公开(公告)号：KR1020110086326A

公开(公告)日：2011-07-28

申请号：KR1020100006000

申请日：2010-01-22

Applicant: 한국과학기술연구원

Inventor： 송수창 ,  박미란 ,  포타트리무디

IPC: A61L27/14 ,  A61L27/54 ,  A61L27/52

CPC classification number: A61L27/14 ,  A61L27/52 ,  A61L27/54

Abstract: PURPOSE: A polyphosphazene composition for biomaterials is provided to make chemical crosslinking that bioactive substance is covalently bonded possible. CONSTITUTION: A polyphosphazene composition for biomaterials can be used for bioactive substance transfer materials, orthopedic surgery materials, biomaterials for histotechnology, blood vessel absorption prevention materials, and biomaterials by forming gel having more strong intensity through ultraviolet ray irradiation, crosslinking agent addition, additive addition, enzyme addition, and mixing of phosphazene polymer.

Abstract translation: 目的：提供用于生物材料的聚磷腈组合物，以使生物活性物质共价结合成化学交联。 构成：用于生物材料的聚磷腈组合物可用于生物活性物质转移材料，矫形手术材料，组织技术生物材料，血管吸收防止材料和生物材料，通过形成通过紫外线照射具有更强强度的凝胶，交联剂添加剂，添加剂添加剂 ，酶添加和磷腈聚合物的混合。

公开(公告)号：KR100968591B1

公开(公告)日：2010-07-08

申请号：KR1020080040413

申请日：2008-04-30

Applicant: 한국과학기술연구원

Inventor： 송수창 ,  박미란 ,  이선미

IPC: C08G79/02 ,  A61K31/745

CPC classification number: A61K31/56 ,  A61K9/06 ,  A61K31/7052 ,  A61K47/34 ,  C08G65/33306 ,  C08G79/025 ,  C08G2650/50 ,  C08L2203/02

Abstract: 본 발명은 온도 변화에 따라 솔-젤 거동을 보이며 관능기를 갖는 생분해성 및 온도 감응성 포스파젠계 고분자, 그의 제조방법 및 그의 생리 활성 물질 전달 재료로서의 용도에 관한 것이다.
온도 감응성, 생분해성, 포스파젠계 고분자, 하이드로젤, 약물전달시스템, 관능기, 첨가제.

公开(公告)号：KR1020080110473A

公开(公告)日：2008-12-18

申请号：KR1020080040662

申请日：2008-04-30

Applicant: 한국과학기술연구원

Inventor： 송수창 ,  포타트리무디 ,  이선미

IPC: C08G79/02 ,  C08J3/075 ,  A61K47/30

CPC classification number: C08G79/025 ,  A61K9/06 ,  A61K47/34 ,  C08G65/33306 ,  C08G2650/50 ,  C08J3/075 ,  C08J3/246 ,  C08J3/28 ,  C08J2385/02 ,  C08L85/02 ,  C08L2203/02

Abstract: A polymer hydrogel is provided to form chemical cross-linkage in mixing and to ensure excellent strength and sol-gel movement by containing a phosphazene-based polymer in a constant concentration. A phosphazene-based polymer has a structure of the chemical formula 1. In the chemical formula 1, P has a value of 7 - 50; in NHCH(R1)CO2R2, R1 is selected from a group consisting of H, CH3, CH2SH, CH(CH3) 2, CH2 CH(CH3)2, CH(CH3) C2H5, CH2CH2SCH3, CH2C6H5, CH2C6H4OH and CH2C2NH2C6H4 and R2 is selected from a group consisting of CH3, C2H5, C3H7, C4H9, CH2C6H5 and CH2CHCH2; R3 is CH(W); R4 is selected from a group consisting of CO2, CONHCH(X)CO2CO2, and CH2CO2 and CO2CH(CH3)CO2; R4 is selected from a group consisting of CO2, CONHCH(X)CO2CO2, CH2CO2 and CO2CH(CH3)CO2; R5 is selected from a group consisting of H, CH3 and C2H5; and W and X are selected from a group consisting of H, CH3, CH(CH3)2, CH2CH(CH3)2, CH(CH3)C2H5, CH2CH2SCH3, CH2C6H5, CH2C2NH2C6H4, CO2C2H5, (CH2)2CO2C2H5, CH2OH, CH(CH3)OH, CH2C6H4OH, CH2COOH, CH2CH2COOH, CH2CONH2, C4H8NH2, C3H6 NHC(=NH)NH2, CH2C3N2H3 and CH2SH.

