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    N-(3,3-diphenylpropyl) aminoethyl esters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid, compositions and use
    311.
    发明授权
    N-(3,3-diphenylpropyl) aminoethyl esters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid, compositions and use 失效
    1,4-二氢-2,6-二甲基 - 吡啶-3,5-二羧酸的N-（3,3-二苯基丙基）氨基乙基酯，组合物和用途

    公开(公告)号：US4705797A

    公开(公告)日：1987-11-10

    申请号：US701672

    申请日：1985-02-14

    Applicant: Dante Nardi ,  Amedeo Leonardi ,  Gabriele Graziani ,  Giorgio Bianchi

    Inventor： Dante Nardi ,  Amedeo Leonardi ,  Gabriele Graziani ,  Giorgio Bianchi

    IPC: A61K31/41 ,  A61K31/435 ,  A61K31/44 ,  A61K31/455 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07C67/00 ,  C07C201/00 ,  C07C205/56 ,  C07D211/90 ,  C07D413/04 ,  C07D413/14

    CPC classification number: C07D413/04 ,  C07C205/56 ,  C07D211/90

    Abstract: Novel antihypertensive and coronary dilating asymmetric diesters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid (or the stereoisomers or pharmaceutically acceptable acid addition salts thereof) have the general formula (I): ##STR1## wherein Ph is phenyl, Ar is 2-nitrophenyl, 3-nitrophenyl, 2,3-dichlorophenyl or benzofurazan-4-yl, A is a straight or branched chain alkylene radical having from 2 to 6 carbon atoms, R is a straight or branched chain alkyl radical having from 1 to 6 carbon atoms, optionally mono-substituted by an alkoxy substituent having from 1 to 6 carbon atoms, R.sub.1 is hydrogen, hydroxy or an alkyl radical having from 1 to 4 carbon atoms, and R.sub.2 is hydrogen or methyl. The subject diesters are facilely prepared from the aldehydes ArCHO and esters of acetoacetic and 3-aminocrotonic acids.

    Abstract translation: 1,4-二氢-2,6-二甲基 - 吡啶-3,5-二羧酸（或其立体异构体或其药学上可接受的酸加成盐）的新型抗高血压和冠状动脉扩张不对称二酯具有通式（I）：（I）其中Ph是苯基，Ar是2-硝基苯基，3-硝基苯基，2,3-二氯苯基或苯并呋咱-4-基，A是具有2至6个碳原子的直链或支链亚烷基，R是 具有1至6个碳原子的直链或支链烷基，任选被具有1至6个碳原子的烷氧基取代基单取代，R 1是氢，羟基或具有1至4个碳原子的烷基，R 2 是氢或甲基。 受试二酯由醛ArCHO和乙酰乙酸和3-氨基巴豆酸的酯容易地制备。

    Preparation of 2,4-dichloro-3-alkyl-6-nitrophenols
    313.
    发明授权
    Preparation of 2,4-dichloro-3-alkyl-6-nitrophenols 失效
    2,4-二氯-3-烷基-6-硝基苯酚的制备

    公开(公告)号：US4670608A

    公开(公告)日：1987-06-02

    申请号：US826710

    申请日：1986-03-19

    Applicant: Christian Paetz ,  Karlfried Wedemeyer

    Inventor： Christian Paetz ,  Karlfried Wedemeyer

    IPC: C07B61/00 ,  B01J27/00 ,  C07C67/00 ,  C07C201/00 ,  C07C201/12 ,  C07C205/12 ,  C07C205/26 ,  C07C215/76 ,  G03C7/34 ,  C07C79/32

    CPC classification number: G03C7/346 ,  C07C201/12 ,  C07C201/16 ,  C07C213/02

    Abstract: 2,4-Dichloro-3-alkyl-6-nitrophenols are prepared by chlorinating, with chlorine in the presence of a catalyst, 1-alkyl-4-nitrobenzenes having a C.sub.2 -C.sub.8 -alkyl radical until the content of trichloroalkylnitrobenzenes is at least 60% by weight in the chlorination mixture, removing the catalyst from the chlorination mixture, then hydrolyzing the chlorination mixture, removing the precipitated reaction product, and treating it with an aqueous inorganic acid. The 2,4-dichloro-3-alkyl-6-nitrophenols are new.

    Abstract translation: 2,4-二氯-3-烷基-6-硝基苯酚的制备方法是在催化剂存在下用氯氯化具有C 2 -C 8烷基的1-烷基-4-硝基苯，直到三氯烷基硝基苯的含量至少为 在氯化混合物中为60重量％，从氯化混合物中除去催化剂，然后水解氯化混合物，除去沉淀的反应产物，并用无机酸水溶液处理。 2,4-二氯-3-烷基-6-硝基苯酚是新的。

    Heat developable light-sensitive material
    314.
    发明授权
    Heat developable light-sensitive material 失效
    热可显影的感光材料

