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公开(公告)号：US09399781B2
公开(公告)日：2016-07-26
申请号：US14350923
申请日：2012-10-03
Inventor： Florent Collas , Remy Marchal , Benjamin Clement , Ana Maria Lopez Contreras , Pieternel A.M Claassen
IPC: C12P7/04 , C12N9/00 , C12N9/10 , C12N9/04 , C12N9/88 , C12N15/52 , C12P7/06 , C12P7/16 , C12P7/18 , C12P7/52 , C12P7/54
CPC classification number: C12P7/04 , C12N9/0006 , C12N9/1029 , C12N9/13 , C12N9/88 , C12N15/52 , C12P7/065 , C12P7/16 , C12P7/18 , C12P7/52 , C12P7/54 , Y02E50/10 , Y02E50/17 , Y02P20/52
Abstract: The expression vector includes: the nucleic acids coding for the polypeptides forming a polypeptide complex having an enzyme activity allowing acetoacetyl-CoA to be converted to acetoacetate; optionally, at least one nucleic acid coding for a polypeptide having an enzyme activity allowing acetoacetate to be converted to acetone; and at least one nucleic acid coding for a polypeptide having an enzyme activity allowing acetone to be converted to isopropanol; the expression of the nucleic acids being controlled by a single constitutive promoter located upstream of the abovementioned nucleic acids.
Abstract translation: 表达载体包括：编码形成具有允许乙酰乙酰辅酶A转化为乙酰乙酸酯的酶活性的多肽复合物的多肽的核酸; 任选地，编码具有允许乙酰乙酸酯转化为丙酮的酶活性的多肽的至少一种核酸; 和编码具有允许丙酮转化为异丙醇的酶活性的多肽的至少一种核酸; 核酸的表达由位于上述核酸上游的单个组成型启动子控制。
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公开(公告)号：US20160158342A1
公开(公告)日：2016-06-09
申请号：US14890994
申请日：2014-05-16
Applicant: Stichting Dienst Landbouwkundig Onderzoek
Inventor： Petrus Antonius van Rijn , Hendricus Gerardus Petrus van Gennip , Sandra Gerarda Petra van de Water , Femke Feenstra
CPC classification number: A61K39/15 , A61K39/12 , A61K2039/525 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , C12N7/00 , C12N7/04 , C12N2720/12051 , C12N2720/12121 , C12N2720/12134 , C12N2720/12151 , C12N2720/12162 , C12N2720/12164 , C12N2720/12171 , C12N2720/12251 , C12N2720/12351
Abstract: The invention relates to methods for producing a propagation-competent strain of a mutant Reoviridae virus, and to a propagation-competent strain of a mutant Reoviridae virus that is obtainable by a method of the invention. The invention further relates to a propagation-competent strain of a mutant Reoviridae virus, comprising a deletion of a genetic region that is relevant for propagation of the virus, and to a vaccine, comprising a propagation-competent strain of a mutant Reoviridae virus.
Abstract translation: 本发明涉及用于产生突变型叶病毒科病毒的繁殖感受态菌株的方法，以及可通过本发明方法获得的突变型病毒科病毒株的繁殖感受态菌株。 本发明还涉及突变型病毒科病毒的繁殖能力菌株，其包含与病毒繁殖有关的遗传区域的缺失，以及包含突变型病毒科病毒科的繁殖感受态菌株的疫苗。
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33.发明申请A Method for Determining the Vase Life or Storage History of One or More Cut Flowers, Wherein the Method Comprises Assaying Xylose Concentration or Beta-Xylosidase Expression/Activity 审中-公开确定一个或多个切花的花瓶寿命或储存历史的方法，其中该方法包括测定木糖浓度或β-木糖苷酶表达/活性公开(公告)号：US20160145697A1
公开(公告)日：2016-05-26
申请号：US14900682
申请日：2014-07-02
Applicant: STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK
Inventor： Ernst Johannes Woltering , Uilke Van Meeteren
CPC classification number: C12Q1/6895 , C12Q1/34 , C12Q2600/13 , C12Q2600/158 , G01N33/0098
Abstract: A method for determining the vase life or storage history of one or more cut flowers, wherein the method comprises assaying a test sample obtained from the one or more cut flowers for one or more of: (a) an indicator representative of xylose concentration; (b) an indicator representative of β-xylosidase expression; and (c) an indicator representative of β-xylosidase activity; to determine a value for (each of) the one or more indicators in the test sample.
