公开(公告)号：EP1936339B1

公开(公告)日：2010-03-03

申请号：EP06026763.0

申请日：2006-12-22

Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

Inventor： Gohle, Christoph ,  Schliesser, Albert ,  Hänsch, Theodor W.

IPC: G01J3/42 ,  G01N21/31 ,  H04B10/155

CPC classification number: G01J3/433 ,  G01J3/10 ,  G01J3/26 ,  G01J3/457

公开(公告)号：EP2150786A2

公开(公告)日：2010-02-10

申请号：EP08805847.4

申请日：2008-05-26

Applicant: University Claude Bernard Lyon I ,  Centre National de la Recherche Scientifique

Inventor： KASPARIAN, Jérôme ,  WOLF, Jean-Pierre

IPC: G01J3/457

CPC classification number: G01J3/42 ,  F21S41/675 ,  G01J3/457 ,  G01N21/31 ,  G01N21/538 ,  G01N2021/1795 ,  G01N2021/4709 ,  G01S7/4802 ,  G01S17/95 ,  Y02A90/19

Abstract: The invention relates to a method of optical teledetection of compounds in a medium in which: - a detection measurement is carried out by emitting into the medium, short pulses of light at least 3 nm wide, and detecting a part of the light backscattered by the medium by means of a detection unit with temporal resolution, - a reference measurement in which the emitted light or the backscattered light is filtered by virtue of addressable filtering means, simulating the optical spectrum of the light at the working wavelengths of at least one given compound to be searched for, - a comparison of a detection measurement and of a reference measurement, so as to deduce therefrom the possible presence of the compound or compounds searched for in the medium, - the addressable filtering means are modified dynamically, and a series of reference measurements and a series of corresponding comparisons are performed for a series of different compounds liable to be present in the medium, as well as a device adapted for implementing such a method.

公开(公告)号：EP1938062A1

公开(公告)日：2008-07-02

申请号：EP06820258.9

申请日：2006-10-05

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE

Inventor： FICHET, Pascal

IPC: G01J3/443 ,  G01N21/71

CPC classification number: G01J3/443 ,  G01J3/457 ,  G01N21/718

Abstract: The invention relates to an optical emission spectroscopy method for qualitatively and quantitatively analyzing samples involving excitation by laser (18) using a database created on monoelementary aqueous solutions all having the same concentration of a pure element, this database containing, for each element, wavelengths of emission lines and their respective intensity.

公开(公告)号：EP1100966A4

公开(公告)日：2006-03-22

申请号：EP99935853

申请日：1999-07-23

Applicant: APPLIED SPECTRAL IMAGING LTD

Inventor： MCNAMARA GEORGE ,  SOENKSEN DIRK ,  CABIB DARIO ,  BUCKWALD ROBERT

IPC: G01N33/53 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/42 ,  C12Q1/68 ,  G01J3/28 ,  G01J3/457 ,  G01N21/78 ,  G01N33/50 ,  G01N33/533 ,  G01N33/569 ,  G01N33/58

CPC classification number: G01J3/457 ,  G01J3/2823 ,  G01J2003/2866 ,  G01N33/5005 ,  G01N33/56966

Abstract: A method of in situ analysis of a biological sample comprising the steps of (a) staining the biological sample with N stains of which a first stain is selected from the group consisting of a first immunohistochemical stain, a first histological stain and a first DNA ploidy stain, and a second stain is selected from the group consisting of a second immunohistochemical stain, a second histological stain and a second DNA ploidy stain, with provisions that N is an integer greater than three and further that (i) if the first stain is the first immunohistochemical stain then the second stain is either the second histological stain or the second DNA ploidy stain; (ii) if the first stain is the first histological stain then the second stain is either the second immunohistochemical stain or the second DNA ploidy stain; whereas (iii) if the first stain is the first DNA ploidy stain then the second stain is either the second immunohistochemical stain or the second histological stain; and (b) using a spectral data collection device for collecting spectral data from the biological sample, the spectral data collection device and the N stains are selected such that a spectral component associated with each of the N stains is collectable.

公开(公告)号：EP0867711B1

公开(公告)日：2003-07-09

申请号：EP98104556.0

申请日：1998-03-13

Applicant: ALV-Laser Vertriebsgesellschaft mbH

Inventor： Peters, Wilhelm, Ing.(grad.)

IPC: G01N21/51 ,  G01N21/47

CPC classification number: G01J3/4412 ,  G01J3/457 ,  G01J2003/2866

公开(公告)号：EP0822395B1

公开(公告)日：2003-03-26

申请号：EP97113097.6

申请日：1997-07-30

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： Schrof, Wolfgang, Dr. ,  Klingler, Jürgen, Dr. ,  Horn, Dieter, Dr.

