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31.发明申请
公开(公告)号：WO2022130196A1
公开(公告)日：2022-06-23
申请号：PCT/IB2021/061688
申请日：2021-12-14
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
Inventor： RAO, Venigalla B. , ZHU, Jingen
IPC: C12N7/00 , C12N9/22 , C07K14/005 , A61K39/215 , C12N15/70
Abstract: The present disclosure relates to a system for and a method of incorporating SARS-CoV-2 genes and proteins into T4 phages. The present disclosure also relates to vaccine against SARS-CoV-2 containing recombinant T4 phages created using the method provided in the present disclosure.
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公开(公告)号：WO2022130104A1
公开(公告)日：2022-06-23
申请号：PCT/IB2021/061315
申请日：2021-12-03
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
Inventor： PEGG, Ian L. , PENAFIEL, Miguel
Abstract: Methods and materials are described for the removal of iodate from aqueous solutions. The methods comprise reduction of the iodate to iodide and subsequent or concurrent removal of the iodide by sorption, ion exchange, or precipitation. These methods are effective for the removal of radioactive iodine from radioactive and nuclear wastes.
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公开(公告)号：WO2022023850A1
公开(公告)日：2022-02-03
申请号：PCT/IB2021/056248
申请日：2021-07-21
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
Inventor： RAO, Venigalla B. , ZHU, Jingen
IPC: C12N15/86 , C12N15/113 , C12N9/22 , C12N15/10 , C12N15/88 , A61K48/00 , A61K31/7088 , C12N2795/00043 , C12N2795/00051 , C12N7/00
Abstract: Described is an "artificial virus" (AV) programmed with biomolecules that can enter human cells and carry out precise human genome modification. The AVs comprise: at least one viral vector, such as bacteriophage T4; at least one therapeutic molecule, such as DNA, RNA, protein and their complex; and a lipid coating. Also described is a method of human genome modification, using such an AV, and a method of program such an AV.
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34.发明申请
公开(公告)号：WO2019116124A1
公开(公告)日：2019-06-20
申请号：PCT/IB2018/059056
申请日：2018-11-16
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
Inventor： GONG, Weiliang , XU, Hui , LUTZE, Werner , PEGG, Ian L.
CPC classification number: C04B28/006 , C04B2103/0011 , C04B12/04 , C04B14/106 , C04B18/06 , C04B18/08 , C04B18/141 , C04B18/162 , C04B22/0013 , C04B22/062 , C04B22/085 , C04B22/14 , C04B22/142 , C04B20/008 , C04B2103/20
Abstract: The present disclosure provides a geopolymer composition having a controllable setting time comprising: at least one reactive aluminosilicate; at least one retarder; and at least one alkali silicate activator solution.
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公开(公告)号：WO2003073064A3
公开(公告)日：2003-09-04
申请号：PCT/US2003/005265
申请日：2003-02-25
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA , WANG, Yue, Joseph
Inventor： WANG, Yue, Joseph
IPC: G06K9/64
Abstract: The present invention describes a partial independent component (PICA) technique for blindly separating partially independent and/or gaussian-like sources from mixed observations over an informative index subspace, which allows various applications in independent component imaging. The present invention estimates a demixing matrix using only the independent and/or nongaussian portion of the observations. The present invention also demonstrates the principle of the approach on both controlled cases and real-world problems, and describes many extended applications of such a technique.
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Patent Agency Ranking
公开(公告)号：WO1995001758A1
公开(公告)日：1995-01-19
申请号：PCT/US1994007296
申请日：1994-07-01
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
IPC: A61B19/00
Abstract: The disclosed embodiments of the inventions disclosed in this application develop a "protection" electric, magnetic or electromagnetic field or fields which are either superimposed upon an ambient field which is detrimental to the health of living systems, or is incorporated into the electrical circuit of the device which is generating the detrimental field. Either arrangement is successful in "confusing" living cells, and thereby reducing the harmful effects of the otherwise detrimental field.
Abstract translation: 在本申请中公开的本发明的实施例中，开发出一种“保护”的电，磁场或电磁场或场，其叠加在不利于生命系统的健康的环境场上，或被并入到 产生有害场的装置。 任何一种安排都是成功的“混淆”活细胞，从而减少其他有害的领域的有害影响。
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37.发明申请
公开(公告)号：WO2023285922A1
公开(公告)日：2023-01-19
申请号：PCT/IB2022/056234
申请日：2022-07-06
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
Inventor： RAO, Venigalla B. , BATRA, Himanshu
IPC: C12N15/86 , C07K14/005 , C12N7/00 , C12N5/0783
Abstract: Described is an engineered viral particle programmed with T cell targeting specificity. The viral particles comprise: at least one viral vector, such as bacteriophage T4; and at least one CD4-binding protein displayed on the surface of the viral vector. Also described is a method of reactivate latent HIV-1 and cure patient with HIV-1 infection, using such an engineered viral particle.
