FLOW-THROUGH HIGH HYDROSTATIC PRESSURE MICROFLUIDIC SAMPLE PREPARATION DEVICE AND RELATED METHODS THEREFOR

    公开(公告)号:WO2012024523A3

    公开(公告)日:2012-02-23

    申请号:PCT/US2011/048302

    申请日:2011-08-18

    Abstract: Described herein is a sample preparation device including a sample delivery source, an inline means of transferring the sample from the sample source into a deformable channel within a pressure vessel, and out of the channel into downstream analysis components, a deformable channel disposed within the pressure vessel, the deformable channel having an inlet end and an outlet end fluidly connectable to high pressure valves and a means to measure the fluid pressure within the deformable channel, an external source of a controlled pressurized fluid fluidly connectable to the pressure vessel and a controller system that monitors and controls the sample fluid pressure by control of the external pressure vessel fluid.

    SYSTEM FOR HIGH PRESSURE, HIGH SHEAR PROCESSING OF FLUIDS
    35.
    发明申请
    SYSTEM FOR HIGH PRESSURE, HIGH SHEAR PROCESSING OF FLUIDS 审中-公开
    高压,流体高剪切加工系统

    公开(公告)号:WO2016160667A1

    公开(公告)日:2016-10-06

    申请号:PCT/US2016/024452

    申请日:2016-03-28

    Inventor: TING, Edmund, Y.

    Abstract: A method for high fluid shear processing of a fluid uses an isolator that has a first sub-chamber for containing a first fluid and a second sub-chamber for containing a second fluid defined by a separator positioned in the chamber and movable between a first end of the chamber and a second end of the chamber. The two sub-chambers are in pressure communication with each other but are not in fluid communication with each other. A first fluid is pumped at an ultrahigh pressure into the first-sub chamber, and the pressure in the first sub-chamber causes a second fluid to be processed to be discharged from the second sub-chamber into a processing valve. A system is also provided for performing the steps of this method.

    Abstract translation: 用于流体的高流体剪切处理的方法使用隔离器,其具有用于容纳第一流体的第一子室和用于容纳由位于室中的分离器限定的第二流体的第二子室,该第二流体可在第一端 的腔室和腔室的第二端。 两个子室彼此压力连通但不彼此流体连通。 将第一流体以超高压泵送到第一副室中,并且第一子室中的压力使得第二流体被处理从第二子室排出到处理阀中。 还提供了一种用于执行该方法的步骤的系统。

    SAMPLE PREPARATION DEVICES AND METHODS
    36.
    发明申请
    SAMPLE PREPARATION DEVICES AND METHODS 审中-公开
    样品制备装置和方法

    公开(公告)号:WO2015184360A1

    公开(公告)日:2015-12-03

    申请号:PCT/US2015/033338

    申请日:2015-05-29

    Abstract: Devices and methods for sample preparation via pressure cycling technology are disclosed. The device for sample preparation comprises a tube having an inner surface, a top, and a bottom, the tube configured to contain a sample at the bottom and to be received into a pressure chamber for sample preparation, a cap detachably connected to the top of the tube, and a tapered elongate member extending from the cap into the tube, the tapered elongate member configured to contact the inner surface of the tube and the sample in the bottom of the tube, wherein the tube is deformable such that in operation under pressure the tube is deformed against the tapered elongate member to promote disruption of the sample.

    Abstract translation: 公开了通过压力循环技术进行样品制备的装置和方法。 用于样品制备的装置包括具有内表面,顶部和底部的管,所述管被配置为在底部容纳样品并被接收到用于样品制备的压力室中,所述管可拆卸地连接到 所述管和从所述盖延伸到所述管中的锥形细长构件,所述锥形细长构件构造成接触所述管的内表面和所述管的底部中的样品,其中所述管是可变形的,使得在压力下操作 管对锥形细长构件变形以促进样品的破坏。

    PRESSURE CYCLING SYSTEMS AND RELATED METHOD
    40.
    发明申请
    PRESSURE CYCLING SYSTEMS AND RELATED METHOD 审中-公开
    压力循环系统及相关方法

    公开(公告)号:WO2008092102A3

    公开(公告)日:2008-10-16

    申请号:PCT/US2008052089

    申请日:2008-01-25

    Inventor: TING EDMUND Y

    Abstract: A pressure cycling system includes a reaction chamber configured to receive a sample and a charge pump in fluid communication with the reaction chamber. The charge pump is operable to convey a fluid from a fluid source toward the reaction chamber. The system also includes a check valve disposed between the charge pump and the reaction chamber. The check valve is operable to inhibit the flow of fluid from the reaction chamber toward the charge pump. A pressure intensifier is in fluid communication with the reaction chamber. The pressure intensifier is pneumatically operable to adjust a pressure in the reaction chamber. A controller is configured to control operation of the charge pump and the pressure intensifier. The controller is configured to pressurize the reaction chamber to a first pressure through operation of the charge pump. The controller is also configured to fluctuate the pressure in the reaction chamber between a second pressure and a third pressure through operation of the pressure intensifier.

    Abstract translation: 压力循环系统包括配置成接收样品的反应室和与反应室流体连通的电荷泵。 电荷泵可操作以将流体从流体源传送到反应室。 该系统还包括设置在电荷泵和反应室之间的止回阀。 止回阀可操作以阻止流体从反应室朝向电荷泵的流动。 增压器与反应室流体连通。 增压器可气动地操作以调节反应室中的压力。 控制器被配置为控制电荷泵和增压器的操作。 控制器被配置为通过操作电荷泵将反应室加压至第一压力。 控制器还被配置为通过操作压力增加器来在第二压力和第三压力之间波动反应室中的压力。

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