公开(公告)号：KR1020140102456A

公开(公告)日：2014-08-22

申请号：KR1020130015768

申请日：2013-02-14

Applicant: 재단법인대구경북과학기술원

Inventor： 이가현 ,  정상원 ,  이세근 ,  이성준 ,  김은주 ,  김현철 ,  최진현 ,  서송이

IPC: A61K47/48 ,  A61K47/38 ,  A61K9/127 ,  A61K31/573

CPC classification number: A61K47/61 ,  A61K9/127 ,  A61K31/573 ,  A61K2121/00

Abstract: The present invention relates to a polymer micelle-medicine complex based on a cellulose-graft-polylactide-based amphiphilic polymer and to a method for producing the same. More specifically, the polymer micelle-medicine complex includes an amphiphilic copolymer having a hydrophilic block including cellulose and a hydrophobic block including polylactide and is formed in a core-shell structure consisting of a hydrophobic core unit and a hydrophilic shell unit. Prednisolone acetate which is a refractory drug is encapsulated in the core unit of the core-shell structure so as to constitute the polymer micelle-medicine complex. The polymer micelle-medicine complex according to the present invention effectively solubilizes the refractory drug and changes the molecular variants of the amphiphilic copolymer so that a micelle having improved stability is produced. Accordingly, the encapsulation efficiency of the refractory drug is maximized and releasing behavior can be easily controlled.

Abstract translation: 本发明涉及基于纤维素接枝聚丙交酯的两亲聚合物的聚合物胶束 - 药物复合物及其制备方法。 更具体地，聚合物胶束 - 药物复合物包括具有包含纤维素的亲水性嵌段和包含聚丙交酯的疏水性嵌段的两亲共聚物，并且形成在由疏水性核心单元和亲水性壳单元组成的核 - 壳结构中。 作为难治性药物的醋酸泼尼松龙被封装在芯 - 壳结构的核心单元中，以构成聚合物胶束 - 药物复合物。 根据本发明的聚合物胶束 - 药物复合物有效地溶解耐火药物并改变两亲性共聚物的分子变体，从而产生具有改善的稳定性的胶束。 因此，耐火药物的包封效率最大化，并且可以容易地控制释放行为。

公开(公告)号：KR1020130139671A

公开(公告)日：2013-12-23

申请号：KR1020120063335

申请日：2012-06-13

Applicant: 재단법인대구경북과학기술원 ,  주식회사 삼양사

Inventor： 이성준 ,  이세근 ,  정상원 ,  김은주 ,  김현철

IPC: C08J3/12 ,  B01J2/02 ,  B01J2/14 ,  C08F12/08

Abstract: The present invention relates to a device for forming homogeneous monomer droplets and, more specifically, to a device for forming homogeneous monomer droplets, which forms droplets with uniform shapes for making polymer particles in a bead type such as polystyrene beads, thereby improving uniformity in shapes and sizes of polymer beads. According to the present invention, the device collects a monomer solution with low viscosity at one point using a distribution plate and separately transfers the collected monomer solution to each droplet hole formed at a multi-hole distribution plate when the monomer solution is transferred, thereby forming monomer droplets with improved uniformity.

Abstract translation: 本发明涉及一种用于形成均匀单体液滴的装置，更具体地说，涉及一种用于形成均匀单体液滴的装置，其形成具有均匀形状的液滴，以使聚合物颗粒形成诸如聚苯乙烯珠的珠粒，从而改善形状的均匀性 和聚合物珠粒的尺寸。 根据本发明，该装置使用分配板在一点收集低粘度的单体溶液，并且当单体溶液转移时，将收集的单体溶液分别转移到形成在多孔分布板上的每个液滴孔，由此形成 具有改善均匀性的单体液滴。

公开(公告)号：KR1020130054676A

公开(公告)日：2013-05-27

申请号：KR1020110120209

申请日：2011-11-17

Applicant: 재단법인대구경북과학기술원

Inventor： 김현철 ,  정상원 ,  김은주 ,  이세근 ,  이성준

IPC: C08F290/06 ,  C08G83/00 ,  A61K9/127 ,  A61K47/48

CPC classification number: C08F226/10 ,  A61K47/69 ,  C08F220/56 ,  C08G63/08 ,  C08G65/32

Abstract: PURPOSE: A core cross-linked polymer micelle composition is provided to improve biostability, to minimize side effect due to toxicity of chemicals, and to be used as a drug carrier. CONSTITUTION: A core cross-linked polymer micelle composition is represented by chemical formula 1. In the chemical formula 1, P is an aqueous polymer, X is a fat-soluble polymer, Y is a connection ring, and Z is polycysteine with 3-20 cysteine. The aqueous polymer P is one or more linear, block, graft, or dendrimer polymer selected form polyethylene glycol, polyvinylpyrrolidone, and poly[N-2-(hydroxypropyl)methacrylamide]. The molecular weight of the aqueous polymer P is 500-20,000 Dalton.

