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    COMBINATION THERPAY COMBINING CAR + T CELLS WITH APPROPRIATELY TIMED IMMUNODULATORY ANTIBODIES
    31.
    发明申请
    COMBINATION THERPAY COMBINING CAR + T CELLS WITH APPROPRIATELY TIMED IMMUNODULATORY ANTIBODIES 审中-公开
    组合使用具有特异性定时免疫抑制抗体的CAR + T细胞的组合

    公开(公告)号：WO2017035117A1

    公开(公告)日：2017-03-02

    申请号：PCT/US2016/048135

    申请日：2016-08-23

    Applicant: UNIVERSITY OF HOUSTON SYSTEM

    Inventor： VARADARAJAN, Navin ,  ROMAIN, Gabrielle ,  COOPER, Laurence ,  SINGH, Harjeet

    IPC: C12N5/0783 ,  G01N33/50 ,  A61K35/17

    CPC classification number: A61K35/17 ,  C12N5/0636 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2501/53 ,  C12N2501/599 ,  G01N33/502

    Abstract: In some embodiments, the present disclosure pertains to a method of enhancing chimeric antigen receptor expressing T cell function. In some embodiments, the method comprises activating the chimeric antigen receptor expressing T cells. In some embodiments, the method further comprises determining the differential expression of at least one molecule on the chimeric antigen receptor T cells. In some embodiments, the method comprises targeting the at least one molecule. In some embodiments, the present disclosure pertains to a method of treating a tumor in a subject in need thereof. In some embodiments, the method comprises administering to the subject an infusion of chimeric antigen receptor expressing T cells. In some embodiments, the method further comprises determining the differential expression of at least one molecule on the chimeric antigen receptor T cells. In some embodiments, the method comprises targeting the at least one molecule, wherein the molecule is differentially expressed upon activation of the chimeric antigen receptor expressing T cells.

    Abstract translation: 在一些实施方案中，本公开涉及增强表达T细胞功能的嵌合抗原受体的方法。 在一些实施方案中，该方法包括激活表达T嵌合抗原的T细胞。 在一些实施方案中，所述方法还包括测定嵌合抗原受体T细胞上至少一个分子的差异表达。 在一些实施方案中，该方法包括靶向至少一种分子。 在一些实施方案中，本公开涉及在有需要的受试者中治疗肿瘤的方法。 在一些实施方案中，所述方法包括向受试者施用表达T细胞的嵌合抗原受体的输注。 在一些实施方案中，所述方法还包括测定嵌合抗原受体T细胞上至少一个分子的差异表达。 在一些实施方案中，所述方法包括靶向所述至少一种分子，其中所述分子在表达T细胞的嵌合抗原受体活化时被差异表达。

    METHOD OF ACTIVATING TWO-DIMENSIONAL MATERIALS FOR MULTIVALENT/POLYATOMIC-ION INTERCALATION BATTERY ELECTRODES
    32.
    发明申请
    METHOD OF ACTIVATING TWO-DIMENSIONAL MATERIALS FOR MULTIVALENT/POLYATOMIC-ION INTERCALATION BATTERY ELECTRODES 审中-公开
    激活用于多元/聚原子离子间电池电极的二维材料的方法

    公开(公告)号：WO2017003734A2

    公开(公告)日：2017-01-05

    申请号：PCT/US2016/038311

    申请日：2016-06-20

    Applicant: UNIVERSITY OF HOUSTON SYSTEM

    Inventor： YAO, Yan ,  YOO, Hyun, Deog

    IPC: H01M4/139 ,  H01M4/04 ,  H01M4/13 ,  H01M10/054

    CPC classification number: H01M4/0445 ,  H01M4/13 ,  H01M4/136 ,  H01M4/139 ,  H01M4/1397 ,  H01M4/5815 ,  H01M10/054

    Abstract: A method for activating two-dimensional host materials for a multivalent/polyatomic ion battery may include adding a pillaring salt in electrolyte. This process may be followed by in-situ electrochemically intercalating the pillaring ions, solvent molecules and multivalent ions into the van der Waals gap of host materials. After the activation process, the host material is transformed into an interlayer-expanded 2D material with significantly enhanced specific capacity and rate performance for multivalent ion intercalation.

