公开(公告)号：EP0291527B1

公开(公告)日：1993-07-28

申请号：EP88900214.3

申请日：1987-12-02

Applicant: RADIOMETER A/S

Inventor： LARSEN, Eiler

IPC: G01N27/36 ,  G01N33/49

CPC classification number: G01N27/4165 ,  Y10T436/10

Abstract: The use of an aqueous, synthetic composition comprising Ca++ and having a controlled, specified pH value for revealing the presence of protein contamination on the membrane of a pH measuring electrode.

公开(公告)号：EP0210417B1

公开(公告)日：1990-09-05

申请号：EP86108426.7

申请日：1986-06-20

Applicant: RADIOMETER A/S

Inventor： Lundsgaard, Finn Chresten

IPC: G01N21/31

CPC classification number: G01N21/31 ,  G01N2021/3129 ,  Y10T436/113332

公开(公告)号：EP0100463B1

公开(公告)日：1987-10-07

申请号：EP83106737.6

申请日：1983-07-08

Applicant: RADIOMETER A/S

Inventor： Pedersen, Knud Gronlund

IPC: G01N27/46 ,  G01N27/56 ,  A61B5/14

CPC classification number: A61B5/14542 ,  A61B5/1477 ,  G01N27/404

公开(公告)号：EP0126103B1

公开(公告)日：1987-01-28

申请号：EP83903532.6

申请日：1983-10-31

Applicant: RADIOMETER A/S

Inventor： ENGELL, John, Emil ,  MORTENSEN, Svend

IPC: G01N27/30 ,  G01N27/40

CPC classification number: C04B35/447 ,  C04B35/16 ,  C04B35/481 ,  C04B35/624 ,  C04B35/62655 ,  C04B2235/3201 ,  C04B2235/3217 ,  C04B2235/3244 ,  C04B2235/3418 ,  C04B2235/3427 ,  C04B2235/441 ,  C04B2235/447 ,  C04B2235/5409 ,  C04B2235/77 ,  C04B2235/80 ,  C04B2235/81 ,  G01N27/333 ,  H01M6/185

Abstract: An ion-sensitive measuring electrode device with an ion-sensitive element based on ion-conducting crystalline ceramic material. The electrode device shows a selectivity to the Na+ ion versus the H+ ion corresponding to the selectivity of the known sodium-sensitive glass-based solid membrane electrodes. Ion-sensitive measuring electrode devices showing good selectivity properties are provided on the basis of ion-conducting crystalline material, the crystal structure of which comprises a three-dimensionally extending interstitial space containing positions for the ion, especially material in which the interstitial space has bottlenecks which just permits passage of the ion. A method for preparing polycrystalline ceramic material based on oxides of zirconium, phosphor and silicon is also provided.

公开(公告)号：EP0039136B1

公开(公告)日：1985-12-04

申请号：EP81301299.4

申请日：1981-03-26

Applicant: RADIOMETER A/S

Inventor： Poulsen, Jorgen

IPC: G01N27/28 ,  G01N27/46

CPC classification number: A61B5/14542 ,  A61B5/1477 ,  A61B5/1491 ,  G01N27/404 ,  G01N27/4162

公开(公告)号：EP0051288B1

公开(公告)日：1985-08-28

申请号：EP81109290.7

申请日：1981-10-29

Applicant: RADIOMETER A/S

Inventor： Aas, Flemming ,  Jeppesen, Borge

IPC: B01L3/14

CPC classification number: B01L3/50825 ,  Y10S220/19

公开(公告)号：EP0061190A1

公开(公告)日：1982-09-29

申请号：EP82102365.2

申请日：1982-03-22

Applicant: RADIOMETER A/S

Inventor： Jensen, Ole Jörgen ,  Melberg, Steen Gyldendaal

IPC: A61B5/00 ,  G01N27/28

CPC classification number: A61B5/14539 ,  A61B5/1491

Abstract: An electrode device for the determination of the partial pressure of CO 2 , Pco 2 , in particular an electrode device for transcutaneous determination of Pco 2 .
The interior electrolyte (6) of the electrode device is adapted to the exterior electrolyte (5) in such a manner that the potential difference measured over the exterior reference electrode (8) and the interior reference electrode (7) is substantially temperature-independent with a temperature dependence for the CO 2 partial pressure determination in the range of -1%/°C - +1%/°C.
The interior electrolyte (6) preferably contains a pH-buffer system based on phenyl phosphonic acid.

