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公开(公告)号：KR1020170039018A
公开(公告)日：2017-04-10
申请号：KR1020150138054
申请日：2015-09-30
Applicant: 경북대학교 산학협력단 , 강릉원주대학교산학협력단 , 한국과학기술연구원 , 울산과학기술원
IPC: H02N11/00
Abstract: 본발명은자성유체를이용한고효율연속발전사이클장치에관한것으로서, 보다상세하게는자성을띄는나노입자인자성유체와, 상기자성유체가내부로통과되어순환되는순환파이프와, 상기순환파이프의외측에상기순환파이프의길이방향을따라소정구간권선되는코일로구성된유도발전부와, 상기순환파이프의상하길이방향을따라상기코일의외측을감싸도록영구자석이복수개배치되되, 상기인접한영구자석은동일한극성끼리상호마주보도록설치되는자화방향변환부를포함하여제공된다. 상기와같은본 발명에따르면, 순환파이프에설치되는영구자석이동일한극성끼리상호마주보도록복수개배치시켜, 자성유체의나노입자가활발하게교란되어발전효율이높아지는효과가있다. 또한, 자성유체에비자성체인기포가비균질적으로흐르도록공급시켜시간에따른자속의변화를유도하여고효율로연속적인발전이가능하도록하는효과가있다.
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公开(公告)号：KR1020150111705A
公开(公告)日：2015-10-06
申请号：KR1020140035407
申请日：2014-03-26
Applicant: 한국과학기술연구원
CPC classification number: A61K41/0057 , A61K9/1075 , A61K9/5123 , A61K9/5146 , A61K49/003 , A61K49/0082 , A61K9/16 , A61K9/127 , A61K47/30 , A61K47/50 , A61K49/04
Abstract: 본발명은생체영상및 광역학치료를위한메틸렌블루나노입자와, 이의암 치료제및 조영제로서의용도에관한것이다. 본발명의국소암표적성광치료제로사용되기위한메틸렌블루나노입자는조성이임상사용중이거나인체유래인물질만으로구성되어, 임상진입장벽이낮고상용화가능성이매우높은나노제제이며, 암표적성, 일항산소발생성능과함께근적외형광을나타내므로광학영상화등 생체영상진단과암 표적광역학치료에동시에사용될수 있다.
Abstract translation: 本发明涉及用于生物成像和光动力学治疗的亚甲蓝纳米颗粒，其抗癌药物，并且用作造影剂。 用于本发明的局部癌症靶向光疗法的亚甲蓝纳米颗粒可以同时用于生物成像诊断例如光学成像等，同时用于癌症靶向光动力学治疗，通过临床使用或仅由 代表人体的物质，代表癌症靶向性，单线态氧的发生能力和近红外荧光，作为具有低临床入门障碍和高商业化可能性的纳米医药。
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公开(公告)号：KR101485389B1
公开(公告)日：2015-01-26
申请号：KR1020130024657
申请日：2013-03-07
Applicant: 한국과학기술연구원
CPC classification number: A61K49/0093 , A61K49/0002 , A61K49/0032 , A61K49/0054
Abstract: 본 발명은 조영제 조성물 및 이를 이용한 바이오 영상화 방법에 관한 것이다. 본 발명의 조영제 조성물은 생분자인 DNA 나노 구조체를 주요 성분으로 포함하기 때문에, 본질적으로 비세포독성 및 비면역성이며, 다른 유기 또는 무기 기반 조영제 조성물에서 관찰될 수 있는 안전성 문제를 야기할 가능성이 낮다. 또한, 본 발명의 조영제 조성물은 우수한 세포 내 섭취 및 안정성을 나타내어 충분한 조영 증강 효과를 통해 질병의 진단을 용이하게 할 뿐만 아니라, 기존에 탐색이 어려웠던 감시림프절까지 영상화할 수 있기 때문에, 암의 전이 여부를 용이하게 판단하고, 저침습적 치료의 임상 적용을 가능하게 한다.