Abstract translation: 提供聚合物水凝胶以在混合中形成化学交联，并通过含有恒定浓度的磷腈基聚合物来确保优异的强度和溶胶 - 凝胶运动。 磷腈基聚合物具有化学式1的结构。在化学式1中，P的值为7-50; 在NHCH（R1）CO2R2中，R1选自H，CH3，CH2SH，CH（CH3）2，CH2CH（CH3）2，CH（CH3）C2H5，CH2CH2SCH3，CH2C6H5，CH2C6H4OH和CH2C2NH2C6H4，R2是 选自由CH 3，C 2 H 5，C 3 H 7，C 4 H 9，CH 2 C 6 H 5和CH 2 CHCH 2组成的组; R3是CH（W）; R 4选自CO 2，CONHCH（X）CO 2 CO 2和CH 2 CO 2和CO 2 CH（CH 3）CO 2; R 4选自CO 2，CONHCH（X）CO 2 CO 2，CH 2 CO 2和CO 2 CH（CH 3）CO 2; R5选自H，CH3和C2H5; 并且W和X选自H，CH 3，CH（CH 3）2，CH 2 CH（CH 3）2，CH（CH 3）C 2 H 5，CH 2 CH 2 SCH 3，CH 2 C 6 H 5，CH 2 C 2 NH 2 C 6 H 4，CO 2 C 2 H 5，（CH 2）2 CO 2 C 2 H 5，CH 2 OH，CH（ CH3）OH，CH2C6H4OH，CH2COOH，CH2CH2COOH，CH2CONH2，C4H8NH2，C3H6 NHC（= NH）NH2，CH2C3N2H3和CH2SH。

公开(公告)号：KR1020050012533A

公开(公告)日：2005-02-02

申请号：KR1020030051521

申请日：2003-07-25

Applicant: 한국과학기술연구원

Inventor： 송수창 ,  이배훈

IPC: C08G79/02

CPC classification number: C08G79/025 ,  A61K9/0024 ,  A61K9/06 ,  A61K47/34

Abstract: PURPOSE: Provided are a temperature sensitive polyphosphazene-based polymer which is biodegradable and shows sol-gel behavior according to the change of temperature, its preparation method, and a temperature sensitive hydrogel for an injection-type drug transporter using the polymer. CONSTITUTION: The polyphosphazene-based polymer is represented by the formula 1, wherein R is CH2CH(CH3)2, CH(CH3)C2H5 or C7H7; R' is CH2COOC2H5 or CH(CH3)COOC2H5; R'' is OC2H5, NHCH2COOC2H5, NHCH2COOC7H7, NHCH(CH2CH(CH3)2)COOC2H5 or NHCH(CH(CH3)C2H5)COOC2H5; a and b are a number of 0.1-1.0; c and d are a number of 0-1.9; a+b+c+d is 2.0; n is 10-10,000; and m is 10-50. The method comprises the steps of reacting the polydichlorophosphazene of the formula 3 and an amino acid ethyl ester represented by H2NCH(R)COOCH2CH3 in a molar ratio of 1 : 0.1-1.9; reacting the obtained product with 0-1.9 equivalent of a compound represented by H2NCH2COOR' or H2NCH2COR''; and reacting the obtained product with 2 equivalent of an aminomethoxy polyethylene glycol represented by NH2-(CH2-CH2-O)m-CH3 based on the remaining chlorine group.

Abstract translation: 目的：提供一种基于温度敏感性的聚磷腈基聚合物，其可生物降解，并且根据温度变化，其制备方法和使用该聚合物的注射型药物转运体的温敏水凝胶具有溶胶 - 凝胶行为。 构成：聚磷腈基聚合物由式1表示，其中R是CH 2 CH（CH 3）2，CH（CH 3）C 2 H 5或C 7 H 7; R'是CH 2 COOC 2 H 5或CH（CH 3）COOC 2 H 5; R“是OC 2 H 5，NHCH 2 COOC 2 H 5，NHCH 2 COOC 7 H 7，NHCH（CH 2 CH（CH 3）2）COOC 2 H 5或NHCH（CH（CH 3）C 2 H 5）COOC 2 H 5; a和b是0.1-1.0的数; c和d是0-1.9的数; a + b + c + d为2.0; n是10-10,000; m为10-50。 该方法包括以下步骤：使式3的聚二氯磷腈与由H 2 NCH（R）COOCH 2 CH 3表示的氨基酸乙酯的摩尔比为1:0.1-1.9; 将得到的产物与0-1.9当量的由H 2 NHCH 2 COOR'或H 2 NCH 2 COR“表示的化合物反应; 并使所得产物与基于剩余氯基团的由NH 2 - （CH 2 -CH 2 -O）m -CH 3表示的氨基甲氧基聚乙二醇2当量反应。