    Abstract translation: 用于激活多价/多原子离子电池的二维主体材料的方法可以包括在电解质中添加柱撑盐。 该过程之后可以将柱状离子，溶剂分子和多价离子原位电化学嵌入基质材料的范德华间隙中。 在活化过程之后，主体材料转化为层间扩展的2D材料，其具有显着增强的用于多价离子嵌入的比容量和倍率性能。

    SYSTEMS AND METHODS FOR SCOUR MONITORING WITH FIBER OPTIC SENSORS
    33.
    发明申请
    SYSTEMS AND METHODS FOR SCOUR MONITORING WITH FIBER OPTIC SENSORS 审中-公开
    用于光纤传感器监测的系统和方法

    公开(公告)号：WO2016191530A1

    公开(公告)日：2016-12-01

    申请号：PCT/US2016/034256

    申请日：2016-05-26

    Applicant: UNIVERSITY OF HOUSTON SYSTEM

    Inventor： SONG, Gangbing ,  KONG, Xuan ,  HO, Siu Chun, Michael

    IPC: G01N21/17 ,  G01M3/04 ,  G02B6/02 ,  G02B6/12

    CPC classification number: G01M3/141 ,  G01M3/12 ,  G01M3/38 ,  G01N21/7703 ,  G01N21/774 ,  G01N2021/7723 ,  G02B6/0208 ,  G02B6/02209

    Abstract: A scour monitoring system may provide a housing that is separated into multiple segments that are fluidically isolated from each other. The scour monitoring system may be position adjacent to a structure to be monitored for bridge scouring. Each of the segments may provide a water- swellable material positioned near or in contact with a fiber Bragg grating (FBG) cable. If water penetrates a segment, the water- swellable material may expand to deform the FBG cable. The wavelength of the FBG cable may be monitored periodically for changes, thereby providing moisture detection when a change in wavelength is detected.

    Abstract translation: 冲刷监测系统可提供分离成彼此流体隔离的多个部分的壳体。 冲刷监测系统可以位于邻近待监测的桥梁冲刷结构。 每个段可以提供位于光纤布拉格光栅（FBG）电缆附近或接触的水溶胀材料。 如果水渗透一段，则水溶胀性材料可能膨胀以使FBG电缆变形。 可以周期性地监测FBG电缆的波长以进行变化，从而当检测到波长变化时提供水分检测。

    CONTACTS FOR BI-TE- BASED MATERIALS AND METHODS OF MANUFACTURE
    34.
    发明申请
    CONTACTS FOR BI-TE- BASED MATERIALS AND METHODS OF MANUFACTURE 审中-公开
    基于双组分材料的接触和制造方法

    公开(公告)号：WO2016171766A1

    公开(公告)日：2016-10-27

    申请号：PCT/US2015/065129

    申请日：2015-12-10

    Applicant: UNIVERSITY OF HOUSTON SYSTEM

    Inventor： REN, Zhifeng ,  LIU, Weishu

    IPC: H01L35/34 ,  H01L35/02 ,  H01L35/14 ,  H01L35/16 ,  H01L35/18

    CPC classification number: H01L35/20 ,  C01B19/002 ,  H01L35/08 ,  H01L35/16 ,  H01L35/18 ,  H01L35/22 ,  H01L35/34

    Abstract: Systems and methods of manufacturing thermoelectric devices comprising at least one electrical contact fabricated using hot-pressing to increase the bonding strength at the contact interface(s) and reducing the contact resistance. The hot pressed component may include a first and a second metallic layer each in contact with a thermoelectric layer, and where a contact resistance between the first metallic layer and the thermoelectric layer or between the second metallic layer and the thermoelectric layer is less than about 10 μΩ cm 2 . When interlayers are employed in a thermoelectric device, first hot pressed contact interface is formed between the thermoelectric layer and the first interlayer and a second hot pressed contact interface is formed between the thermoelectric layer and the second interlayer, and at least one of the first and the second hot pressed contact interfaces comprises a bonding strength of at least 16 MPa.