Abstract translation: 一种用于确定一个或多个切花的花瓶寿命或储存历史的方法，其中所述方法包括测定从一种或多种切花获得的测试样品中的一种或多种：（a）代表木糖浓度的指示剂; （b）代表β-木糖苷酶表达的指标; 和（c）代表β-葡萄糖苷酶活性的指标; 以确定测试样本中的一个或多个指示符的（每个）的值。
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34.发明申请PROCESS AND INTERMEDIATES FOR THE PRODUCTION OF FURAN-2,5-DICARBOXYLIC ACID OR DERIVATIVES THEREOF 有权制备FURAN-2,5-DICARBOXYLIC酸或其衍生物的方法和中间体公开(公告)号：US20160075672A1
公开(公告)日：2016-03-17
申请号：US14786723
申请日：2014-05-08
Applicant: STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK
Inventor： Jacobus van Haveren , Daniël Stephan van Es , Frits van der Klis , Henricus Wilhelmus Carolina Raaijmakers
IPC: C07D307/68
CPC classification number: C07D307/68 , C07D307/56
Abstract: Disclosed is a method of making 5-formyl-2-furoic acid and furan-2,5-dicarboxylic acid. The method involves the use of 5-keto-aldonic acids as intermediates, as these can be subjected to ring formation by a cyclodehydration reaction under mild conditions. The 5-formyl-2-furoic acid or carboxylic derivative thereof is subjected to oxidation so as to form furan-2,5-dicarboxylic acid. The 5-keto-aldonic acid intermediates can be obtained by isomerization of uronic acids which can be obtained from sugar beet pulp, chicory pulp, fruit peals including orange peels, or non-terrestrial sources like seaweeds. A preferred source is sugar beet pulp.
Abstract translation: 公开了制备5-甲酰基-2-糠酸和呋喃-2,5-二羧酸的方法。 该方法包括使用5-酮基醛糖酸作为中间体，因为它们可以在温和条件下通过环化脱水反应进行环形成。 使5-甲酰基-2-糠酸或其羧酸衍生物进行氧化，形成呋喃-2,5-二羧酸。 5-酮基醛糖酸中间体可以通过糖糖酸异构化得到，该糖醛酸可由甜菜浆，菊苣浆，果皮，包括橙皮或非陆地来源如海藻得到。 优选的来源是甜菜浆。
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公开(公告)号：US09079844B2
公开(公告)日：2015-07-14
申请号：US14390211
申请日：2013-03-28
Applicant: Stichting Dienst Landbouwkundig Onderzoek
Inventor： Daniël Stephan Van Es , Jacobus van Haveren , Henricus Wilhelmus Carolina Raaijmakers , Frits van der Klis , Gerardus Petrus Franciscus Maria van Engelen , Augustinus Emmanuël Frissen
IPC: C07C51/235 , B01J23/52 , C07H1/00 , C07H7/033 , C07C59/285 , B01J23/66 , B01J21/04 , B01J21/06
CPC classification number: C07C51/235 , B01J21/04 , B01J21/063 , B01J23/52 , B01J23/66 , C07C59/285 , C07H1/00 , C07H7/033
Abstract: Disclosed is the oxidation of uronic acids, such as galacturonic acid, to the corresponding aldaric acids (characterized by the formula HOOC—(CHOH)n-COOH, with n being an integer of from 1 to 5) such as galactaric acids. The starting material comprising the uronic acid is subjected to oxygen under the influence of a supported gold catalyst and in the presence of a base. The oxidation occurs in good selectivity and yield, under unexpectedly mild conditions. A source of galacturonic acids is pectin, such as that derived from sugar beet pulp.
