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    EP0553246A4 -
    34.
    发明公开
    EP0553246A4 - 失效
    EP0553246A4 - Google专利

    公开(公告)号：EP0553246A4

    公开(公告)日：1994-08-31

    申请号：EP91919611

    申请日：1991-10-17

    Applicant: ST. LOUIS UNIVERSITY

    Inventor： BUCHOLZ, RICHARD, D.

    IPC: A61B5/00 ,  A61B5/055 ,  A61B5/06 ,  A61B5/107 ,  A61B6/00 ,  A61B6/12 ,  A61B8/00 ,  A61B17/88 ,  A61B19/00

    CPC classification number: A61B5/0073 ,  A61B5/0064 ,  A61B5/055 ,  A61B5/06 ,  A61B5/1077 ,  A61B6/12 ,  A61B6/501 ,  A61B6/5247 ,  A61B8/00 ,  A61B8/0808 ,  A61B8/5238 ,  A61B34/20 ,  A61B90/10 ,  A61B90/14 ,  A61B90/36 ,  A61B90/39 ,  A61B2017/00738 ,  A61B2034/105 ,  A61B2034/2055 ,  A61B2034/2068 ,  A61B2034/2072 ,  A61B2090/363 ,  A61B2090/364 ,  A61B2090/378 ,  A61B2090/3788 ,  A61B2090/3945 ,  A61B2090/3954 ,  A61B2090/3983 ,  B82Y15/00

    Abstract: A system for determining a position of a probe (302) relative to an object such as a head (390) of a body of a patient. The head includes a surface such as a forehead (394) having a contour. The head is placed in a cradle (392) equipped with an arc (393). The cross-sectional images of the head are determined relative to the arc. A hand-held unit (380) optically scans the forehead and the arc. During scanning to generate the cross-sectional images, the optical scanner (380) is used to determine the position of the forehead (394) relative to the cradle (392). During surgery, the optical scanner (380) also determines the position of the forehead (394) relative to a base ring (306). An array (300) for receiving radiation emitted from the probe (302) and from the base ring (306) generates signals indicating the position of the tip of the probe (302) relative to the base ring (306). A stereotactic imaging system selects and displays the image of the head closest to the measured position of the tip of the probe (302).

    Abstract translation: 一种用于确定探头（302）相对于诸如患者身体的头部（390）的物体的位置的系统。 头部包括诸如具有轮廓的前额（394）的表面。 头部放置在配有弧形（393）的支架（392）中。 头部的横截面图像相对于弧线确定。 手持式单元（380）光学扫描前额和弧线。 在扫描以产生横截面图像期间，使用光学扫描器（380）来确定前额（394）相对于摇架（392）的位置。 在手术期间，光学扫描仪（380）还确定前额（394）相对于基环（306）的位置。 用于接收从探针（302）和从基环（306）发射的辐射的阵列（300）产生指示探针（302）的尖端相对于基环（306）的位置的信号。 立体成像系统选择并显示最接近探头尖端的测量位置的头部图像（302）。

    Filamentous fungi functional replicating extrachromosomal element
    35.
    发明公开
    Filamentous fungi functional replicating extrachromosomal element 失效
    Zur Replikation eines extrachromosomalen元素befähigtefadenartige Pilze。

    公开(公告)号：EP0099226A1

    公开(公告)日：1984-01-25

    申请号：EP83303903.5

    申请日：1983-07-05

    Applicant: ST. LOUIS UNIVERSITY

    Inventor： Lambowitz, Alan M.

    IPC: C12N15/00

    CPC classification number: C12N15/80

    Abstract: ( D A functional extrachromosomal element capable of replication in filamentous fungi is provided. The extrachromosomal element employs (1) a mitochondrial replicating element or (2) a lower organism replication sequence recognized by the fungus, in combination with foreign DNA to provide replication, transcription, and translation of foreign regulatory elements and genes. The extrachromosomal element is exemplified by a mitochondrial replicating system from Neurospora.
    The cell strain strain E. coli HB101 containing the plasmid pALS-1-1 has been deposited at the A.T.C.C. on July 13, 1982, for patent purposes and given the designation ATCC 39157.
    The cell strain E. coli HB101 containing the plasmid pALS-2 has been deposited at the A.T.C.C. on July 13, 1982, for patent purposes and given the designation ATCC 39158.

    Abstract translation: 提供了能够在丝状真菌中复制的功能性染色体外元件。 染色体外元件使用（1）线粒体复制元件或（2）由真菌识别的下部生物复制序列，与外来DNA组合以提供外源调节元件和基因的复制，转录和翻译。 染色体外元件的例子是来自神经孢子虫的线粒体复制体系。 含有质粒pALS-1-1的细胞株菌株大肠杆菌HB101已经在A.T.C.C. 1982年7月13日，专利申请并命名为ATCC 39157.含有质粒pALS-2的细胞株大肠杆菌HB101已经存放在A.T.C.C. 于1982年7月13日授予专利，并命名为ATCC 39158。

    System combining proton beam irradiation and magnetic resonance imaging
    40.
    发明公开
    System combining proton beam irradiation and magnetic resonance imaging 审中-公开
    结合系统，用于质子照射，以及用于磁共振成像

    公开(公告)号：EP1121957A3

    公开(公告)日：2003-03-19

    申请号：EP01300783.6

    申请日：2001-01-30

    Applicant: ST. LOUIS UNIVERSITY

    Inventor： Buchholz, Richard D. ,  Miller, D. Douglas

    IPC: A61N5/10

    CPC classification number: A61N5/1049 ,  A61B5/0555 ,  A61N5/1037 ,  A61N5/1064 ,  A61N5/1067 ,  A61N5/107 ,  A61N2005/1055 ,  A61N2005/1087

    Abstract: A system which coordinates proton beam irradiation with an open magnetic resonance imaging (MRI) unit to achieve near-simultaneous, noninvasive localization and radiotherapy of various cell lines in various anatomic locations. A reference image of the target aids in determining a treatment plan and repositioning the patient within the MRI unit for later treatments. The patient is located within the MRI unit so that the target and the proton beam are coincident. MRI monitors the location of the target. Target irradiation occurs when the target and the proton beam are coincident as indicated by the MRI monitoring. The patient rotates relative to the radiation source. The target again undergoes monitoring and selective irradiation. The rotation and selective irradiation during MRI monitoring repeats according to the treatment plan.

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