公开(公告)号：KR100321296B1

公开(公告)日：2002-03-18

申请号：KR1019990048800

申请日：1999-11-05

Applicant: 한국과학기술연구원

Inventor： 손연수 ,  송수창 ,  이상범

IPC: C07F9/00

CPC classification number: C07F9/65815

Abstract: 본발명은다음화학식 1로표시되는온도감응성을갖는신규한고리형포스파젠삼량체및 그의제조방법에관한것이다. (식중, HNA는아미노산기로서글라이신기(-NHCHCOO), 아미노말론산기(-NHCH(COO)), 아스파르트산기(-NHCH(CHCOO)COO), 및글루타민산기(-NHCH(CHCHCOO)COO) 중에서선택되며, R은에틸기또는벤질기중에서선택된다. m은폴리(알콕시에틸렌글리콜)의반복단위로서 2, 7, 12 및 16 중에서선택되고 n은알킬사슬의길이를나타내는정수로서 0, 1, 및 3 중에서선택됨)

公开(公告)号：KR100307724B1

公开(公告)日：2001-09-24

申请号：KR1019990010847

申请日：1999-03-29

Applicant: 한국과학기술연구원

Inventor： 송수창 ,  손연수

IPC: A61K33/24

Abstract: 본발명은일반식(VI)의당질의알카리토금속염과일반식(VII)의황산백금(II)유도체를 1:1 몰비로반응시킨후 부산물인황산바륨을제거하여얻어지는일반식(I)의당질-백금(II)착물복합체의제조에관한것이다. 다음일반식(I)로표시되는당질-백금(II)착물복합체. 상기일반식(I)에서 R은당질및 당질유도체로서글루코스아민(CHNO), 만노스아민(CHNO), β-갈락토스유도체인 N-아미노부틸-O-β-D-갈락토피라노실-(1→ 4)-D-글루콘아미드(CHNO), α-글루코스유도체인 N-아미노부틸-O-α-D-글루코피라노실-(1→4)-D-글루콘아미드(CHNO), β-글루코스유도체인N-아미노부틸-O-β -D-글루코피라노실-(1→4)-D-글루콘아미드(CHNO)중에서선택되며, n은 1 또는 2이다.

公开(公告)号：KR1020000002785A

公开(公告)日：2000-01-15

申请号：KR1019980023695

申请日：1998-06-23

Applicant: 한국과학기술연구원

Inventor： 손연수 ,  송수창 ,  이상범

IPC: C08G79/02

CPC classification number: C08G79/02 ,  C08L83/10

Abstract: PURPOSE: Polyphosphagen and temperature sensitive and biodegradable properties are given by substituting polydichlorophosphagen with methoxypolyethyleneglycol and amino acid ester. CONSTITUTION: The title compound(I) is manufactured. In formula, NHA is amino acid group selected from glycine(-NHCH2COO¬-), alanine(-NHCH(CH3)COO¬-), beta-alanine(-NHCH2CH2COO¬-), aminomalonic acid(-NHCH(COO¬-)2), aspartic acid(NHCH(CH2COO¬-)COO¬-), and glutamic acid(-NHCCH(CH2CH2COO¬-)COO¬-), R is methyl, ethyl, or benzyl, m is repeat unit of polyethyleneglycol and integer selected from 2, 7 and 16, x is 0.2-1.8 of mole content of polyethyleneglycol, and n is 10-100 of degree of polymerization.

Abstract translation: 目的：聚磷酸酯和温度敏感和可生物降解性质是用甲氧基聚乙二醇和氨基酸酯代替聚二氯磷酸酯。 构成：制备标题化合物（I）。 在式中，NHA是选自甘氨酸（-NHCH 2 COO-），丙氨酸（-NHCH（CH 3）COO-），β-丙氨酸（-NHCH 2 CH 2 COO-），氨基马来酸（-NHCH（COO-） 2），天冬氨酸（NHCH（CH 2 COO-）COO-））和谷氨酸（-NHCCH（CH 2 CH 2 COO-））COO-），R是甲基，乙基或苄基，m是聚乙二醇和整数的重复单元 选自2,7和16，x是聚乙二醇的摩尔含量为0.2-1.8，n为10-100聚合度。