公开(公告)号：WO1993013048A1

公开(公告)日：1993-07-08

申请号：PCT/US1992010984

申请日：1992-12-16

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  IYER, Lokanathan, M. ,  LYON, Kenneth, S. ,  BROTHERTON, Vince

IPC: C07C211/63

CPC classification number: C07C219/08 ,  C07C233/38 ,  C08F20/34 ,  C08F20/60

Abstract: High molecular weight buffering compositions and polymeric buffering compositions incorporating such compositions are described. The compositions are useful in applications where lower molecular weight buffers are unsatisfactory because of their tendency to leak out of an encapsulating membrane. Methods of making such compositions are described, as well as a particular application in a fiber optic carbon dioxide physiological probe.

公开(公告)号：WO1993012975A1

公开(公告)日：1993-07-08

申请号：PCT/US1992011078

申请日：1992-12-17

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  JONAS, Henrietta ,  GYGAX, Ralph, Allen ,  MALONE, William, Thomas

IPC: B65D01/02

CPC classification number: B65D1/165 ,  B65D1/16

Abstract: There is disclosed a retortable plastic container (10) having a sidewall (11) and bottom wall (12) integrally formed as a single piece. The bottom wall has a heel portion (15) and a recessed center portion (16). The heel has a resting surface (14) and an inside corner (22). The recessed center portion has an outside corner (20). The container has an outside surface. The container is made in accordance with equations relating to reforming pressure and low fill equilibrium pressure and may be fabricated utilizing a variety of manufacturing modes since the providing of acceptable container configurations is not based on relative wall thicknesses. The bottom configuration, independent of relative wall thickness, eliminates paneling and other problems normally associated with plastic containers when they are subjected to sterilization.

Abstract translation: 公开了具有一体形成为单件的侧壁（11）和底壁（12）的可蒸煮塑料容器（10）。 底壁具有脚跟部分（15）和凹入的中心部分（16）。 鞋跟具有搁置表面（14）和内角（22）。 凹入的中心部分具有外角（20）。 容器有一个外表面。 容器根据与重整压力和低填充平衡压力有关的方程制成，并且可以利用各种制造模式来制造，因为提供可接受的容器构造不是基于相对的壁厚。 底部结构，独立于相对的壁厚，消除了当塑料容器进行灭菌时通常与塑料容器相关的镶板和其他问题。

公开(公告)号：WO1993012833A1

公开(公告)日：1993-07-08

申请号：PCT/US1992011055

申请日：1992-12-22

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  RUDZENA, William, L. ,  ADOLF, Wayne, F. ,  CARON, Lois, L. ,  TRIPP, Edward, S.

IPC: A61M37/00

CPC classification number: A61M39/10 ,  A61M39/02 ,  A61M2039/1027 ,  A61M2039/1083

Abstract: A drug infusion manifold (10) that includes a housing defining a plurality of spaced apart fluid chambers (26) have a closed first end portion (28) and an opposing second end portion (30). The second end portions of immediately adjacent chambers are in fluid communication through channels (32) extending therebetween. A plurality of spaced apart fluid inlets (34) are formed in the housing in fluid communication with a corresponding fluid chamber. A check valve means (36) is provided in each fluid chamber for directing drugs and/or solutions from the inlets into the chamber and precluding fluid from the chamber. An outlet (38) is formed in the housing in direct fluid communication with at least one of the chambers.

公开(公告)号：WO1993012767A1

公开(公告)日：1993-07-08

申请号：PCT/US1992009895

申请日：1992-11-16

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  VAN SCOIK, Kurt, G. ,  KESKE, Ernest, R. ,  CIPOLLO, Kent, L. ,  WEIS, Jeffery, K.

IPC: A61K09/14

CPC classification number: A61K9/2886 ,  A61K9/2077 ,  A61K9/2095 ,  Y10S514/891 ,  Y10S514/96

Abstract: A tablet is prepared from a powdered mixture by compacting the powder to remove air therefrom and causing physical granulation therein to yield a compact material containing granules. The granules are liberated from the compacted material and compressed into a tablet which is then provided with a coating. The starting powder mixture contains at least one material selected from amino acids, keto acids and polypeptides. The resultant tablet may be used in the treatment of chronic renal failure.

