303/44 ,  C07C201/16 ,  C07B57/00

CPC classification number: C07C303/44 ,  B03C1/24 ,  B03C7/026 ,  C07B57/00 ,  C07C201/16 ,  Y10T436/143333 ,  Y10T436/25375

Abstract: Among other things, for use in directional motion of chiral objects in a mixture, a field is applied across the chamber and is rotating relative to the chamber to cause rotation of the chiral objects. The rotation of the objects causes them to move directionally based on their chirality. The method applies to sugars, proteins, and peptides, among other things, and can be used in a wide variety of applications.

Abstract translation: 除其他之外，为了在混合物中的手性物体的定向运动中使用场，跨过腔室施加场并相对于腔室旋转以引起手性物体的旋转。 物体的旋转导致它们基于手性方向移动。 该方法适用于糖，蛋白质和肽等，并可用于各种应用。

公开(公告)号：US08529771B2

公开(公告)日：2013-09-10

申请号：US13514648

申请日：2010-12-13

Applicant: Ruediger Fritz ,  Renate Hempel ,  Michael Zoellinger ,  Anne-Kathrin Merten ,  Doris Zschieschang ,  Ina Homann ,  Annett Gersdorf ,  Holger Allardt ,  Reiner Reetz ,  Elvira Flegel

Inventor： Ruediger Fritz ,  Renate Hempel ,  Michael Zoellinger ,  Anne-Kathrin Merten ,  Doris Zschieschang ,  Ina Homann ,  Annett Gersdorf ,  Holger Allardt ,  Reiner Reetz ,  Elvira Flegel

IPC: C02F1/20 ,  C02F3/00 ,  C02F9/00 ,  C02F1/68

CPC classification number: C07C201/16 ,  C07C205/06 ,  C07C205/12

Abstract: A process for working up alkaline process wastewater from the nitration of aromatic compounds to mono-, di- and trinitroaromatics, said alkaline process wastewater having a pH of 7.5 to 13, comprising the steps of a) acidifying the alkaline process wastewater by adding concentrated sulfuric acid which originates from the workup of the aqueous, sulfuric acid-containing phase obtained in the nitration to a pH below 5, which forms a mixture A consisting of organic phase which separates out and acidic aqueous phase, b) contacting the mixture A with fresh sewage sludge, and c) removing the sewage sludge.

Abstract translation: 所述碱性工艺废水的pH为7.5至13，包括以下步骤：a）通过加入浓硫酸来酸化碱性工艺废水，所述方法是将芳香族化合物硝化为单，二和三硝基芳烃的碱性工艺废水 酸，其来源于在硝化中获得的含水硫酸相的pH值低于5，其形成由分离出酸性水相的有机相组成的混合物A，b）将混合物A与新鲜的 污水污泥，以及c）清除污水污泥。

公开(公告)号：US20130150608A1

公开(公告)日：2013-06-13

申请号：US13324176

申请日：2011-12-13

Applicant: Beth A. Winsett ,  James I. Arnett, II ,  Kenwyn M. Leger ,  Brady A. Compton

Inventor： Beth A. Winsett ,  James I. Arnett, II ,  Kenwyn M. Leger ,  Brady A. Compton

IPC: C07C7/04 ,  C07C45/82 ,  C07C68/08 ,  C07C41/42 ,  C07C209/84 ,  C07C67/54 ,  C07C319/28 ,  C07C201/16 ,  C07C37/76 ,  C07C17/383

CPC classification number: C07C7/04 ,  C07C2/66 ,  C07C7/05 ,  C07C17/383 ,  C07C37/14 ,  C07C201/12 ,  C07C201/16 ,  C07C209/68 ,  C07C209/84 ,  C07C319/28 ,  C07C205/06 ,  C07C211/45 ,  C07C39/06 ,  C07C321/30 ,  C07C15/24

Abstract: This invention is directed to an improvement in the process for the production of alkylaromatic compounds that results in lower levels of residual unreacted materials in the final product. This invention comprises: 1) alkylation of an aromatic compound with an alkylating agent and a catalyst to produce an effluent stream comprising an alkylaromatic compound and unreacted materials; 2) heating the effluent stream; 3) stripping the effluent stream in a stripping device in the presence of steam; 4) separating a stripping stream from the stripping device, the stripping stream rich in unreacted materials; and 5) separating a product stream from the stripping device, the product stream rich in alkylated aromatic compound.

