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公开(公告)号：KR1020130083810A
公开(公告)日：2013-07-23
申请号：KR1020120122161
申请日：2012-10-31
Applicant: 가톨릭대학교 산학협력단
IPC: C07K14/47 , G01N33/536 , G01N33/68 , G01N33/52 , G01N33/53
CPC classification number: G01N33/564 , G01N2800/102
Abstract: PURPOSE: The rheumatoid arthritis diagnosis kit is provided to diagnose rheumatoid arthritis more quickly and correctly by detecting the citrullinemic autoantigen within the specimen sample. CONSTITUTION: An antigen detection method for rheumatoid arthritis diagnosis comprises step of detecting the citrullinemic autoantigen from the biological specimen. The detection of the citrullinemic autoantigen detects the citrullinemic autoantigen from the biological specimen by treating the primary antibody that includes variable domain of light chain having sequence number 4 of amino acid and variable domain of heavy chain having sequence number 3 of amino acid in the biological specimen and treating its antigen-binding fragment. The rheumatoid arthritis diagnostic kit includes the monoclonal antibody or its antigen-binding fragment that specifically unites with the citrullinemic protein.
Abstract translation: 目的：通过检测样品样品中的瓜氨酸血症自身抗原，提供类风湿关节炎诊断试剂盒，更快速，准确地诊断类风湿关节炎。 构成：用于类风湿关节炎诊断的抗原检测方法包括从生物样本中检测瓜氨酸血症自身抗原的步骤。 瓜氨酸血症自身抗原的检测通过在生物样本中处理包括具有序列号4的氨基酸和可变结构域的重链可变结构域的轻链的第一抗体来检测生物标本中的血尿酸自身抗原 并治疗其抗原结合片段。 类风湿性关节炎诊断试剂盒包括与瓜氨酸蛋白质特异性结合的单克隆抗体或其抗原结合片段。
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32.发明公开ＣＴＬＡ４ 및 ＩＬ２１Ｒ 을 포함하는 융합 단백질 및 이를 포함하는 관절염 예방 및 치료용 조성물 有权包含CTLA4和IL21R的融合蛋白及其组合物，用于预防或治疗包含其的ARTHRITI
公开(公告)号：KR1020130031137A
公开(公告)日：2013-03-28
申请号：KR1020110094885
申请日：2011-09-20
Applicant: 가톨릭대학교 산학협력단 , 주식회사 와이바이오로직스
Abstract: PURPOSE: A fusion protein is provided to suppress T cell activity and to prevent or treat arthritis. CONSTITUTION: A fusion protein contains CTLA4(cytotoxic T-lymphocyte antigen 4) and IL21R(Interleukin-21 receptor). The fusion protein has an amino acid of sequence number 1. IL21R and CTLA4 have amino acid sequences of sequence numbers 2 and 3, respectively. The fusion protein additionally contains an immunoglobulin Fc region at N-terminal or C-terminal. A transformant is prepared by transforming a host cell with a recombinant vector containing a gene encoding the fusion protein. [Reference numerals] (AA) Stimulation (-); (BB) Stimulation (+); (CC) CTLA4 +IL-21Fc dual target(fusion protein)
Abstract translation: 目的：提供融合蛋白以抑制T细胞活性和预防或治疗关节炎。 构成：融合蛋白含有CTLA4（细胞毒性T淋巴细胞抗原4）和IL21R（白细胞介素-21受体）。 融合蛋白具有序列号1的氨基酸.IL21R和CTLA4分别具有序列号2和3的氨基酸序列。 融合蛋白另外含有N-末端或C-末端的免疫球蛋白Fc区。 通过用含有编码融合蛋白的基因的重组载体转化宿主细胞来制备转化体。 （附图标记）（AA）刺激（ - ）; （BB）刺激（+）; （CC）CTLA4 + IL-21Fc双靶（融合蛋白）
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公开(公告)号：KR1020130031128A
公开(公告)日：2013-03-28
申请号：KR1020110094862
申请日：2011-09-20
Applicant: 가톨릭대학교 산학협력단
IPC: A61K31/496 , A61K31/4965 , A61P19/02 , A61P19/00
CPC classification number: A61K31/495 , C07D241/04 , Y10S514/825
Abstract: PURPOSE: A pharmaceutical composition containing meclizine is provided to protect cartilage and bone tissue and to prevent and treat arthritis. CONSTITUTION: A pharmaceutical composition for preventing and treating arthritis contains a compound of chemical formula 1 or a pharmaceutically acceptable salt thereof. The pharmaceutically acceptable salt is hydrochloride. The arthritis includes osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, reactive arthritis, systemic lupus erythematosus, polymyositis, or polymyalgia rheumatic.
