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    IMAGE PROCESSING METHOD AND SYSTEM FOR MICROFLUIDIC DEVICES
    31.
    发明申请
    IMAGE PROCESSING METHOD AND SYSTEM FOR MICROFLUIDIC DEVICES 审中-公开
    图像处理方法和微流体装置系统

    公开(公告)号：WO2005011947A9

    公开(公告)日：2006-10-26

    申请号：PCT/US2004024591

    申请日：2004-07-28

    Applicant: FLUIDIGM CORP ,  TAYLOR COLIN JON ,  SUN GANG ,  DUBE SIMANT

    Inventor： TAYLOR COLIN JON ,  SUN GANG ,  DUBE SIMANT

    IPC: B01L3/00 ,  B29C20060101 ,  C12Q1/68 ,  G06K9/00 ,  G06K9/62 ,  G06T7/00 ,  B29C

    CPC classification number: G06K9/36 ,  B01L3/5027 ,  G06K9/00 ,  G06K9/00127 ,  G06K9/00134 ,  G06K9/6232 ,  G06T7/0008 ,  G06T7/0012 ,  G06T7/254 ,  G06T7/33 ,  G06T2207/30004

    Abstract: A method for processing an image of a microfluidic device. The method includes receiving a first image of a microfluidic device. The first image corresponds to a first state. Additionally, the method includes receiving a second image of the microfluidic device. The second image corresponds to a second state. Moreover, the method includes transforming the first image and the second image into a third coordinate space. Also, the method includes obtaining a third image based on at least information associated with the transformed first image and the transformed second image, and processing the third image to obtain information associated with the first state and the second state.

    Abstract translation: 一种用于处理微流体装置的图像的方法。 该方法包括接收微流体装置的第一图像。 第一图像对应于第一状态。 另外，该方法包括接收微流体装置的第二图像。 第二图像对应于第二状态。 此外，该方法包括将第一图像和第二图像变换为第三坐标空间。 此外，该方法包括至少基于与变换的第一图像和变换的第二图像相关联的信息获得第三图像，并且处理第三图像以获得与第一状态和第二状态相关联的信息。

    A MICROFLUIDIC DESIGN AUTOMATION METHOD AND SYSTEM
    34.
    发明申请
    A MICROFLUIDIC DESIGN AUTOMATION METHOD AND SYSTEM 审中-公开
    一种微流体设计自动化方法和系统

    公开(公告)号：WO0200343A3

    公开(公告)日：2002-06-06

    申请号：PCT/US0120639

    申请日：2001-06-27

    Applicant: FLUIDIGM CORP

    Inventor： LEE MICHAEL ,  WORTHINGTON GAJUS ,  HARRIS GREGORY ,  MONTGOMERY JAMES

    IPC: B01F13/00 ,  B01F15/00 ,  B01L3/00 ,  B81B1/00 ,  B81C99/00 ,  G06F17/50

    CPC classification number: G06F17/50 ,  B01F13/0059 ,  B01F15/00824 ,  B01F15/00935 ,  B01J2219/00997 ,  B01L3/5027 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/12 ,  B81B1/00 ,  B81C99/006 ,  G06F17/509 ,  G06F2217/16 ,  H01H2029/008

    Abstract: The design of customized microfluidic systems using a CAD system (10) is disclosed. In one embodiment, a microfluidic circuit design method (200) is provided. The method includes developing synthesizable computer code for the design. Next, a microfluidic circuit schematic, including a plurality of symbols for microfluidic components, is generated either interactively or using the synthesizable computer code. The microfluidic circuit schematic is then functionally simulated. The microfluidic components are placed and routed (430) on a template to form a physical layout. Then the physical layout (410) is physically simulated (800) using dynamic simulation models of the microfluidic components; and the physical layout is written to a layout file (900).

