Abstract:
A fermented green tea and a preparation method thereof are provided to reduce astringent and bitter taste of fermented green tea and to remove smells of various bacteria by aging and fermenting green tea using a food microorganism under the optimal condition. A method for preparing fermented green tea comprises the following steps of: adding water to green tea leaves until the moisture content becomes 30-60% on a total weight basis and inoculating bacteria to the green tea leaves; fermenting the inoculated green tea leaves under the condition of 7~35°C and 4.0~8.0 of pH for 1-10 days; and aging the fermented green tea leaves for 7-15 days. The aging step is performed at 5~20°C with basalt laying on the fermented green tea leaves. The bacteria are selected among Saccharomyces cerevisiae, Lactobacillus casei, Bacillus subtilis, Lactobacillus bulgaricus, Lactobacillus plantarum and Leuconostoc mesenteroides.
Abstract:
본 발명은 프럭토스 1,6-디포스페이트(D-fructose 1,6-diphosphate) 또는 그 유도체를 유효성분으로 함유하여 피부의 건조증상을 개선함을 특징으로 하는 피부외용제 조성물에 관한 것으로, 보다 상세하게는 피부세포의 분화를 촉진하여 새로운 각질의 재생산을 돕고, 피부에 보습기능을 담당하고 있는 천연보습인자(natural moisturizing factor, NMF)를 생산하고, 피부 내부로부터 수분유지에 필요한 지질의 합성을 증가시킴으로써, 피부의 수분함유능력 증강, 피부 건조의 방지, 그리고 아토피(atopy) 및 접촉성 피부염 증상의 예방, 개선 또는 치료에 효과가 있는 프럭토스 1,6-디포스페이트 또는 그 유도체를 함유하는 피부 외용제 조성물에 관한 것이다. 프럭토스 1,6-디포스페이트(D-fructose 1,6-diphosphate) * 보습 * 각질형성세포 분화 * 필라그린 * 지질생합성 * 세라마이드 * 천연보습인자 * 피부건조 * 아토피 * 접촉성 피부염
Abstract:
A method of manufacturing green tea with a high content of Gallocatechin-3-gallate(GCG) by subjecting green tea leaf to steam treatment at high temperature and pressure to epimerize epigallocatechin-3-gallate(EGCG) after steaming or roasting treatment of the green tea leaf is provided to increase the content of GCG by a thermal conversion method. To make green tea with a high content of Gallocatechin-3-gallate, green tea leaf is treated with steam or roasted. In the process, the steam treatment is performed more than 2 times or roasting time is increased by more than 20%. The steam treatment or roasting is performed within 30min. After the steam treatment or roasting, steam sterilization treatment is additionally performed for 1 to 240min.
Abstract:
A method for preparing gallocatechin gallate is provided to increase the solubility of epigallocatechin gallate into a reaction solvent by using an organic solvent and increase the conversion rate into the gallocatechin gallate through epimerization by adjusting the pH, thereby capable of increasing the production amount of the gallocatechin gallate. A method for preparing gallocatechin gallate comprises a step of converting epigallocatechin gallate into the gallocatechin gallate by dissolving the epigallocatechin gallate in an alcohol-based solvent such as ethanol and methanol or a polyol based solvent such as butylene glycol, propylene glycol and polyethylene glycol and then heating the solution at a temperature of about 120 deg.C for 30-60 minutes.
Abstract:
A composition containing (-)catechin is provided to increase expression of adiponectin by inhibiting expression of a transition factor KLF7(Kruppel-like factor 7) and promotes sugar absorption in adipocytes of mammals, so that the composition is useful for preventing and treating diabetes mellitus, arteriosclerosis and obesity. A composition for preventing and treating diabetes mellitus, arteriosclerosis and obesity contains 0.01-30 wt.%, preferably 1-15 wt.% of (-)catechin represented by the formula(1), wherein the (-)catechin is isolated from green tea. The daily dosage of (-)catechin is 0.1-50 mg/kg, preferably 1-20 mg/kg and the expression of adiponectin in a mammal adipocyte is increased by treating an adipocyte with (-)catechin for 24 hours.
