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公开(公告)号：KR101396880B1
公开(公告)日：2014-05-19
申请号：KR1020120096721
申请日：2012-08-31
Applicant: 한국과학기술연구원 , 서울대학교산학협력단
Abstract: 본 발명의 단당류/에틸렌 옥사이드 교대 폴리아미드는 하기 화학식 1 또는 화학식 2로 표시된다.
[화학식 1]
[화학식 2]
상기 화학식 1 및 화학식 2에서, 상기 A, B, 및 n의 정의는 발명의 상세한 설명에 기재된 바와 같다. 상기 폴리아미드는 수소결합을 이용한 자기결합(self assembled)이 가능하여, 수계 분산 자기 결합 나노입자를 형성할 수 있고, 암세포 이미지 프로브용 조영제로 활용될 수 있다.-
公开(公告)号：KR1020140029054A
公开(公告)日：2014-03-10
申请号：KR1020120096721
申请日：2012-08-31
Applicant: 한국과학기술연구원 , 서울대학교산학협력단
Abstract: Self-assembled nanoparticles of monosaccharide/ethylene oxide alternating polyamides according to the present invention are represented by the chemical formula 1 or the chemical formula 2. In the chemical formula 1 and the chemical formula 2, A, B and n are defined in the specification of the present invention. The polyamides can form water-dispersed and self-assembled nanoparticles, and can be used as a contrast medium for probing the images of cancer cells because the polyamides can be self-assembled using hydrogen bonds.
Abstract translation: 根据本发明的单糖/环氧乙烷交替聚酰胺的自组装纳米颗粒由化学式1或化学式2表示。在化学式1和化学式2中，A，B和n在说明书中定义 的本发明。 聚酰胺可以形成水分散和自组装的纳米颗粒，并且可以用作用于探测癌细胞的图像的造影剂，因为聚酰胺可以使用氢键自组装。
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公开(公告)号：KR101823490B1
公开(公告)日：2018-01-30
申请号：KR1020160115883
申请日：2016-09-08
Applicant: 한국과학기술연구원
CPC classification number: A61K49/226 , A61K47/34 , G01N21/64 , C08G73/0206 , A61K49/0019 , A61K49/0093 , C08J3/075 , C08J3/24 , C08L79/02 , C08L2203/02
Abstract: 본발명은옥사미드결합에의해가교결합된폴리아민계고분자를포함하는나노겔, 상기나노겔의제조방법, 상기나노겔을포함하는초음파영상용조영제, 상기조영제를포함하는염증성질환의초음파진단용조성물, 상기조영제의제조방법, 및상기초음파진단용조성물을이용한염증성질환의진단을위한정보의제공방법에관한것이다.
Abstract translation: 本发明草酰胺通过键连接的聚胺系纳米凝胶的交联中，纳米凝胶的制造方法，其包括聚合物，造影剂，其包含纳米凝胶超声成像，炎性疾病，包括造影剂的超声波诊断组合物， 制造造影剂的方法以及使用超声波诊断组合物提供用于诊断炎性疾病的信息的方法。
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公开(公告)号：KR101454236B1
公开(公告)日：2014-10-27
申请号：KR1020130009894
申请日：2013-01-29
Applicant: 한국과학기술연구원
Abstract: 본 발명은 Gd-PEI 나노겔 및 이를 포함하는 조영제 또는 약제학적 조성물에 관한 것이다. 본 발명의 Gd-PEI 나노겔은 무정형이고 유연한 성질을 가지므로 RES 시스템을 효과적으로 통과할 수 있고, 최소한의 세포 독성을 나타내며, 우수한 인 비보 종양 표적화가 가능하므로, 조영제 및 약물 전달체로서의 높은 생의학적 잠재력을 갖는다.
