公开(公告)号：WO2009006317A1

公开(公告)日：2009-01-08

申请号：PCT/US2008/068613

申请日：2008-06-27

Applicant: MARTEK BIOSCIENCES CORPORATION ,  RAMAN, Krishna ,  LEE, Jung ,  LEININGER, Neil ,  LUIGART, Chris

Inventor： RAMAN, Krishna ,  LEE, Jung ,  LEININGER, Neil ,  LUIGART, Chris

IPC: C07C51/00 ,  C07C57/00

CPC classification number: C07C69/587 ,  A21D2/16 ,  A23K20/158 ,  A23L33/12 ,  C07C67/03 ,  C07C67/08 ,  C07C67/60 ,  C11C3/003 ,  C07C69/533

Abstract: The present invention includes methods for producing and purifying esters of polyunsaturated fatty acids that include reacting a composition having triglycerides with polyunsaturated fatty acid residues in the presence of an alcohol and a base to produce an ester of a polyunsaturated fatty acid from the triglycerides. The composition can be a polyunsaturated fatty acid-containing composition that has not been conventionally processed. The reacted composition can be further processed by distillation.

Abstract translation: 本发明包括用于生产和纯化多不饱和脂肪酸酯的方法，其包括在醇和碱的存在下使具有甘油三酯的组合物与多不饱和脂肪酸残基反应以从甘油三酸酯生产多不饱和脂肪酸的酯。 组合物可以是未经常规加工的含多不饱和脂肪酸的组合物。 可以通过蒸馏进一步处理反应的组合物。

公开(公告)号：WO2008103753A2

公开(公告)日：2008-08-28

申请号：PCT/US2008/054456

申请日：2008-02-20

Applicant: MARTEK BIOSCIENCES CORPORATION ,  ARTERBURN, Linda ,  BARCLAY, William ,  DANGI, Bindi ,  FLATT, James ,  LEE, Jung ,  VINJAMOORI, Dutt ,  VAN ELSWYK, Mary

Inventor： ARTERBURN, Linda ,  BARCLAY, William ,  DANGI, Bindi ,  FLATT, James ,  LEE, Jung ,  VINJAMOORI, Dutt ,  VAN ELSWYK, Mary

IPC: A61K31/202

CPC classification number: A61K31/202 ,  A23L33/12 ,  A61K8/361 ,  A61K31/60 ,  A61K45/06 ,  A61Q19/00 ,  C07C59/42 ,  C07D303/36 ,  C07D303/48 ,  A61K2300/00

Abstract: Disclosed are novel oxylipins, referred to herein as docosanoids and eicosanoids, that are derived from C22 polyunsaturated fatty acids and from C20 polyunsaturated fatty acids, respectively, and methods of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6), docosatrienoic acid (C22:3n-3) (DTrAn-3), docosadienoic acid (C22:2n-6) (DDAn-6), eicosatrienoic acid (C20:3n-3) (ETrAn-3) eicosapentaenoic acid and arachidonic acid as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUF A)-rich oils and compositions that contain enhanced and effective amounts of LCPUF A-derived oxylipins, and particularly, docosanoids.

Abstract translation: 本文公开了分别衍生自C22多不饱和脂肪酸和C20多不饱和脂肪酸的本文称为二十二烷酸和类二十烷酸的新型氧化喜树碱，以及制备和使用这种氧化喜树碱的方法。 还公开了二十二碳五烯酸（C22：5n-6）（DPAn-6），二十二碳五烯酸（C22：5n-3）（DPAn-3）和二十二碳四烯酸（DTAn-6：C22：4n-6） （C22：3n-3）（DTrAn-3），二十二碳二烯酸（C22：2n-6）（DDAn-6），二十碳三烯酸（C20：3n-3）（ETrAn-3），二十碳五烯酸和花生四烯酸 作为生产新的羟基脂质的基质，以及由此生成的羟基脂质。 还公开了在治疗和营养或美容应用中DPAn-6，DPAn-3，DTAn-6和/或由其衍生的氧化脂质和/或衍生自C22脂肪酸结构的新型二十二烷酸的用途， 抗炎或抗神经变性化合物。 本发明还涉及生产长链多不饱和酸（LCPUF A）丰富的油和组合物的新方法，所述油和组合物包含增强的和有效量的LCPUF A衍生的羟基脂类，特别是二十二烷酸类。

公开(公告)号：WO2007121273A2

公开(公告)日：2007-10-25

申请号：PCT/US2007/066471

申请日：2007-04-11

Applicant: MARTEK BIOSCIENCES CORPORATION ,  ABRIL, Jesus Ruben ,  CRANDELL, Michelle

Inventor： ABRIL, Jesus Ruben ,  CRANDELL, Michelle

IPC: A23D9/00

CPC classification number: A23D9/00 ,  A23D9/007

Abstract: The present invention includes a food oil composition comprising a blend of a first oil comprising an LC PUFA and a second oil comprising substantially no LC PUFA. The first oil can preferably comprise an omega-3 LC PUFA, an omega-6 LC PUFA or mixtures thereof. The present invention also provides methods of food preparation, more particularly, methods for skillet-frying, deep-frying, methods for preparing edible lipid-containing food sauces, methods for preparing extruded food products, and methods for enhancing the LC PUFA content of a food product, particularly previously cooked food products, and food products prepared in accordance with such methods. Such compositions and methods are useful, for example, for increasing intake of LC PUFAs.

