公开(公告)号：US20210380637A1

公开(公告)日：2021-12-09

申请号：US17284309

申请日：2019-10-07

Applicant: KAGOSHIMA UNIVERSITY ,  DAICEL CORPORATION

Inventor： Yuji ITO ,  Seiichi UCHIMURA

IPC: C07K1/22 ,  C07K17/00 ,  C07K7/08 ,  B01D15/10 ,  B01D15/38

Abstract: The purpose of the present invention is to provide a solid-phase carrier on which an IgG-binding peptide is immobilized, the peptide being usable for IgG purification, having resistance to repeated washing with an alkaline solution after IgG purification, and having a high binding affinity for IgG. Specifically, the present invention relates to a solid-phase carrier on which an IgG-binding peptide is immobilized, wherein the two cysteine residues on the outside of the peptide are linked as shown in the following formula: (in the formula, the upper cysteine residue is on the N-terminal side of the peptide, and the lower cysteine residue is on the C-terminal side of the peptide).

公开(公告)号：US20210277847A1

公开(公告)日：2021-09-09

申请号：US17255696

申请日：2019-06-27

Applicant: Kagoshima University

Inventor： Hiroshi Katanoda

IPC: F02K9/72 ,  F02K9/12 ,  F02K9/50

Abstract: A readily combustible portion (110) includes a readily combustible exposed surface (111) that is exposed to a flow channel (CA). A combustion-resistant portion (140), which comprises a material that is more resistant to combustion than the readily combustible portion (110), covers an outer surface of the readily combustible portion (110) on the opposite side from the readily combustible exposed surface (111) in a direction orthogonal to a length direction parallel to a direction in which a hybrid rocket is propelled. The combustion-resistant portion (140) includes a thick portion (120) that serves as a stopper that prevents peeling of the readily combustible portion (110) from the combustion-resistant portion (140) in a direction from a starting end surface (100a) toward a terminating end surface (100b).

公开(公告)号：US11110414B2

公开(公告)日：2021-09-07

申请号：US16320458

申请日：2017-07-21

Applicant: Kagoshima University

Inventor： Takashi Goshima

IPC: B01F11/02 ,  B01F3/04 ,  B01F5/06 ,  B01F15/00 ,  B01F5/00

Abstract: A bubble generation device includes: a metallic narrow tube (10) through which water passes; and a pump that pressure-feeds the water containing a gas component into the metallic narrow tube (10). A drawer (11) in which a path through which the water passes is narrower than the front and the rear thereof in the flow direction of the water is disposed on the inside of the metallic narrow tube (10). The drawer (11) has the rectangular cross section orthogonal to the flow direction. The gas component contained in the water is dissolved in the water by pressure-feeding the water to the drawer (11), bubbles are evolved due to a decrease in pressure in the drawer (11), turbulent flow is generated in the water in the drawer (11) to crush bubbles in the water by the shearing force thereof, and bubbles are crushed by a shock wave caused by transonic flow occurring in the water that has exited from the drawer (11).

公开(公告)号：US20210147541A1

公开(公告)日：2021-05-20

申请号：US17255784

申请日：2019-06-26

Applicant: Kyowa Kirin Co., Ltd. ,  KAGOSHIMA UNIVERSITY

Inventor： Nobuaki TAKAHASHI ,  Ryosuke NAKANO ,  Sayaka MAEDA ,  Takenao YAMADA ,  Yuji ITO

IPC: C07K16/28

Abstract: The invention relates to an antibody which binds to cell adhesion molecule 3 (CADM3) or an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment thereof, a nucleic acid comprising a nucleotide sequence encoding the antibody or the antibody fragment thereof, a transformant cell comprising a vector comprising the nucleic acid, a method for producing the antibody or the antibody fragment thereof, a composition comprising the antibody or the antibody fragment thereof, and a method for detecting or measuring an antigen present in the brain, a method for diagnosing or treating a brain disease, a method for enhancing the property of accumulating in a brain of an antibody, and a method for increasing the amount of an antibody in the brain, each of which using the antibody or the antibody fragment thereof, and the like.

公开(公告)号：US11001557B2

公开(公告)日：2021-05-11

申请号：US16479081

申请日：2018-01-16

Applicant: Kagoshima University ,  Nobelpharma Co., Ltd.

Inventor： Masanori Baba ,  Masaaki Toyama ,  Norikazu Sakakibara

IPC: C07D215/44 ,  A61P31/12 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention pertains to an antiviral drug for severe fever with thrombocytopenia syndrome, which contains a compound represented by formula (I) or a salt thereof, or a solvate of the compound or salt (In the formula, R1 and R2 are the same or different from each other, and each represents a substituted or unsubstituted C1-10 alkyl group, R1 and R2 may form a substituted or unsubstituted 5- or 6-member ring in conjunction with an adjacent nitrogen atom, and X represent a halogen atom.)

