Abstract:
A pressurizable sample system includes a microplate having a planar plate surface and several sample wells. Each sample well has a flange positioned circumferentially around an outer surface of the sample well and against the planar plate surface. The sample system further includes a capping plate with a planar cap surface and several caps projecting from the planar cap surface. Each cap has a geometrical configuration in complementary correspondence with the configuration of the sample well.
Abstract:
The systems and techniques of the present invention can also synergistically utilize mechanical disruption processes with the use of high hydrostatic pressure extraction, such as pressure cycling extraction techniques to achieve high yield of difficult to extract sample constituents without generating high shear stress or high temperatures.
Abstract:
A product carrier (10) for use in ultrahigh pressure processing substances is substantially fluidically closed, and is insulated, to prevent heat transfer from the product being treated to the cooler wall of the pressure vessel. The insulating material (18) has compression heating properties, such that as the product is pressurized, the temperature of the insulation increases as does the temperature of the product and pressure media, thereby helping to prevent heat transfer from the product to the surrounding media and pressure vessel wall.
Abstract:
A method and apparatus for diagnosing components in high-pressure pumps to indicate when a component of the pump head is malfunctioning and to identify the malfunctioning component. In one embodiment, a high-pressure pump head incorporating a diagnostic system in accordance with the invention has a pressurization chamber and a pressurizing member at least partially received in the pressurization chamber. The pressurizing member moves within the pressurization chamber along an intake action to draw fluid into the pressurization chamber and along a pressurizing action to compress fluid in the pressurization chamber. An inlet fluid control assembly is coupled to the pressurization chamber to allow fluid to enter the pressurization chamber during the intake action, and a pressurized fluid control assembly is coupled between the pressurization chamber and an outlet chamber to selectively allow pressurized fluid into the outlet chamber during the pressurizing action. The pump head may also include a diagnostic system to indicate the operational status of each of the inlet fluid control assembly, the pressurized fluid control assembly and other components of the pump head upstream from the inlet fluid control assembly with respect to a fluid flow through the pump head during the pressurizing action.
Abstract:
Described herein is a sample preparation device including a sample delivery source, an inline means of transferring the sample from the sample source into a deformable channel within a pressure vessel, and out of the channel into downstream analysis components, a deformable channel disposed within the pressure vessel, the deformable channel having an inlet end and an outlet end fluidly connectable to high pressure valves and a means to measure the fluid pressure within the deformable channel, an external source of a controlled pressurized fluid fluidly connectable to the pressure vessel and a controller system that monitors and controls the sample fluid pressure by control of the external pressure vessel fluid.
Abstract:
A connector for a pressure vessel includes a connector assembly having a first plurality of contacts, and a receiver assembly configured to be positioned within a receiver aperture formed in a closure of the pressure vessel and having a second plurality of contacts. The receiver assembly is configured to receive the connector assembly and place each of the first plurality of contacts in electrical contact with a corresponding one of the second plurality of contacts. A seal is provided between the connector assembly and the wall of the pressure vessel, for substantially sealing the receiver aperture from pressure within the vessel. The connector assembly is configured to be coupled to a product carrier, and sensors positioned in the vessel are coupled via the connector assembly to a data acquisition unit. When the closure is lowered onto the vessel, the receiver assembly contacts the connector assembly coupled to the carrier, closing the electrical contacts connecting the sensors to the acquisition unit.
Abstract:
An assembly for changing the temperature of ultrahigh-pressure fluid as it flows through ultrahigh-pressure tubing includes several thermally conductive blocks. Each block has a first bore through which the ultrahigh-pressure tubing passes, and a second bore containing a source of heating or cooling. Alternatively, resistance heating is used to increase the temperature of the ultrahigh-pressure fluid, by coupling electrodes to the outer surface of the tubing. The ultrahigh-pressure fluid is heated or cooled after it is pressurized, and is then discharged from the ultrahigh-pressure tubing at a selected temperature for use. For example, the ultrahigh-pressure fluid at a selected temperature may be discharged through a nozzle to form an ultrahigh-pressure fluid jet to cut or clean any desired surface or object, or it may be discharged to a pressure vessel to pressure treat a substance.
Abstract:
A pressure cycling system includes a reaction chamber configured to receive a sample and a charge pump in fluid communication with the reaction chamber. The charge pump is operable to convey a fluid from a fluid source toward the reaction chamber. The system also includes a check valve disposed between the charge pump and the reaction chamber. The check valve is operable to inhibit the flow of fluid from the reaction chamber toward the charge pump. A pressure intensifier is in fluid communication with the reaction chamber. The pressure intensifier is pneumatically operable to adjust a pressure in the reaction chamber. A controller is configured to control operation of the charge pump and the pressure intensifier. The controller is configured to pressurize the reaction chamber to a first pressure through operation of the charge pump. The controller is also configured to fluctuate the pressure in the reaction chamber between a second pressure and a third pressure through operation of the pressure intensifier.
Abstract:
The systems and techniques of the present invention can also synergistically utilize mechanical disruption processes with the use of high hydrostatic pressure extraction, such as pressure cycling extraction techniques to achieve high yield of difficult to extract sample constituents without generating high shear stress or high temperatures.
Abstract:
A pressurizable sample system includes a microplate having a planar plate surface and several sample wells. Each sample well has a flange positioned circumferentially around an outer surface of the sample well and against the planar plate surface. The sample system further includes a capping plate with a planar cap surface and several caps projecting from the planar cap surface. Each cap has a geometrical configuration in complementary correspondence with the configuration of the sample well.