Abstract translation: 本发明包括食用油组合物，其包含包含LC PUFA的第一种油和基本上不含LC PUFA的第二种油的共混物。 第一种油可优选包含ω-3 LC PUFA，ω-6 LC PUFA或其混合物。 本发明还提供了食品制备方法，更具体地，涉及煎炸油炸，油炸方法，食用含脂肪食品酱的制备方法，制备挤压食品的方法，以及提高LC PUFA含量的方法 食品，特别是先前熟食的食品，以及按照这种方法制备的食品。 这样的组合物和方法可用于例如增加LC PUFA的摄取。

公开(公告)号：WO2006046943A2

公开(公告)日：2006-05-04

申请号：PCT/US2004/034965

申请日：2004-10-22

Applicant: MARTEK BIOSCIENCES CORPORATION ,  WEAVER, Craig, A. ,  KOBZEFF, Joseph, M. ,  BEHRENS, Paul, W. ,  FICHTALI, Jaouad ,  BELL, Rebecca

Inventor： WEAVER, Craig, A. ,  KOBZEFF, Joseph, M. ,  BEHRENS, Paul, W. ,  FICHTALI, Jaouad ,  BELL, Rebecca

IPC: C12N7/04

CPC classification number: C12P7/62 ,  C12P7/6472

Abstract: Disclosed are methods of preparing high-quality polyunsaturated fatty acid-containing lipids from a lipid-containing material that include enzymatic treatment of components of the material and/or pressure disruption of the material. Lipid-containing materials include biomass, such as microorganisms. The invention further includes products containing the lipid compositions, such as dietary supplements, food products, pharmaceutical formulations, humanized animal milk, and infant formula.

Abstract translation: 公开的是从含脂质材料制备高质量多不饱和脂肪酸的脂质的方法，其包括材料成分的酶处理和/或材料的压力破坏。 含脂质的材料包括生物质，如微生物。 本发明还包括含有脂质组合物的产品，例如膳食补充剂，食品，药物制剂，人源化动物奶和婴儿配方奶粉。

公开(公告)号：WO2006044646A2

公开(公告)日：2006-04-27

申请号：PCT/US2005/036998

申请日：2005-10-13

Applicant: MARTEK BIOSCIENCES CORPORATION ,  WEAVER, Craig, A. ,  ZIRKLE, Ross ,  METZ, James, G.

Inventor： WEAVER, Craig, A. ,  ZIRKLE, Ross ,  METZ, James, G.

IPC: C12P7/64 ,  C07H21/04 ,  C12N9/10 ,  C12N1/21 ,  C12N15/74

CPC classification number: C12P7/6472 ,  C07K14/195 ,  C12N9/001 ,  C12N9/1029 ,  C12N15/52 ,  C12N15/8247 ,  C12P7/62 ,  C12P7/6427

Abstract: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.

Abstract translation: 公开了来自细菌微生物的完整的多不饱和脂肪酸（PUFA）聚酮化合物合成酶（PKS）系统

公开(公告)号：WO2004087879A2

公开(公告)日：2004-10-14

申请号：PCT/US2004/009323

申请日：2004-03-26

Applicant: MARTEK BIOSCIENCES CORPORATION

Inventor： METZ, James, G. ,  WEAVER, Craig, A. ,  BARCLAY, William, R. ,  FLATT, James, H.

IPC: C12N

CPC classification number: C12P7/6427 ,  C12N9/1029 ,  C12N15/52 ,  C12N15/8247 ,  C12P7/6472

Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.

Abstract translation: 本发明通常涉及多不饱和脂肪酸（PUFA）聚酮化合物合酶（PKS）系统，其同源物，分离的核酸分子和编码这种PUFA PKS系统的生物活性结构域的重组核酸分子，包括PUFA PKS的转基因生物 系统，制备和使用这些系统用于生产感兴趣的生物活性分子的方法，以及用于鉴定具有这种PUFA PKS系统的新的细菌和非细菌微生物的新方法。

公开(公告)号：WO2004028469A2

公开(公告)日：2004-04-08

申请号：PCT/US2003/030483

申请日：2003-09-29

Applicant: MARTEK BIOSCIENCES CORPORATION ,  ARTERBURN, Linda ,  BENISEK, Diane ,  HOFFMAN, James ,  OKEN, Harry, A. ,  VAN ELSWYK, Mary

Inventor： ARTERBURN, Linda ,  BENISEK, Diane ,  HOFFMAN, James ,  OKEN, Harry, A. ,  VAN ELSWYK, Mary

IPC: A61K

CPC classification number: A61K31/20 ,  A61K31/202

Abstract: This invention is directed to methods of treating patients with metabolic syndrome, prediabetes and/or Type 11 diabetes mellitus by administering docosahexaenoic acid (DHA) alone or in combination with diabetes-related medications.