公开(公告)号：US10772887B2

公开(公告)日：2020-09-15

申请号：US16322356

申请日：2017-08-02

Applicant: Kagoshima University

Inventor： Daisuke Kodama ,  Shuji Izumo

IPC: A61K31/506 ,  A61P25/00 ,  A61K45/00 ,  A61P19/00

Abstract: A novel therapeutic agent and novel anti-HTLV-1 drug for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is provided. A substance capable of inhibiting tyrosine kinase encoded by the ABL1 gene is contained as an active ingredient.

公开(公告)号：US20190226552A1

公开(公告)日：2019-07-25

申请号：US16321554

申请日：2017-09-29

Applicant: AISIN AW CO., LTD. ,  NATIONAL UNIVERSITY CORPORATION OITA UNIVERSITY ,  Kagoshima University

Inventor： Yoichi OI ,  Masaki WAJIMA ,  Hiroki NAGAI ,  Takao SAKAMOTO ,  Takahiro RYU ,  Takashi NAKAE ,  Kenichiro MATSUZAKI

IPC: F16F15/137 ,  F16F15/14 ,  F16H45/02

CPC classification number: F16F15/145 ,  F16F15/1202 ,  F16F15/13128 ,  F16F15/137 ,  F16F15/14 ,  F16F2228/001 ,  F16H45/02

Abstract: In a vibration damping device 20, the moment of inertia J1 of a driven member 15, the moment of inertia J2 of an inertial mass body 23, the mass m of crank members 22, the distance L3 between the center of gravity G of the crank member 22 and the fulcrum of swinging of the crank member 22 with respect to the inertial mass body 23, and the distance L4 between this fulcrum and the center of rotation RC are determined so that torque fluctuation of an object for which vibration is to be damped, which is derived based on angular displacement and angles obtained by solving an equation of motion for the driven member 15 and an equation of motion for the entire vibration damping device 20 is equal to a target value.

公开(公告)号：US10263634B2

公开(公告)日：2019-04-16

申请号：US15753855

申请日：2016-08-03

Applicant: KAGOSHIMA UNIVERSITY

Inventor： Kenichi Ohhata

IPC: H03M1/56 ,  H03M1/36 ,  G04F10/00 ,  H03M1/14 ,  H03M1/12 ,  H03M1/10 ,  H03M1/00

Abstract: AD conversion is performed by using a combination of a parallel AD converter that includes a plurality of comparators to compare an input potential of an analog input signal sampled by a track and hold circuit and reference potentials different from one another and determines a value of a predetermined number of bits on the higher-order side of a digital signal and a single-slope AD converter that reduces the input potential of the analog input signal sampled by the track and hold circuit at a constant speed, converts a time taken until the reduced input potential becomes equal to a reference potential corresponding to the value determined by the parallel AD converter to a digital value, and determines a remaining value on the lower-order side of the digital signal, and thereby the number of bits of the single-slope AD converter can be reduced and high-speed AD conversion is enabled with a small area and low power consumption.

公开(公告)号：US09710931B2

公开(公告)日：2017-07-18

申请号：US14428924

申请日：2013-09-19

Applicant: KAGOSHIMA UNIVERSITY

Inventor： Sakuichi Ohtsuka ,  Shoko Hira ,  Ken Kihara

IPC: G06T11/00 ,  H04N1/60 ,  H04N9/64 ,  H04N9/77

CPC classification number: G06T11/001 ,  H04N1/6075 ,  H04N9/643 ,  H04N9/77

Abstract: Techniques are provided in which a “dichromat” (e.g., a color-blind person) is able to identify the hue of an object without determining the color difference signals that are applied to the original color image. Such features may be implemented by performing hue rotation processing on each pixel data of the original color image captured.

公开(公告)号：US20170067110A1

公开(公告)日：2017-03-09

申请号：US15307061

申请日：2015-04-27

Applicant: KAGOSHIMA UNIVERSITY

Inventor： Hiroshi TAKASHIMA ,  Yujiro HIGUCHI ,  Akihiro HASHIGUCHI ,  Akiko YOSHIMURA

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12M1/00 ,  C12Q2600/156

Abstract: The present invention relates to a detection method for a genetic disease, and specifically relates to detection of disease-causing genes for autosomal recessive inherited Charcot-Marie-Tooth disease (CMT). In the method according to the present invention, a mutation(s) in MME (membrane metallo-endopeptidase) gene, FAT3 (FAT tumor suppressor homolog 3) gene, and/or SELRC1 (Sell repeat containing 1) gene in a biological sample are/is detected.

Abstract translation: 本发明涉及遗传性疾病的检测方法，具体涉及常染色体隐性遗传性Charcot-Marie-Tooth病（CMT）的致病基因的检测。 在本发明的方法中，生物样品中的MME（膜金属内肽酶）基因，FAT3（FAT肿瘤抑制同源物3）基因和/或SELRC1（Sell repeat containing 1）基因的突变为 /被检测。