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    METHODS FOR MANUFACTURING A MICROSTRUCTURE
    31.
    发明公开
    METHODS FOR MANUFACTURING A MICROSTRUCTURE 有权
    一种用于生产微结构

    公开(公告)号：EP2207749A2

    公开(公告)日：2010-07-21

    申请号：EP08838017.5

    申请日：2008-10-03

    Applicant: Micronit Microfluidics B.V.

    Inventor： VAN'T OEVER, Ronny ,  BLOM, Marko, Theodoor ,  OONK, Johannes

    IPC: B81C1/00

    CPC classification number: B81C1/00119 ,  B81B2203/0376 ,  B81C1/00103 ,  B81C2201/0146

    Abstract: Methods for manufacturing a microstructure, wherein use is made of powder blasting and/or etching and a single mask layer with openings and structures of varying dimensions, characterized in that the mask layer at least at one given point in time has been wholly worn away within at least one region by mask erosion while the microstructure is not yet wholly realized. Use can be made of a combination of 'vertical' erosion, i.e. parallel to the thickness direction, and 'horizontal' erosion, i.e. perpendicularly of the thickness direction, of the mask layer. The horizontal mask erosion occurs at the edges of the mask structure. By selecting the size of the mask openings and the mask structures in a correct manner the mask layer in a region with smaller mask structures will be fully worn away at a given point in time, while in another region with larger structures the mask layer still has sufficient thickness to serve as protection against the powder blasting or etching.

    METHOD OF DIVIDING A SUBSTRATE INTO A PLURALITY OF INDIVIDUAL CHIP PARTS
    32.
    发明公开
    METHOD OF DIVIDING A SUBSTRATE INTO A PLURALITY OF INDIVIDUAL CHIP PARTS 审中-公开
    方法分离基板在几个单独安排

    公开(公告)号：EP1456115A2

    公开(公告)日：2004-09-15

    申请号：EP02789027.6

    申请日：2002-12-19

    Applicant: Micronit Microfluidics B.V.

    Inventor： VAN'T OEVER, Ronny

    IPC: B81C1/00 ,  B41J2/00

    CPC classification number: B81C1/00888

    Abstract: The present invention relates to a method for dividing a substrate into a number of individual chip parts, comprising the steps of: forming a number of chip parts in the substrate, comprising, for each chip part, of arranging recesses in the substrate for containing fluid; arranging one or more breaking grooves in the substrate along individual chip parts; applying mechanical force to the substrate to break the substrate along the breaking grooves. The invention also relates to a substrate as well as a chip part.

    CHANNEL FOR TRAPPING PARTICLES TO BE FED TO SAID CHANNEL WITH A FLUID
    33.
    发明公开
    CHANNEL FOR TRAPPING PARTICLES TO BE FED TO SAID CHANNEL WITH A FLUID 审中-公开
    CHANNEL捕捉颗粒喂养在所述的通道与液体

    公开(公告)号：EP3130401A1

    公开(公告)日：2017-02-15

    申请号：EP16183611.9

    申请日：2016-08-10

    Applicant: Micronit Microfluidics B.V. ,  Janssen Pharmaceutica, N.V. ,  NXP B.V.

    Inventor： BLOM, Marko Theodoor ,  BRIVIO, Monica ,  TANZI, Simone ,  REUVEKAMP, Simon ,  VAN DORST, Bieke ,  STUYVER, Lieven Jozef ,  VAN DER SAR, Elfried

    IPC: B01L3/00

    CPC classification number: G01N33/54313 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2400/0406 ,  B01L2400/086 ,  G01N33/54386

    Abstract: The invention relates to a channel for trapping particles to be fed to said channel with a fluid, said channel having a bottom and opposite sidewalls, the sidewalls defining a width of the channel, said channel further comprising:
    - a first channel part;
    - a second channel part in fluid through flow connection with said first channel part and downstream of said first channel part;
    - an elevated structure provided in said channel that divides said channel in said first channel part and said second channel part and for trapping particles in said first channel part;
    - at least one flow gap provided by said elevated structure for providing said fluid through flow connection between the first channel part and the second channel part for allowing, in use, at least some fluid to flow past said elevated structure into said second channel part while trapping said particles in said first channel part;
    wherein said elevated structure is substantially U-shaped and has a base extending substantially between the opposite sidewalls of the channel and two legs extending from the base in an upstream direction, wherein at least part of said U-shaped elevated structure defines at least part of a particle trapping area for trapping the particles to be fed to said channel.
    The invention further relates to a flow cell comprising such a channel. The invention also relates to an assembly comprising such a flow cell and a detection means. The invention also relates to a method for trapping particles in such a channel. And finally, the invention relates to a method for analyzing a sample using such an assembly.

