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    COMBINATORIAL LIBRARIES OF LABELED BIOCHEMICAL COMPOUNDS AND METHODS FOR PRODUCING SAME
    3.
    发明申请
    COMBINATORIAL LIBRARIES OF LABELED BIOCHEMICAL COMPOUNDS AND METHODS FOR PRODUCING SAME 审中-公开
    标记生物化学化合物的组合图书及其生产方法

    公开(公告)号：WO1997000887A1

    公开(公告)日：1997-01-09

    申请号：PCT/US1996010526

    申请日：1996-06-13

    Applicant: MARTEK BIOSCIENCES CORPORATION

    Inventor： MARTEK BIOSCIENCES CORPORATION ,  BROWN, Jonathan, M. ,  ALLNUTT, F., C., Thomas ,  CHEN, Hao ,  RADMER, Richard

    IPC: C07K01/04

    CPC classification number: C07H21/00 ,  C07K1/047

    Abstract: Combinatorial libraries of labeled biochemical compounds and methods for producing such combinatorial libraries comprising the steps of producing labeled individual units, combining at least two of the labeled individual units so as to produce a labeled biochemical compound, and repeating this process at least once so as to produce a combinatorial library of labeled biochemical compounds. Also, methods for determining the conformation of a biochemical compound which comprise producing a combinatorial library of labeled biochemical compounds, contacting the combinatorial library of labeled biochemial compounds with a target receptor molecule so that a selected labeled biochemical compound binds to the target receptor molecule, and determining the conformation of the selected labeled biochemical compound when bound to the receptor molecule.

    Abstract translation: 标记的生物化学化合物的组合文库和用于生产这种组合文库的方法，其包括以下步骤：产生标记的单个单元，将至少两个标记的单个单元结合以产生标记的生物化学化合物，并重复该过程至少一次，以便 生成标记生物化学化合物的组合文库。 另外，用于确定生物化学化合物构象的方法，其包括产生标记的生物化学化合物的组合文库，使标记的生物化学化合物的组合文库与靶受体分子接触，使得选定的标记的生化化合物与靶受体分子结合，以及 当与受体分子结合时，确定所选标记的生物化学化合物的构象。

    TRUE ALVEOLAR BREATH COLLECTING APPARATUS AND METHOD
    6.
    发明申请
    TRUE ALVEOLAR BREATH COLLECTING APPARATUS AND METHOD 审中-公开
    真正的阴道收集装置和方法

    公开(公告)号：WO1994018885A1

    公开(公告)日：1994-09-01

    申请号：PCT/US1994002141

    申请日：1994-02-23

    Applicant: MARTEK BIOSCIENCES CORPORATION

    Inventor： MARTEK BIOSCIENCES CORPORATION ,  DELENTE, Jacques, J.

    IPC: A61B05/097

    CPC classification number: A61B5/097 ,  Y10T436/20

    Abstract: A simplified, user-friendly method and apparatus for collecting and storing a human breath sample and for detecting and indicating whether the stored breath sample is a true alveolar sample. The invention includes in one embodiment thereof a preferably transparent container (1) and a breath delivery device (6) for directing a subject's breath into the container (1). A closure device (5) is provided for accomodating the insertion of the breath delivery device (6) into the container (1) and for substantially sealing the container (1). A detector (12) is provided for being positioned within the sealed container (1) for detecting and indicating to an observer whether the breath sample stored in the container (1) is a true alveolar sample.