Abstract translation: 通过粉碎粉末从其中除去空气并在其中引起物理造粒以产生含有颗粒的致密材料，从粉末混合物制备片剂。 颗粒从压实的材料中释放并压制成片剂，然后提供涂层。 起始粉末混合物含有至少一种选自氨基酸，酮酸和多肽的材料。 所得片剂可用于治疗慢性肾功能衰竭。

公开(公告)号：WO1993012661A1

公开(公告)日：1993-07-08

申请号：PCT/US1992010935

申请日：1992-12-17

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  NARDELLI, Christy, A. ,  HOGARTH, Arthur, J., C., L., ,  SIMPSON, James, M. ,  DAAB-KRZYKOWSKI, Andre ,  MAZER, Terrence, B.

IPC: A23C09/00

CPC classification number: A23C7/043 ,  A23C9/1465 ,  A23J3/08

Abstract: A method of separating phosphorus from condensed skim milk and from whey protein involves exposing the respective starting material to alumina particle while the starting material has a pH in the range of about 6.0 to 6.5. The alumina particles may be conditioned prior to use by exposing the particles to a solution containing a sulfate moiety. Both batch and continuous methods are disclosed. The figure is a graph showing the effect of alumina treatment on the calcium to phosphorus ratio in condensed skim milk.

公开(公告)号：WO1993012253A1

公开(公告)日：1993-06-24

申请号：PCT/US1991009204

申请日：1991-12-09

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  SALT, Steven, Dale ,  SIEGEL, Neal, Arthur

IPC: C12Q01/28

CPC classification number: C12Q1/28 ,  C12Q2326/40

Abstract: A method to determine the presence or amount of peroxidase or hydrogen peroxide employing a sulfonephthalein dye or a phthalein dye having a major absorbance peak in the visible region, preferably at a wavelength from between about 500 nanometers to about 700 nanometers, and which absorbance peak is subject to a degree of oxidative extinguishment without strong alkali treatment, is disclosed. The method is performed by forming a reaction system comprising such sulfonephthalein dye or phthalein dye, and a test sample containing an unknown amount of (i) peroxide, (ii) a peroxidase, (iii) a compound which is capable of being oxidized to generate hydrogen peroxide, or (iv) a catalyst which participates in such oxidation, wherein the hydrogen peroxide causes peroxidase-catalyzed extinguishment of the absorbance peak of such dye whereby the unknown amount under determination can be determined by monitoring such extinguishment.

Abstract translation: 一种确定过氧化物酶或过氧化氢的存在或量的方法，其使用在可见光区域中具有主要吸收峰的磺酞染料或酞菁染料，优选在约500纳米至约700纳米之间的波长处， 受到一定程度的氧化灭火而没有强碱处理。 该方法通过形成包含这种磺酞染料或酞菁染料的反应体系和含有未知量的（i）过氧化物，（ii）过氧化物酶，（iii）能够被氧化产生的化合物的测试样品 过氧化氢，或（iv）参与这种氧化的催化剂，其中过氧化氢引起过氧化物酶催化的这种染料的吸收峰的熄灭，由此可以通过监测这种灭火来确定待测量的未知量。

公开(公告)号：WO1993011696A2

公开(公告)日：1993-06-24

申请号：PCT/US1992010728

申请日：1992-12-09

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  LARKIN, Mark, E.

IPC: A61B0

CPC classification number: A61M39/045 ,  Y10S604/905

Abstract: A connecting system is provided with a connector adapted to be mounted to the end of a conduit for removably engaging a blunt cannula to establish fluid communication between the conduit and cannula. The connector has a housing which defines a passage for communicating with the conduit and which defines an opening to the passage. The housing also defines a generally frustoconical seating surface which decreases in diameter in the direction toward the opening. A generally fluid-impervious, resilient seal is retained within the housing passage against the seating surface. The seal defines a slit which can accommodate penetration by the blunt cannula and which can reseal upon withdrawal of the blunt cannula.

Abstract translation: 连接系统设置有适于安装到导管的端部的连接器，用于可移除地接合钝头套管以建立导管和插管之间的流体连通。 连接器具有壳体，该壳体限定用于与导管连通并且限定通道的开口的通道。 壳体还限定了在朝向开口的方向上直径减小的大致截头圆锥形的座面。 通常不透液体的弹性密封件抵靠着座面保持在壳体通道内。 该密封件限定了狭缝，其可容纳钝头套管的穿透，并且在拔出钝头套管时可以重新密封。

公开(公告)号：WO1993009077A2

公开(公告)日：1993-05-13

申请号：PCT/US1992009300

申请日：1992-10-30

Applicant: ABBOTT LABORATORIES ,  WANG, Xiu, C. ,  KALARITIS, P. ,  CHANG, Michelle, L.

