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公开(公告)号：KR100867596B1
公开(公告)日：2008-11-10
申请号：KR1020070034924
申请日：2007-04-10
Applicant: (주)아모레퍼시픽
IPC: G01N33/48 , G01N33/533
Abstract: 본 발명은 피부 각질 박리량을 정량할 수 있는 평가법으로서, 기존의 형광염색을 통해 육안적으로 각질 박리량을 평가하는 부분을 개선하여 이미지 분석 프로그램을 이용함으로써 각질박리량을 수치화하고, 객관적으로 각질 박리량을 검증할 수 있는 방법에 관한 것이다. 보다 상세하게는 피부 표면의 각질층을 형광염색시약으로 염색한 다음, 형광염색된 피부 표면에 각질 박리용 시료를 도포한 후 사진을 촬영하여 형광이미지를 얻음으로써 추적 관찰을 실시하고, 촬영한 사진의 형광이미지는 이미지 분석 프로그램을 이용함으로써 형광강도를 수치화하고, 형광이미지를 이용하여 3차원 이미지화 할 수 있다. 이를 통해 기존의 육안 판정에 의존하던 각질 박리 평가를 수치적으로 객관화 할 수 있으며, 3차원 이미지 변환을 통해 각질 박리 효과를 가시화 할 수 있다.
각질 박리, 형광염색, 댄실 클로라이드(Dansyl chloride), 디히드록시아세톤(Dihydroxyacetone), 이미지 분석, 형광강도, 흑백 전환-
公开(公告)号：KR1020080091901A
公开(公告)日：2008-10-15
申请号：KR1020070034924
申请日：2007-04-10
Applicant: (주)아모레퍼시픽
IPC: G01N33/48 , G01N33/533
Abstract: A method for measuring the amount of human stratum corneum exfoliation is provided to digitize the stratum corneum exfoliation amount using an image analysis program by improving a conventional technique of evaluating the stratum corneum exfoliation amount visually through fluorescence staining, thereby verifying the stratum corneum amount objectively. A method for measuring the amount of human stratum corneum exfoliation comprises the steps of: (a) coating a fluorescent staining sample such as Dansyl chloride and dihydroxyacetone on a stratum corneum of skin surface for fluorescence-staining; (b) coating a sample for exfoliation such as glycolic acid, lactic acid, malic acid, citric acid, tartaric acid, salicylic acid and papain enzyme on the fluorescent-stained stratum corneum for 4-14 days to perform exfoliation; (c) fluorescence-photographing the exfoliated stratum corneum to obtain a fluorescent image; and (d) setting up an analysis area of the fluorescent image and digitizing fluorescence strength of the analysis by using an image analysis program. Further, the step (a) of coating a fluorescent staining sample is performed for 6 hrs.
Abstract translation: 提供了用于测量人角质层脱落量的方法，通过改进通过荧光染色目视评估角质层剥离量的常规技术，通过图像分析程序对角质层去角质量进行数字化，从而客观地验证角质层数量。 用于测量人角质层剥离量的方法包括以下步骤：（a）将荧光染色样品如丹酰氯和二羟基丙酮涂覆在皮肤表面的角质层上用于荧光染色; （b）在荧光染色的角质层上涂覆乙醇酸，乳酸，苹果酸，柠檬酸，酒石酸，水杨酸和木瓜蛋白酶等剥离性样品4-14天，进行剥离; （c）荧光拍摄剥离的角质层以获得荧光图像; 和（d）通过使用图像分析程序设置荧光图像的分析区域和数字化分析的荧光强度。 此外，涂布荧光染色样品的步骤（a）进行6小时。
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33.发明公开자외선 차단제의 ｉｎ ｖｉｔｒｏ 워터 레지스턴스 ＳＰＦ측정 시스템 및 이를 이용한 ＳＰＦ 측정 방법 有权用于测量SUNSCREEN药剂的耐水性SPF的体系及其使用方法测定SUNSCREEN AGENT的体外耐水性SPF
公开(公告)号：KR1020070106080A
公开(公告)日：2007-11-01
申请号：KR1020060038518
申请日：2006-04-28
Applicant: (주)아모레퍼시픽
IPC: G01M99/00
Abstract: A system for measuring the in-vitro water resistance SPF of a sunscreen agent and a method for measuring the SPF by using the same are provided to predict the water resistance degree of a product without performing an actual clinic test. A system for measuring the in-vitro water resistance SPF of a sunscreen agent includes a drive section(10), and a rotary blade(20). The drive section includes a rotational shaft(11). The rotational shaft is submerged in the water in a washing tub. The rotary blade is installed at one end of the rotational shaft. An ultraviolet sunscreen agent is coated on a surface of the rotary blade. The ultraviolet sunscreen agent is washed out in the water by rotating the rotary blade driven by the drive section. The rotary blade has a plurality of blade ribs(22) extended vertically at one end of the rotational shaft, and substrates(24) coated with the ultraviolet sunscreen agent.