    Abstract translation: 一种用于收集和存储人类呼吸样本并用于检测和指示储存的呼吸样品是否为真正肺泡样品的简化的，用户友好的方法和装置。 本发明在其一个实施方案中包括优选透明的容器（1）和用于将受试者的呼吸引导到容器（1）中的呼吸输送装置（6）。 提供闭合装置（5），用于容纳将呼吸输送装置（6）插入容器（1）中并基本上密封容器（1）。 提供检测器（12），用于定位在密封容器（1）内，用于检测并向观察者指示储存在容器（1）中的呼吸样品是真正的肺泡样品。

    GENERATION AND SCREENING OF SYNTHETIC DRUG LIBRARIES
    8.
    发明申请
    GENERATION AND SCREENING OF SYNTHETIC DRUG LIBRARIES 审中-公开
    合成药物库的生成和筛选

    公开(公告)号：WO1995021850A1

    公开(公告)日：1995-08-17

    申请号：PCT/US1995001389

    申请日：1995-02-08

    Applicant: MARTEK BIOSCIENCES CORPORATION

    Inventor： MARTEK BIOSCIENCES CORPORATION ,  CHEN, Hao ,  RADMER, Richard, J.

    IPC: C07H03/06

    CPC classification number: C07H3/04 ,  B01J2219/00702 ,  B01J2219/00731 ,  C07H3/06 ,  C07H5/06 ,  C07H15/04 ,  C40B40/12

    Abstract: Methods are provided for generating highly diverse mixtures of compounds which may be screened for biological activities. Once the activity is found, the component of the mixture which is responsible for the activity can be isolated by fractionation and assay for the biological activity. Polyhydroxylated organic monomers and oligomers are used as starting materials for generating the libraries.

    Abstract translation: 提供了用于产生可被筛选用于生物活性的高度多样化合物混合物的方法。 一旦发现活性，负责活性的混合物的组分可以通过分离和测定生物活性来分离。 多羟基化有机单体和低聚物用作生成文库的起始材料。

    COMPOSITIONS AND METHODS FOR PROTEIN STRUCTURAL DETERMINATIONS
    9.
    发明申请
    COMPOSITIONS AND METHODS FOR PROTEIN STRUCTURAL DETERMINATIONS 审中-公开
    蛋白质结构测定的组合物和方法

    公开(公告)号：WO1994018339A1

    公开(公告)日：1994-08-18

    申请号：PCT/US1994001329

    申请日：1994-02-07

    Applicant: MARTEK BIOSCIENCES CORPORATION ,  BROWN, Jonathan, Miles

    Inventor： MARTEK BIOSCIENCES CORPORATION

    IPC: C12P13/04

    CPC classification number: G01N33/68 ,  C07B59/001 ,  C07K2299/00 ,  C12N1/12 ,  C12P13/04 ,  C12Q1/04 ,  G01N33/534 ,  G01N33/58 ,  G01N33/6803 ,  Y02P20/55 ,  Y10T436/105831

    Abstract: A method for determining three-dimensional structural information of a protein involves producing the protein in a form substantially labeled with C or N or both or substantially labeled with N and C and partially labeled with H and subjecting the protein to nuclear magnetic resonance spectroscopic analysis. The isotopically labeled protein is produced by a method which involves producing a substantially labeled microbial protein hydrolysate, subjecting the protein hydrolysate to cation exchange chromatography to produce a partially purified labeled amino acid mixture, subjecting the partially purified labeled amino acid mixture to anion exchange chromatography to produce a purified labeled amino acid mixture and supplementing the purified labeled amino acid mixture with isotopically labeled cysteine and optionally with isotopically labeled glutamine and asparagine.

    Abstract translation: 用于测定蛋白质的三维结构信息的方法包括以13 C或15 N或两者基本上标记的形式产生蛋白质，或者基本上用15 N和13 C标记，并部分地用 并使蛋白质进行核磁共振光谱分析。 同位素标记的蛋白质通过包括产生基本上标记的微生物蛋白质水解产物的方法产生，使蛋白质水解产物进行阳离子交换层析以产生部分纯化的标记氨基酸混合物，将部分纯化的标记氨基酸混合物进行阴离子交换色谱 产生纯化的标记的氨基酸混合物，并用同位素标记的半胱氨酸和任选与同位素标记的谷氨酰胺和天冬酰胺补充纯化的标记的氨基酸混合物。

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