公开(公告)号：KR101214942B1

公开(公告)日：2012-12-26

申请号：KR1020100050565

申请日：2010-05-28

Applicant: 서강대학교산학협력단

Inventor： 지대윤 ,  이병세 ,  권혜림 ,  추소영

IPC: C07D249/04 ,  C07D405/12 ,  A61K49/00

CPC classification number: Y02P20/55

Abstract: 본발명은 1,2,3-트리아졸기를갖는설포네이트전구체, 이의제조방법및 응용에관한것으로, 분자내친핵성치환반응을유도하여반응을보다빠르게하는효과가있고, 설포네이트이탈기의 1,2,3-트리아졸은대표적인클릭화학인구리-촉매하의알킨/아자이드 [3+2]고리화반응으로쉽게도입할수 있으며, 양전자방출단층촬영술(Positron Emission Tomography)에가장핵심적인 [F]방사성의약품제조를위한효과적인설포네이트전구체로응용될수 있다.

公开(公告)号：KR1020120127111A

公开(公告)日：2012-11-21

申请号：KR1020110045388

申请日：2011-05-13

Applicant: 서강대학교산학협력단

Inventor： 이철수 ,  지대윤 ,  허은영 ,  김종민 ,  이병세 ,  길희섭

IPC: G21G4/08 ,  A61K51/00 ,  G21G7/00 ,  A61J3/00

CPC classification number: B01J19/004 ,  A61J1/2037 ,  A61J1/2089 ,  A61J3/002 ,  B01J2219/00135 ,  B01J2219/00141 ,  B01J2219/00164 ,  B65B3/003 ,  C07B59/00 ,  G21G1/0005

Abstract: PURPOSE: An apparatus and a method for synthesizing F-18 labeled radiopharmaceuticals are provided to automatically synthesize radiopharmaceuticals using a single separable cassette and a control device. CONSTITUTION: A first organic solvent supply unit(121) supplies a first organic solvent for eliminating water from a polymer precursor cartridge. A second organic solvent supply unit(123) supplies an organic solvent including acid or a second organic solvent which is a mixture of the organic solvent and water. An alkaline aqueous solution supply unit(125) supplies an alkaline aqueous solution for neutralizing a composite solution in a composite container. A third organic solvent supply unit(127) supplies a third organic solvent for eluting F-18 labeled compounds in a polymeric compound cartridge.

Abstract translation: 目的：提供用于合成F-18标记的放射性药物的装置和方法，以使用单个可分离盒和控制装置自动合成放射性药物。 构成：第一有机溶剂供应单元（121）提供用于从聚合物前体料筒中除去水的第一有机溶剂。 第二有机溶剂供应单元（123）提供包括酸或作为有机溶剂和水的混合物的第二有机溶剂的有机溶剂。 碱性水溶液供给单元（125）提供用于中和复合容器中的复合溶液的碱性水溶液。 第三有机溶剂供应单元（127）提供第三有机溶剂用于在聚合物化合物盒中洗脱F-18标记的化合物。

公开(公告)号：KR1020110130977A

公开(公告)日：2011-12-06

申请号：KR1020100050565

申请日：2010-05-28

Applicant: 서강대학교산학협력단

Inventor： 지대윤 ,  이병세 ,  권혜림 ,  추소영

IPC: C07D249/04 ,  C07D405/12 ,  A61K49/00

CPC classification number: Y02P20/55 ,  C07D249/04 ,  A61K51/0453 ,  C07D403/12

Abstract: PURPOSE: A method for preparing a sulfonate precursor with 1,2,3-triazole group is provided to manufacture [^18F]radioactive chemical. CONSTITUTION: A sulfonate compound with 1,2,3-triazole group is denoted by chemical formula 1. A method for preparing the sulfonate compound comprises: a step of reacting azidoalkanesufonyl chloride of chemical formula 3 with an aliphatic alcohol functional group of chemical formula 4 under the presence of organic solvent and base to prepare an azidoalkane sulfonate compound of chemical formula 5; and a step of reacting the compound of chemical formula 5 with terminal alkyne functional group of chemical formula 6 under the presence of organic solvent and copper catalyst. The base is bicarbonate ion, carbonate ion, alkali metal salt, triethylamine, diisopropylethylamine, pyridine, lutidine, and collidine.

Abstract translation: 目的：制备具有1,2,3-三唑基团的磺酸酯前体的方法，以制备[^ 18F]放射性化学品。 构成：具有1,2,3-三唑基的磺酸酯化合物由化学式1表示。制备磺酸酯化合物的方法包括：使化学式3的叠氮基烷基磺酰氯与化学式4的脂族醇官能团反应的步骤 在有机溶剂和碱的存在下，制备化学式5的叠氮烷基磺酸酯化合物; 以及在有机溶剂和铜催化剂存在下使化学式5的化合物与化学式6的末端炔官能团反应的步骤。 碱是碳酸氢根离子，碳酸根离子，碱金属盐，三乙胺，二异丙基乙胺，吡啶，二甲基吡啶和可力丁。