公开(公告)号：KR1020090107156A

公开(公告)日：2009-10-13

申请号：KR1020080032506

申请日：2008-04-08

Applicant: 조선대학교산학협력단

Inventor： 최후균

IPC: A61K31/122 ,  A61K47/32 ,  A61K9/16

Abstract: PURPOSE: A solid dispersion composition containing coenzyme Q is provided to significantly improve solubility of coenzyme Q and enhance bioavailability. CONSTITUTION: A solid dispersion composition containing a coenzyme Q contains the coenzyme Q and its derivative as active ingredient. The solid dispersion composition containing a coenzyme Q also comprises polyoxyethylene-polyoxypropylene copolymer as a carrier of solid dispersion. The content of the coenzyme Q is 1-40 weight% based on total weight. The polyoxyethylene-polyoxypropylene copolymer is poloxamer 407.

Abstract translation: 目的：提供含有辅酶Q的固体分散体组合物，以显着提高辅酶Q的溶解度，提高生物利用度。 构成：含有辅酶Q的固体分散体组合物含有辅酶Q及其衍生物作为活性成分。 含有辅酶Q的固体分散体组合物还包含聚氧乙烯 - 聚氧丙烯共聚物作为固体分散体的载体。 辅酶Q的含量基于总重量为1-40重量％。 聚氧乙烯 - 聚氧丙烯共聚物是泊洛沙姆407。

公开(公告)号：KR100895942B1

公开(公告)日：2009-05-07

申请号：KR1020070044677

申请日：2007-05-08

Applicant: 조선대학교산학협력단

Inventor： 최후균 ,  강건욱 ,  전명관 ,  김상찬 ,  김윤균

IPC: A61K9/22 ,  A61K9/19 ,  A61K36/00

CPC classification number: A61K9/0056 ,  A61K36/27

Abstract: 본 발명은 생약 추출물을 함유한 제제로서 구강 내에서 신속히 붕해되도록 고안된 구강 내 속붕해성 제제이다. 구강 내 속붕해성 제제는 구강 내에서 신속하게 용해되거나 붕해가 되기 때문에 환자가 쉽게 복용할 수 있다. 특히 연하력이 약한 환자, 예를 들면 소아 또는 고령 환자나 정신질환을 겪는 환자들에게 유용하게 적용할 수 있는 제제이다. 또한 일반적인 경구제제와는 달리 구강 내 속붕해성 제제는 제제를 복용할 때 물이 필요 없다. 이런 점은 여행 중이거나 즉시 물을 얻을 수 없는 환자들에게는 특히 유용하다. 따라서 구강 내 속붕해성 제제를 생약 추출물 또는 한방제제에 적용한다면 환자의 순응도를 향상시킬 수 있을 것으로 기대한다.
생약 추출물, 한방제제, 구강, 속붕해성, 제제

公开(公告)号：KR1020080099570A

公开(公告)日：2008-11-13

申请号：KR1020070045284

申请日：2007-05-10

Applicant: 조선대학교산학협력단

Inventor： 강건욱 ,  최후균 ,  김상찬

IPC: A61K36/232 ,  A61K36/804 ,  A61K36/236 ,  A61P17/00

Abstract: A pharmaceutical composition is provided to prevent and treat dermatitis diseases by comprising an extract from complex crude drug as an active ingredient. A composition of preventing and treating dermatitis diseases comprises an extract from complex crude drug such as Menthae Herba, Scutellariae Radix, Cornu rhinoceri asiatici, Angelicae gigantis Radix, moutan Cortex Radicis, rehmanniae Radix crudus, glycyrrhizae radix, lonicerae Flos, ledebouriellae Radix, Forsythiae Fructus, paeoniae Radix rubra, cnidii Rhizoma and nepetae Spica as an active ingredient. The dermatitis disease is atopic dermatitis, contact dermatitis, seborrhoeic dermatitis, pruritus, housewives' eczema, erythroderma or a psoriasis. The composition is used as cream, gel, patch, aerosol propellant, Ointments, plasters, lotion material, liniments, pastes or a cataplasma agent.

Abstract translation: 提供药物组合物以通过包含来自复合生物药物的提取物作为活性成分来预防和治疗皮炎疾病。 预防和治疗皮炎疾病的组合物包括复方生药如薄荷草，黄芩，犀牛，当归，山茱萸，地黄，甘草，金银花，龙胆，连翘， ，芍药，ii藜和n螨作为活性成分。 皮炎病是特应性皮炎，接触性皮炎，脂溢性皮炎，瘙痒症，家庭主妇湿疹，红皮病或牛皮癣。 该组合物用作奶油，凝胶，贴片，气溶胶推进剂，软膏，膏药，洗剂材料，搽剂，糊剂或粘膜剂。

公开(公告)号：KR1020080099058A

公开(公告)日：2008-11-12

申请号：KR1020070044677

申请日：2007-05-08

Applicant: 조선대학교산학협력단

Inventor： 최후균 ,  강건욱 ,  전명관 ,  김상찬 ,  김윤균

IPC: A61K9/22 ,  A61K9/19 ,  A61K36/00

CPC classification number: A61K9/0056 ,  A61K36/27

Abstract: A composition for fast disintegrating tablet is provided to minimize an amount of an excipient except an active component using a herbal extract, to simplify a manufacturing process, to improve an taking-medicine adaptability of patients by improving a taste of herb medicine extract having a strong bitter taste, to improve an taking-medicine adaptability of pediatric patients and to improve a problem that a weight of fast disintegrating tablet is excessive by minimizing a used amount of the excipient except the active component. A composition for fast disintegrating tablet contains one or more herb medicine extracts of 40 - 99 weight% as an active component and is manufactured by freeze-drying. The herb medicine extract is manufactured by using water or an organic solvent.