Inventor： ABBOTT LABORATORIES

IPC: C07C0

CPC classification number: C07C201/12 ,  C07C51/363 ,  C07C51/60 ,  C07C205/12 ,  C07C205/45 ,  C07C205/56 ,  C07C205/58 ,  C07C253/30 ,  C07C63/70 ,  C07C255/41

Abstract: A process for the preparation of 2-chloro-4,5-difluorobenzoic acid and 2,4,5-trifluorobenzoic acid as well as synthetic intermediates useful in and prepared according thereto, comprising reacting a nitrobenzene having formula (II), wherein X is chloro or fluoro, with an appropriate carbanion to form a compound having formula (III) wherein one of Y and Z is chloro and the other is nitro, and R is a radical selected from the group consisting of -CCl3, -CH2NO2, -CH(NO2)R , -CH(CO2R )2, -CH(C(O)R )2, -CH(CN)CO2R , -CH(CO2R )COR and -COR where R is alkyl or arylalkyl and R is alkyl, aryl or arylalkyl and, where appearing more than once in such a radical, R and R may be the same or different at each occurrence.

Abstract translation: 一种制备2-氯-4,5-二氟苯甲酸和2,4,5-三氟苯甲酸的方法，以及可用于和制备的合成中间体，包括使具有式（II）的硝基苯（其中X为 氯或氟，与适当的碳负离子形成具有式（III）的化合物，其中Y和Z之一是氯，另一个是硝基，R是选自-CCl 3，-CH 2 NO 2，-CH （NO 2）R 1，-CH（CO 2 R 1）2，-CH（C（O）R 2）2，-CH（CN）CO 2 R 1，-CH（CO 2 R 1） COR 2和-COR 2，其中R 1是烷基或芳基烷基，R 2是烷基，芳基或芳基烷基，并且在这样的基团中出现不止一次，R 1和R 2 >在每次出现时可能相同或不同。

公开(公告)号：WO1993004205A1

公开(公告)日：1993-03-04

申请号：PCT/US1992007189

申请日：1992-08-21

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MEHTA, Smriti, U. ,  JOHNSON, Jill, E. ,  DAILEY, Stephen, H. ,  DESAI, Suresh, M. ,  DEVARE, Sushil, G.

IPC: C12Q01/70

CPC classification number: C07K14/005 ,  C07K16/109 ,  C07K2317/34 ,  C12N2770/24222 ,  G01N33/5767 ,  Y10S436/82

Abstract: Monoclonal antibodies which specifically bind to Hepatitis C Virus (HCV) E2/NS1 antigen. Also provided are hybridoma cell lines which secrete these monoclonal antibodies, methods for using these monoclonal antibodies, and assay kits for assays which contain these monoclonal antibodies.

Abstract translation: 特异性结合丙型肝炎病毒（HCV）E2 / NS1抗原的单克隆抗体。 还提供了分泌这些单克隆抗体的杂交瘤细胞系，使用这些单克隆抗体的方法和用于含有这些单克隆抗体的测定的测定试剂盒。

公开(公告)号：WO1993004089A1

公开(公告)日：1993-03-04

申请号：PCT/US1992006964

申请日：1992-08-21

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  DESAL, Suresh, M. ,  DAILEY, Stephen, H. ,  DEVARE, Sushil, G.

IPC: C07K15/28

CPC classification number: C07K14/005 ,  A61K39/00 ,  C12N2770/24222

Abstract: The present invention provides a unique recombinant antigen representing the distinct NS5 antigenic region of the HCV genome which can be used as reagents for the detection of antibodies and antigen in body fluids from individuals exposed to hepatitis C virus (HCV). The present invention also provides an assay for detecting the presence of an antibody to an HCV antigen in a sample by contacting the sample with the recombinant antigen. Preferred assay formats include a screening assay, a confirmatory assay, a competition or neutralization assay and an immunodot assay.

Abstract translation: 本发明提供了代表HCV基因组的不同NS5抗原性区域的独特重组抗原，其可以用作检测暴露于丙型肝炎病毒（HCV）的个体的体液中的抗体和抗原的试剂。 本发明还提供了通过使样品与重组抗原接触来检测样品中HCV抗原的存在的测定。 优选的测定形式包括筛选测定，确认测定，竞争或中和测定和免疫斑点测定。