    Abstract translation: 本发明涉及的信道用于捕集颗粒被供给到所述通道与具有底部和相对的侧壁的流体，所述通道，所述侧壁限定所述通道的宽度，所述通道还包括： - 第一信道部分; - 在流体流的第二通道部分通过与所述第一信道部分和所述第一通道部分的下游连接; - 在所述信道提供的那样高架结构分割所述信道在所述第一通道部分和所述第二通道部分和用于在所述第一通道部分捕集颗粒; - 由所述高架结构用于提供所述流体通过第一通道部分和用于允许所述第二通道部分之间的流动连接，在使用中，至少一些流体流经过所述高架结构到所述第二信道的一部分而提供的至少一个流动间隙 所述捕获在所述第一通道部分的颗粒; worin所述高架结构是大致为U形，并且具有基部的通道的相对侧壁和两个腿来在上游方向上从所述基座延伸之间基本上延伸worin所述U形高架结构的至少一部分定义的至少一部分 用于捕集的颗粒的颗粒捕集面积要被馈送到所述通道中。 本发明还涉及到一个流动池，其包括寻求的信道。 因此，本发明涉及在组件包括寻求的流动池和一个检测装置。 因此本发明涉及一种用于在搜索频道捕集颗粒的方法。 最后，本发明涉及一种用于分析使用搜索到组件的样品的方法。

    Method for manufacturing microfluidic chips, device for functionalizing microfluidic chips, microfluidic chip and device for holding a microfluidic chip
    34.
    发明公开
    Method for manufacturing microfluidic chips, device for functionalizing microfluidic chips, microfluidic chip and device for holding a microfluidic chip 审中-公开
    一种用于制备的微流体芯片，设备的微流控芯片的官能化，所述微流体芯片和保持装置用于微流体芯片的过程

    公开(公告)号：EP2772306A1

    公开(公告)日：2014-09-03

    申请号：EP14157523.3

    申请日：2014-03-03

    Applicant: Micronit Microfluidics B.V.

    Inventor： Olde Riekerink, Marinus Bernardus ,  Buesink, Wilfred ,  Koelewijn-Hubers, Arenda Hendrika Jacoba ,  Blom, Marko Theodoor ,  van't Oever, Ronny

    IPC: B01J19/00 ,  B01L3/00 ,  B81B1/00 ,  B81C1/00

    Abstract: The invention relates to a method for manufacturing microfluidic chips having at least one capillary for through-flow of a fluid, comprising the steps of:
    (a) providing a starting material;
    (b) forming at least one shared capillary in the starting material, said shared capillary comprising an fluidic inlet and an fluidic outlet;
    (c) functionalizing the chips by supplying a functionalization fluid to the shared capillary; and
    (d) dividing the starting material into separate chips.
    The invention further relates to a device for functionalizing microfluidic chips having at least one capillary for through-flow of a fluid, said device comprising a material holder for holding a starting material in a fixed position during functionalization, said material holder comprising at least one inlet connector for connecting at least one shared capillary formed in the starting material to a functionalization fluid supply.
    The invention further relates to a microfluidic chip and a device for holding a microfluidic chip.

    Abstract translation: 本发明涉及一种用于制造具有至少一个毛细管的微流体芯片，用于通过流动的流体的方法，包括以下步骤：（a）提供一起始材料; （B）在起始材料中形成至少一个共享的毛细管，所述共享毛细管流体入口和流体的出口，包括： （C）官能化通过供应官能流体到共享毛细管的芯片; 和（d）将所述起始原料为单独的芯片。 本发明还涉及一种设备，用于官能化具有用于通流的流体的，所述装置包括一个材料保持器用于在官能化过程中的固定位置保持起始材料的至少一个毛细管的微流体芯片，所述材料保持器包括至少一个入口 连接器，用于连接在起始材料而形成的流体供给官能的至少一个共享的毛细管。 本发明还涉及到微流体芯片和用于保持微流体芯片的装置。

    Method of dividing a substrate into a plurality of individual chip parts
    35.
    发明公开
    Method of dividing a substrate into a plurality of individual chip parts 审中-公开
    用于在基板分离成多个单独的组件的方法

    公开(公告)号：EP2390225A3

    公开(公告)日：2014-03-12

    申请号：EP11178879.0

    申请日：2002-12-19

    Applicant: Micronit Microfluidics B.V.

