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31.发明公开
公开(公告)号：EP0846259A1
公开(公告)日：1998-06-10
申请号：EP96927526.0
申请日：1996-08-20
Applicant: Foss Electric A/S
Inventor： CHRISTENSEN, Steen, Kold , BORN, Christian , ASMUSSEN, Tove , LARSEN, Mogens, Bering
CPC classification number: G01N15/1456 , G01N2015/1486 , G06M11/00
Abstract: A method and apparatus for determining the number of particles or cells in a liquid sample. The method comprises: a) determining the number of particles or cells in a first volume of the liquid sample, b) determining the statistical uncertainty of the determined number of particles in said first volume, c) if the determined uncertainty is larger than a predetermined value, determining the number of particles or cells in a further volume of the liquid sample, d) adding the numbers of cells or particles determined in steps a) and c), e) determining the statistical uncertainty of the number of particles determined in step d), f) repeating steps d) and e) with a further volume of the liquid sample, until the uncertainty determined in step e) is lower than said predetermined value or until a predetermined total volume of the liquid sample in which the number of cells or particles has been determined exceeds a predetermined volume being larger than said first volume. In this way, the volume examined and the uncertainty of the measurement may be selected so that a suitable compromise between the uncertainty and the time required to perform the measurement can be obtained. The apparatus according to the invention comprises a liquid flow system allowing the measurement sequence to be interrupted as soon as the calculating means decide that the uncertainty of the actual cell count is small enough to rely on the present determination. The apparatus will then be ready to carry on with the next sample, thereby maintaining a high capacity while obtaining reliable cell counts.
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公开(公告)号：EP0796424A1
公开(公告)日：1997-09-24
申请号：EP95940972.0
申请日：1995-12-07
Applicant: Foss Electric A/S
Inventor： ANDERSEN, Hans, Villemoes
Abstract: A method is suggested for obtaining information on the electromagnetic spectrum of a sample, the method comprising (a) generating a plurality of substantially identical signals, (b) determining the shape of a first number of the signals by performing a first number of scans of a first range of signal width, (c) determining the shape of a second number of the signals by performing a second number of scans of a second range of signal width, the second range being comprised by the first range and comprising a portion of the first range in which the signals have maximum absolute amplitude, (d) combining data from the first number of scans and the second number of scans so as to obtain data corresponding to the shape of the signals, and (e) performing a mathematical transformation of the combined data so as to obtain the information on the electromagnetic spectrum of the sample. According to this method, the electromagnetic spectrum - and especially an absorption spectrum for use in quantitative analysis of the sample - may be obtained faster than is possible using prior art methods.
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33.发明授权
公开(公告)号：EP0734523B1
公开(公告)日：1997-08-13
申请号：EP95903765.6
申请日：1994-12-09
Applicant: Foss Electric A/S
Inventor： ARNVIDARSON, Börkur , NYGAARD, Lars , HANSEN, Per, Waaben
CPC classification number: G01N25/04 , G01N21/3577 , G01N33/04
Abstract: The present invention relates to a method for quantitatively assessing the amount of any extraneous water contained in a milk sample, the method comprising the steps of (a) performing a determination of the infrared (IR) attenuation of the sample in at least one waveband, (b) quantitatively assessing the amount of any extraneous water in the sample on the basis of the determination (a) and predetermined regression coefficients derived from multivariate calibration with respect to the relationship between infrared attenuation in the at least one waveband and the amount of extraneous water. The invention furthermore relates to a similar method for determining the freezing point depression of the sample. In addition, the invention relates to a method for the establishment of a set of regression coefficients for use in an instrument which determines the amount of extraneous water or the freezing point depression of a milk sample.
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Patent Agency Ranking
公开(公告)号：DE69608252T2
公开(公告)日：2000-11-02
申请号：DE69608252
申请日：1996-02-09
Applicant: FOSS ELECTRIC A S HILLEROD
Inventor： VILLEMOES HANS , KJAER LISA , WAABEN PER , RIDDER CARSTEN
Abstract: PCT No. PCT/DK96/00068 Sec. 371 Date Apr. 3, 1996 Sec. 102(e) Date Apr. 3, 1996 PCT Filed Feb. 9, 1996 PCT Pub. No. WO96/24832 PCT Pub. Date Aug. 15, 1996A method for standardizing a spectrometer generating an optical spectrum from a sample, comprising generating at least one optical spectrum from at least one standardization sample each having a chemical composition resulting in the optical spectrum showing a characteristic pattern in a predetermined frequency range, comparing information relating to the pattern(s) to corresponding information relating to at least one reference pattern previously defined as the desired standard response from the at least one standardization sample, determining, based on the comparison, standardizing parameters describing the transition of the pattern(s) of the generated spectrum or spectra to the reference pattern(s) and storing said standardizing parameters in the spectrometer or a computer connected thereto, so that the spectrometer, when presented to an unknown sample, will, using the standardization parameters, generate an optical spectrum substantially identical to that which would be generated in a corresponding spectrometer standardized with a sample of the same chemical composition using the same previously defined reference pattern(s). The present method relates to standardization of the instrument to a well-defined state into which any number of instruments may be brought. In this state, calibrations may be transferred freely from instrument to instrument.