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Patent Agency Ranking
公开(公告)号：KR1020140110401A
公开(公告)日：2014-09-17
申请号：KR1020130024657
申请日：2013-03-07
Applicant: 한국과학기술연구원
CPC classification number: A61K49/0093 , A61K49/0002 , A61K49/0032 , A61K49/0054
Abstract: The present invention relates to a contrast medium composition and a method of bio imagination using the same. The contrast medium composition of the present invention includes DNA nanostructure, which is a biomolecule, as an active ingredient; is fundamentally non-cytotoxic and non-immunogenic; and is not likely to induce safety problems that may be observed in other organic or inorganic contrast medium composition. In addition, the contrast medium composition of the present invention not only facilitates diagnosis of disease through sufficient contrast enhancement effect by showing excellent cellular uptake and intracellular stability but can visualize even SLNs which is difficult to be visualized traditionally, thus enabling easy examination of cancer metastasis and application of lower invasive treatment.
Abstract translation: 本发明涉及造影剂组合物和使用其的生物想象力的方法。 本发明的造影剂组合物包含作为活性成分的作为生物分子的DNA纳米结构体; 基本上是非细胞毒性和非免疫原性的; 并且不可能引起在其它有机或无机造影剂组合物中可能观察到的安全问题。 此外，本发明的造影剂组合物不仅通过显示优异的细胞摄取和细胞内稳定性而能够通过充分的对比度增强效果来促进疾病的诊断，而且可以使传统上难以显现的SLN甚至可视化，因此能够容易地检查癌症转移 并应用低侵入性治疗。
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公开(公告)号：KR1020140096821A
公开(公告)日：2014-08-06
申请号：KR1020130009894
申请日：2013-01-29
Applicant: 한국과학기술연구원
CPC classification number: A61K49/12 , A61K9/06 , A61K33/24 , A61K47/34 , A61K49/0054 , A61K49/1803 , A61K2121/00 , B82Y5/00
Abstract: The present invention relates to a Gd-PEI nanogel and a contrast agent or a pharmaceutical composition comprising the same. The Gd-PEI nanogel has an amorphous shape and a flexible nature, and thus passes through an RES system. The Gd-PEI nanogel expresses minimum cytotoxin and enables excellent targeting of in-vivo tumor, thereby ensuring high biomedical potential power as the contrast agent and a drug carrier.
Abstract translation: 本发明涉及Gd-PEI纳米凝胶和造影剂或包含其的药物组合物。 Gd-PEI纳米凝胶具有无定形形状和柔性，从而通过RES系统。 Gd-PEI纳米凝胶表达最小的细胞毒素，能够实现体内肿瘤的优异靶向，从而确保作为造影剂和药物载体的高生物医学潜力。
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公开(公告)号：KR1020140056961A
公开(公告)日：2014-05-12
申请号：KR1020120123478
申请日：2012-11-02
Applicant: 한국과학기술연구원
CPC classification number: H01B1/02 , B22F1/0007 , B22F1/0018 , B22F1/0025 , B22F1/0062 , B22F1/02 , B22F9/24 , B82Y40/00 , C09D11/52
Abstract: A method for fabricating copper nanoparticles having oxidation resistance and copper nanoparticles having oxidation resistance which comprises: a solution manufacturing step which manufactures a first stirring solution by preparing a first solution including solvents, polymers, and organic acids and stirring the first solution; a reaction step which manufactures a second reaction solution by mixing the first stirring solution, copper precursors, and a first reducing agent; a manufacturing step which manufactures a third reaction solution by mixing the second reaction solution with a second reducing agent; and a collection step which isolates and collects the copper nanoparticles included in the third reaction solution. Therefore, the method for fabricating copper nanoparticles can manufacture copper nanoparticles at room temperature in air atmosphere with a simple process and facilitate mass production of the copper nanoparticles using an environmentally-friendly method which applies aqueous solvents as first. Especially, the copper nanoparticles according to the present invention have enhanced oxidation resistance so that the copper nanoparticles can be stored for 3 months at room temperatures in the air without being oxidized.