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38.发明申请
公开(公告)号：WO2022096961A1
公开(公告)日：2022-05-12
申请号：PCT/IB2021/056400
申请日：2021-07-15
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
Inventor： PEGG, Ian L. , GONG, Weiliang
IPC: C04B28/06 , C04B12/00 , C04B14/28 , C04B22/00 , C04B40/00 , C04B103/10 , C04B103/32 , C04B103/30 , C04B111/62
Abstract: A high performance concrete composition comprising: (i) at least one Class C fly ash, (ii) at least one calcium aluminate cement, (iii) at least one aggregate, and (iv) water.
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39.发明申请
公开(公告)号：WO2017013584A1
公开(公告)日：2017-01-26
申请号：PCT/IB2016/054292
申请日：2016-07-19
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
Inventor： RAO, Venigalla B. , ALSALMI, Wadad
IPC: A61K39/395 , A61K39/12 , A61K39/00
CPC classification number: C07K14/005 , A61K9/7023 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/54 , A61K2039/627 , C07K1/22 , C07K1/36 , C07K14/162 , C07K2319/00 , C07K2319/20 , C07K2319/21 , C07K2319/22 , C07K2319/40 , C07K2319/50 , C12N7/00 , C12N2740/16022 , C12N2740/16043 , C12N2740/16051 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16234
Abstract: Provided herein are HIV vaccines that encompasses recombinant trimers that mimic native HIV-1 envelope trimers. Also provided are methods of administering to a subject in need thereof an HIV vaccine provided herein to elicit antibodies against a recombinant trimer in the subject. A recombinant trimer is formed by a recombinant protein comprising a recombinant HIV-1 gp140 fused to a tag through a linker at C-terminus of the recombinant HIV-1 gp140, wherein the linker is sufficiently long so that the tag is accessible for binding by a binding molecule bound on a solid matrix during purification of the recombinant trimer.
Abstract translation: 本文提供涵盖模仿天然HIV-1包膜三聚体的重组三聚体的HIV疫苗。 还提供了向有需要的受试者施用本文提供的HIV疫苗以引发针对受试者中重组三聚体的抗体的方法。 重组三聚体由包含重组HIV-1 gp140的重组蛋白形成，重组HIV-1 gp140通过重组HIV-1 gp140的C-末端的接头与标签融合，其中接头足够长，使得标签可通过 在纯化重组三聚体期间结合在固体基质上的结合分子。
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40.发明申请
公开(公告)号：WO2017013545A1
公开(公告)日：2017-01-26
申请号：PCT/IB2016/054207
申请日：2016-07-14
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
Inventor： RAO, Venigalla B. , ALSALMI, Wadad
IPC: C07K14/005 , C07K1/14 , C07K1/16 , C07K1/22 , C07K1/36
CPC classification number: C07K14/005 , A61K9/7023 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/54 , A61K2039/627 , C07K1/22 , C07K1/36 , C07K14/162 , C07K2319/00 , C07K2319/20 , C07K2319/21 , C07K2319/22 , C07K2319/40 , C07K2319/50 , C12N7/00 , C12N2740/16022 , C12N2740/16043 , C12N2740/16051 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16234
Abstract: An approach of producing recombinant trimers that mimic native HIV-1 envelope trimers is developed. A recombinant protein forming the recombinant trimers encompasses a recombinant HIV-1 gpl40 fused to a tag through a linker at C-terminus of the recombinant HIV-1 gpl40. The linker is sufficiently long so that the tag is accessible for binding by a binding molecule bound on a solid matrix. After expressed in a cell, the recombinant protein is secreted into the culture medium and assembles into recombinant trimers therein. The recombinant trimers may be directly purified from the culture medium. Cleaved and uncleaved trimers from different clade viruses are produced.
Abstract translation: 开发了生产模仿天然HIV-1包膜三聚体的重组三聚体的方法。 形成重组三聚体的重组蛋白包含通过重组HIV-1 gp120的C末端的接头与标签融合的重组HIV-1 gp140。 接头足够长，使得标签可通过结合在固体基质上的结合分子进行结合。 在细胞中表达后，将重组蛋白分泌到培养基中并在其中组装成重组三聚体。 重组三聚体可以从培养基中直接纯化。 产生来自不同进化枝病毒的切割和未切割的三聚体。
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