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公开(公告)号：DE69513197T2
公开(公告)日：2000-02-24
申请号：DE69513197
申请日：1995-12-07
Applicant: FOSS ELECTRIC A S HILLEROD
Inventor： ANDERSEN HANS
Abstract: PCT No. PCT/DK95/00492 Sec. 371 Date May 13, 1997 Sec. 102(e) Date May 13, 1997 PCT Filed Dec. 7, 1995 PCT Pub. No. WO96/18089 PCT Pub. Date Jun. 13, 1996A method is suggested for obtaining information on the electromagnetic spectrum of a sample, the method comprising (a) generating a plurality of substantially identical signals, (b) determining the shape of a first number of the signals by performing a first number of scans of a first range of signal width, (c) determining the shape of a second number of the signals by performing a second number of scans of a second range of signal width, the second range being comprised by the first range and comprising a portion of the first range in which the signals have maximum absolute amplitude, (d) combining data from the first number of scans and the second number of scans so as to obtain data corresponding to the shape of the signals, and (e) performing a mathematical transformation of the combined data so as to obtain the information on the electromagnetic spectrum of the sample. According to this method, the electromagnetic spectrum-and especially an absorption spectrum for use in quantitative analysis of the sample-may be obtained faster than is possible using prior art methods.
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公开(公告)号：DE69513197D1
公开(公告)日：1999-12-09
申请号：DE69513197
申请日：1995-12-07
Applicant: FOSS ELECTRIC A S HILLEROD
Inventor： ANDERSEN HANS
Abstract: PCT No. PCT/DK95/00492 Sec. 371 Date May 13, 1997 Sec. 102(e) Date May 13, 1997 PCT Filed Dec. 7, 1995 PCT Pub. No. WO96/18089 PCT Pub. Date Jun. 13, 1996A method is suggested for obtaining information on the electromagnetic spectrum of a sample, the method comprising (a) generating a plurality of substantially identical signals, (b) determining the shape of a first number of the signals by performing a first number of scans of a first range of signal width, (c) determining the shape of a second number of the signals by performing a second number of scans of a second range of signal width, the second range being comprised by the first range and comprising a portion of the first range in which the signals have maximum absolute amplitude, (d) combining data from the first number of scans and the second number of scans so as to obtain data corresponding to the shape of the signals, and (e) performing a mathematical transformation of the combined data so as to obtain the information on the electromagnetic spectrum of the sample. According to this method, the electromagnetic spectrum-and especially an absorption spectrum for use in quantitative analysis of the sample-may be obtained faster than is possible using prior art methods.
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公开(公告)号：DE69608252D1
公开(公告)日：2000-06-15
申请号：DE69608252
申请日：1996-02-09
Applicant: FOSS ELECTRIC A S HILLEROD
Inventor： VILLEMOES HANS , KJAER LISA , WAABEN PER , RIDDER CARSTEN
Abstract: PCT No. PCT/DK96/00068 Sec. 371 Date Apr. 3, 1996 Sec. 102(e) Date Apr. 3, 1996 PCT Filed Feb. 9, 1996 PCT Pub. No. WO96/24832 PCT Pub. Date Aug. 15, 1996A method for standardizing a spectrometer generating an optical spectrum from a sample, comprising generating at least one optical spectrum from at least one standardization sample each having a chemical composition resulting in the optical spectrum showing a characteristic pattern in a predetermined frequency range, comparing information relating to the pattern(s) to corresponding information relating to at least one reference pattern previously defined as the desired standard response from the at least one standardization sample, determining, based on the comparison, standardizing parameters describing the transition of the pattern(s) of the generated spectrum or spectra to the reference pattern(s) and storing said standardizing parameters in the spectrometer or a computer connected thereto, so that the spectrometer, when presented to an unknown sample, will, using the standardization parameters, generate an optical spectrum substantially identical to that which would be generated in a corresponding spectrometer standardized with a sample of the same chemical composition using the same previously defined reference pattern(s). The present method relates to standardization of the instrument to a well-defined state into which any number of instruments may be brought. In this state, calibrations may be transferred freely from instrument to instrument.
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公开(公告)号：DE69512037T2
公开(公告)日：2000-01-27
申请号：DE69512037
申请日：1995-03-16
Applicant: FOSS ELECTRIC A S HILLEROD
Inventor： AGIDIUS POUL
IPC: C12Q1/04
Abstract: PCT No. PCT/DK95/00119 Sec. 371 Date Sep. 16, 1996 Sec. 102(e) Date Sep. 16, 1996 PCT Filed Mar. 16, 1995 PCT Pub. No. WO95/25174 PCT Pub. Date Sep. 21, 1995A method is disclosed for conditioning samples (of e.g. milk or meat) containing fat globules and somatic cells and/or protein particles before they are subjected to fluorescence measurements in order to determine the bacterial content, as well as methods for performing the determination of bacterial content in such samples. The conditioning method involves the treatment of the samples with an ion-chelating agent, a proteolytic enzyme, detergent, and a bacteriologically specific fluorochrome such as ethidium bromide. Detergent is used in a concentration resulting in substantially no dissolution of the fat globules and the conditioned samples thus loses insignificant amounts of fat globules. The assessment of fluorescence is preferably performed in a conventional flow cytometer. As no separation of fat globules is necessary, the methods are simple and fast. The bacterial determinations have proved reliable when compared to standard methods.
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