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31.发明公开당전이 효소 및 대사조절된 대장균 및 이를 이용한 퀘세틴 3-Ｏ-글루코사이드-7-Ｏ-람노사이드의 합성방법 有权工程化的ESHERICHIA COLI表达尿苷 - 二磷酸（UDP） - 依赖性糖蛋白衍生物和使用其的3-O-葡糖苷-7-O-硫代吗啉的合成
公开(公告)号：KR1020140035097A
公开(公告)日：2014-03-21
申请号：KR1020120101504
申请日：2012-09-13
Applicant: 건국대학교 산학협력단
Abstract: The present invention relates to a method for producing 3-O-glucoside-7-O-rhamnoside made in plants using Escherichia coli, and more specifically, to metabolic-adjusted Escherichia coli and synthesis of quercetin 3-O-glucoside-7-O-rhamnoside using the same.
Abstract translation: 本发明涉及使用大肠杆菌制备3-O-葡萄糖苷-7-O-鼠李糖苷的方法，更具体地说，涉及代谢调节的大肠杆菌和槲皮素3-O-葡萄糖苷-7-O的合成 - 鼠李糖苷使用它们。
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公开(公告)号：KR101270124B1
公开(公告)日：2013-05-31
申请号：KR1020110097968
申请日：2011-09-28
Applicant: 건국대학교 산학협력단
IPC: C07H15/26 , C07D407/12 , C12N15/29 , C12N15/32
Abstract: 본발명은신규한화합물퀘세틴 3--6-deoxy-L-taloside 및그 화합물의제조방법에대한것으로더욱상세하게는대사조절된대장균을이용한퀘세틴 3--6-deoxy-L-taloside 의합성에관한것이다.
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33.发明公开모노아민옥시다제-Ａ의 저해 활성을 갖는 신규한 칼콘 화합물 피라졸릴나프탈레놀 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 심혈관계 질환의 예방 및 치료용 조성물 有权对单胺氧化酶A具有抑制作用的新型氯化钠化合物及其制备方法及其组合物，用于治疗和预防心血管疾病
公开(公告)号：KR1020130002369A
公开(公告)日：2013-01-08
申请号：KR1020110061472
申请日：2011-06-24
Applicant: 건국대학교 산학협력단
IPC: C07D231/06 , A61K31/415 , A61P9/00
Abstract: PURPOSE: A composition containing novel chalcone compound pyrazolylnaphthalenol derivatives for preventing and treating cardiovascular diseases is provided to suppress MAO-A(monoamine oxidase)-A. CONSTITUTION: A novel chalcone compound pyrazoylynaphthalenol derivative is denoted by chemical formula 1. The derivative is 1-(1-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl)naphthalen-2-ol. The derivative suppresses MAO-A. A method for preparing the derivative comprises: a step of reacting 2-hydroxy-1-acetonaphthone and 4-trimethoxybenzaldehyde under the presence of a base to prepare a chalcone compound, 4,5-benzo-1-hydroxy-4`-methoxycalcone; and a step of reacting the chalcone compounds with 4-fluorophenylhydrazine to prepare pyrazoylylnaphthalenol derivative 1-(4-fluorophenyl)-5-(4-methoxyphenyl)-4,5-dehydro-1H-pyrazole-3-yl-naphthalene-2-ol. A pharmaceutical composition for preventing and treating cardiovascular diseases contains the derivative or a pharmaceutically acceptable salt thereof as an active ingredient.
Abstract translation: 目的：提供含有新型查耳酮化合物吡唑基萘酚衍生物用于预防和治疗心血管疾病的组合物，以抑制MAO-A（单胺氧化酶）-A。 组成：新颖的查耳酮化合物吡唑啉萘酚衍生物由化学式1表示。衍生物为1-（1-（4-氟苯基）-5-（4-甲氧基苯基）-4,5-二氢-1H-吡唑-3-基 ）萘-2-醇。 该衍生物抑制MAO-A。 制备该衍生物的方法包括：在碱存在下使2-羟基-1-乙醛和4-三甲氧基苯甲醛反应制备查尔酮化合物，4,5-苯并-1-羟基-4'-甲氧基钙; 和查尔酮化合物与4-氟苯肼反应制备吡嗪基萘酚衍生物的步骤1-（4-氟苯基）-5-（4-甲氧基苯基）-4,5-脱氢-1H-吡唑-3-基 - 萘-2-酮 醇。 用于预防和治疗心血管疾病的药物组合物含有作为活性成分的衍生物或其药学上可接受的盐。
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34.发明公开
公开(公告)号：KR1020120049684A
公开(公告)日：2012-05-17
申请号：KR1020100111070
申请日：2010-11-09
Applicant: 건국대학교 산학협력단
IPC: C07H7/06 , C07D311/22 , C12N15/63 , C12N9/10
Abstract: PURPOSE: A gene producing quercetin 3-O-N-cetyl glucosamine and a method thereof are provided to be applied to various food or pharmaceutical products. CONSTITUTION: A quercetin-3-O-N-acetyl glucosamine compound is a conjugate of quercetin and N-acetytl glucosamine. A gene mediating quercetin and N-acetyl glucosamine has a base sequence of sequence number 1. A method for preparing the compound comprises: a step of preparing an expression vector containing the gene; a step of transforming the expression vector to a host cell; a step of adding quercetin to the host cell.
