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    UN PROCEDIMIENTO PARA PREPARAR PEPTIDOS ANTAGONISTAS DE BRADIQUININA.
    31.
    发明专利
    UN PROCEDIMIENTO PARA PREPARAR PEPTIDOS ANTAGONISTAS DE BRADIQUININA. 未知

    公开(公告)号：ES2008115A6

    公开(公告)日：1989-07-16

    申请号：ES8700382

    申请日：1987-02-16

    Applicant: STEWART JOHN M ,  VAVREK RAYMOND J

    IPC: C07K7/18 ,  A61K37/02

    Abstract: UN PROCEDIMIENTO PARA PREPARAR PEPTIDOS ANTAGONISTAS DE BRADIQUININA DE FORMULA: A-ARG-B-C-D-W-X-Y-Z-ARG, DONDE A ES AMINOACIDO O HIDROGENO Y LOS DEMAS SIMBOLOS REPRESENTAN AMINOACIDOS, EN EL QUE SE UNE A UN SOPORTE POLIMERO UN AMINOACIDO QUE TIENE UN GRUPO BLOQUEANTE DE BOC O FMOC, SE DESBLOQUEA EL AMINOACIDO UNIDO A DICHO SOPORTE ELIOMINANDO EL GRUPO BLOQUEANTE DE BOC O FMOC CON UNA SOLUCION APROPIADA, SE CONTINUA ENLAZANDO UNO O MAS AMINOACIDOS CON DICHO AMINOACIDO DESBLOQUEADO, Y SE ESCINDE SIMULTANEAMENTE EL PEPTIDO DE DICHO SOPORTE POLIMERO Y SE DESBLOQUEA EL GRUPO BLOQUEANTE TRATANDO DICHOS SOPORTES Y PEPTIDO CON UNA SOLUCION QUE CONTENGA UN AGENTE ELIMINAR DE GRUPOS BLOQUEANTES. ADEMAS DE ESTA VIA DE OBTENCION EN FASE SOLIDA, LOS PEPTIDOS PUEDEN PREPARARSE POR UNA VIA DE OBTENCION EN SOLUCION QUE TAMBIEN SE DESCRIBE EN LA MEMORIA. LOS COMPUESTOS OBTENIDOS SON UTILES PARA TRATAR EXCESOS DE BRADIQUININA EN HUMANOS O ANIMALES.

    33.
    发明专利
    未知

    公开(公告)号：BR8606723A

    公开(公告)日：1987-08-11

    申请号：BR8606723

    申请日：1986-06-11

    Applicant: STEWART JOHN M ,  VAVREK RAYMOND J

    Inventor： STEWART JOHN M ,  VAVREK RAYMOND J

    IPC: A61K38/00 ,  C07K7/18 ,  A61K37/42

    Abstract: The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with an aromatic amino acid or the D-configuration converts bradykinin agonists into a bradykinin antagonist. The invention further includes additional modifications at other positions within the novel 7-position modified bradykinin antagonists which increase enzyme resistance, antagonist potency and/or specificity of the new bradykinin antagonists. The analogs produced are useful in treating conditions and diseases of the mammal and human body in which an excess of bradykinin or related kinins are produced or injected as by bites into the body.

    34.
    发明专利
    未知

    公开(公告)号：SE7607382L

    公开(公告)日：1977-04-06

    申请号：SE7607382

    申请日：1976-06-29

    Applicant: STEWART JOHN

    IPC: B27G13/02 ,  B23C5/04 ,  B23C5/18 ,  B23Q11/00 ,  B27G13/04 ,  B27G13/00

    Abstract: A helical cutterhead for a wood planer for reducing noise level during planing by supressing vibration and sound radiation by having more than one knife blade engaged in the workpiece at any instant by satisfying the minimum condition of the formula L= pi D cot phi /N is less than the workpiece width and in which L is the contact distance, D is the cutterhead diameter, N is the number of knife blades, and phi is the helix angle, and in which L is less than 4 inches.

    35.
    发明专利
    未知

    公开(公告)号：FR2322700A1

    公开(公告)日：1977-04-01

    申请号：FR7626339

    申请日：1976-09-01

    Applicant: STEWART JOHN

    IPC: B27G13/02 ,  B23C5/04 ,  B23C5/18 ,  B23Q11/00 ,  B27G13/04 ,  B27G13/08 ,  B27C1/04

    Abstract: A helical cutterhead for a wood planer for reducing noise level during planing by supressing vibration and sound radiation by having more than one knife blade engaged in the workpiece at any instant by satisfying the minimum condition of the formula L= pi D cot phi /N is less than the workpiece width and in which L is the contact distance, D is the cutterhead diameter, N is the number of knife blades, and phi is the helix angle, and in which L is less than 4 inches.

    Improvements relating to indicating instruments
    38.
    发明专利
    Improvements relating to indicating instruments 未知

    公开(公告)号：GB684029A

    公开(公告)日：1952-12-10

    申请号：GB2745249

    申请日：1949-10-26

    Applicant: FERRANTI LTD ,  STEWART JOHN ,  ALLEN CHARLES R

    IPC: G01D13/02

    Abstract: 684,029. Indicating-apparatus. FERRANTI, Ltd., STEWART, J., and ALLEN, C. Jan. 10, 1951 [Oct. 26, 1949], No. 27452/49. Class 106 (iv). Indicating - apparatus comprises a pointer 10, Fig. 1, traversing a circular scale 12 graduated from zero to a power of ten, a revolution counter 15 close to the zero mark indicating the number of complete revolutions the pointer has made with respect to zero when the pointer indicates zero or is near zero in the lower half of the scale and that number plus one when the pointer is near zero in the upper half of the scale, and a plurality of revolution counters 24, 25, 26, 27 close to other marks 2, 4, 6, 8 at least one in each half of the scale indicating the said number when the pointer is in their vicinity. The revolution counters comprise rollers with eleven equal spaces, marked with numerals 0, 1 ... 9 and a blank, which appear in elongated apertures 13, 20 to 23, the degree of rotation of the rollers being offset successively by a fifth of a space so that a numeral appears centrally in an aperture when the pointer is at the corresponding graduation mark. A sector-like opaque screen 30, moved by the pointer spindle 11 in a plane between the counters and dial, obscures the counters while they are changing from one numeral to the next. The pointer is made of two wires 10 1 to avoid obscuring the scale. In a modification shown in Fig. 7, a gearwheel 62 on the pointer spindle 11 drives through gear-wheels 63, 64, 56 a shaft 52 on which are fixed bevel gears 50, 51, 55 driving bevel gears 46, 47, 61 fixed on shafts 40, 43, 57 on which are mounted the rollers 26, 27; 25, 24; 15, the resultant reduction gear ratio being 11 : 1. The numerals on the drums may be marked at an angle to offset the skew position of the shafts 40, 43 and so appear in their apertures parallel to the scale numerals. In other modifications the rollers could be arranged with their axes horizontal so that their numerals traverse the apertures vertically. The rollers could move impulsively. The figure " 0 " on the rollers could be replaced by another blank, the scale could be graduated anticlockwise and the zero could be at the bottom. To indicate up to 999, the scale may be marked from 0 to 100 while the rollers indicate the hundreds, or the scale may be marked from 0 to 10 and each counter have an additional " hundreds " display on the left of the " tens " one.

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