Abstract translation: 提供了一种用于快速崩解片剂的组合物，以使使用草药提取物的活性成分以外的赋形剂的量最小化，简化制造工序，通过提高具有强烈作用的药材提取物的味道来提高患者的服药适应性 苦味，提高儿科患者的药物适应性，并通过最小化活性成分以外的赋形剂的使用量来改善快速崩解片剂的重量过多的问题。 用于快速崩解片剂的组合物含有一种或多种作为活性组分的40-99重量％的草药提取物，并通过冷冻干燥制造。 草药提取物通过使用水或有机溶剂制造。

公开(公告)号：KR1020080028575A

公开(公告)日：2008-04-01

申请号：KR1020060094007

申请日：2006-09-27

Applicant: 조선대학교산학협력단

Inventor： 최후균

IPC: A61K9/70

CPC classification number: A61K9/7061 ,  A61K31/5415

Abstract: A meloxicam transdermal delivery patch agent is provided to avoid side effects caused by oral administration of the meloxicam, prevent the meloxicam from being metabolized by first-pass metabolism at liver and maximize the therapeutic effect of the meloxicam by improving low skin permeation when the meloxicam is administered transdermally. A meloxicam transdermal delivery patch agent comprises at least one absorption promoting agent selected from the group consisting of a sorbitan fatty acid derivative, a vegetable oil ester of polyethyleneglycol. polyethyleneglycol corn oil glyceride, and polyethyleneglycol almond oil glyceride and at least one adhesive selected from the group consisting of an acrylic-based polymer having a hydroxy group and an acrylic based polymer without a functional group. A method for preparing the patch agent comprises the steps of: (a) dissolving meloxicam in dimethylformamide; (b) adding at least one of the absorption promoting agent to the solution obtained from the step(a) with agitating to mix them; (c) adding an adhesive solution including the acrylic-based polymer having the hydroxy group or no functional group to the mixture obtained from the step(b) with agitation; (d) applying the mixture obtained from the step(c) to a silicone coated releasing paper and drying it; and (e) transferring the acrylic based adhesive layer to a rear side layer.

Abstract translation: 提供美洛昔康透皮贴剂，以避免口服美洛昔康引起的副作用，防止美洛昔康由于肝脏的首过代谢而被代谢，并通过改善美洛昔康的低皮肤渗透性来最大化美洛昔康的治疗效果 透皮给药。 美洛昔康透皮贴剂包含至少一种选自山梨糖醇酐脂肪酸衍生物，聚乙二醇植物油酯的吸收促进剂。 聚乙二醇玉米油甘油酯和聚乙二醇杏仁油甘油酯和至少一种选自具有羟基的丙烯酸类聚合物和不具有官能团的丙烯酸类聚合物的粘合剂。 制备贴剂的方法包括以下步骤：（a）将美洛昔康溶于二甲基甲酰胺中; （b）将至少一种吸收促进剂加入到由步骤（a）获得的溶液中，搅拌混合; （c）在搅拌下向包含步骤（b）得到的混合物中加入包含具有羟基或无官能团的丙烯酸类聚合物的粘合剂溶液; （d）将从步骤（c）获得的混合物施加到涂有硅氧烷的释放纸上并将其干燥; 和（e）将丙烯酸类粘合剂层转移到后侧层。

公开(公告)号：KR1020050022156A

公开(公告)日：2005-03-07

申请号：KR1020030086249

申请日：2003-12-01

Applicant: 조선대학교산학협력단

Inventor： 최후균 ,  권경애

IPC: A61K9/70

CPC classification number: A61K9/7023 ,  A61K31/4418

Abstract: PURPOSE: Patch preparation for treatment of nail disease caused by fungus is provided, which patch preparation contains high concentration of antifungal agent within a matrix, so that crystallization is inhibited during long-term storage, and permeation effect of the patch preparation is continuously expressed. CONSTITUTION: The patch preparation for treatment of nail disease caused by fungus comprises (1) nonpolar copolymer comprising polystyrene; (2) 1 to 20 wt.% of antifungal agent such as cyclopirox or cyclopirox olamine salt; (3) 0.1 to 10 wt.% of a crystallization inhibiting agent; (4) 10 to 70 wt.% of one rosin and rosin derivatives as an adhesion increasing agent; and (5) 0.5 to 30 wt.% of carbohydrate oil as a plasticizer.

Abstract translation: 目的：提供用于治疗由真菌引起的指甲疾病的贴片制剂，该贴片制剂在基质内含有高浓度的抗真菌剂，使得长期保存期间结晶受到抑制，并且不断表现贴剂制剂的渗透作用。 构成：用于治疗由真菌引起的指甲疾病的贴片制剂包括（1）包含聚苯乙烯的非极性共聚物; （2）1至20重量％的抗真菌剂如环戊烯或环戊醇胺盐; （3）0.1〜10重量％的结晶抑制剂; （4）10〜70重量％的一种松香和松香衍生物作为增粘剂; 和（5）0.5〜30重量％的碳水化合物油作为增塑剂。