    Abstract translation: 公开了使用CAD系统（10）的定制微流体系统的设计。 在一个实施例中，提供了微流体电路设计方法（200）。 该方法包括为设计开发可合成的计算机代码。 接下来，以交互方式或使用可合成计算机代码生成包括用于微流体组分的多个符号的微流体电路示意图。 然后功能性模拟微流体电路原理图。 将微流体组件放置并布线（430）在模板上以形成物理布局。 然后使用微流体组件的动态仿真模型物理模拟（800）物理布局（410） 并将物理布局写入布局文件（900）。

    SINGLE-PARTICLE ANALYSIS OF PARTICLE POPULATIONS
    35.
    发明申请
    SINGLE-PARTICLE ANALYSIS OF PARTICLE POPULATIONS 审中-公开
    颗粒群体的单粒子分析

    公开(公告)号：WO2013177206A3

    公开(公告)日：2014-01-30

    申请号：PCT/US2013042086

    申请日：2013-05-21

    Applicant: FLUIDIGM CORP ,  ANDERSON MEGAN ,  CHEN PEILIN ,  FOWLER BRIAN ,  KAPER FIONA ,  LEBOFSKY RONALD ,  MAY ANDREW

    Inventor： ANDERSON MEGAN ,  CHEN PEILIN ,  FOWLER BRIAN ,  KAPER FIONA ,  LEBOFSKY RONALD ,  MAY ANDREW

    IPC: C12Q1/68

    CPC classification number: C12Q1/6813 ,  B01D15/08 ,  C12Q1/6806 ,  C12Q2563/159 ,  C12Q2563/179 ,  C12Q2565/629

    Abstract: In certain embodiments, the invention provides methods and devices for assaying single particles in a population of particles, wherein at least two parameters are measured for each particle. One or more parameters can be measured while the particles are in the separate reaction volumes. Alternatively or in addition, one or more parameters can be measured in a later analytic step, e.g., where reactions are carried out in the separate reaction volumes and the reaction products are recovered and analyzed. In particular embodiments, one or more parameter measurements are carried out "in parallel," i.e., essentially simultaneously in the separate reaction volumes.

    Abstract translation: 在某些实施方案中，本发明提供了用于测定颗粒群体中的单个颗粒的方法和装置，其中针对每个颗粒测量至少两个参数。 当颗粒处于分开的反应体积中时，可以测量一个或多个参数。 或者或另外，可以在稍后的分析步骤中测量一个或多个参数，例如其中在分开的反应体积中进行反应并回收和分析反应产物。 在具体实施方案中，一个或多个参数测量“并行地进行”，即基本上同时在单独的反应体积中进行。

    MULTIFUNCTIONAL PROBE-PRIMERS
    36.
    发明申请
    MULTIFUNCTIONAL PROBE-PRIMERS 审中-公开
    多功能探测器

    公开(公告)号：WO2012106668A3

    公开(公告)日：2013-01-10

    申请号：PCT/US2012023870

    申请日：2012-02-03

    Applicant: FLUIDIGM CORP ,  LIVAK KENNETH J

    Inventor： LIVAK KENNETH J

    IPC: C12Q1/68 ,  C07H21/00

    CPC classification number: C12Q1/6876 ,  C12Q1/6818 ,  C12Q1/6823 ,  C12Q2525/161 ,  C12Q2525/197 ,  C12Q2565/1015

    Abstract: Methods and reagents for detection and analysis of nucleic acids are provided. Certain methods involves an encoding amplification in which a target sequence is associated with probe-binding sequences and optionally with indexing sequences, (2) an optional distribution step in which the product of the encoding amplification is split into multiple aliquots, and (3) a decoding and detection step in which the presence, absence, quantity, or relative amount of the target sequence in the aliquots is determined. The detection step makes use of a multifunctional "self-digesting" molecular probe comprising a primer polynucleotide and a probe oligonucleotide, linked in a 5'-5' orientation.

    Abstract translation: 提供了用于检测和分析核酸的方法和试剂。 某些方法涉及编码扩增，其中靶序列与探针结合序列和任选的索引序列相关，（2）任选的分布步骤，其中编码扩增的产物被分成多个等分试样，和（3）a 解码和检测步骤，其中确定等分试样中靶序列的存在，不存在，数量或相对量。 检测步骤使用包含以5'-5'取向连接的引物多核苷酸和探针寡核苷酸的多功能“自消化”分子探针。

    SELECTIVE TAGGING OF SHORT NUCLEIC ACID FRAGMENTS AND SELECTIVE PROTECTION OF TARGET SEQUENCES FROM DEGRADATION
    38.
    发明申请
    SELECTIVE TAGGING OF SHORT NUCLEIC ACID FRAGMENTS AND SELECTIVE PROTECTION OF TARGET SEQUENCES FROM DEGRADATION 审中-公开
    选择性标记短核酸片段和选择性保护目标序列从降解

