中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

21 records (took 0.032 seconds)

    자가면역 질환의 예방과 치료를 위한 ＩＬ-６ 수용체에 대한 항체를 발현하는 미니서클
    3.
    发明公开
    자가면역 질환의 예방과 치료를 위한 ＩＬ-６ 수용체에 대한 항체를 발현하는 미니서클 有权
    MINICIRCLE表达抗IL-6R抗体，用于预防和治疗自身免疫性疾病

    公开(公告)号：KR1020130126547A

    公开(公告)日：2013-11-20

    申请号：KR1020130053292

    申请日：2013-05-10

    Applicant: 가톨릭대학교 산학협력단

    Inventor： 주지현 ,  김영균 ,  이효주

    IPC: A61K48/00 ,  A61K39/395 ,  A61P37/00

    CPC classification number: A61K48/00 ,  C12N15/63 ,  Y10S424/81 ,  Y10S514/825

    Abstract: The present invention relates to a pharmaceutical composition containing a minicircle vector which expresses anti-IL-6R for treating autoimmune diseases. The pharmaceutical composition of the present invention contains (a) a gene expression cassette containing a promoter, a gene encoding anti-IL-6R monoclonal antibodies, and a transcription terminator; (b) a site-specific recombinant region located at the outside of the gene expression cassette; and (c) a non-viral vector which does not contain a replication origin and a selection marker gene as active ingredients.

    Abstract translation: 本发明涉及含有表达用于治疗自身免疫性疾病的抗IL-6R的小环载体的药物组合物。 本发明的药物组合物含有（a）含有启动子，编码抗IL-6R单克隆抗体的基因和转录终止子的基因表达盒; （b）位于基因表达盒外侧的位点特异性重组区; 和（c）不含复制起点和选择标记基因作为活性成分的非病毒载体。

    항종양괴사인자 수용체 2를 발현하도록 설계된 미니서클 벡터를 이용한 자가면역질환 치료
    6.
    发明公开
    항종양괴사인자 수용체 2를 발현하도록 설계된 미니서클 벡터를 이용한 자가면역질환 치료 有权
    使用设计用于表达TNFR2的微型矢量进行自发性疾病的治疗

    公开(公告)号：KR1020130126549A

    公开(公告)日：2013-11-20

    申请号：KR1020130053356

    申请日：2013-05-10

    Applicant: 가톨릭대학교 산학협력단

    Inventor： 주지현 ,  김영균 ,  이효주

    IPC: A61K48/00 ,  A61K38/16 ,  A61P37/00

    CPC classification number: Y02A50/473 ,  A61K38/177 ,  A61K38/1774 ,  A61K48/00 ,  C07K14/70578 ,  C12N15/63 ,  Y10S514/825

    Abstract: The present invention relates to a pharmaceutical composition containing a minicircle vector which expresses tumor necrosis factor receptor type 2 (TNFR2) for treating autoimmune diseases. The pharmaceutical composition of the present invention contains: (a) a gene expression cassette containing a promoter, a gene encoding TNFR2 proteins or a fragment containing extracellular region of TNFR2, and a terminator; b) a site-specific recombinant region located at the outside of the gene expression cassette; and a non-viral vector which does not contain a replication origin and a selection marker gene as active ingredients.

    Abstract translation: 本发明涉及含有表达用于治疗自身免疫性疾病的2型肿瘤坏死因子受体（TNFR2）的小环载体的药物组合物。 本发明的药物组合物含有：（a）含有启动子，编码TNFR2蛋白的基因或含有TNFR2胞外区的片段的基因表达盒和终止子; b）位于基因表达盒外侧的位点特异性重组区; 和不含复制起点和选择标记基因作为活性成分的非病毒载体。

    시트룰린화된 단백질에 특이적인 단클론 항체 및 이를 생산하는 하이브리도마 세포주
    7.
    发明授权
    시트룰린화된 단백질에 특이적인 단클론 항체 및 이를 생산하는 하이브리도마 세포주 有权
    特定蛋白质和其生产的杂交细胞系的单克隆抗体

    公开(公告)号：KR101237002B1

    公开(公告)日：2013-02-25

    申请号：KR1020120054963

    申请日：2012-05-23

    Applicant: 가톨릭대학교 산학협력단

    Inventor： 주지현 ,  김영균 ,  이효주 ,  김주련 ,  정혜린 ,  문수진 ,  강귀영 ,  김인제

    IPC: C07K16/18 ,  C12N5/12 ,  G01N33/53

    CPC classification number: G01N33/564 ,  C12N5/163 ,  G01N2800/102

    Abstract: PURPOSE: A monoclonal antibody which specifically detects proteins with a citrulline residue and a hybridoma cell line are provided to detect citrullinated proteins and to diagnose and treat autoimmune diseases. CONSTITUTION: A monoclonal antibody or an antigen-binding fragment thereof for diagnosing rheumatic arthritis contains a heavy chain variable region with an amino acid sequence of sequence number 3 and a light chain variable region with an amino acid of sequence number 4. The monoclonal antibody or the fragment is produced from a hybridoma(deposit number KCLRF-BP-00276). A method for providing information for diagnosing rheumatoid arthritis comprises a step of measuring antigen-antibody response of citrullinated proteins in a sample. A composition for diagnosing rheumatoid arthritis contains the monoclonal antibody or the fragment. A kit for diagnosing rheumatoid arthritis contains the antibody or the fragment. [Reference numerals] (AA) Cultivating Myeloma cell strain; (BB) Myeloma cell; (CC) Antigen; (DD) Spleen cell; (EE) Fusing in poly(ethylene glycol); (FF) Selecting and cultivating hybrid cells; (GG) Selecting antibody producing cells; (HH) Mass cultivating; (II) Producing clone; (JJ) Freezing; (KK) Thawing; (LL) Inducing tumor; (MM,NN) Antibody

    Abstract translation: 目的：提供特异性检测瓜氨酸残基和杂交瘤细胞系的蛋白质的单克隆抗体，用于检测瓜氨酸化蛋白质并诊断和治疗自身免疫性疾病。 构成：用于诊断风湿性关节炎的单克隆抗体或其抗原结合片段含有具有序列号3的氨基酸序列的重链可变区和具有序列号4的氨基酸的轻链可变区。单克隆抗体或 该片段由杂交瘤（保藏号KCLRF-BP-00276）产生。 用于提供用于诊断类风湿性关节炎的信息的方法包括测量样品中瓜氨酸化蛋白质的抗原 - 抗体应答的步骤。 用于诊断类风湿性关节炎的组合物含有单克隆抗体或片段。 用于诊断类风湿关节炎的试剂盒含有抗体或片段。 （AA）培养骨髓瘤细胞株; （BB）骨髓瘤细胞; （CC）抗原; （DD）脾细胞; （EE）熔融聚（乙二醇）; （FF）选择和培养杂交细胞; （GG）选择产生抗体的细胞; （HH）大规模耕种; （二）生产克隆; （JJ）冷冻; （KK）解冻; （LL）诱导肿瘤; （MM，NN）抗体

Patent Agency Ranking