公开(公告)号：WO2020006504A1

公开(公告)日：2020-01-02

申请号：PCT/US2019/039969

申请日：2019-06-28

Applicant: LOMA LINDA UNIVERSITY ,  FACULTY PHYSICIANS AND SURGEONS OF LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE ,  THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF VETERANS AFFAIRS

Inventor： XIAOBING, Zhang ,  BAYLINK, David ,  CHEN, Wanqui ,  LAU, Kin-Hing William

IPC: A61K38/17 ,  A61K38/18 ,  A61K38/30 ,  A61K48/00

Abstract: In one aspect, anabolic agent fusion proteins and compositions comprising anabolic agent fusion proteins are provided. In some embodiments, the anabolic agent fusion protein comprises a platelet derived growth factor (PDGF) or a fibroblast growth factor (FGF) and an Asp-Ser-Ser tripeptide (DSS) repeat sequence. In another aspect, methods of promoting bone growth and methods of treating a fracture using anabolic agent fusion proteins and compositions comprising anabolic agent fusion proteins are provided.

公开(公告)号：DE60109581D1

公开(公告)日：2005-04-28

申请号：DE60109581

申请日：2001-01-25

Applicant: LOMA LINDA UNIVERSITY LOMA LIN

Inventor： SHABAHANG SHAHROKH ,  SZALAY A ,  YU YONG

IPC: A61K6/00 ,  C12N1/21 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  G01N33/50 ,  C12Q1/22 ,  C12N1/20

Abstract: A method for the evaluation of a material to determine whether the material is susceptible to bacterial contamination or colonization comprising providing bacteria which are modified to produce a first detectable signal, exposing the material being evaluated to the bacteria and determining whether the first signal is present determining whether the first signal is present on the material or within the material.

公开(公告)号：CA2909188A1

公开(公告)日：2014-10-16

申请号：CA2909188

申请日：2014-04-10

Applicant: FACULTY PHYSICIANS AND SURGEONS OF LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE

Inventor： BALDWIN DALTON DUANE

IPC: A61B17/29 ,  A61B17/34

Abstract: Surgical tools for use during scarless or near scarless surgical procedures. At least some of the surgical tools can include a handle portion and a working end removably connected to the handle portion.

公开(公告)号：DE69921330T2

公开(公告)日：2006-03-09

申请号：DE69921330

申请日：1999-08-11

Applicant: LOMA LINDA UNIVERSITY LOMA LIN

Inventor： FLETCHER M

IPC: A01N63/00 ,  A61K39/00 ,  A61K39/02 ,  A61P1/02 ,  A61P31/04 ,  C07K14/195

公开(公告)号：DE60109581T2

公开(公告)日：2006-01-19

申请号：DE60109581

申请日：2001-01-25

Applicant: LOMA LINDA UNIVERSITY LOMA LIN

Inventor： SHABAHANG SHAHROKH ,  SZALAY A ,  YU YONG

IPC: A61K6/00 ,  C12N1/20 ,  C12N1/21 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/22 ,  G01N33/50

Abstract: A method for the evaluation of a material to determine whether the material is susceptible to bacterial contamination or colonization comprising providing bacteria which are modified to produce a first detectable signal, exposing the material being evaluated to the bacteria and determining whether the first signal is present determining whether the first signal is present on the material or within the material.

公开(公告)号：DE69921330D1

公开(公告)日：2004-11-25

申请号：DE69921330

申请日：1999-08-11

Applicant: LOMA LINDA UNIVERSITY LOMA LIN

Inventor： FLETCHER M

IPC: A61P1/02 ,  A61P31/04 ,  C07K14/195 ,  A61K39/02 ,  A01N63/00 ,  A61K39/00

公开(公告)号：AU2002303545A1

公开(公告)日：2002-11-11

申请号：AU2002303545

申请日：2002-04-30

Applicant: LOMA LINDA UNIVERSITY SURGERY

Inventor： SALO JONATHAN C

IPC: A61K9/127 ,  A61K49/00 ,  A61B5/00

公开(公告)号：AU2014250896A1

公开(公告)日：2015-11-05

申请号：AU2014250896

申请日：2014-04-10

Applicant: FACULTY PHYSICIANS AND SURGEONS OF LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE

Inventor： BALDWIN DALTON DUANE

IPC: A61B17/29 ,  A61B17/34

Abstract: Surgical tools for use during scarless or near scarless surgical procedures. At least some of the surgical tools can include a handle portion and a working end removably connected to the handle portion.

公开(公告)号：CA2914359A1

公开(公告)日：2014-12-11

申请号：CA2914359

申请日：2014-06-03

Applicant: FACULTY PHYSICIANS AND SURGEONS OF LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE ,  UNIV LOMA LINDA

Inventor： BALDWIN DALTON DUANE ,  YEO ALEXANDER ,  MARTIN JACOB

IPC: A61B17/34 ,  A61M25/01 ,  A61M25/095 ,  A61M25/10

Abstract: A needle access assembly and method for obtaining percutaneous needle access with little or no fluoroscopy. The method can include selecting a target for percutaneous access, directing a laser guide at a desired needle-insertion angle and in line with the selected target, aligning the needle access assembly with the laser, and inserting the needle into the target.

公开(公告)号：DE69726306T2

公开(公告)日：2004-10-14

申请号：DE69726306

申请日：1997-09-24

Applicant: LOMA LINDA UNIVERSITY LOMA LIN

Inventor： SZALAY A ,  WANG GEFU ,  WANG YUBAO

IPC: C12N15/09 ,  C07K14/00 ,  C07K14/435 ,  C07K16/00 ,  C07K16/40 ,  C07K19/00 ,  C12N9/02 ,  C12N15/02 ,  C12P21/04 ,  C12P21/08 ,  C12P21/06 ,  C12N1/20 ,  C07H21/04

Abstract: A fusion gene is provided comprising the cDNA of Renilla luciferase and the cDNA of the "humanized" Aequorea green fluorescent protein. The fusion gene was used to produce a novel protein, the "Renilla-GFP fusion protein," which displayed both the luciferase activity of Renilla luciferase, and the green fluorescence of GFP. The Renilla-GFP fusion gene is useful as a double marker for monitoring gene expression quantitatively in UV light and by enzyme activity.