34.
    发明专利
    未知

    公开(公告)号:DE69231291D1

    公开(公告)日:2000-08-31

    申请号:DE69231291

    申请日:1992-03-25

    Abstract: PCT No. PCT/AU92/00124 Sec. 371 Date Nov. 17, 1993 Sec. 102(e) Date Nov. 17, 1993 PCT Filed Mar. 25, 1992 PCT Pub. No. WO92/17165 PCT Pub. Date Oct. 15, 1992The invention provides a pharmaceutical or veterinary implant, which when parenterally administered releases a pulse of at least one biologically active material at a controllable time interval after implantation. The implant comprises the biologically active material; an excipient comprising at least one water soluble material and at least one water insoluble material; and a polymer film coating adapted to rupture at a predetermined period of time after implantation, and wherein the excipients and polymers are biocompatible. The biologically active material is selected from the group consisting of antigens, antibodies, hormones, growth promotants, antibiotics, nutrients, minerals and vitamins. Preferably the excipient comprises a combination of two or more water-soluble and water-insoluble materials.

    39.
    发明专利
    未知

    公开(公告)号:DE02740997T1

    公开(公告)日:2004-07-15

    申请号:DE02740997

    申请日:2002-06-27

    Inventor: COMPER D

    Abstract: The invention provides a method of generating and analyzing a urinary protein fragmentation profile, in terms of the size, and sequence of particular fragments derived from intact filtered proteins together with the position where enzymes scission occurs along the protein polypeptide chain is characteristic of the diseased state of the kidney. With the recognition that filtered proteins are degraded during renal passage, the methods described in this application will be able to detect protein fragments derived from proteins generated by non-renal disease. Non-renal disease such as cancers may generate increased levels of proteins into the circulation. The urinary analysis of these filtered proteins would currently not detect the intact form of these proteins. Therefore, a method as described to detect and analyze fragments resulting from degradation during renal passage that will be able to detect the seriousness of the disease.

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