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    A PROCESS FOR SUBSTITUTION ON AROMATIC RINGS
    341.
    发明申请
    A PROCESS FOR SUBSTITUTION ON AROMATIC RINGS 审中-公开
    取代芳香环的方法

    公开(公告)号：WO2010061382A3

    公开(公告)日：2010-08-19

    申请号：PCT/IL2009001099

    申请日：2009-11-23

    Applicant: SAPHIER MAGAL

    Inventor： SAPHIER MAGAL

    IPC: C07C201/08 ,  C07C213/02 ,  C07C215/76

    CPC classification number: C07C201/08 ,  C07B43/02 ,  C07C209/02 ,  C07C209/66 ,  C07C213/02 ,  C07C227/16 ,  C07C211/46 ,  C07C215/76 ,  C07C229/36 ,  C07C205/06 ,  C07C205/12 ,  C07C205/22

    Abstract: A process for preparing a substituted aromatic compound, comprising combining an aromatic compound and cuprous (Cu+) ions in a reaction vessel in an essentially oxygen-free environment, and adding to said reaction vessel a source of an electrophile or a nucleophile substituent, to form an aromatic compound product which is ring-substituted with said electrophile or nucleophile at a position which was originally occupied by hydrogen, and isolating the substituted aromatic compound from the reaction mixture.

    Abstract translation: 一种制备取代的芳族化合物的方法，包括在基本上无氧的环境下将芳族化合物和亚铜（Cu +）离子结合在反应容器中，并向所述反应容器中加入亲电试剂或亲核取代基的来源以形成 在最初被氢占据的位置上被所述亲电试剂或亲核试剂环取代的芳族化合物产物，并从反应混合物中分离取代的芳族化合物。

    PROCESS FOR PRODUCING BIS(4-HYDROXY-3-NITROPHENYL) COMPOUND
    344.
    发明申请
    PROCESS FOR PRODUCING BIS(4-HYDROXY-3-NITROPHENYL) COMPOUND 审中-公开
    生产双（4-羟基-3-硝基苯基）化合物的方法

    公开(公告)号：WO01081293A1

    公开(公告)日：2001-11-01

    申请号：PCT/JP2001/003434

    申请日：2001-04-23

    IPC: C07C201/08 ,  C07C205/22 ,  C07C205/38 ,  C07C315/04 ,  C07C317/22 ,  C07C319/20 ,  C07C323/20

    CPC classification number: C07C201/08 ,  C07C315/04 ,  C07C317/22 ,  C07C205/22 ,  C07C205/38

    Abstract: A process for producing a bis(4-hydroxy-3-nitrophenyl) compound, characterized in that a bis(4-hydroxyphenyl) compound comprising two phenyl groups bonded to each other directly or through an electron-donating bridging group, sulfoxide group, sulfone group, or carbonyl group is nitrated with nitric acid in an inert solvent substantially in the absence of any other acid. By the process, the target compound reduced in the content of trinitro-substituted compounds can be produced in high yield. Recrystallizing the compound easily gives in high yield a high-purity product suitable for use as a raw material for a heat-resistant polymer, etc., because the content of trinitro-substituted compounds in that compound is low.

    Abstract translation: 一种制备双（4-羟基-3-硝基苯基）化合物的方法，其特征在于包含直接或通过给电子桥连基团彼此键合的两个苯基的双（4-羟基苯基）化合物，亚砜基，砜 基团或羰基在惰性溶剂中用硝酸硝化，基本上不存在任何其它酸。 通过该方法，可以高产率制备三硝基取代的化合物含量降低的目标化合物。 由于该化合物中的三硝基取代的化合物的含量低，因此可以容易地使化合物重结晶适合用作耐热聚合物等的原料的高纯度产品。