    公开(公告)号：WO2010115044A3

    公开(公告)日：2011-03-31

    申请号：PCT/US2010029690

    申请日：2010-04-01

    Applicant: FLUIDIGM CORP ,  ZIMMERMANN BERNHARD G

    Inventor： ZIMMERMANN BERNHARD G

    IPC: C12Q1/68 ,  C12N15/10 ,  C12N15/11

    CPC classification number: C12N15/1093 ,  C12N15/10 ,  C12N15/1065 ,  C12N15/1072 ,  C12Q1/6846 ,  C12Q2521/307 ,  C12Q2521/325 ,  C12Q2537/159

    Abstract: Methods are provided for selective tagging of short nucleic acids comprising a short target nucleotide sequence over longer nucleic acids comprising the same target nucleotide sequence. The methods can involve performing one or two cycles of amplification of a sample comprising long nucleic acids and short nucleic acids, each comprising the same target nucleotide sequence with at least two target-specific primers or primer pairs under suitable annealing conditions, wherein the primer pairs comprise: an inner primer or primer pair that can amplify the target nucleotide sequence on long and short nucleic acids (wherein each inner primer comprises a 5' nucleotide tag; and an outer primer or primer pair that amplifies the target nucleotide sequence on long nucleic acids, but not on short nucleic acids); whereby the amplification after a second cycle produces at least one tagged target nucleotide sequence that comprises two nucleotide tags, one from each inner primer, with the target nucleotide sequence located between the nucleotide tags.

    Abstract translation: 提供了用于在包含相同靶核苷酸序列的较长核酸上选择性标记包含短目标核苷酸序列的短核酸的方法。 所述方法可以包括在合适的退火条件下进行包含长核酸和短核酸的样品的一个或两个循环的扩增，每个循环包含相同的靶核苷酸序列与至少两个靶特异性引物或引物对，其中引物对 包括：可以扩增长和短核酸上的靶核苷酸序列的内部引物或引物对（其中每个内引物包含5'核苷酸标签;以及扩增长核酸上的靶核苷酸序列的外引物或引物对 ，但不在短核酸上）; 由此在第二周期之后的扩增产生至少一个标记的靶核苷酸序列，其包含两个核苷酸标签，每个内引物中的一个，靶核苷酸序列位于核苷酸标签之间。

    METHOD AND APPARATUS FOR BIOLOGICAL SAMPLE ANALYSIS
    39.
    发明申请
    METHOD AND APPARATUS FOR BIOLOGICAL SAMPLE ANALYSIS 审中-公开
    生物样品分析方法和设备

    公开(公告)号：WO2008067552A3

    公开(公告)日：2008-11-27

    申请号：PCT/US2007086146

    申请日：2007-11-30

    Applicant: FLUIDIGM CORP ,  SUN GANG ,  RAMAKRISHNAN RAMESH ,  JONES ROBERT C

    Inventor： SUN GANG ,  RAMAKRISHNAN RAMESH ,  JONES ROBERT C

    IPC: C12P19/34 ,  G06T11/20

    CPC classification number: C12Q1/686 ,  C12Q2565/629 ,  C12Q2565/501 ,  C12Q2545/114

    Abstract: A method of adjusting amplification curves in a PCR experiment includes receiving a plurality of amplification curves for a sample and computing a first parameter for each of the plurality of amplification curves. The method also includes computing a second parameter for each of the plurality of amplification curves and computing a third parameter using at least a portion of the first or second parameters. The method further includes computing an offset for each of the plurality of amplification curves. The offset is a function of the first parameter and the third parameter. Moreover, the method includes adjusting at least one of the plurality of amplification curves by subtracting the offset.

    Abstract translation: 在PCR实验中调整扩增曲线的方法包括接收样品的多个扩增曲线并且计算多个扩增曲线中的每一个的第一参数。 该方法还包括为多个放大曲线中的每一个计算第二参数并且使用第一或第二参数的至少一部分来计算第三参数。 该方法还包括计算多个扩增曲线中的每一个的偏移。 偏移量是第一个参数和第三个参数的函数。 此外，该方法包括通过减去偏移来调整多个放大曲线中的至少一个。

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