Abstract:
A skin external composition for inhibiting phagocytosis of keratinocytes comprising genistein or daidzein is provided to reduce mobility of melanosomes transferred from melanocytes in keratinocytes by inhibiting phagocytosis of keratinocytes activated by exposure to ultra violet ray without cytotoxicity, so that chloasma, freckles and speckles are treated and prevented. The skin external composition for inhibiting phagocytosis of keratinocytes comprises at least one selected from genistein and daidzein, wherein the amount of genistein or daidzein is 0.0001-10 wt.%; the genistein or daidzein is an isoflavone produced from Leguminosae plants and shows estrogen effects; and the composition is formulated as cream, lotion, ointment, aqueous solution, suspension, dispersion or emulsion.
Abstract:
A cosmetic composition comprising the extract of Equisetum arvense L. as an effective ingredient is provided to promote growth of keratinocytes, remove reactive oxygen species, increase biosynthesis of procollagen type 1 by reducing biosynthesis of MMP-1(matrix metaloproteinase-1), and inhibit aging. The cosmetic composition for promoting growth of keratinocytes, removing reactive oxygen species, increasing biosynthesis of procollagen type 1 by reducing biosynthesis of MMP-1, or inhibiting aging comprises the extract of Equisetum arvense L. and at least one extract selected from Lonicera japonica Thunberg extract, Prunus armeniaca extract, Plantago asiatica extract and Coix lacryma-jobi extract, wherein the amount of the medicinal herb extract is 0.0001 to 25 wt.% based on the total weight of the composition; the medicinal herb extracts are prepared with water; and the composition further comprises 1,3-butyleneglycol.
Abstract:
PURPOSE: Provided is a melanogenesis-suppressing peptide which effectively suppresses the activation of tyrosinase in the melanogenesis cells. A topical skin-whitening composition containing the melanogenesis-suppressing peptide involves excellent skin whitening effect, and effective improvement and prevention of chloasma, freckles, and other melanin pigmentation. CONSTITUTION: The melanogenesis-suppressing peptide is selected from the group consisting of peptides with the amino acid sequences of SEQ ID NO 1-4. A method of manufacturing the melanogenesis-suppressing peptide comprises the steps of preparing chemical peptide random-sequenced mixtures with 76 cases of 4(locations)x19(amino acids); selecting two or three amino acids per the respective peptide locations with enzyme activity inhibitory effect from the peptide mixtures using tyrosinase extracted from mushrooms; synthesizing secondary peptides based on the selected peptide sequences; and testing the whitening effect and the cell stability of the secondary peptides, and finally selecting the peptide with the amino acid sequences of SEQ ID NO 1-4.
Abstract translation:目的:提供有效抑制黑素生成细胞中酪氨酸酶活化的黑素生成抑制肽。 含有黑素生成抑制肽的局部皮肤美白组合物具有优异的皮肤美白效果,有效改善和防止黄褐斑,雀斑和其他黑色素色素沉着。 构成:黑素生成抑制肽选自具有SEQ ID NO 1-4的氨基酸序列的肽。 制备黑素生成抑制肽的方法包括以下步骤:制备具有76个4(位置)x19(氨基酸)的76个化学肽随机排序的混合物; 使用从蘑菇提取的酪氨酸酶从肽混合物中选择两个或三个氨基酸,每个肽位置具有酶活性抑制作用; 基于所选择的肽序列合成二级肽; 并测试第二肽的美白效果和细胞稳定性,最后选择具有SEQ ID NO 1-4的氨基酸序列的肽。
Abstract:
본 발명은 유효성분으로 문형 추출물에 인동 추출물, 행인 추출물, 감국 추출물 및 의이인 추출물로 이루어진 군으로부터 선택된 하나 이상을 더 함유하는 조성물에 관한 것으로, 더 구체적으로는 각질형성세포 성장촉진 효과, 활성산소 소거효과, MMP-1의 생합성 감소를 통한 타입 1 프로콜라겐의 생합성촉진 효과 및 노화방지 효과를 가지는 조성물에 관한 것이다. 문형*인동*행인*감국*의이인*각질형성세포*활성산소*타입1 프로콜라겐