Abstract translation: 公开了将糖醛酸如半乳糖醛酸氧化成相应的阿拉德酸（其特征在于式HOOC-（CHOH）n-COOH，n为1至5的整数），如乳糖酸。 包含糖醛酸的起始材料在负载的金催化剂的影响下和在碱的存在下进行氧化。 在意想不到的温和条件下，氧化以良好的选择性和产率出现。 半乳糖醛酸的来源是果胶，例如衍生自甜菜糖浆的果胶。
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Patent Agency Ranking
公开(公告)号：US20150183954A1
公开(公告)日：2015-07-02
申请号：US14400814
申请日：2013-06-04
Inventor： Daniel Stephen VanEs , Jacobus VanHaveren , Augustinus Emmanuel Frissen , Johannes Cornelis VandeKolk
IPC: C08K5/1535
CPC classification number: C08K5/1535 , C08J5/18 , C08J2327/06 , C08K5/0016 , C08L27/06
Abstract: Plasticized, unpigmented and pigmented PVC films are described which utilize a biobased, phthalate ester alternative primary plasticizer. The films show comparable color performance to the phthalate ester-plasticized unpigmented or pigmented PVC films, even where the neat biobased plasticizer has a much higher Pt—Co color as measured according to DIN-6271 (ASTM D 1209) compared to the neat phthalate ester plasticizer. Biobased primary plasticizers in the form of diesters of furan-2,5-dicarboxylic acid are especially contemplated, and provide increased thermal stability to the PVC films as an added benefit.
Abstract translation: 描述了增塑的，未着色的和着色的PVC膜，其利用生物基邻苯二甲酸酯替代的主要增塑剂。 与邻苯二甲酸酯类相比，即使在纯生物基增塑剂具有比DIN-6271（ASTM D 1209）测量的Pt-Co颜色高得多的情况下，该胶片显示出与邻苯二甲酸酯增塑的未着色或着色的PVC膜相当的颜色性能。 增塑剂 特别考虑了呋喃-2,5-二羧酸二酯形式的基于生物的初级增塑剂，并为PVC膜提供了增加的热稳定性，作为额外的益处。
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37.发明申请PROCESS AND INTERMEDIATES FOR THE PRODUCTION OF FURAN-2,5-DICARBOXYLIC ACID OR DERIVATIVES THEREOF 审中-公开制备FURAN-2,5-DICARBOXYLIC酸或其衍生物的方法和中间体
公开(公告)号：WO2014182171A1
公开(公告)日：2014-11-13
申请号：PCT/NL2014/050293
申请日：2014-05-08
Applicant: STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK
Inventor： VAN HAVEREN, Jacobus , VAN ES, Daniël Stephan , VAN DER KLIS, Frits , RAAIJMAKERS, Henricus Wilhelmus Carolina
IPC: C07D307/56
CPC classification number: C07D307/68 , C07D307/56
Abstract: Disclosed is a method of making 5-formyl-2-furoic acid and furan- 2,5-dicarboxylic acid. The method involves the use of 5-keto-aldonic acids as intermediates, as these can be subjected to ring formation by a cyclodehydration reaction under mild conditions. The 5-formyl-2-furoic acid or carboxylic derivative thereof is subjected to oxidation so as to form furan-2,5-dicarboxylic acid. The 5-keto-aldonic acid intermediates can be obtained by isomerization of uronic acids which can be obtained from sugar beet pulp, chicory pulp, fruit peals including orange peels, or non- terrestrial sources like seaweeds. A preferred source is sugar beet pulp.
Abstract translation: 公开了5-甲酰基-2-糠酸和呋喃-2,5-二羧酸的制备方法。 该方法涉及使用5-酮基醛糖酸作为中间体，因为它们可以在温和条件下通过环化脱水反应进行环形成。 使5-甲酰基-2-糠酸或其羧酸衍生物进行氧化，形成呋喃-2,5-二羧酸。 5-酮基醛糖酸中间体可以通过糖糖的异构化得到，该糖醛酸可以由甜菜浆，菊苣浆，果皮，包括橙皮或非陆地来源如海藻获得。 优选的来源是甜菜浆。
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公开(公告)号：WO2014168473A1
公开(公告)日：2014-10-16
申请号：PCT/NL2014/050216
申请日：2014-04-07
Applicant: STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK
Inventor： VAN ES, Daniël Stephan , VAN DER KLIS, Frits , VAN HAVEREN, Jacobus , GOSSELINK, Richard Johannes Antonius
CPC classification number: C07C37/50 , C07C1/20 , C07C37/54 , C07C41/18 , C07C45/512 , C07C45/59 , C07C2521/18 , C07C2523/42 , C07C2523/44 , C07C2523/46 , C07C2601/14 , C10G3/42 , C10G3/44 , C10G3/52 , C10G2400/30 , Y02P30/20 , C07C39/04 , C07C43/23 , C07C43/2055 , C07C43/205 , C07C49/84 , C07C49/403 , C07C15/04 , C07C13/18
Abstract: A catalytic method is disclosed for the valorization of lignin. The method comprises subjecting lignin to a catalyzed hydrothermal conversion reaction, said reaction being conducted in the presence of water at an alkaline pH > 8 and a temperature of 200°C-300°C, under the influence of a noble metal catalyst comprising a carbon support. The same reaction can also be applied to subsequently defunctionalize one or more phenolic compounds, notably guaiacol, so as to produce six-membered cyclic hydrocarbons, such as phenol.