Abstract translation: 本发明涉及通过单独施用二十二碳六烯酸（DHA）或与糖尿病相关药物联合治疗代谢综合征，糖尿病前期和/或11型糖尿病患者的方法。

公开(公告)号：WO2003105606A1

公开(公告)日：2003-12-24

申请号：PCT/US2003/019108

申请日：2003-06-18

Applicant: MARTEK BIOSCIENCES CORPORATION ,  ABRIL, Jesus, Ruben ,  STAGNITTI, George, E.

Inventor： ABRIL, Jesus, Ruben ,  STAGNITTI, George, E.

IPC: A23L1/29

CPC classification number: A61K8/06 ,  A23D7/003 ,  A23D7/0053 ,  A23D7/011 ,  A23L33/115 ,  A23L33/12 ,  A23V2002/00 ,  A61K8/4993 ,  A61K8/553 ,  A61K8/92 ,  A61Q17/005 ,  A61Q19/00 ,  B01F17/0021 ,  B01F17/0028 ,  B01F17/0057 ,  B01F17/0064 ,  B01F17/0085 ,  A23V2250/1868 ,  A23V2200/10 ,  A23V2250/1842 ,  A23V2250/5086

Abstract: Methods for making highly stable, oxidation-resistant emulsions comprising an oil, an emulsifier, an emulsion stabilizer and water are provided. The invention is particularly well suited for oils that are susceptible to oxidation, such as long chain polyunsaturated fatty acid oils. The resulting emulsion is highly stable and resistant to oxidation, and is useful in a number of products and as a stand-alone product.

Abstract translation: 提供了制备包含油，乳化剂，乳化稳定剂和水的高度稳定的抗氧化乳液的方法。 本发明特别适用于易氧化的油，例如长链多不饱和脂肪酸油。 所得乳液高度稳定并且耐氧化，并且可用于许多产品和作为独立产品。

公开(公告)号：WO2003092628A2

公开(公告)日：2003-11-13

申请号：PCT/US2003/014177

申请日：2003-05-05

Applicant: MARTEK BIOSCIENCES CORPORATION ,  KOBZEFF, Joseph, M. ,  WEAVER, Craig, A.

Inventor： KOBZEFF, Joseph, M. ,  WEAVER, Craig, A.

IPC: A61K

CPC classification number: A23D9/00 ,  A23L33/115 ,  A23L33/12 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/202 ,  C11B1/025 ,  C11B3/001 ,  C11B5/0021 ,  C12N1/06 ,  C12N1/066 ,  C12P7/6472 ,  A23V2250/1882

Abstract: A high-quality lipid composition is disclosed having low oxidative deterioration such as measured by low anisidine values. Also disclosed are methods of preparing the same from a lipid-containing material that include enzymatic degradation of protein and/or carbohydrate components of the material. Lipid-containing materials include biomass, such as microorganisms. The invention further includes products containing the lipid compositions, such as dietary supplements, food products, pharmaceutical formulations, humanized animal milk, and infant formula.

Abstract translation: 公开了具有低氧化劣化的高质量脂质组合物，例如通过低茴香胺值测量的。 还公开了从包含材料的蛋白质和/或碳水化合物成分的酶降解的含脂质材料制备该方法。 含脂质的材料包括生物质，如微生物。 本发明还包括含有脂质组合物的产品，例如膳食补充剂，食品，药物制剂，人源化动物奶和婴儿配方食品。

公开(公告)号：WO1997000887A1

公开(公告)日：1997-01-09

申请号：PCT/US1996010526

申请日：1996-06-13

Applicant: MARTEK BIOSCIENCES CORPORATION

Inventor： MARTEK BIOSCIENCES CORPORATION ,  BROWN, Jonathan, M. ,  ALLNUTT, F., C., Thomas ,  CHEN, Hao ,  RADMER, Richard

IPC: C07K01/04

CPC classification number: C07H21/00 ,  C07K1/047

Abstract: Combinatorial libraries of labeled biochemical compounds and methods for producing such combinatorial libraries comprising the steps of producing labeled individual units, combining at least two of the labeled individual units so as to produce a labeled biochemical compound, and repeating this process at least once so as to produce a combinatorial library of labeled biochemical compounds. Also, methods for determining the conformation of a biochemical compound which comprise producing a combinatorial library of labeled biochemical compounds, contacting the combinatorial library of labeled biochemial compounds with a target receptor molecule so that a selected labeled biochemical compound binds to the target receptor molecule, and determining the conformation of the selected labeled biochemical compound when bound to the receptor molecule.

Abstract translation: 标记的生物化学化合物的组合文库和用于生产这种组合文库的方法，其包括以下步骤：产生标记的单个单元，将至少两个标记的单个单元结合以产生标记的生物化学化合物，并重复该过程至少一次，以便 生成标记生物化学化合物的组合文库。 另外，用于确定生物化学化合物构象的方法，其包括产生标记的生物化学化合物的组合文库，使标记的生物化学化合物的组合文库与靶受体分子接触，使得选定的标记的生化化合物与靶受体分子结合，以及 当与受体分子结合时，确定所选标记的生物化学化合物的构象。