Abstract translation: 本发明涉及生产烷基芳族化合物的方法的改进，其导致最终产物中残留未反应物质的较低水平。 本发明包括：1）用烷基化剂和催化剂烷基化芳族化合物以产生包含烷基芳族化合物和未反应物质的流出料流; 2）加热流出物流; 3）在蒸汽存在下，在汽提装置中汽提流出物流; 4）从汽提装置中分离汽提物流，富含未反应物质的汽提流; 和5）从汽提装置中分离产物流，产物流富含烷基化芳族化合物。

公开(公告)号：US20120234773A1

公开(公告)日：2012-09-20

申请号：US13514648

申请日：2010-12-13

Applicant: Ruediger Fritz ,  Renate Hempel ,  Michael Zoellinger ,  Anne-Kathrin Merten ,  Doris Zschieschang ,  Ina Homann ,  Annett Gersdorf ,  Holger Allardt ,  Reiner Reetz ,  Elvira Flegel

Inventor： Ruediger Fritz ,  Renate Hempel ,  Michael Zoellinger ,  Anne-Kathrin Merten ,  Doris Zschieschang ,  Ina Homann ,  Annett Gersdorf ,  Holger Allardt ,  Reiner Reetz ,  Elvira Flegel

IPC: C02F1/68 ,  C02F1/20

CPC classification number: C07C201/16 ,  C07C205/06 ,  C07C205/12

Abstract: A process for working up alkaline process wastewater from the nitration of aromatic compounds to mono-, di- and trinitroaromatics, said alkaline process wastewater having a pH of 7.5 to 13, comprising the steps of a) acidifying the alkaline process wastewater by adding concentrated sulfuric acid which originates from the workup of the aqueous, sulfuric acid-containing phase obtained in the nitration to a pH below 5, which forms a mixture A consisting of organic phase which separates out and acidic aqueous phase, b) contacting the mixture A with fresh sewage sludge, and c) removing the sewage sludge.

Abstract translation: 所述碱性工艺废水的pH为7.5至13，包括以下步骤：a）通过加入浓硫酸来酸化碱性工艺废水，所述方法是将芳香族化合物硝化为单，二和三硝基芳烃的碱性工艺废水 酸，其来源于在硝化中获得的含水硫酸相的pH值低于5，其形成由分离出酸性水相的有机相组成的混合物A，b）将混合物A与新鲜的 污水污泥，以及c）清除污水污泥。

公开(公告)号：US20110092748A1

公开(公告)日：2011-04-21

申请号：US12879824

申请日：2010-09-10

Applicant: Mahesh Sawant ,  Daniel M. Trauth ,  John G. Pendergast, JR.

Inventor： Mahesh Sawant ,  Daniel M. Trauth ,  John G. Pendergast, JR.

IPC: C07C201/16 ,  F28D21/00

CPC classification number: C07C201/06 ,  B01J10/00 ,  B01J19/00 ,  C07C201/08 ,  C07C201/16 ,  C07C205/02

Abstract: Disclosed are a process and an apparatus for synthesizing nitroalkanes by reaction of a hydrocarbon feedstock with aqueous nitric acid. Energy and capital costs may be reduced by recycling a majority of the aqueous phase back to the reactor.

Abstract translation: 公开了通过烃原料与硝酸水溶液反应来合成硝基烷烃的方法和装置。 通过将大部分水相回收到反应器中，可以减少能源和资本成本。