Abstract translation: 目的：提供含麦地利的药物组合物，以保护软骨和骨组织，并预防和治疗关节炎。 构成：用于预防和治疗关节炎的药物组合物含有化学式1的化合物或其药学上可接受的盐。 药学上可接受的盐是盐酸盐。 关节炎包括骨关节炎，类风湿性关节炎，强直性脊柱炎，反应性关节炎，系统性红斑狼疮，多发性肌炎或风湿性多肌痛。
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公开(公告)号：KR101237002B1
公开(公告)日：2013-02-25
申请号：KR1020120054963
申请日：2012-05-23
Applicant: 가톨릭대학교 산학협력단
CPC classification number: G01N33/564 , C12N5/163 , G01N2800/102
Abstract: PURPOSE: A monoclonal antibody which specifically detects proteins with a citrulline residue and a hybridoma cell line are provided to detect citrullinated proteins and to diagnose and treat autoimmune diseases. CONSTITUTION: A monoclonal antibody or an antigen-binding fragment thereof for diagnosing rheumatic arthritis contains a heavy chain variable region with an amino acid sequence of sequence number 3 and a light chain variable region with an amino acid of sequence number 4. The monoclonal antibody or the fragment is produced from a hybridoma(deposit number KCLRF-BP-00276). A method for providing information for diagnosing rheumatoid arthritis comprises a step of measuring antigen-antibody response of citrullinated proteins in a sample. A composition for diagnosing rheumatoid arthritis contains the monoclonal antibody or the fragment. A kit for diagnosing rheumatoid arthritis contains the antibody or the fragment. [Reference numerals] (AA) Cultivating Myeloma cell strain; (BB) Myeloma cell; (CC) Antigen; (DD) Spleen cell; (EE) Fusing in poly(ethylene glycol); (FF) Selecting and cultivating hybrid cells; (GG) Selecting antibody producing cells; (HH) Mass cultivating; (II) Producing clone; (JJ) Freezing; (KK) Thawing; (LL) Inducing tumor; (MM,NN) Antibody
Abstract translation: 目的：提供特异性检测瓜氨酸残基和杂交瘤细胞系的蛋白质的单克隆抗体，用于检测瓜氨酸化蛋白质并诊断和治疗自身免疫性疾病。 构成：用于诊断风湿性关节炎的单克隆抗体或其抗原结合片段含有具有序列号3的氨基酸序列的重链可变区和具有序列号4的氨基酸的轻链可变区。单克隆抗体或 该片段由杂交瘤（保藏号KCLRF-BP-00276）产生。 用于提供用于诊断类风湿性关节炎的信息的方法包括测量样品中瓜氨酸化蛋白质的抗原 - 抗体应答的步骤。 用于诊断类风湿性关节炎的组合物含有单克隆抗体或片段。 用于诊断类风湿关节炎的试剂盒含有抗体或片段。 （AA）培养骨髓瘤细胞株; （BB）骨髓瘤细胞; （CC）抗原; （DD）脾细胞; （EE）熔融聚（乙二醇）; （FF）选择和培养杂交细胞; （GG）选择产生抗体的细胞; （HH）大规模耕种; （二）生产克隆; （JJ）冷冻; （KK）解冻; （LL）诱导肿瘤; （MM，NN）抗体
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Patent Agency Ranking
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公开(公告)号：KR101551927B1
公开(公告)日：2015-09-18
申请号：KR1020130107489
申请日：2013-09-06
Applicant: 가톨릭대학교 산학협력단
IPC: A01K67/027
Abstract: 본발명은구강내 세균인포르피로모나스진지발리스 () 균을동물에감염시킨후 관절염을유도하거나또는관절염을유도한후 포르피로모나스진지발리스 () 균을동물에감염시켜관절염동물모델을제조하는방법및 상기제조방법에의해제조된동물모델에관한것이다.
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公开(公告)号：KR101510830B1
公开(公告)日：2015-04-10
申请号：KR1020130053064
申请日：2013-05-10
Applicant: 가톨릭대학교 산학협력단
CPC classification number: Y02A50/473
Abstract: 본발명은생리활성단백질을발현하는미니서클벡터를포함하는줄기세포치료제에관한것으로, 보다구체적으로, 생리활성단백질을발현하는미니서클벡터를포함하는줄기세포, 이를포함하는약학조성물및 약물전달용조성물에관한것이다.
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公开(公告)号：KR1020150028620A
公开(公告)日：2015-03-16
申请号：KR1020130107489
申请日：2013-09-06
Applicant: 가톨릭대학교 산학협력단
IPC: A01K67/027
CPC classification number: A01K67/027 , A01K2207/10 , A01K2267/0325
Abstract: 본 발명은 구강 내 세균인 포르피로모나스 진지발리스 (
Porphyromonas
gingivalis ) 균을 동물에 감염시킨 후 관절염을 유도하거나 또는 관절염을 유도한 후 포르피로모나스 진지발리스 (
Porphyromonas
gingivalis ) 균을 동물에 감염시켜 관절염 동물 모델을 제조하는 방법 및 상기 제조방법에 의해 제조된 동물 모델에 관한 것이다.Abstract translation: 本发明涉及一种制备类风湿性关节炎动物模型的方法，其特征在于包括以下步骤：用牙龈卟啉单胞菌（Porphyromonas gingivalis）感染动物，其为口腔细菌并诱导关节炎; 或诱导关节炎并用牙龈卟啉单胞菌感染动物，以及由此制备的动物模型。
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