公开(公告)号：EP0051288A1

公开(公告)日：1982-05-12

申请号：EP81109290.7

申请日：1981-10-29

Applicant: RADIOMETER A/S

Inventor： Aas, Flemming ,  Jeppesen, Borge

IPC: B01L3/14

CPC classification number: B01L3/50825 ,  Y10S220/19

Abstract: A capillary tube (12) containing a sample is anaerobicly sealed by means of closure caps each comprising an end wall (9) and a skirt portion (13). Each open end of the capillary tube is sealed by inserting the open tube end into the cap skirt portion, and in orderto avoid that a volume of air is forced into the capillary tube, the space defined between the open tube end and the cap end wall is vented to the atmosphere through one or more venting passages (3) defined in the walls of the closure cap or between the inner surface of the cap skirt portion and the adjacent outer peripheral surface of the capillary tube. The open tube end is brought into sealing engagement with sealing means (4) on the cap end wall (9), and frictional engagement established between the inner surface of the cap skirt portion (13) and adjacent outer peripheral surface parts of the capillary tube secures that said sealing engagement is maintained.

公开(公告)号：EP0039136A3

公开(公告)日：1982-01-20

申请号：EP81301299

申请日：1981-03-26

Applicant: RADIOMETER A/S

Inventor： Poulsen, Jorgen

IPC: G01N27/28 ,  G01N27/46

CPC classification number: A61B5/14542 ,  A61B5/1477 ,  A61B5/1491 ,  G01N27/404 ,  G01N27/4162

Abstract: An electrode device for electrochemical measurement of the concentration of the partial pressure of a gas in a liquid or a gas mixture; comprises a measuring surface constituted by or comprising the sensitive part (4) of a measuring electrode and a membrane (6). placed in front of the measuring surface and delimiting a volume of electrolyte solution (5) which is in contact with the measuring electrode. The membrane is permeable to thegas to be determined, and a given distance is obtained and maintained between the measuring surface and the membrane by means of particles (7). When assembling the electrode device, a dispersion of the particles in the electrolyte to be incorporated in the electrode device is applied on the measuring surface and/or the membrane in excess, and the electrode device is assembled, whereby excess dispersion is pressed out. The dispersion of the particles in the electrolyte is gelled so that it is stable. By using particles for obtaining and maintaining the distance between the measuring surface and the membrane, it is possible to obtain very small distances between the measuring surface and the membrane, and the thickness of thin electrolyte layers is easy to control using particles, thus reducing the response time of the electrode. Furthermore, the thickness of the electrolyte layer is adjusted automatically when assembling the electrode device and the membrane between which a dispersion of particles is placed.

公开(公告)号：EP0386072B1

公开(公告)日：1994-01-26

申请号：EP88909718.4

申请日：1988-11-03

Applicant: RADIOMETER A/S

Inventor： JENSEN, Niels, Henrik

IPC: G01N21/64

CPC classification number: G01N21/62 ,  G01N2021/6482

Abstract: The concentration of molecular oxygen in a sample is determined by exciting oxygen molecules of the sample from the electronic ground state to the excited 1DELTAg state (excited singlet state), measuring a 1270-nm luminescence characteristic of the excited oxygen molecules (singlet oxygen) and correlating the luminescence characteristic measured with the concentration of molecular oxygen in the sample. Normally, the 1270-nm luminescence characteristic is the 1270-nm luminescence intensity. Preferably, the oxygen molecules are excited by being subjected to diffusion contact with a sensitizer such as a porphyrin or a porphyrin-related compound, e.g. a transition metal complex of a porphyrin. The sensitizer is brought into an oxygen-exciting electronic state by absorption of electromagnetic radiation such as light, the oxygen-exciting electronic state optionally being adapted to the measuring system employed by means of a quencher such as a substituted polyene. The sensitizer may be present in an organic solvent or a polymer such as polyvinylchloride. The oxygen-containing sample is preferably a sample of biological origin such as a blood sample.