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公开(公告)号：KR1020120121937A
公开(公告)日：2012-11-07
申请号：KR1020110039143
申请日：2011-04-26
Applicant: 한국과학기술연구원
CPC classification number: C07D239/60 , C07C39/373 , C07C47/565 , C07C49/248 , C07C49/747 , C07C69/732 , C07C69/94 , C07C255/36 , C07C255/40 , C07C255/41 , C07C309/73 , C07C317/46 , C07C2602/08 , C07D403/10 , Y10T436/206664
Abstract: PURPOSE: A fluorescent nanoprobe for detecting hydrogen peroxide is provided to be quickly embodied by organic base in nanoparticles, and to be used for detecting sulfuric acid in rear time and to be used for cell-imaging in vivo-imaging, chemical analysis, etc. CONSTITUTION: A fluorescent nanoprobe for detecting hydrogen peroxide is represented by chemical formula 1. In chemical formula 1, A is an electron-accepting substituent selected ester, aldehyde, nitrile, nitrobenzene, sulfonated benzene, indane, babituric acid, and derivatives thereof, an electron-accepting substituent. The fluorescent nanoprobe comprises the sulfonated benzene compound and water. A manufacturing method of the fluorescent nanoprobe comprises: a step of mixing sulfonated benzene compound represented by chemical formula 3 and organic solvent; and a step of obtaining fluoresncent nanoprobe by removing the organic solvent.
Abstract translation: 目的：提供一种用于检测过氧化氢的荧光探针，可以通过纳米颗粒中的有机碱快速实现，并用于后期检测硫酸，并用于体内成像，化学分析等细胞成像。 组成：用于检测过氧化氢的荧光纳米探针由化学式1表示。在化学式1中，A是选择的电子接受性取代基酯，醛，腈，硝基苯，磺化苯，茚满，巴布酸及其衍生物， 受电子取代基。 荧光纳米探针包含磺化苯化合物和水。 荧光纳米探针的制造方法包括：将由化学式3表示的磺化苯化合物与有机溶剂混合的步骤; 以及通过除去有机溶剂获得荧光剂纳米探针的步骤。
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Patent Agency Ranking
公开(公告)号：KR101065241B1
公开(公告)日：2011-09-19
申请号：KR1020090041898
申请日：2009-05-13
Applicant: 한국과학기술연구원
CPC classification number: A61K49/0019 , A61K49/0093
Abstract: 본 발명은 시아노 치환 폴리아릴렌비닐렌 고분자의 나노 입자 및 상기 고분자 나노 입자의 표면에 흡착되어 있는 생체 적합성 계면활성제를 함유하는 발광 고분자 나노 입자 및 그 제조 방법에 관한 것으로서, 상기 제조 방법은 (1) 일반식 OHC-Ar
1 -CHO로 표시되는 디알데히드 단량체, NC-Ar
2 -CN으로 표시되는 디시아나이드 단량체 및 액상 계면활성제를 균일하게 혼합하는 단계, (2) 얻어진 혼합물에 물을 가하여 미셀 수계 분산액을 제조하는 단계 및 (3) 중합 촉매를 가하고 상온 및 상압에서 콜로이드 중합시키는 단계를 포함한다. 본 발명에 따른 발광 고분자 나노 입자는 표면이 생체 적합성 계면활성제로 안정화되어 있어 안정한 수계 분산상을 형성할 수 있고, 생체 분자 표지 또는 세포 및 생체 내 영상에 적합한 입자 크기 및 형광 효율을 나타내므로, 세포 또는 생체용 발광 조영제로 사용될 수 있다.-
公开(公告)号：KR1020120135365A
公开(公告)日：2012-12-13
申请号：KR1020110053409
申请日：2011-06-02
Applicant: 한국과학기술연구원
CPC classification number: A61K41/0071 , A61K47/542 , A61K47/60 , A61K47/6907 , A61K47/6939
Abstract: PURPOSE: A method for preparing near infrared photosensitizer organic nanoparticles of aqueous dispersion and a photodynamic therapeutic agent containing the same are provided to ensure low toxicity and to induce cancer cell apoptosis in vivo or in vitro. CONSTITUTION: A nano-photosensitizer of aqueous dispersion contains: a core with a photosensitizer; bio-affinity polymers covering the core; and water. The core further comprises a heavy-atomic dispersion agent corresponding to the photosensitizer. The heavy-atomic dispersion agent is a hydrophobic molecule containing iodine or heavy metals. The wavelength of the photosensitizer is 500-900 nm. A photodynamic therapeutic agent contains the nano-photosensitizer.