    PROCESS FOR THE PREPARATION OF INSECTICIDAL PHEYNYLHYDRAZINE DERIVATIVES
    345.
    发明申请
    PROCESS FOR THE PREPARATION OF INSECTICIDAL PHEYNYLHYDRAZINE DERIVATIVES 审中-公开
    杀虫剂衍生物衍生物的制备方法

    公开(公告)号：WO01032599A1

    公开(公告)日：2001-05-10

    申请号：PCT/US2000/028593

    申请日：2000-10-16

    IPC: C07C205/22 ,  C07C205/37 ,  C07C213/02 ,  C07C217/84 ,  C07C241/02 ,  C07C243/22 ,  C07C245/22 ,  C07C281/02 ,  C07C201/08

    CPC classification number: C07C201/08 ,  C07C201/12 ,  C07C213/02 ,  C07C241/02 ,  C07C245/22 ,  C07C281/02 ,  C07C217/84 ,  C07C243/22 ,  C07C205/22 ,  C07C205/37

    Abstract: Disclosed herein is an improvement in a method for making compounds having the structural formulae (I) or (II) wherein: X is a) phenyl; lower phenylalkoxy, phenoxy; or benzyl; or b) one subtituent from group a) and one or more substituents selected from C1-C4 alkoxy; hydroxyl; halogen; lower alkyl; and lower alkylthio; or c) along with the phenyl to which it is attached, forms a multiple fused ring heterocycle such as dibenzofuranyl; Y is H, C1-C4 alkanoyl, C1-C4 haloalkanoyl, dialkoxyphosphoryl, alkylaminocarbonyl, haloalkylsulfonyl, or C1-C4 alkoxy carbonyl; and R is H, C1-C6 alkyl, C1-C6 alkoxy, C3-C6 cycloalkoxy, haloalkyl, alkoxyalkyl, arylalkoxy, alkenyl, alkylthio, alkoxycarbonyl, alkylamino, heteroaryl, arylalkyl, haloalkoxy, aryloxy, or C3-C6 cycloalkyl; and Z is O or S, wherein the improvement comprises the steps of: A) selecting as a starting material a compound of structural formula (III); B) dissolving compound III in an organic solvent selected from the group consisting of methyl t-butyl ether, ethylene glycol dimethyl ether, 2-methoxyethyl ether, acetonitrile, and acetic acid, and C) nitrating with nitric acid to form a compound of structural formula (IV).

    Abstract translation: 本文公开了制备具有结构式（I）或（II）的化合物的方法的改进，其中：X为a）苯基; 低级苯基烷氧基，苯氧基; 或苄基; 或b）a）的一个取代基和一个或多个选自C 1 -C 4烷氧基的取代基; 羟; 卤素; 低级烷基 和低级烷硫基; 或c）与其连接的苯基一起形成多重稠环杂环，例如二苯并呋喃基; Y是H，C 1 -C 4烷酰基，C 1 -C 4卤代烷酰基，二烷氧基磷酰基，烷基氨基羰基，卤代烷基磺酰基或C 1 -C 4烷氧基羰基; C 1 -C 6烷基，C 1 -C 6烷氧基，C 3 -C 6环烷氧基，卤代烷基，烷氧基烷基，芳基烷氧基，烯基，烷硫基，烷氧基羰基，烷基氨基，杂芳基，芳烷基，卤代烷氧基，芳氧基或C 3 -C 6环烷基; 并且Z是O或S，其中改进包括以下步骤：A）选择结构式（III）的化合物作为原料; B）将化合物III溶解在选自甲基叔丁基醚，乙二醇二甲醚，2-甲氧基乙基醚，乙腈和乙酸的有机溶剂中，C）用硝酸硝化形成结构式 式（IV）。

    PROCESS FOR MAKING CERTAIN BENZOIC ACID COMPOUNDS
    346.
    发明申请
    PROCESS FOR MAKING CERTAIN BENZOIC ACID COMPOUNDS 审中-公开
    制备某些苯甲酸化合物的方法