Abstract translation: 公开了一种用于木质素增值的催化方法。 该方法包括使木质素进行催化的水热转化反应，所述反应在碱性pH> 8和温度为200℃-300℃的水存在下，在含有碳的贵金属催化剂的影响下进行 支持。 同样的反应也可以应用于随后使一种或多种酚类化合物，特别是愈创木酚的官能化，以产生六元环烃，如苯酚。
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公开(公告)号：WO2014048930A1
公开(公告)日：2014-04-03
申请号：PCT/EP2013/069873
申请日：2013-09-24
Inventor： BAT, Erhan , JONKHEIJM, Pascal , VAN AMERONGEN, Aart , HÜSKENS, Jurriaan
CPC classification number: B01J19/0046 , B01J2219/00382 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00619 , B01J2219/00659 , B05D1/18 , C40B60/14
Abstract: The invention relates to a stamp for making a microarray of biomolecules, wherein the stamp comprises a stamp body comprising: a stamping surface for stamping the biomolecules onto a substrate; a plurality of reservoirs for liquids comprising the biomolecules, wherein each of the reservoirs has a bottom wall and; a plurality of channels extending between each of the bottom wall and the stamping surface, wherein each of the reservoirs and the channels comprises a macroporous hydrogel and wherein the stamping surface is provided with a hydrophobic coating.
Abstract translation: 本发明涉及用于制造生物分子的微阵列的印模，其中所述印模包括印模体，其包括：冲压表面，用于将生物分子冲压到基底上; 用于包含生物分子的液体的多个储存器，其中每个储存器具有底壁， 在每个底壁和冲压表面之间延伸的多个通道，其中每个储存器和通道包括大孔水凝胶，并且其中冲压表面设置有疏水涂层。
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公开(公告)号：WO2013137735A1
公开(公告)日：2013-09-19
申请号：PCT/NL2013/050184
申请日：2013-03-15
Inventor： VAN LEEUWEN, Johannes Leendert , HOGEWERF, Pieter Hendrik , IPEMA, Albertus Hendrik , DE KONING, Cornelis Johannes Aloysius Marie , VAN DEN BOOGAART, Josephus Gerardus Maria , VAN TURNHOUT, Marinus Cornelis
Abstract: Method of mechanically milking a lactating animal, such as a cow, a goat and a sheep, comprising: · providing an animal having at least one teat (110), said teat comprising an elongate shaft (112) and a teat end (114) at an end of said shaft, said teat end comprising a teat canal (116) having an external orifice (118); · milking the teat (110) by repeatedly alternatingly increasing and decreasing a diameter (D) of at least a longitudinal portion of its shaft (112), while maintaining a substantially axi-symmetric shape of said portion of the shaft, and while continuously applying a milking vacuum to the teat end (114) so as to extract milk from the external orifice (118) of the teat canal (116). Also disclosed is a teat cup liner for practicing the disclosed method.
Abstract translation: 包括：·提供具有至少一个奶头（110）的动物，所述奶头包括细长轴（112）和奶头端（114），所述乳头包括至少一个乳头， 在所述轴的端部，所述奶头端部包括具有外部孔口（118）的奶嘴管道（116）; ·通过重复地交替地增加和减小其轴（112）的至少纵向部分的直径（D），同时保持所述轴的所述部分的基本上轴对称的形状，并且在连续施加时，挤奶奶头（110） 向奶头端（114）挤奶的真空，以便从奶头管（116）的外部孔口（118）中提取牛奶。 还公开了一种用于实施所公开的方法的奶杯杯衬套。
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