Abstract translation: 目的：提供一种制备近红外光敏剂水性分散体有机纳米颗粒的方法和含有该分散体的光动力学治疗剂，以确保低毒性，并在体内或体外诱导癌细胞凋亡。 构成：含水分散体的纳米光敏剂包含：具有光敏剂的核心; 覆盖芯的生物亲和聚合物; 和水。 核心还包括对应于光敏剂的重原子分散剂。 重原子分散剂是含有碘或重金属的疏水分子。 光敏剂的波长为500-900nm。 光动力治疗剂含有纳米光敏剂。
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公开(公告)号：KR1020110061432A
公开(公告)日：2011-06-09
申请号：KR1020090118079
申请日：2009-12-01
Applicant: 한국과학기술연구원
CPC classification number: A61K49/0017 , A61K49/0021 , A61K49/0054 , A61K49/1824 , G01N33/49 , G01N33/58
Abstract: PURPOSE: Aqueous-dispersed chemical-luminescent nanoparticles, a producing method thereof, and a use thereof are provided to accurately and extensively diagnose active oxygen related disease by directly imaging hydrogen peroxide. CONSTITUTION: Aqueous-dispersed chemical-luminescent nanoparticles contain the following: 0.01~3wt% of core containing a hydrophobic chemical-luminescent substance; 0.5~30wt% of surfactant surrounding the core; and 67~99.49wt% water. The luminescent wavelength of the hydrophobic chemical-luminescent substance is 650~900nm. The hydrophobic chemical-luminescent substance is formed with a peroxyoxalate derivative and a fluorescent material. The surfactant is poloxamer.
Abstract translation: 目的：通过直接成像过氧化氢，提供水分散化学发光纳米颗粒及其制备方法及其用途，以准确和广泛地诊断活性氧相关疾病。 构成：含水分散化学发光纳米粒子含有以下物质：含有疏水性化学发光物质的核心的0.01〜3重量％ 核心表面活性剂占0.5〜30wt％; 和67〜99.49重量％的水。 疏水化学发光物质的发光波长为650〜900nm。 疏水性化学发光物质由过氧草酸酯衍生物和荧光物质形成。 表面活性剂是泊洛沙姆。
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公开(公告)号：KR1020140096821A
公开(公告)日：2014-08-06
申请号：KR1020130009894
申请日：2013-01-29
Applicant: 한국과학기술연구원
CPC classification number: A61K49/12 , A61K9/06 , A61K33/24 , A61K47/34 , A61K49/0054 , A61K49/1803 , A61K2121/00 , B82Y5/00
Abstract: The present invention relates to a Gd-PEI nanogel and a contrast agent or a pharmaceutical composition comprising the same. The Gd-PEI nanogel has an amorphous shape and a flexible nature, and thus passes through an RES system. The Gd-PEI nanogel expresses minimum cytotoxin and enables excellent targeting of in-vivo tumor, thereby ensuring high biomedical potential power as the contrast agent and a drug carrier.
Abstract translation: 本发明涉及Gd-PEI纳米凝胶和造影剂或包含其的药物组合物。 Gd-PEI纳米凝胶具有无定形形状和柔性，从而通过RES系统。 Gd-PEI纳米凝胶表达最小的细胞毒素，能够实现体内肿瘤的优异靶向，从而确保作为造影剂和药物载体的高生物医学潜力。
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公开(公告)号：KR1020100122810A
公开(公告)日：2010-11-23
申请号：KR1020090041898
申请日：2009-05-13
Applicant: 한국과학기술연구원
CPC classification number: A61K49/0019 , A61K49/0093
Abstract: PURPOSE: An electroluminescent polymer nanoparticle and a manufacturing method thereof are provided to form a stable water-base dispersed phase with the stabilized surface processed with a biocompatible surfactant, and to use the nanoparticle as a contrast agent for a cell or an organism. CONSTITUTION: An electroluminescent polymer nanoparticle contains a nanoparticle of a cyano-substituted polyarylenevinylene polymer marked with chemical formula 1, and a biocompatible surfactant adsorped to the surface of the nanoparticle of the cyano-substituted polyarylenevinylene polymer. In the chemical formula 1, n is an integer of 10~10,000.
Abstract translation: 目的：提供一种电致发光聚合物纳米颗粒及其制备方法，以形成具有用生物相容性表面活性剂处理的稳定化表面的稳定的水基分散相，并且使用纳米颗粒作为细胞或生物体的造影剂。 构成：电致发光聚合物纳米颗粒包含用化学式1标记的氰基取代的聚亚芳基亚乙烯基聚合物的纳米颗粒和吸附到氰基取代的聚亚芳基亚乙烯基聚合物的纳米颗粒表面的生物相容性表面活性剂。 在化学式1中，n为10〜10000的整数。
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