Abstract translation: 目的：提供核心交联聚合物胶束组合物以改善生物稳定性，以最小化由于化学药物毒性引起的副作用，并用作药物载体。 构成：核心交联聚合物胶束组合物由化学式1表示。在化学式1中，P为水性聚合物，X为脂溶性聚合物，Y为连接环，Z为多元半胱氨酸， 20半胱氨酸。 水性聚合物P是选自聚乙二醇，聚乙烯吡咯烷酮和聚[N-2-（羟丙基）甲基丙烯酰胺]的一种或多种线性，嵌段，接枝或树枝状聚合物聚合物。 水性聚合物P的分子量为500〜20,000道尔顿。

公开(公告)号：KR1020120050190A

公开(公告)日：2012-05-18

申请号：KR1020100111577

申请日：2010-11-10

Applicant: 재단법인대구경북과학기술원

Inventor： 정상원 ,  김은주 ,  김현철 ,  이세근 ,  이성준 ,  백철수

IPC: B82B3/00 ,  G01N33/68

CPC classification number: G01N33/6803 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00

Abstract: PURPOSE: A magnetic nanoparticles which are surface modified with phosphocholine, a formation method thereof, and a protein isolation method using thereof are provided to simplify isolating process in order to easily isolate using magnetic nano particles which is surface modified with the choline phosphate and a magnet. CONSTITUTION: A magnetic nanoparticles which are surface modified with phosphocholine comprises magnetic nano particles and materials having choline phosphate group. The choline phosphate is combined with magnetic nano particle surface and is exposed. A formation method of material having choline phosphate comprises a step of radical polymerizing monomers having choline phosphate groups which is represented by the following structural formula at surfaces of the magnetic nano particles. The structural formula 1 is Choline phosphate -X-R. A isolation method of C-reactive protein comprises next steps: adding magnetic nanoparticles which are surface modified with choline phosphate to sample solution containing the C-reactive protein; forming a complex of the C-reactive proteins and magnetic nano particles; isolating the composite from the sample solution by using the magnet; and isolating the C-reactive protein from the isolated composite by using a dissociating agent.

Abstract translation: 目的：提供用磷酸胆碱表面改性的磁性纳米颗粒，其形成方法和使用其的蛋白质分离方法，以简化隔离过程，以便使用磷酸胆碱和磁体表面改性的磁性纳米颗粒容易地分离 。 构成：用磷酸胆碱表面改性的磁性纳米颗粒包括磁性纳米颗粒和具有磷酸胆碱基团的材料。 磷酸胆碱与磁性纳米颗粒表面结合并暴露。 具有磷酸胆碱的材料的形成方法包括在磁性纳米颗粒的表面上自由基聚合由下列结构式表示的具有磷酸胆碱基团的单体的步骤。 结构式1是胆碱磷酸酯-X-R。 C-反应蛋白的分离方法包括以下步骤：将含有磷酸胆碱的表面改性的磁性纳米颗粒加入到含有C-反应蛋白的样品溶液中; 形成C-反应蛋白和磁性纳米颗粒的复合物; 通过使用磁体从样品溶液中分离出复合物; 并通过使用离解剂从分离的复合物中分离C反应蛋白。

公开(公告)号：KR1020120048348A

公开(公告)日：2012-05-15

申请号：KR1020100109942

申请日：2010-11-05

Applicant: 재단법인대구경북과학기술원

Inventor： 정상원 ,  김은주 ,  김현철 ,  이세근 ,  이성준 ,  백철수

IPC: G01N33/68 ,  G01N33/553

Abstract: PURPOSE: A chip for detecting C-reactive proteins is provided to improve binding constant to the C-reactive proteins and detection effect. CONSTITUTION: A chip for detecting C-reactive proteins comprises: a metal substrate; and a molecularly imprinted layer which is formed on a metal substrate and contains phospho choline groups. The metal substrate contains gold, silver, copper, palladium, or combination thereof. The molecularly imprinted layer contains a monomolecular layer of HS-CnH2n+1-phospho choline or HC≡C-CH2-CmH2m+1-phospho choline. The chip also has a blocking layer on the metal substrate.