Abstract translation: 目的：提供一种产生槲皮素3-O-N-十六烷基葡糖胺的基因及其制备方法，适用于各种食品或药品。 构成：槲皮素-3-O-N-乙酰葡糖胺化合物是槲皮素和N-乙酰氨基葡糖胺的缀合物。 介导槲皮素和N-乙酰葡糖胺的基因具有序列号1的碱基序列。制备该化合物的方法包括：制备含有该基因的表达载体的步骤; 将表达载体转化到宿主细胞的步骤; 向宿主细胞添加槲皮素的步骤。
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公开(公告)号：KR101079295B1
公开(公告)日：2011-11-04
申请号：KR1020090005220
申请日：2009-01-21
Applicant: 건국대학교 산학협력단
Abstract: 본발명은신규한아트로박터속(sp.)에속하는신규균주및 그균주를포함하는농용미생물제제에대한발명으로, 더욱상세하게는토마토잿빛곰팡이병에대한항균성물질을개발하기위하여토양에서분리한아트로박터속(sp.) Ahn005 KACC91402균으로부터항균성물질을조사하여농용미생물제제로의이용에대한발명이다.
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Patent Agency Ranking
公开(公告)号：KR1020110005182A
公开(公告)日：2011-01-17
申请号：KR1020090062758
申请日：2009-07-09
Applicant: 건국대학교 산학협력단
CPC classification number: C12N9/1048 , C12P19/18 , C12P19/58
Abstract: PURPOSE: A method for producing isorhamnetin-3-O-glucoside using mutant of glycosyltransferase is provided to ensure response in isorhamnetin. CONSTITUTION: A mutant of glycosyltransferase has an amino acid sequence of sequence number 1. The mutant of the glycosyltransferase is specific to isorhamnetin. The mutant of the glycosyltransferase is cloned in a poplar. A gene of glycosyltransferase encoding the mutant of glycosyltransferase has a base sequence of sequence number 2. The mutant of glycosyltransferase is prepared using a strain transformed by a recombinant expression vector containing the gene. The isorhamnetin-3-O-glucoside is prepared using the mutant.
Abstract translation: 目的：提供使用糖基转移酶突变体产生异鼠李素-3-O-葡萄糖苷的方法，以确保异鼠李素的反应。 构成：糖基转移酶的突变体具有序列号1的氨基酸序列。糖基转移酶的突变体对异鼠李素素是特异性的。 将糖基转移酶的突变体克隆在杨树中。 编码糖基转移酶突变体的糖基转移酶基因具有序列号2的碱基序列。使用由含有该基因的重组表达载体转化的菌株制备糖基转移酶突变体。 使用突变体制备异鼠李素-3-O-葡萄糖苷。
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37.发明公开신규한 아트로박터에 속하는 신규 균주 및 그 균주를 포함하는 토마토 잿빛곰팡이병 방제용 미생물제제 失效一个新的ARTHROBACTER SP。 和包含TOMATO GREY模具的菌株的生物杀虫剂
公开(公告)号：KR1020100085761A
公开(公告)日：2010-07-29
申请号：KR1020090005220
申请日：2009-01-21
Applicant: 건국대학교 산학협력단
Abstract: PURPOSE: A novel Arthrobacter sp. strain and an agricultural microorganism formulation containing the same are provided to ensure antibacterial activity and to prevent tomato gray mold. CONSTITUTION: An Arthrobacter oxidans strain has an effect of preventing Botrytis cinerea. The strain is Arthrobacter sp. Ahn005(KACC91402). A composition for preventing or treating tomato gray mold contains the Arthrobacter sp. Ahn005(KACC91402) and agriculturally acceptable carrier.