Abstract translation: 一种制造具有抗氧化性的铜纳米颗粒的方法和具有抗氧化性的铜纳米颗粒的方法，其包括：溶液制造步骤，通过制备包含溶剂，聚合物和有机酸的第一溶液并搅拌第一溶液来制造第一搅拌溶液; 反应步骤，通过混合第一搅拌溶液，铜前体和第一还原剂制备第二反应溶液; 通过将第二反应溶液与第二还原剂混合来制造第三反应溶液的制造步骤; 以及分离并收集第三反应溶液中所含的铜纳米颗粒的收集步骤。 因此，制造铜纳米颗粒的方法可以在室温下在空气气氛中以简单的方法制造铜纳米颗粒，并且使用首先应用水溶剂的环保方法促进铜纳米颗粒的批量生产。 特别地，根据本发明的铜纳米颗粒具有增强的抗氧化性，使得铜纳米颗粒可以在室温下在空气中储存3个月而不被氧化。
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公开(公告)号：KR1020140029054A
公开(公告)日：2014-03-10
申请号：KR1020120096721
申请日：2012-08-31
Applicant: 한국과학기술연구원 , 서울대학교산학협력단
Abstract: Self-assembled nanoparticles of monosaccharide/ethylene oxide alternating polyamides according to the present invention are represented by the chemical formula 1 or the chemical formula 2. In the chemical formula 1 and the chemical formula 2, A, B and n are defined in the specification of the present invention. The polyamides can form water-dispersed and self-assembled nanoparticles, and can be used as a contrast medium for probing the images of cancer cells because the polyamides can be self-assembled using hydrogen bonds.
Abstract translation: 根据本发明的单糖/环氧乙烷交替聚酰胺的自组装纳米颗粒由化学式1或化学式2表示。在化学式1和化学式2中，A，B和n在说明书中定义 的本发明。 聚酰胺可以形成水分散和自组装的纳米颗粒，并且可以用作用于探测癌细胞的图像的造影剂，因为聚酰胺可以使用氢键自组装。
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公开(公告)号：KR1020140002287A
公开(公告)日：2014-01-08
申请号：KR1020120070376
申请日：2012-06-28
CPC classification number: H01M8/1004 , B82Y30/00 , H01M8/1067 , H01M8/1086 , Y02P70/56
Abstract: The present invention relates to a polymer electrolyte membrane-electrode assembly with an enhanced hydrophobicity by maximizing the surface area by forming a nanopattern with a high aspect ratio on the catalytic carrier on the surface of a catalyst layer in order to supply ultra hydrophobicity to the surface of the catalyst layer, and by coating a hydrophobic thin film on the surface, and a manufacturing method thereof. The present invention provides a manufacturing method of a polymer electrolyte membrane-electrode assembly, which comprises a step of forming a nanopattern with a high aspect ratio by plasma-etching the catalyst carrier on the surface of a catalyst layer forming MEA; and a step of forming a hydrophobic thin film on the nanopattern formed on the catalyst carrier. [Reference numerals] (AA) Ultra hydrophobicity surface treatment (plasma etching + hydrophobic thin film coating); (BB) Catalyst layer; (CC,GG) Catalyst carrier; (DD) Catalyst; (EE,HH) Polymer electrolyte membrane; (FF) Hydrophobic thin film
Abstract translation: 本发明涉及通过在催化剂层表面上的催化载体上形成具有高纵横比的纳米图案来最大化表面积而具有增强的疏水性的聚合物电解质膜 - 电极组件，以便向表面提供超疏水性 的催化剂层，并且通过在表面上涂布疏水性薄膜及其制造方法。 本发明提供一种聚合物电解质膜 - 电极组件的制造方法，其包括通过在形成MEA的催化剂层的表面上等离子体蚀刻催化剂载体，形成具有高纵横比的纳米图案的步骤; 以及在形成在催化剂载体上的纳米图案上形成疏水性薄膜的工序。 （附图标记）（AA）超疏水性表面处理（等离子体蚀刻+疏水性薄膜涂布） （BB）催化剂层; （CC，GG）催化剂载体; （DD）催化剂; （EE，HH）聚合物电解质膜; （FF）疏水薄膜
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