    Abstract translation: 制造热电器件的系统和方法包括使用热压制造的至少一个电接触以增加接触界面处的接合强度并降低接触电阻。 热压部件可以包括与热电层接触的第一和第二金属层，并且其中第一金属层和热电层之间或第二金属层与热电层之间的接触电阻小于约10 μΩcm2。 当在热电装置中使用中间层时，在热电层和第一中间层之间形成第一热压接触界面，并且在热电层和第二中间层之间形成第二热压接触界面，并且第一和第 第二热压接触界面包括至少16MPa的结合强度。

    SCRATCH RESISTANT FLEXIBLE TRANSPARENT ELECTRODES AND METHODS FOR FABRICATING ULTRATHIN METAL FILMS AS ELECTRODES
    36.
    发明申请
    SCRATCH RESISTANT FLEXIBLE TRANSPARENT ELECTRODES AND METHODS FOR FABRICATING ULTRATHIN METAL FILMS AS ELECTRODES 审中-公开
    耐刮擦柔性透明电极及其制造方法作为电极制作超薄金属膜

    公开(公告)号：WO2016130717A1

    公开(公告)日：2016-08-18

    申请号：PCT/US2016/017408

    申请日：2016-02-10

    Applicant: UNIVERSITY OF HOUSTON SYSTEM

    Inventor： REN, Zhifeng ,  GUO, Chuanfei ,  LIU, Yuan

    IPC: H01B5/14 ,  H01B3/08 ,  H01B3/46 ,  H01B3/30 ,  H01B1/02

    CPC classification number: H01B1/02 ,  H01B3/08

    Abstract: Systems and methods of fabricating electrodes, including thin metallic films, include depositing a first metallic layer on a substrate and passivating the deposited layer. The processes of deposition and passivation may be done sequentially. In some embodiments, a plurality of substrates may be coated with a metallic layer and further processed at a later time, including passivation and disposal of additional layers as discussed herein.

    Abstract translation: 制造包括薄金属膜的电极的系统和方法包括在衬底上沉积第一金属层并钝化沉积层。 沉积和钝化的过程可以顺序进行。 在一些实施例中，多个基底可以涂覆有金属层并且在稍后的时间进一步处理，包括如本文所述的钝化和处理附加层。

    SOIL-RESISTANT, STAIN-RESISTANT COATINGS AND METHODS OF APPLYING ON TEXTILE OR OTHER FLEXIBLE MATERIALS
    39.
    发明申请
    SOIL-RESISTANT, STAIN-RESISTANT COATINGS AND METHODS OF APPLYING ON TEXTILE OR OTHER FLEXIBLE MATERIALS 审中-公开
    耐腐蚀，抗静电涂料和应用于纺织或其他柔性材料的方法

    公开(公告)号：WO2016077532A1

    公开(公告)日：2016-05-19

    申请号：PCT/US2015/060301

    申请日：2015-11-12

    Applicant: UNIVERSITY OF HOUSTON SYSTEM

    Inventor： CURRAN, Seamus ,  LIAO, Kang-shyang ,  WANG, Alexander ,  ALLEY, Nigel, J. ,  HALDAR, Amrita

    IPC: D06M13/00 ,  D06M11/00

    CPC classification number: D06M13/507 ,  D06M13/50 ,  D06M13/503 ,  D06M13/513 ,  D06M13/517 ,  D06M15/643 ,  D06M15/657 ,  D06M23/10 ,  D06M2101/32 ,  D06M2101/34 ,  D06M2200/01 ,  D06M2200/05 ,  D06M2200/11 ,  D06M2200/12

    Abstract: A process of fabricating the composition coating may include selecting a textile material substrate, utilizing a sol-gel comprising a silane or silane derivative and metal oxide precursor to coat the substrate, and optionally coating the substrate with a hydrophobic chemical agent and/or other chemical agents to create a surface with nanoscopic or microscopic features. The process may utilize an all solution process or controlled environment for fabricating a composition coating that prevent wetting or staining of a substrate. The composition coatings for treating textile materials improve soil-resistance and stain-resistance of the textile materials. The composition coatings and their use for treating textile materials can also impart water repellency, oil repellency, ease of cleaning stains and removing particulates. In addition, the composite solution may impart additional properties such as physical strength to the textile whilst retaining the original appearance.

    Abstract translation: 制备组合物涂层的方法可以包括选择纺织材料基材，利用包含硅烷或硅烷衍生物和金属氧化物前体的溶胶 - 凝胶涂覆基材，以及任选地用疏水化学试剂和/或其它化学品涂覆基材 用于制造具有纳米级或微观特征的表面的试剂。 该方法可以利用全溶液方法或控制环境来制造防止基底润湿或染色的组合物涂层。 用于处理纺织材料的组合物涂层改善了纺织材料的耐污性和抗污性。 组合物涂料及其用于处理纺织材料的用途还可以赋予防水性，拒油性，易于清洁污渍和除去微粒的作用。 此外，复合溶液可以赋予纺织品附加的特性，例如物理强度，同时保持原始外观。

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