公开(公告)号：US11939614B2

公开(公告)日：2024-03-26

申请号：US17691933

申请日：2022-03-10

Applicant: National Research Council of Canada ,  University of Saskatchewan

Inventor： Jonathan E. Page ,  Steve Gagne

IPC: C12N15/82 ,  C12N15/52 ,  C12N15/70 ,  C12P7/22 ,  C12P17/06

CPC classification number: C12P17/06 ,  C12N15/52 ,  C12N15/70 ,  C12P7/22 ,  C12Y404/01026

Abstract: Nucleic acid molecules encoding polypeptides having polyketide synthase activity have been identified and characterized. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds in organisms. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.

公开(公告)号：US20240023541A1

公开(公告)日：2024-01-25

申请号：US18029316

申请日：2021-09-29

Applicant: THE UNIVERSITY OF SASKATCHEWAN

Inventor： Michael Moser ,  Jasleen Bhatti ,  Wenjun Zhang ,  Anthony Tony ,  Bing Zhang

IPC: A01N1/02

CPC classification number: A01N1/021 ,  A01N1/0247 ,  A01N1/0252 ,  A01N1/0284

Abstract: The invention discloses a temperature control, optionally cooling, apparatus comprising: a first and second and/or plurality of fillable chambers each having a first layer, a second layer, an elongated edge, preferably longitudinal edge, an inlet and an outlet in the elongated, preferably longitudinal edge, and retention members between the first layer and second layer in a series of spaced veins creating a continuous channel extending from the inlet to the outlet; and a method of cooling and or maintaining an organ comprising: a method for cooling, warming and/or maintaining the temperature of an organ prior to or during a transplant procedure, the method comprising: contacting the organ with temperature control, optionally the cooling and/or temperature maintaining, apparatus; securing the apparatus to the organ; attaching the inlets of the first and second and/or plurality of fillable chambers of the apparatus to a circulation fluid source; and/or infusing circulation fluid into the inlet, through the continuous channel, and out the outlet of each of the first and second and/or plurality of fillable chambers of the apparatus.

公开(公告)号：US11839652B2

公开(公告)日：2023-12-12

申请号：US16630744

申请日：2018-07-17

Applicant: University of Saskatchewan

Inventor： Susantha Gomis ,  Shelly Popowich ,  Kalhari Venukala Bandara Goonewardene ,  Suresh Tikoo ,  Marianna Foldvari

IPC: A61K39/39 ,  A23K20/153 ,  A23K50/75 ,  C12N15/117 ,  A61K47/69 ,  A61K47/58 ,  A61K47/61 ,  A61K9/00 ,  A61K47/10 ,  A61K47/18 ,  A61K47/24 ,  A61K39/00

CPC classification number: A61K39/39 ,  A23K20/153 ,  A23K50/75 ,  C12N15/117 ,  A61K9/0078 ,  A61K47/10 ,  A61K47/183 ,  A61K47/24 ,  A61K47/58 ,  A61K47/61 ,  A61K47/6911 ,  A61K47/6929 ,  A61K2039/544 ,  A61K2039/552 ,  A61K2039/58 ,  A61K2039/6093 ,  C12N2310/17 ,  C12N2310/315 ,  C12N2320/32

Abstract: This application relates to compositions comprising one or more CpG oligodeoxynucleotides complexed to nanoparticles comprising a gemini surfactant and optionally a muco-adhesive polymer, which can be used for intrapulmonary delivery to induce immunity in feed animals, and the methods of making and uses thereof.

公开(公告)号：US20230310007A1

公开(公告)日：2023-10-05

申请号：US18023429

申请日：2021-08-31

Applicant: University of Saskatchewan

Inventor： Yigang Luo ,  Wen Jun Zhang ,  Shaoqing Du ,  Robert Bigsby ,  Stephanie Ruscheinsky ,  Chenwang Yuan

IPC: A61B17/122

CPC classification number: A61B17/1222

Abstract: An adaptor for a surgical clip driver is disclosed herein. The adaptor includes a first body and a second body. Each of the first body and the second body has an opening extending inwardly that is configured to receive a portion of a jaw of the surgical clip driver. The first body also includes a first body retaining member configured to retain a first portion of each of the two or more surgical clips and the second body also includes a second body retaining member configured to retain a second portion of each of the two or more surgical clips. When the first body and the second body are received on the surgical clip driver, the first body retaining member and the second body retaining member face each other and are aligned with each other to receive and retain the two or more surgical clips. A cartridge for retaining surgical clips is also disclosed herein.