    公开(公告)号：US4668615A

    公开(公告)日：1987-05-26

    申请号：US767981

    申请日：1985-08-21

    Applicant: Ken Kawata ,  Yoshiharu Yabuki ,  Kozo Sato ,  Hiroyuki Hirai

    Inventor： Ken Kawata ,  Yoshiharu Yabuki ,  Kozo Sato ,  Hiroyuki Hirai

    IPC: G03C8/40 ,  C07C51/00 ,  C07C57/30 ,  C07C61/39 ,  C07C62/32 ,  C07C67/00 ,  C07C201/00 ,  C07C205/56 ,  C07C239/00 ,  C07C279/02 ,  C07C313/00 ,  C07C317/44 ,  C07D213/55 ,  C07D215/12 ,  C07D215/14 ,  C07D263/56 ,  G03C1/06 ,  G03C1/498 ,  G03C7/00 ,  G03C1/40 ,  G03C5/54

    CPC classification number: C07C61/39 ,  C07C205/56 ,  C07C57/30 ,  C07C62/32 ,  G03C1/49845 ,  Y10S430/156

    Abstract: A heat developable light-sensitive material containing a compound represented by the general formula (I):[Ar.sub.n (R).sub.3-n CCO.sub.2 H].sub.l .multidot.B.sub.m (I)wherein ar represents an aryl group or a heterocyclic group; R represents a substituent other than an aryl group and a heterocyclic group; Ar and R may be bonded in a part thereof to form a ring; B represents a mono- or diacidic base which has a pKa of 7 or more and contains 12 or less carbon atoms; n represents an integer from 1 to 3; l and m each represents an integer of 1 or 2 and maintain a relationship in that a number of positive charge and a number of negative charge are equal; when n represents 1 or 2, two R's or Ar's may be the same or different, when n represents 3, three Ar's may be the same or different; and the substituent represented by Ar or R may be further substituted with a substituent. The compound represented by the general formula (I) is a base precursor which is stable at normal temperature but rapidly decomposes to release a base by heating and therefore the heat developable light-sensitive material containing the base precursor has excellent preservability and provides images having good image quality, i.e., low fog density and high image density upon a short period of developing time.

    Abstract translation: 含有通式（I）表示的化合物的热显影性感光材料：[Arn（R）3-nCCO2H] lxBm（I）其中ar表示芳基或杂环基; R表示除芳基和杂环基以外的取代基; Ar和R可以部分结合形成环; B表示pKa为7以上且含有12个以下碳原子的单或二酸碱基; n表示1〜3的整数， l和m各自表示1或2的整数，并且保持正电荷数和负电荷数相等的关系; 当n表示1或2时，两个R或Ar可以相同或不同，当n表示3时，三个Ar可以相同或不同; 并且由Ar或R表示的取代基可以进一步被取代基取代。 由通式（I）表示的化合物是在常温下稳定但快速分解以通过加热而释放碱的基础前体，因此含有碱性前体的可热显影的感光材料具有优异的保存性并提供具有良好的图像 图像质量，即在较短的显影时间内的低雾密度和高图像密度。

    Process and installation for manufacturing nitromethane
    315.
    发明授权
    Process and installation for manufacturing nitromethane 失效
    生产硝基甲烷的工艺和安装

    公开(公告)号：US4626607A

    公开(公告)日：1986-12-02

    申请号：US695047

    申请日：1985-01-25

    Applicant: Bernard Jacquinot ,  Jacques Quibel ,  Roger Mari

    Inventor： Bernard Jacquinot ,  Jacques Quibel ,  Roger Mari

    IPC: C07C1/00 ,  C07C67/00 ,  C07C201/00 ,  C07C201/08 ,  C07C205/02 ,  C07C79/04

    CPC classification number: C07C201/08

    Abstract: The invention concerns the manufacture of nitromethane by nitration of mene in a homogeneous gaseous phase, the nitrating agent being nitric acid, nitrogen peroxide or mixtures thereof. According to the disclosed process, the molar ratio methane/nitrating agent is between 0.1 and 5; the reaction contact time between 0.1 and 120 seconds; the reaction pressure between 1 and 35 bars; the temperature between 270.degree. and 600.degree. C. The nitration is carried out in the presence of an active agent of the halogen or derivative type introduced in a molar ratio at the most equal to 3. An installation is disclosed for industrially manufacturing nitromethane.

    Abstract translation: 本发明涉及通过在均相气相中硝化甲烷来制造硝基甲烷，硝化剂是硝酸，过氧化氮或其混合物。 根据所公开的方法，甲烷/硝化剂的摩尔比在0.1和5之间; 反应接触时间在0.1〜120秒之间; 反应压力在1至35巴之间; 温度在270℃至600℃之间。硝化在以等于3的摩尔比引入的卤素或衍生物类型的活性剂存在下进行。在工业上制造硝基甲烷的设备被公开。

    Process for the preparation of phenylglyoxylic acid esters
    317.
    发明授权
    Process for the preparation of phenylglyoxylic acid esters 失效
    苯乙醛酸酯的制备方法