Abstract translation: 提供了一种用于测量防晒剂的体外抗水性SPF的系统和使用该防晒剂的SPF测量方法，以预测产品的耐水性，而不进行实际临床试验。 用于测量防晒剂的体外防水性SPF的系统包括驱动部分（10）和旋转叶片（20）。 驱动部分包括旋转轴（11）。 旋转轴浸入洗涤桶中的水中。 旋转叶片安装在旋转轴的一端。 紫外线防晒剂涂覆在旋转刀片的表面上。 通过旋转由驱动部驱动的旋转刀片，紫外线防晒剂在水中洗出。 旋转刀片具有在旋转轴的一端处垂直延伸的多个叶片肋（22）和涂覆有紫外线防晒剂的基底（24）。
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公开(公告)号：KR1020050022251A
公开(公告)日：2005-03-07
申请号：KR1020040020401
申请日：2004-03-25
Applicant: (주)아모레퍼시픽
IPC: C07C239/14
Abstract: PURPOSE: Provided are a hydroxamic acid derivative which shows an antiaging effect and is improved in safety and stability to the skin stimulus and discoloration, its preparation method, and an antiaging skin preparation for external use and a collagenase and elastase expression inhibitor containing the derivative. CONSTITUTION: The hydroxamic acid derivative is represented by the formula 1, wherein R1 and R2 are H, a C1-C10 alkyl group or a C3-C6 cycloalkyl group; R3 is CONH, NHCO, CONR5 or NR5CO (wherein R5 is H or a C1-C10 alkyl group); and R4 is -(CH)n- (wherein n is 0 or 1). The method comprises the steps of reacting benzoic acid and methyl 4-aminobenzoate or 4-aminophenylacetic acid methyl ester or reacting aniline and monomethyl terephthalate, to prepare a benzamide compound; substituting the amino bond of the benzamide compound into an alkyl bond; hydrolyzing the methyl ester group to prepare an acid; and reacting the obtained acid with hydroxyl amine·HCl salt to prepare the hydroxamic acid derivative of the formula 1.
Abstract translation: 目的：提供一种异羟肟酸衍生物，其表现出抗衰老作用，并且改善了皮肤刺激和变色的安全性和稳定性，其制备方法和外用抗衰老皮肤制剂以及含有该衍生物的胶原酶和弹性蛋白酶表达抑制剂。 构成：异羟肟酸衍生物由式1表示，其中R 1和R 2是H，C 1 -C 10烷基或C 3 -C 6环烷基; R3是CONH，NHCO，CONR5或NR5CO（其中R5是H或C1-C10烷基）; 且R 4为 - （CH）n - （其中n为0或1）。 该方法包括使苯甲酸和4-氨基苯甲酸甲酯或4-氨基苯乙酸甲酯或苯胺与对苯二甲酸单甲酯反应制备苯甲酰胺化合物的步骤; 将苯甲酰胺化合物的氨基取代成烷基键; 水解甲基酯以制备酸; 并使所得酸与羟胺·HCl盐反应制备式1的异羟肟酸衍生物。
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Patent Agency Ranking
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公开(公告)号：KR1020170105974A
公开(公告)日：2017-09-20
申请号：KR1020160029447
申请日：2016-03-11
Applicant: (주)아모레퍼시픽
IPC: A61B5/00
CPC classification number: G06T7/40 , G06T7/0016 , G06T7/602 , G06T2207/10024 , G06T2207/20024 , G06T2207/30088
Abstract: 실시예들은피부영상에서피부결블랍(blob)을결정하는피부결블랍결정부, 상기피부영상내 상기피부결블랍에대한총면적, 평균면적, 개수, 총테두리길이, 테두리길이평균, 방향성, 각도중 적어도하나를측정하는피부결블랍정보측정부및 측정된결과를기초로상기피부영상의피부결을평가하는피부결평가부를포함하는피부결블랍을이용한피부결평가장치및 이를이용한평가방법에관련된다.
Abstract translation: 实例是皮肤纹理确定皮肤斑点（BLOB）在皮肤上的图像块判定部件的质感，在皮肤上的图像内的皮肤纹理的斑点总面积，平均面积，数量，总边界长度，边长平均，取向的角 它涉及到皮肤纹理团块信息测量中的至少一个来测量部件以及使用该皮肤斑点包括评估皮肤纹理单元，用于评估的测量结果皮肤纹理评价装置的基础上，在皮肤图像的皮肤的纹理的纹理，并使用相同的方法评价 。
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公开(公告)号：KR1020170038226A
公开(公告)日：2017-04-07
申请号：KR1020150137284
申请日：2015-09-30
Applicant: (주)아모레퍼시픽
Abstract: 본발명은인체에서직접, 비침습적이고반복적으로측정이가능하며, 재현성있고, 정확한정량분석이가능한모발탄력성평가방법에관한것으로, 본발명에따른평가방법을이용함으로써, 모발의탄력성을평가하기위한시간및 비용을절감할수 있을뿐 아니라신뢰도높은정량분석이가능하여제품개발시품질보증의수단으로기여할수 있다.
Abstract translation: 本发明涉及一种能够对人体进行直接的，非侵入性的和重复的测量并且能够进行可重复的和准确的定量分析的毛发弹性评估方法，通过使用根据本发明的评估方法， 节省时间和成本以及可靠的定量分析，这可以有助于产品开发的质量保证。
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公开(公告)号：KR1020160097760A
公开(公告)日：2016-08-18
申请号：KR1020150019976
申请日：2015-02-10
Applicant: (주)아모레퍼시픽
Abstract: 본발명은메이크업화장품의도포(塗布) 균일성을평가하는방법에관한것으로서, a) 도포된메이크업화장품의이미지를촬영하고, 적어도 2 이상의국소(局所) 면적들을지정하는단계, b) 촬영된이미지의색차(色差)를비교하는단계및 c) 비교된색차로부터도포된메이크업화장품의도포균일성을평가하는단계를포함한다. 본발명의도포균일성평가방법은관능평가방식아닌정량적이고객관적인평가를가능하게한다.
Abstract translation: 本发明涉及一种评价化妆品的应用均匀性的方法，包括以下步骤：a）拍摄所应用的化妆品的图像，并指定至少两个局部区域; b）比较拍摄图像的色差; 以及c）从比较的色差评估化妆品化妆品的应用均匀性。 评价本发明的应用均匀性的方法使得评价是定量和客观的，这不是感官评价。
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