Abstract translation: 目的：一种新型节杆菌 提供含有该菌株的农业微生物制剂以确保抗菌活性并防止番茄灰霉病。 构成：氧化节杆菌菌株具有防止灰葡萄孢属（Botrytis cinerea）的作用。 菌株是节杆菌属 Ahn005（KACC91402）。 用于预防或治疗番茄灰霉病的组合物含有节杆菌属（Arthrobacter sp。）。 Ahn005（KACC91402）和农业可接受的载体。
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38.发明公开신규한 아트로박터 속에 속하는 신규 균주 및 그 균주를 포함하는 토마토 역병 방제용 미생물제제 失效一个新的ARTHROBACTER SP。 和包含TOMATO LATE BLIGHT的菌株的生物杀虫剂
公开(公告)号：KR1020100085759A
公开(公告)日：2010-07-29
申请号：KR1020090005218
申请日：2009-01-21
Applicant: 건국대학교 산학협력단
Abstract: PURPOSE: A novel strain and a microorganism formulation containing the same are provided to prevent ecosystem damage and potato or tomato late blight. CONSTITUTION: An Arthrobacter oxidans strain has an effect of preventing Phytophthora infestans. The strain is Arthrobacter Ahn004(KACC91401) which is isolated from domestic fermented seafood. A composition for preventing or treating tomato or potato late blight contains Arthrobacter Ahn004(KACC91401) strain and agriculturally acceptable carrier.
Abstract translation: 目的：提供含有其的新型菌株和微生物制剂以防止生态系统损害，马铃薯或番茄晚疫病。 构成：氧化节杆菌菌株具有预防致病疫霉的作用。 该菌株是从国内发酵的海鲜中分离的节杆菌Ahn004（KACC91401）。 用于预防或治疗番茄或马铃薯晚疫病的组合物含有节杆菌Ahn004（KACC91401）菌株和农业上可接受的载体。
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公开(公告)号：KR1020100045774A
公开(公告)日：2010-05-04
申请号：KR1020080104874
申请日：2008-10-24
Applicant: 건국대학교 산학협력단
Abstract: PURPOSE: A novel Arthrobacter sp. novel strain and nematocide composition containing the same are provided to use as a nematidical agent. CONSTITUTION: An Arthrobacter sp. novel strain has an effect of killing C. elegance. Arthrobacter sp. strain is Arthrobacter Ahn008 KACC91405. The novel strain is isolated from soil and growth temperature is 20-45°C. A nematocide composition contains 0.001-10 weight% of Arthrbacter sp. Ahn008 KACC91405 or culture medium thereof. The composition further contains Ph-adjustable additive, surfactant, emulsifier, chelating agent, salt, corrosion inhibiting agent, dye, perfume, and dispersing agent.
Abstract translation: 目的：一种新型节杆菌 提供含有其的新型应变和杀线虫剂组合物作为杀虫剂。 构成：节杆菌属 新型菌株具有杀死C.优雅的作用。 节杆菌属 菌株是节杆菌Ahn008 KACC91405。 该菌株与土壤分离，生长温度为20-45℃。 杀线虫组合物含有0.001-10重量％的Arthrbacter sp。 AAN008 KACC91405或其培养基。 该组合物还含有Ph-可调添加剂，表面活性剂，乳化剂，螯合剂，盐，腐蚀抑制剂，染料，香料和分散剂。
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40.发明授权
公开(公告)号：KR100782084B1
公开(公告)日：2007-12-04
申请号：KR1020060037830
申请日：2006-04-26
Applicant: 건국대학교 산학협력단
Abstract: 본 발명은 식물로부터 유래한 메틸전이효소들 (o-methyltransferases), 그들의 유전자, 상기 메틸전이효소를 생산하는 재조합 발현 벡터들 및 형질전환 미생물들, 이들을 이용한 메틸전이효소의 제조방법 그리고 이들을 이용한 다중 메틸화 (multiple methylation)된 대사산물의 생산방법에 관한 것이다.
보다 상세하게는, 본 발명은 벼와 콩으로부터 각각 분리한 서로 선택성이 다른 메틸전이효소들, 그들의 유전자, 상기 메틸전이효소 유전자들을 하나 이상 포함하는 재조합 발현 벡터들, 이로 형질전환 된 대장균들, 이들을 이용한 메틸전이효소의 제조방법 및 상기 메틸전이효소들을 다중 발현하는 미생물을 이용한 어마닌 (ermanin; 5,7-dihydroxy-3,4-dimethylflavone)의 대량 생산방법에 관한 것으로서, 본 발명의 메틸전이효소의 제조방법은 유용하지만 화학적 합성이 매우 어려운 대사산물을 생물전환 반응으로 통해 보다 용이하게 적은 비용으로 대량 생산할 수 있으므로 새로운 의약품 개발에 널리 사용될 수 있다.
메틸전이효소, 재조합 발현 벡터들, 다중 메틸화, 어마닌, 켐퍼롤Abstract translation: 本发明涉及源自植物的o-甲基转移酶，其基因，用于产生甲基转移酶和转化微生物的重组表达载体，使用其产生甲基转移酶的方法， 更具体地涉及用于生产多种甲基化代谢物的方法。
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