    公开(公告)号：US4596885A

    公开(公告)日：1986-06-24

    申请号：US875707

    申请日：1978-02-06

    Applicant: Winfried Lunkenheimer ,  Andreas Wittig ,  Wilfried Draber ,  Helmut Timmler

    Inventor： Winfried Lunkenheimer ,  Andreas Wittig ,  Wilfried Draber ,  Helmut Timmler

    IPC: C07C69/716 ,  C07C67/00 ,  C07C69/738 ,  C07C201/00 ,  C07C205/56 ,  C07D253/06 ,  C07D253/07 ,  C07C69/76

    CPC classification number: C07D253/06 ,  C07D253/07

    Abstract: A process for the preparation of a phenylglyocylic acid ester of the formula ##STR1## wherein R.sup.1 represents alkyl,X represents halogen, alkyl, halogenoalkyl, alkoxy or nitro, andn represents 0, 1, 2, or 3by contacting a benzoyl cyanide of the formula ##STR2## wherein X and n have the meanings stated above, in a sulphuric acid/water system in the presence of chloride ions at a temperature between 0.degree. and 70.degree. C. to form phenylglyoxylic acid amide and reacting the phenylglyoxylic acid amide without isolation with an alcohol of the formula R.sup.1 -OH, wherein R.sup.1 has the meaning stated above, optionally in the presence of a diluent, at a temperature between 40.degree. and 100.degree. C.

    Abstract translation: 制备式（Ⅶ）的苯基乙二酸酯的方法，其中R 1表示烷基，X表示卤素，烷基，卤代烷基，烷氧基或硝基，n表示0,1,2或3， 在硫酸/水体系中，在氯离子存在下，在0〜70℃的温度下，式（ⅩⅧ）的苯甲酰氰（其中X和n具有上述含义），形成苯基乙醛酸酰胺 并且使苯基乙醛酸酰胺与分子式为R 1 -OH的醇反应，其中R 1具有上述含义，任选在稀释剂存在下，在40℃至100℃的温度下反应。

    Process for selective C-alkylation of phenols
    318.
    发明授权
    Process for selective C-alkylation of phenols 失效
    苯酚选择性C烷基化方法

    公开(公告)号：US4594460A

    公开(公告)日：1986-06-10

    申请号：US713691

    申请日：1985-03-19

    Applicant: Gerard Mignani ,  Didier Morel

    Inventor： Gerard Mignani ,  Didier Morel

    IPC: C07C39/06 ,  B01J31/00 ,  C07B37/02 ,  C07B61/00 ,  C07C27/00 ,  C07C37/14 ,  C07C39/08 ,  C07C39/19 ,  C07C39/225 ,  C07C39/24 ,  C07C41/00 ,  C07C41/30 ,  C07C43/23 ,  C07C43/315 ,  C07C45/00 ,  C07C47/27 ,  C07C47/565 ,  C07C49/835 ,  C07C67/00 ,  C07C69/013 ,  C07C69/732 ,  C07C69/84 ,  C07C69/92 ,  C07C201/00 ,  C07C205/22 ,  C07C213/08 ,  C07C215/76 ,  C07C253/00 ,  C07C255/36

    CPC classification number: C07C67/343 ,  C07C213/08 ,  C07C37/14 ,  C07C41/30

    Abstract: Substituted phenols of formula ##STR1## in which R.sub.1 is in an ortho or para position relative to the phenol function and denotes ##STR2## R.sub.2 denotes an acyclic radical optionally substituted by alkyl, hydroxy, alkoxycarbonyl, cyano or formyl, or a phenyl or naphthyl radical, and R denotes hydrogen or 1 to 4 substituents chosen from halogen, OH optionally in the form of ether or ester, alkyl, NO.sub.2, CHO optionally in the form of acetal, CH.sub.3 CO--, C.sub.6 H.sub.5 CO--, NH.sub.2, alkylamino, dialkylamino or alkoxycarbonyl, it being understood that 2 symbols R may form with the phenyl nucleus a condensed aromatic ring, which comprises reacting a butadiene of formula ##STR3## with a phenol for formula ##STR4## in water in the presence of a rhodium-based catalyst, a water-soluble phosphine and optionally an inorganic or organic base. The products of formula (I) are intermediates for the synthesis of vitamin E, antioxidants, perfumes or insecticides.

    Abstract translation: 其中R 1相对于苯酚官能团为邻位或对位的式（I）的取代酚，表示任选被烷基，羟基，烷氧基羰基，氰基或甲酰基取代的无环基，或 苯基或萘基，R表示氢或1至4个选自卤素，任选以醚或酯形式的OH的取代基，烷基，NO 2，CHO，任选以缩醛，CH 3 CO-，C 6 H 5 CO-，NH 2，烷基氨基， 二烷基氨基或烷氧基羰基，应理解为可以与苯基一起形成2个符号R的稠合芳香环，其包括在式（III）中的水中使式（VIII）的二醇与式 存在铑基催化剂，水溶性膦和任选的无机或有机碱。 式（I）的产物是用于合成维生素E，抗氧化剂，香料或杀虫剂的中间体。

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