Abstract:
PURPOSE: A skin external composition containing medicinal herb extract is provided to suppress proliferation of T lymphocyte and prevent or treat atopic dermatitis, contact dermatitis and psoriasis. CONSTITUTION: A skin external composition for prevent or treat atopic dermatitis, contact dermatitis or psoriasis contains 0.001-10 weight% of Thymus quinquecostatus Var. Japonica extract as an active ingredient. The skin external composition contains Asiasari Radix, Perillae Herba, Perillae Semen, Cimicifugae Rhizoma, Melandrii Herba, Solani Nigri Herba, Arctii Semen, Potentillae Radix, Cinnamomi Cortex Spissus, Hoelen rubra, Phaseoli angularis Semen, Ammomi Tsao-ko Frucuts, Alpiniae Katsumadaii Semen, Chenopodium album var. centrorubrum or Pimpinella brachycarpa.
Abstract:
PURPOSE: A skin external composition containing medicinal herb extract is provided to suppress the proliferation of T lymphocyte and prevent or treat atopic dermatitis, contact dermatitis and psoriasis. CONSTITUTION: A skin external composition contains 0.001-10 weight% of medicinal herb extract based on total weight of the composition. The medicinal herb is Asiasari Radix, Perillae Herba, Perillae Semen, Melandrii Herba, Solani Nigri Herba, Arctii Semen, Cinnamomi Cortex Spissus, Hoelen rubra, Phaseoli angularis Semen, Cinnamomi Cortex Spissus, Ammomi Tsao-ko Frucuts, Alpiniae Katsumadaii Semen, Fagopyrum esculentum, or Pimpinella brachycarpa.
Abstract:
A pharmaceutical composition comprising sphingosylphosphorylcholine or derivatives thereof is provided to inhibit proliferation and promote differentiation of keratinocyte, inhibit proliferation of splenocyte and T cell, induce reduction of leucocyte, and reduce mouse ear swelling induced by TPA(tetradecanoyl phorbol acetate), so that the composition is useful for treating psoriasis. A pharmaceutical composition for treating psoriasis comprises sphingosylphosphorylcholine(SPC) represented by the formula(1) or derivatives thereof and is formulated as tablet, pill, powder, sachet, elixir, suspension, emulsion, solution, syrup, aerosol, soft or hard gelatin capsule, sterile injection or sterile powder, wherein the daily dosage is 1-100 mg/kg, preferably 5-70 mg/kg.
Abstract:
본 발명은 아라키돈산 대사물질 또는 그 유도체의 용도에 관한 것으로서, 보다 상세하게는 아라키돈산 대사물질인 12(s)-HPETE, 15(s)-HPETE 또는 그 유도체의 투여량을 조절하여 동물에서 가려움증을 유발하는 방법, 가려움증 억제 물질의 스크리닝 방법 및 그 스크리닝한 가려움증 억제 물질의 약효를 평가하는 방법에 관한 것이다. 본 발명에 의한 아라키돈산 대사물질 또는 그 유도체는 가려움증을 이해하고 연구하는데 유용하며, 이를 바탕으로 가려움증 치료 약을 검색하거나 약효를 평가하여 개발하는데 매우 유용하게 사용될 수 있다. 아라키돈산 대사물질, 12(s)-HPETE, 15(s)-HPETE, 가려움증 억제 물질, 가려움증
Abstract:
본 발명은 바닐로이드 수용체 길항제로서 하기 화학식 1로 표시되는 티오우레아 유도체 또는 약제학적으로 허용가능한 그의 염, 또는 그의 수화물 또는 용매화물과 약제학적으로 허용가능한 담체를 함유하는 소양성 또는 자극성 피부질환의 예방 또는 치료용 조성물에 관한 것이다.
1 상기 화학식 중 R은 수소, 탄소수 1 내지 5의 알킬, 탄소수 2 내지 5의 알케닐, 탄소수 1 내지 5의 알콕시, 하이드록시, 할로겐, 니트로, 시아노, 메톡시카르보닐 또는 카르복실기를 나타낸다. 바닐로이드 수용체 길항제, 티오우레아 유도체, 피부질환, 소양증, 피부자극
Abstract:
PURPOSE: A composition containing musk having effects of strengthening the formation and maintenance of a natural moisturizing factor present in the stratum corneum of the skin and naturally increasing synthesis of lipid between cells is provided. It can be used as a therapeutic agent for preventing skin diseases such as atopic contact dermatitis as well as xeroderma or improving its symptoms. CONSTITUTION: The composition for external for improving the drying of the skin is characterized in that it contains 0.0001 to 20% by weight of musk as an effective ingredient, based on the total weight of the composition. The musk is musk 781 or musk T. The improvement in drying of the skin contains inducing the cell growth of keratinocyte, recovering a skin barrier, promoting the expression of filaggrin, activating PPAR(Peroxisome Proliferator Activated Receptor)-α, increasing biosynthesis of ceramide, improving skin moisturization, preventing atopic, contact dermatitis or improving its symptoms.
Abstract:
PURPOSE: Provided is a composition of external application to the skin containing extract of Adenophorea radix, thereby preventing dryness of the skin, improving moisture retaining property of the skin, and preventing and treating atopic dermatitis and skin inflammation. CONSTITUTION: A composition of external application to the skin is characterized by containing, as an active ingredient, 0.0001-60 wt.% of extract of Adenophorea radix. The composition moisturizes the skin, improves atopic dermatitis or skin inflammation, facilitates the differentiation of keratinocyte and expression of filaggrin, promotes the generation of ceramide, and activates PPAR-alpha.