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    대사조정된 대장균 및 이를 이용한 퀘세틴 3,7-디-Ｏ-람노사이드의 합성 방법
    3.
    发明公开
    대사조정된 대장균 및 이를 이용한 퀘세틴 3,7-디-Ｏ-람노사이드의 합성 방법 有权
    工程化的ESHERICHIA COLI表达尿苷 - 二磷酸（UDP） - 依赖性糖苷转移酶，并从其中合成3,7-DI-O-硫代氨基奎因

    公开(公告)号：KR1020140035098A

    公开(公告)日：2014-03-21

    申请号：KR1020120101505

    申请日：2012-09-13

    Applicant: 건국대학교 산학협력단

    Inventor： 안중훈 ,  김현정 ,  김봉규

    IPC: C12N1/21 ,  C12N15/29 ,  C12N15/70

    Abstract: The present invention relates to a method for producing quercetin 3,7-di-O-rhamnosidemade in plants using Escherichia coli, and more specifically, to metabolic-adjusted Escherichia coli and synthesis of quercetin 3,7-di-O-rhamnosideusing using the same.

    Abstract translation: 本发明涉及使用大肠杆菌生产槲皮素3,7-二-O-鼠李糖多糖的方法，更具体地说，涉及使用代谢调节的大肠杆菌和槲皮素3,7-二-O-鼠李糖苷的合成 相同。

    세포사멸을 조절하는 새로운 나린제닌 유도체들, 그의제조방법 및 그의 항암제로서의 용도
    4.
    发明授权
    세포사멸을 조절하는 새로운 나린제닌 유도체들, 그의제조방법 및 그의 항암제로서의 용도 失效
    用于疫苗的新型奈兰宁衍生物，其制备方法和用于抗原剂的方法

    公开(公告)号：KR100812675B1

    公开(公告)日：2008-03-13

    申请号：KR1020060099919

    申请日：2006-10-13

    Applicant: 건국대학교 산학협력단

    Inventor： 조쌍구 ,  박용선 ,  이훈택 ,  강용진 ,  김현정 ,  이응룡

    IPC: A61K31/35 ,  A61P35/00

    Abstract: A naringenin derivative is provided to be involved with controlling cell signal transmission, activity of activated oxygen species and cell cycle, thereby being widely used as a therapeutic agent of various cancers including large intestine cancer. A naringenin derivative controlling apoptosis is selected from the group consisting of 7-O-(m-methoxybenzyl) naringenin, 7-O-benzoxycarbonylmethyl naringenin, 7-O-benzylnaringenin, 7-O-(2-naphtylmethyl) naringenin, 7-O-(p-fluorobenzyl) naringenin and 7-O-(m-iodobenzyl) naringenin. A pharmaceutical composition for treating large intestine cancer comprises the naringenin derivative as an effective ingredient. A method for preparing the naringenin derivative comprises the steps of: (a) after putting naringenin and alkyl bromide in dimethylformamide, adding K2CO3 thereto and mixing it; (b) adding AcOEt to the mixture obtained from the step(a) and then dissolving it completely; (c) washing it with saline solution and drying; and (d) subjecting the product obtained from the step(c) to a silica gel chromatography for purifying it.

    Abstract translation: 提供了柚皮素衍生物，用于控制细胞信号传导，活性氧活性和细胞周期，广泛用作各种癌症包括大肠癌的治疗剂。 控制细胞凋亡的柚皮苷衍生物选自7-O-（间甲氧基苄基）柚皮素，7-O-苯氧基羰基甲基柚皮素，7-O-苄基栀子腺苷，7-O-（2-萘甲基）柚皮素，7-O 柚皮素和7-（O-碘苄基）柚皮素。 用于治疗大肠癌的药物组合物包含柚皮素衍生物作为有效成分。 制备柚皮苷衍生物的方法包括以下步骤：（a）将柚皮素和烷基溴放入二甲基甲酰胺中，加入K 2 CO 3并混合; （b）将AcOEt加入到从步骤（a）获得的混合物中，然后完全溶解; （c）用盐水洗涤并干燥; 和（d）将由步骤（c）得到的产物进行硅胶色谱纯化。

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