Abstract translation: 目的：提供用于检测C反应蛋白的芯片，以提高C-反应蛋白的结合常数和检测效果。 构成：用于检测C反应蛋白的芯片包括：金属底物; 以及形成在金属基板上并含有磷酸胆碱基团的分子印迹层。 金属基底含有金，银，铜，钯或其组合。 分子印迹层含有HS-CnH2n + 1-磷酸胆碱或HC≡C-CH2-CmH2m + 1-磷酸胆碱的单分子层。 芯片还在金属基板上具有阻挡层。

公开(公告)号：KR101072389B1

公开(公告)日：2011-10-11

申请号：KR1020090117327

申请日：2009-11-30

Applicant: 재단법인대구경북과학기술원

Inventor： 김현철 ,  정상원 ,  김은주 ,  이세근 ,  이성준

IPC: C08G65/48 ,  C08F8/10 ,  A61K9/127 ,  C08F26/10

Abstract: 본발명에따르면, 상기양친매성고분자를이용하여티올민감형약물전달체를제조할수 있다. 상기약물전달체는티올에대한민감도가높아, 티올농도가높은부위의질환에대해약물전달체가쉽게붕괴되면서질화부위에선택적으로많은양의약물을단시간내에효과적으로방출시킬수 있다. 따라서암 또는염증성질환의치료제로서본 발명의약물전달체의사용이기대된다.

公开(公告)号：KR1020110073731A

公开(公告)日：2011-06-30

申请号：KR1020090130454

申请日：2009-12-24

Applicant: 재단법인대구경북과학기술원

Inventor： 정상원 ,  이세근 ,  김현철 ,  김은주 ,  이성준 ,  백철수 ,  이현주

IPC: C07D487/22 ,  A61K31/409 ,  A61P35/00

Abstract: PURPOSE: A soluble nanostructure containing soluble porphyrin derivatives is provided to ensure high photodynamic therapeutic agent and to prevent side effects. CONSTITUTION: A soluble nanostructure for photodynamic therapy contains soluble porphyrin derivative of chemical formula 1. The porphyrin derivative is prepared by amidation of protoporphyrin IX(chemical formula 2) with polyethylene glycol derivatives(chemical formulas 3 and 4) of amino terminal. A coupling agent for amidation is 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride(EDC), N,N'-dicyclohexylcarbodiimide(DCC), or N,N'-diisopropylcarbodiimide(DIC).

Abstract translation: 目的：提供含有可溶性卟啉衍生物的可溶性纳米结构，以确保高光动力治疗剂并防止副作用。 构成：用于光动力学治疗的可溶性纳米结构含有化学式1的可溶性卟啉衍生物。卟啉衍生物通过原卟啉IX（化学式2）与氨基末端的聚乙二醇衍生物（化学式3和4）的酰胺化而制备。 用于酰胺化的偶联剂是1-乙基-3-（3-二甲基氨基丙基）碳二亚胺盐酸盐（EDC），N，N'-二环己基碳二亚胺（DCC）或N，N'-二异丙基碳二亚胺（DIC）。

公开(公告)号：KR1020110060583A

公开(公告)日：2011-06-08

申请号：KR1020090117204

申请日：2009-11-30

Applicant: 재단법인대구경북과학기술원

Inventor： 정상원 ,  김은주 ,  김현철 ,  이세근 ,  이성준 ,  백철수 ,  고태정

IPC: G01N33/483 ,  G01N21/27

Abstract: PURPOSE: A sensor chip for detecting estradiol is provided to simultaneously detect various substances and a smell amount of substance such as estrogen. CONSTITUTION: A sensor chip for detecting estradiol comprises: a substrate having a gold layer; a self-assembled monolayer(SAM) of thiol-acrylate polymers formed on the gold layer; and a molecular polymer layer which is formed by polymerization of the acrylate monomers and cross-linking agent. The sensor chip is applied to surface Plasmon resonance or quartz crystal microbalance. The thiol-acrylate polymer is prepared by mixing a compound with acrylate at both ends with a compound containing multiple thiol groups, and performing photopolymerization.