IPC: G01J3/44 ,  G01J3/457 ,  G01N15/02

CPC classification number: G01J3/457 ,  G01J3/44 ,  G01J2003/2866

公开(公告)号：EP1254353A1

公开(公告)日：2002-11-06

申请号：EP01903729.0

申请日：2001-02-09

Applicant: Evotec OAI AG

Inventor： KASK, Peet

IPC: G01J3/44

CPC classification number: G01N21/6458 ,  G01J3/4406 ,  G01J3/457 ,  G01J2003/2866 ,  G01N21/64 ,  G01N21/6408 ,  G01N2021/6421 ,  G01N2021/6463

Abstract: The present invention relates to a method for characterizing samples having fluorescent particles, comprising the steps of: (a) monitoring intensity fluctuations of fluorescence emitted by the particles in at least one measurement volume by detecting sequences of photon counts by at least one photon detector, (b) determining from the sequences of photon counts intermediate statistical data comprising at least two probability functions, P1(n1),P2(n2),..., of the number of photon counts, n1, n2,..., detected in different sets of counting time intervals, (c) determining from said intermediate statistical data a distribution of particles as a function of at least two arguments, wherein one argument is a specific brightness of the particles, or a measure thereof, and another argument is a diffusion coefficient of the particles, or a measure thereof.

公开(公告)号：EP1169626A1

公开(公告)日：2002-01-09

申请号：EP00918863.2

申请日：2000-04-07

Applicant: Campus Technologies AG

Inventor： WEITZEL, Thilo

IPC: G01J3/453 ,  G01J9/02

CPC classification number: G01J9/02 ,  G01J3/453 ,  G01J3/457 ,  G01J2003/2866

Abstract: The invention relates to a device for optical spectroscopy with means for generating an interference pattern and with a spatially resolving detector that can receive the generated interference pattern. According to the invention, the wave fronts of at least one component beam being involved in the interference pattern are influenced by spectrally dispersive or diffractive optical elements according to the wavelength.

公开(公告)号：EP1033568A3

公开(公告)日：2001-10-10

申请号：EP00103366.1

申请日：2000-02-22

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： Schroff, Wolfgang, Dr. ,  Klingler, Jürgen, Dr. ,  Horn, Dieter, Dr.

IPC: G01N21/65 ,  G01J3/453

CPC classification number: B82Y15/00 ,  G01J3/44 ,  G01J3/457 ,  G01J2003/2866 ,  G01N21/65 ,  G01N21/658

Abstract: Die Erfindung betrifft ein Verfahren zur Bestimmung des Übergangs mindestens eines Referenzwirkstoffs innerhalb eines Meßvolumens einer Probe von an einem in der Probe befindlichen Substrat gebundenen Zustand in einen frei diffundierenden Zustand oder umgekehrt durch Registrierung des Translationsdiffusionsverhaltens des mindestens einen Referenzwirkstoffs mittels der Ramankorrelationsspektroskopie. Ferner betrifft die Erfindung die Verwendung einer Vorrichtung zur Bestimmung des Übergangs mindestens eines Referenzwirkstoffs innerhalb eines Meßvolumens einer Probe von an einem in der Probe befindlichen Substrat gebundenen Zustand in einen frei diffundierenden Zustand oder umgekehrt, wobei die Vorrichtung mindestens die folgenden Elemente aufweist: a. eine Lichtquelle mit variabler Belichtungswellenlänge; b. eine Fokussierungseinrichtung zum Einstellen eines definierten zu untersuchenden Meßvolumens innerhalb einer Probe; c. mindestens eine Einrichtung zur Detektion von durch den Referenzwirkstoff erzeugtem Raman-Streulicht mit guter Zeitauflösung; d. eine Einrichtung zur Durchführung einer Fluktuationsanalyse zur Wirkstoffsuche.

公开(公告)号：EP0867711A3

公开(公告)日：1999-04-14

申请号：EP98104556.0

申请日：1998-03-13

Applicant: ALV-Laser Vertriebsgesellschaft mbH

Inventor： Peters, Wilhelm, Ing.(grad.)

IPC: G01N21/51

CPC classification number: G01J3/4412 ,  G01J3/457 ,  G01J2003/2866

Abstract: Meßgerät zur Bestimmung der statischen und/oder dynamischen Lichtstreuung, das eine Lichtquelle zur Erzeugung eines Laserstrahles aufweist, mit dem eine in einer zylindrischen Küvette enthaltende Probe beleuchtet werden kann, die im Zentrum eines Drehtisches koaxial zu dessen Rotationsachse und orthogonal zum Laserstrahl angeordnet ist, wobei auf dem Drehtisch eine Vielzahl von Detektoren zur Messung des von der Probe gestreuten Lichtes in beliebigen Winkeln nebeneinander angeordnet sind.