公开(公告)号：US11634434B2

公开(公告)日：2023-04-25

申请号：US16328250

申请日：2017-09-08

Applicant: University of Saskatchewan

Inventor： Joseph Kakish ,  Edward Krol ,  Jeremy Lee ,  Kevin Allen

IPC: C07D519/00 ,  A61K51/04 ,  C07D473/12

Abstract: Bifunctional molecules having first and second alpha-synuclein binding agents coupled by a linker are disclosed. The bifunctional molecules have potential utility in the diagnosis, treatment and/or prophylaxis of disorders in which alpha-synuclein is implicated, including Parkinson's disease. Methods of making and using the bifunctional molecules are disclosed.

公开(公告)号：US11306335B2

公开(公告)日：2022-04-19

申请号：US16917362

申请日：2020-06-30

Applicant: National Research Council of Canada ,  University of Saskatchewan

Inventor： Jonathan E. Page ,  Steve Gagne

IPC: C12P7/22 ,  C12P17/06 ,  C12N15/52 ,  C12N15/70

Abstract: Nucleic acid molecules encoding polypeptides having polyketide synthase activity have been identified and characterized. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds in organisms. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.

公开(公告)号：US20210392885A1

公开(公告)日：2021-12-23

申请号：US17309256

申请日：2019-11-19

Applicant: University of Saskatchewan

Inventor： Suzanne R. Abrams ,  Leon Lai ,  Naveen Diddi

IPC: A01N37/42 ,  C07C69/738 ,  C07C59/90 ,  A01P21/00

Abstract: The present application relates to novel 3′-unsaturated abscisic acid (ABA) derivatives of Formula (I) as ABA antagonists. For example, the present application relates to methods of using compounds of Formula (I) for reducing adverse effects of an ABA response in plants such as lentil and promoting germination. (I) The present application also relates to methods of using 3′-phenyl abscisic acid (ABA) derivatives of Formula (II) as ABA antagonists, for example, for reducing adverse effects of an ABA response in plants such as lentil and promoting germination. (II)

公开(公告)号：US20210267890A1

公开(公告)日：2021-09-02

申请号：US17276649

申请日：2019-09-20

Applicant: University of Saskatchewan

Inventor： Ellen K. Wasan ,  Kishor M. Wasan ,  Volker Gerdts ,  Stacy Strom

IPC: A61K9/127 ,  A61K39/39 ,  A61K9/00

Abstract: Methods and compositions for enhancing an immune response, such as a mucosal immune response, to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites.

公开(公告)号：US11064673B2

公开(公告)日：2021-07-20

申请号：US16228640

申请日：2018-12-20

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： Vladimir Vujanovic ,  James J. Germida

IPC: A01H17/00 ,  A01N63/00 ,  B09C1/10 ,  C12R1/465 ,  C12R1/645 ,  C12R1/80 ,  A01N63/30 ,  A01N25/00

Abstract: The present disclosure provides novel endophyte strains or cultures thereof that have a symbiotic relationship with plants. The present disclosure further provides methods of improving seed vitality, biotic and abiotic stress resistance, plant health and yield under both stressed and unstressed environmental conditions, comprising inoculating a seed with the novel endophyte strains and cultivating a plant therefrom.

公开(公告)号：US20210101947A1

公开(公告)日：2021-04-08

申请号：US17044602

申请日：2019-04-04

Applicant: University of Saskatchewan

Inventor： Troy Harkness ,  Terra Gayle Arnason

IPC: C07K14/47 ,  A61P35/00

Abstract: Methods and uses of activators of the APC complex for treating cancer in a subject, inhibiting the growth of a cancer cell, increasing sensitivity to a cancer treatment in a cancer cell or a subject and/or reducing resistance to a cancer treatment in a cancer cell or a subject.