公开(公告)号：KR1020140030396A

公开(公告)日：2014-03-12

申请号：KR1020120094167

申请日：2012-08-28

Applicant: 재단법인대구경북과학기술원

Inventor： 전원배

IPC: C07K14/78 ,  C07K19/00 ,  C12N15/12 ,  C12N5/079

Abstract: The present invention relates to an elastin-like protein and a producing method thereof, and a nerve cell differentiating method using the same protein and the same producing method. The elastin-like protein is used for adhesion, migration, neurite growth, and forming a three dimensional spheroid of a multicell in nerve cell cultivation. According to an embodiment of the present invention, the present invention provides the elastin-like protein which includes a temperature sensitive VGVPG peptide and a RGD integrin receptor ligand, and which acts as an extracellular matrix.

Abstract translation: 本发明涉及弹性蛋白样蛋白及其制备方法，以及使用相同蛋白质和相同制造方法的神经细胞分化方法。 弹性蛋白样蛋白用于粘附，迁移，神经突生长，并在神经细胞培养中形成多细胞的三维球体。 根据本发明的一个实施方案，本发明提供弹性蛋白样蛋白质，其包括温度敏感的VGVPG肽和RGD整联蛋白受体配体，并且其作为细胞外基质。

公开(公告)号：KR101350900B1

公开(公告)日：2014-01-14

申请号：KR1020110118074

申请日：2011-11-14

Applicant: 재단법인대구경북과학기술원

Inventor： 전원배 ,  박진규

IPC: A61L27/14 ,  A61L27/22 ,  A61F2/02 ,  C07K7/08

Abstract: 본 발명은 조직 재생용 생체 모방 다중블록 바이오폴리머 및 이를 이용한 조직 재생 방법에 관한 것으로, 다중블록 바이오폴리머를 이용하여 보다 효과적인 조직 재생을 지원하기 위한 것이다. 본 발명은 일렬로 연결된 m개(m은 2 내지 100의 정수)의 블록이 n개(n은 2 내지 5,000의 정수) 반복되며, m개의 블록 중 하나 이상의 블록은 조직 재생을 위한 세포 부착 기능의 펩타이드 I을 포함하며, 펩타이드 I으로 선택되지 않은 하나 이상의 블록 각각은 PGX의 구조를 가진 펩타이드 II(P는 L-proline, G는 glycine, X는 L- 또는 D-proline을 제외한 19개 L- 또는 D-아미노산), PGXX의 구조를 가진 펩타이드 III, PGXXX의 구조를 가진 펩타이드 IV, PGXGXX의 구조를 가진 펩타이드 V, 다중블록 바이오폴리머의 상호 결합 증진 기능을 하는 펩타이드 VI 중 하나인 것을 특징으로 하는 조직 재생용 생체 모방 다중블록 바이오폴리머 및 이를 이용한 조직 재생 방법을 제공한다.

公开(公告)号：KR1020130053479A

公开(公告)日：2013-05-24

申请号：KR1020110118074

申请日：2011-11-14

Applicant: 재단법인대구경북과학기술원

Inventor： 전원배 ,  박진규

IPC: A61L27/14 ,  A61L27/22 ,  A61F2/02 ,  C07K7/08

CPC classification number: A61L27/14 ,  A61F2/02 ,  A61L27/22 ,  A61L2430/00 ,  C07K7/08

Abstract: PURPOSE: An application of biomimetic multi-block bio-polymers for tissue regeneration and a tissue regeneration method thereof are provided to be effective in a wound treatment by at least one or more blocks among multiple blocks including peptide I of a cell adhesion function for tissue neogenesis. CONSTITUTION: As an application of biomimetic multi-block bio-polymers for tissue regeneration, blocks(110-160) of m(m is a fixed number of 1 to 100) connected in a row are repeated with n(n is the fixed number of 1 to 5,000). At least one block among blocks of m comprises peptide I of a cell adhesion function for tissue neogenesis. Each blocks more than one and not selected peptide I is one among peptide II having a structure of PGX (P is Lproline, G is ofglycine, and X is 19 L- or D- amino acid, except for L- or D-proline), peptide III having the structure of PGXX, peptide IV having the structure of PGXXX, peptide V having the structure of PGXGXX, and peptide VI of having a function with a mutual combination promotion. [Reference numerals] (110) Block 1; (120) Block 2; (130) Block 3; (140) Block 4; (150) Block 5; (160) Block 6

Abstract translation: 目的：提供用于组织再生的生物仿制多嵌段生物聚合物的应用及其组织再生方法，以在包括组织细胞粘附功能的肽I的多个嵌段中的至少一个或多个嵌段的伤口治疗中有效 新生。 构成：作为用于组织再生的仿生多嵌段生物聚合物的应用，重复连续连接的m（m为固定数1〜100）的块（110-160），其中n（n为固定数 1至5,000）。 m个区块中的至少一个区域包含组织新生细胞粘附功能的肽I。 每个阻断多于一个，未选择的肽I是具有PGX结构的肽II之一（P是Lproline，G是甘氨酸，X是19或L-氨基酸，L-或D-脯氨酸除外） ，具有PGXX结构的肽III，具有PGXXX结构的肽IV，具有PGXGXX结构的肽V和具有相互组合促进功能的肽VI。 （附图标记）（110）块1; （120）块2; （130）块3; （140）块4; （150）第5座; （160）块6

公开(公告)号：KR1020090076513A

公开(公告)日：2009-07-13

申请号：KR1020080002507

申请日：2008-01-09

Applicant: 재단법인대구경북과학기술원

Inventor： 김현철 ,  정상원 ,  이수근 ,  전원배

IPC: C07D333/22 ,  C07D409/12

Abstract: A novel polymer linker for an active surface of bio material is provided to form SAMs (self-assembled monolayer) and prevent the oxidation of metal and metal oxide. A polymer linker for an active surface of bio material is denoted by the chemical formula 1. In the chemical formula 1, X is oxygen, sulfur, phosphine, selenium or amine compound, R1 is C1-C24 alkylene group, Q is oxygen, nitrogen, or sulfur, R2 is C0-C12 alkylene group, Z is carboxyl group, amino group, imide group or epoxy group, n is integer of 1-1000 and m is integer of 1-1000. The bio chip comprises a solid substrate on which the polymer linker is coated on the surface. The bio chip is a protein chip.

Abstract translation: 提供用于生物材料的活性表面的新颖的聚合物接头以形成SAM（自组装单层）并防止金属和金属氧化物的氧化。 在化学式1中，X是氧，硫，膦，硒或胺化合物，R 1是C 1 -C 24亚烷基，Q是氧，氮 或硫，R2为C0〜C12亚烷基，Z为羧基，氨基，酰亚胺基或环氧基，n为1-1000的整数，m为1-1000的整数。 生物芯片包括固体基质，聚合物连接体在其上涂覆在表面上。 生物芯片是蛋白质芯片。