    公开(公告)号：WO99035117A1

    公开(公告)日：1999-07-15

    申请号：PCT/IB1998/002116

    申请日：1998-12-28

    IPC: C07C51/15 ,  C07C51/347 ,  C07C51/363 ,  C07C51/367 ,  C07C63/70 ,  C07C65/21 ,  C07C69/76 ,  C07C201/08 ,  C07C205/58 ,  C07C63/04 ,  C07C65/28

    CPC classification number: C07C201/08 ,  C07C51/15 ,  C07C51/353 ,  C07C51/363 ,  C07C51/367 ,  Y02P20/582 ,  C07C63/70 ,  C07C65/21 ,  C07C63/04 ,  C07C65/28 ,  C07C205/58

    Abstract: The subject invention involves processes for making 2,4-difluoro-3-Q1-benzoic acid, wherein Q1 is derived from an electrophilic reagent, comprising the steps of: (a) treating 1-bromo-2,4-difluorobenzene with a strong, non-nucleophilic base; then treating with an electrophilic reagent which provides Q1, or a functional moiety which is then transformed to Q1, producing 1-bromo-2,4-difluoro-3-Q1-benzene; (b) treating the 1-bromo-2,4-difluoro-3-Q1-benzene with an alkali or alkaline earth metal or organometallic reagent; then treating with carbon dioxide, or with a formylating agent followed by oxidation, to produce 2,4-difluoro-3-Q1-benzoic acid. The subject invention also involves optional additional steps to further modify Q1, or to substitute a non-hydrogen moiety at the 5-position, at the 6-position, or at both, of the phenyl ring of the 2,4-difluoro-3-Q1-benzoic acid.

    Abstract translation: 本发明涉及制备2,4-二氟-3-Q1-苯甲酸的方法，其中Q1衍生自亲电子试剂，其包括以下步骤：（a）用强力处理1-溴-2,4-二氟苯 ，非亲核碱 然后用提供Q1的亲电子试剂处理，或将官能部分转化成Q1，生成1-溴-2,4-二氟-3-Q1-苯; （b）用碱金属或碱土金属或有机金属试剂处理1-溴-2,4-二氟-3-Q1-苯; 然后用二氧化碳或甲酰化剂处理，然后氧化，得到2,4-二氟-3-Q1-苯甲酸。 本发明还涉及可选的附加步骤，以进一步修饰Q1，或者在2,4-二氟-3苯基的苯环的6位或2位的5-位上的非氢部分 -Q1-苯甲酸。

    CATALYTIC NITRATION
    347.
    发明申请
    CATALYTIC NITRATION 审中-公开
    催化硝化

    公开(公告)号：WO1996036587A1

    公开(公告)日：1996-11-21

    申请号：PCT/GB1996001186

    申请日：1996-05-17

    Applicant: ZENECA LIMITED ,  DEBOOS, Gareth, Andrew ,  SMITH, Keith ,  MUSSON, Adam, Johnathon

    Inventor： ZENECA LIMITED

    IPC: C07C201/08

    CPC classification number: C07C201/08 ,  C07D333/42 ,  Y02P20/582 ,  C07C205/06 ,  C07C205/12 ,  C07C205/37

    Abstract: A solvent free process for the nitration of an aromatic compound using an aluminosilicate catalyst which has been treated with nitric acid and an acid anhydride. The process enables nitrated aromatic compounds to be produced in high yields and with good regioselectivity. The process also avoids the need to recover the nitrated product from large volumes of solvent and avoids treatment of inorganic acid waste, both of which may be undesirable for environmental reasons.

    Abstract translation: 使用已经用硝酸和酸酐处理的硅铝酸盐催化剂硝化芳族化合物的无溶剂方法。 该方法能够以高产率和良好的区域选择性生产硝化芳族化合物。 该方法还避免了从大量溶剂中回收硝化产物的需要，并且避免了无机酸废物的处理，因为这两个因素在环境方面都是不希望的。

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