Abstract translation: 目的：提供用于检测雌二醇的传感器芯片，以同时检测各种物质和异味等物质​​如雌激素。 构成：用于检测雌二醇的传感器芯片包括：具有金层的基底; 在金层上形成的硫醇 - 丙烯酸酯聚合物的自组装单层（SAM）; 以及通过丙烯酸酯单体和交联剂的聚合形成的分子聚合物层。 传感器芯片应用于表面等离子体共振或石英晶体微量天平。 通过将化合物与丙烯酸酯的两端与含有多个硫醇基的化合物混合并进行光聚合来制备硫醇 - 丙烯酸酯聚合物。

公开(公告)号：KR1020100027568A

公开(公告)日：2010-03-11

申请号：KR1020080086537

申请日：2008-09-03

Applicant: 재단법인대구경북과학기술원

Inventor： 이성준 ,  이세근 ,  김현철 ,  정상원 ,  최진현 ,  이가현

IPC: C08F263/04 ,  C08J3/12

CPC classification number: C08F263/04 ,  C08F8/12 ,  C08F261/04 ,  C08J3/075 ,  C08J3/12

Abstract: PURPOSE: A fabrication method of monodisperse microball-shaped hydrogel particles is provided to prepare polymer particles using relatively inexpensive water-soluble dispersing stabilizers and a large amount of water as a polymerization solvent through a single process. CONSTITUTION: A fabrication method of monodisperse microball-shaped hydrogel particles comprises the steps of: forming monodispersed polyvinyl acetate microspheres using dispersion polymerization of vinyl acetate monomers; and saponifying the polyvinyl acetate microspheres from a dispersing medium in the same arrangement state so that the polyvinyl acetate microspheres have a dual structure of a polyvinyl acetate/polyvinyl alcohol shell.

Abstract translation: 目的：提供单分散微球形水凝胶颗粒的制造方法，通过单一工艺使用相对便宜的水溶性分散稳定剂和大量的水作为聚合溶剂制备聚合物颗粒。 构成：单分散微球状水凝胶颗粒的制造方法包括以下步骤：使用乙酸乙烯酯单体的分散聚合形成单分散的聚乙酸乙烯酯微球; 并以相同的布置状态从分散介质中皂化聚乙酸乙烯酯微球，使得聚乙酸乙烯酯微球具有聚乙酸乙烯酯/聚乙烯醇壳的双重结构。

公开(公告)号：KR100838271B1

公开(公告)日：2008-06-17

申请号：KR1020060138420

申请日：2006-12-29

Applicant: 재단법인대구경북과학기술원

Inventor： 도석주 ,  김참 ,  김호영 ,  이성준 ,  이세근

IPC: H01L31/04 ,  H01L31/0224 ,  H01L31/18

CPC classification number: Y02E10/542 ,  Y02P70/521 ,  H01L31/04 ,  H01L31/0224 ,  H01L31/18

Abstract: A method for manufacturing a transparent counter electrode of a dye-sensitive solar cell is provided to adjust a concentration of platinum nano particles by controlling a process time and a current amount of an electro-reduction process. An electrolyte solution containing platinum ions is provided(110). The electrolyte solution is placed in an electro-chemical reactor(140) with a transparent conductive substrate(120) and a counter electrode(130). Negative and positive voltages are applied on the transparent conductive substrate and the counter electrode, respectively, by using a DC voltage supply(150), such that platinum ions are decreased in the conductive substrate. Voltage/current density and application timing are adjusted, such that the platinum particles are formed in an island shape and the counter electrode has a transparent property.

Abstract translation: 提供一种用于制造感光太阳能电池的透明对电极的方法，通过控制处理时间和电还原处理的当前量来调节铂纳米颗粒的浓度。 提供含有铂离子的电解质溶液（110）。 将电解质溶液放置在具有透明导电基板（120）和对电极（130）的电化学反应器（140）中。 通过使用直流电压源（150）分别在透明导电基板和对电极上施加负电压和正电压，使得导电基板中的铂离子减少。 调整电压/电流密度和施加时刻，使得铂颗粒形成为岛状，并且对电极具有透明性。