Abstract:
본 발명은 베타아밀로이드에 의한 뇌세포 손상 저해 활성을 갖는 그령 추출물 및 상기 추출물에서 분리된 활성성분 트리신(tricin, 화합물 2), 아게코니플라본(ageconyflavone A, 화합물 3), 넥탄드린 B(nectandrin B, 화합물 5) 및 4-케토피놀레시놀(4-ketopinoresinol, 화합물 6) 그리고 이를 함유하는 아밀로이드 관련 질환 예방 또는 치료용 약제학적 조성물에 관한 것이다. 상기 본 발명에 의한 그령 추출물 및 그 활성성분은 천연물 추출물 성분으로서 상대적으로 부작용 및 독성 발현율이 적고 생체 친화적이며 알츠하이머병, 다운증후군, 인지장애, 기억력 감퇴 및 아밀로이드증 등 아밀로이드 관련 질환의 예방 또는 치료에 유용하게 이용될 수 있다.
Abstract:
본 발명은 카포시 육종 허피스 바이러스(Kaposi's sarcoma-associated herpesvirus; KSHV)의 PAN RNA (polyadenylated nuclear RNA) 프로모터; 및 상기 프로모터에 의해 발현되도록 작동가능하게 연결된 리포터 유전자를 포함하는 유전자 구조체를 포함하는, 감마허피스바이러스가 잠복감염된 세포주에서 감마허피스 바이러스의 재활성 유도 천연화합물을 탐색하기 위한 리포터 시스템 및 이를 이용한 검색방법에 관한 것이다. 상기한 본 발명에 의하면, 감마허피스바이러스의 재활성을 유도하여 기존의 항허피스 제제가 작용하도록 할 수 있을 뿐만 아니라 독성도 없는 천연화합물을 검색할 수 있는 이점이 있다. 감마허피스바이러스, KSHV, 재활성, RTA, 천연화합물, HTS, 천오
Abstract:
A natural fungicide composition is provided to treat plant fungal diseases such as gray mold caused by Botrytis cinerea and be naturally decomposed by other microorganisms by comprising an antibacterial natural material of valinomycin derived from actinomyces. A fungicide composition for controlling plant diseases comprises valinomycin having antibacterial activity on plant pathogenic fungus such as Botrytis cinerea and Magnaporthe grisea as an effective ingredient, wherein the valinomycin is obtained by culturing Streptomyces spp. M10(deposition no. KACC 91275P) in an SGGP agar culture medium and then isolating and purifying the cultured filtrate. To control the plant diseases, the valinomycin is used.
Abstract:
The present invention relates to an outdoor experimental warming and precipitation adjusting system comprising a soil part at the bottom thereof; a heating module installed at the top thereof separated from the soil part; and a precipitation reducing tool, a contrasting tool, and a precipitation increasing tool which include a roof part for adjusting precipitation. The precipitation reducing tool further comprises two or more rainwater moving channels which are installed to be tilted and separated from each other on the roof part and have a V-like or semicircle-like cross-sectional shape made of transparent material; a rainwater receiver which is installed at the end of the rainwater moving channel and collects rainwater in a water tank; and a water tank which is connected with the end of the rainwater receiver. The contrasting tool and precipitation tool comprise the roof part in which rainwater moving channels are formed in the same way as in the precipitation reducing tool, but gaps are formed on the bottom surfaces of the rainwater moving channels, so that the rainwater overall falls onto the soil part of the contrasting tool or precipitation increasing tool. The water tank equipped in the precipitation reducing tool is connected with a pipe for moving rainwater to the precipitation increasing tool, and the rainwater moved through the pipe is supplied into the precipitation increasing tool.
Abstract:
PURPOSE: A method for manufacturing antibiotic produced from Bacillus amyloliquefaciens GYL4 is provided to obtain eco-friendly germicide composition with excellent biodegradation property and to prevent cucumber anthracnose. CONSTITUTION: A Bacillus amyloliquefaciens GYL4(deposit number: KACC91655P) has an antifungal activity against plant pathogenic fungi such as Fusarium oxysporum f.sp. lycopersici, Fusarium oxysporum f.sp. lycopersici JCM12575, Colletotrichum cocodes, Colletotrichum gloeosporioides, Colletotrichum orbiculare, or Cylindrocarpon destructans. A method for manufacturing antibiotics with the antifungal activity comprises: a step of extracting a Bacillus amyloliquefaciens GYL4 fungus body, a spore, a mixture thereof, or a culture medium with butanol; and a step of isolating and purifying bacillomycin D1 from the butanol extract.
Abstract:
PURPOSE: A method for measuring androstenone and skatole in backfat is provided to effectively and simultaneously measure the content of androstenone and skatole. CONSTITUTION: A method for measuring abdrostenone and skatole within backfat in a pig comprises: a step of adding methanol to backfat sample, homogenizing, and cooling; a step of centrifuging to separate a methanol layer; a step of adding hexane to the methanol layer to isolate a hexane layer; a step of concentrating the hexane layer and adding ethyl acetate to isolate androstenone and skatole; and a step of measuring the content of the androstenone and skatole using gas chromatography mass spectrometer.