    Inventor： Van't Oever, Ronny

    IPC: B81C1/00 ,  B41J2/00

    CPC classification number: B81C1/00888

    Abstract: The present invention relates to a method for dividing a substrate into a number of individual chip parts, comprising the steps of:
    forming a number of chip parts in the substrate, comprising, for each chip part, of arranging recesses in the substrate for containing fluid;
    arranging one or more breaking grooves in the substrate along individual chip parts;
    applying mechanical force to the substrate to break the substrate along the breaking grooves;

    wherein the steps of arranging recesses in the substrate and arranging breaking grooves in the substrate are performed substantially simultaneously,
    wherein the substrate comprises a first and a second substrate part, and the method comprises the steps of:
    a) arranging in the first substrate part at least one recess for containing fluid;
    b) arranging in the second substrate part passages to the recess in the first substrate part, wherein a first passage forms a fluid feed and a second passage forms a fluid discharge;
    c) arranging one or more breaking grooves in at least one of the substrate parts;
    d) placing the second substrate part on the first substrate part;
    e) breaking the substrate along the breaking grooves.

    Method for manufacturing and testing microfluidic chips
    36.
    发明公开
    Method for manufacturing and testing microfluidic chips 有权
    一种制备和微流控芯片测试过程

    公开(公告)号：EP2269947A3

    公开(公告)日：2014-02-26

    申请号：EP10167629.4

    申请日：2010-06-29

    Applicant: Micronit Microfluidics B.V.

    Inventor： Van 't Oever, Ronny ,  Blom, Marko Theodoor

    IPC: B81C99/00

    CPC classification number: B81C99/004 ,  B81B2201/058 ,  Y10T29/49764

    Abstract: The invention relates to a method for manufacturing and testing microfluidic chips having at least one capillary for through-flow of a fluid. The method comprises the following steps:
    - providing a starting material;
    - forming at least one shared capillary in the starting material;
    - arranging a plurality of functional elements in or over the shared capillary, thus forming a plurality of chips;
    - testing the chips by supplying a test fluid to the shared capillary; and
    - dividing the starting material into separate chips.
    The invention further relates to a device for testing microfluidic chips having at least one capillary for through-flow of a fluid. This device comprises a material holder for holding a starting material in a fixed position during testing, and an inlet connector for connecting a shared capillary formed in the starting material to a test fluid supply.

    Method for manufacturing and testing microfluidic chips
    37.
    发明公开
    Method for manufacturing and testing microfluidic chips 有权
    Verfahren zur Herstellung und zum Testen von mikrofluidischen Chips

    公开(公告)号：EP2269947A2

    公开(公告)日：2011-01-05

    申请号：EP10167629.4

    申请日：2010-06-29

    Applicant: Micronit Microfluidics B.V.

    Inventor： Van 't Oever, Ronny ,  Blom, Marko Theodoor

    IPC: B81C99/00

    CPC classification number: B81C99/004 ,  B81B2201/058 ,  Y10T29/49764

    Abstract: The invention relates to a method for manufacturing and testing microfluidic chips having at least one capillary for through-flow of a fluid. The method comprises the following steps:
    - providing a starting material;
    - forming at least one shared capillary in the starting material;
    - arranging a plurality of functional elements in or over the shared capillary, thus forming a plurality of chips;
    - testing the chips by supplying a test fluid to the shared capillary; and
    - dividing the starting material into separate chips.
    The invention further relates to a device for testing microfluidic chips having at least one capillary for through-flow of a fluid. This device comprises a material holder for holding a starting material in a fixed position during testing, and an inlet connector for connecting a shared capillary formed in the starting material to a test fluid supply.

    Abstract translation: 本发明涉及用于制造和测试具有至少一个用于流体流通的毛细管的微流体芯片的方法。 该方法包括以下步骤： - 提供原料; - 在起始材料中形成至少一个共用毛细管; - 在共享毛细管内或上方布置多个功能元件，从而形成多个芯片; - 通过向共享毛细管提供测试流体来测试芯片; 和 - 将起始材料分成单独的芯片。 本发明还涉及一种用于测试具有至少一个用于流体流通的毛细管的微流体芯片的装置。 该装置包括用于在测试期间将起始材料保持在固定位置的材料保持器和用于将形成在起始材料中的共用毛细管连接到测试流体供应的入口连接器。

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