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Patent Agency Ranking
公开(公告)号：KR1020000019719A
公开(公告)日：2000-04-15
申请号：KR1019980037962
申请日：1998-09-15
Applicant: 한국과학기술연구원
IPC: A61K31/70
CPC classification number: A23L33/10 , A23C9/152 , A23V2002/00 , A23V2200/3262 , A61K31/7048
Abstract: PURPOSE: A pharmaceutical composition and a functional food comprising diosmin are provided, for treating and preventing hyper lipidemia and arteriosclerosis. CONSTITUTION: The pharmaceutical composition comprises diosmin in effective amount; and pharmaceutically acceptable carriers. The functional food comprises 0.01-10 wt%, preferably 0.1-5 wt% of diosmin. Diosmin inhibits HMG CoA (3-hydroxy-3-methylglutaryl coenzyme) being a reduction enzyme which relates to the biosynthesis of cholesterol and ACAT (acyl CoA; cholesterol-O-acyltransferase) which transforms cholesterol into cholesteryl ester, and reduces the concentration of cholesterol in blood and neutral lipids. Also diosmin strongly inhibits the macrophage-lipid complex from being deposited or adsorbed onto the intra trial surface.
Abstract translation: 目的：提供药物组合物和包含diosmin的功能性食品，用于治疗和预防高脂血症和动脉硬化。 构成：药物组合物含有有效量的diosmin; 和药学上可接受的载体。 功能性食品包含diosmin的0.01-10重量％，优选0.1-5重量％。 Diosmin抑制作为还原酶的HMG CoA（3-羟基-3-甲基戊二酰辅酶），其涉及将胆固醇转化为胆固醇酯的胆固醇和ACAT（酰基辅酶A;胆固醇-O-酰基转移酶）的生物合成，并降低胆固醇的浓度 在血液和中性脂质中。 此外，diosmin还强烈地抑制巨噬细胞 - 脂质复合物沉积或吸附到试验表面。
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公开(公告)号：KR1020000019717A
公开(公告)日：2000-04-15
申请号：KR1019980037959
申请日：1998-09-15
Applicant: 한국과학기술연구원
IPC: A61K31/70
CPC classification number: A23L2/52 , A21D2/14 , A23C9/13 , A23C9/152 , A23L7/109 , A23L13/428 , A23L23/00 , A23L27/63 , A61K31/70 , Y10S514/824 , A61K2300/00
Abstract: PURPOSE: A pharmaceutical composition and a functional food comprising bioflavonoids are provided, for treating and preventing hyper lipidemia, arteriosclerosis and a liver disease. CONSTITUTION: The pharmaceutical composition comprises rutin, quercetin or their mixture ineffective amount; and pharmaceutically acceptable carriers. The functional food comprises 0.01-10 wt% of rutin, quercetin or their mixture. Rutin can be obtained from a fruit, a leaf, a trunk and a flower of buck wheat and be used in the form of a powder or an extract. Rutin and quercetin being bioflavonoids inhibit HMG CoA (3-hydroxy-3-methylglutaryl coenzyme) being a reduction enzyme which relates to the biosynthesis of cholesterol and ACAT (acyl CoA; cholesterol-O-acyltransferase) which transforms cholesterol into cholesteryl ester in the body. Therefore rutin and quercetin reduce the concentration of cholesterol in blood, inhibit strongly a macrophage-lipid complex from being deposited or adsorbed onto the intra trial surface, and protect a liver.
Abstract translation: 目的：提供包含生物类黄酮的药物组合物和功能性食品，用于治疗和预防高脂血症，动脉硬化和肝脏疾病。 构成：药物组合物含有芦丁，槲皮素或其混合物无效量; 和药学上可接受的载体。 功能性食品包含0.01-10重量％的芦丁，槲皮素或其混合物。 芦丁可以从水果，叶子，树干和小麦花中获得，并以粉末或提取物的形式使用。 芦丁和槲皮素是生物类黄酮抑制作为还原酶的HMG CoA（3-羟基-3-甲基戊二酰辅酶），其涉及胆固醇和ACAT（酰基CoA;胆固醇-O-酰基转移酶）的生物合成，其将胆固醇转化为身体中的胆固醇酯 。 因此，芦丁和槲皮素降低血液中胆固醇的浓度，强烈地抑制巨噬细胞 - 脂质复合物沉积或吸附到试验表面，并保护肝脏。
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公开(公告)号：KR1019990083000A
公开(公告)日：1999-11-25
申请号：KR1019990011996
申请日：1999-04-07
Applicant: 한국과학기술연구원
IPC: A23L1/221
CPC classification number: A61K36/725 , A23L27/105 , A61K36/75 , A61K36/752 , A61K36/8962 , A61K36/899 , A61K36/9068 , A61K2300/00
Abstract: 본발명은마늘 1 내지 30 중량%, 양파 10 내지 50 중량%, 생강 0.2 내지 10 중량%, 대추 5 내지 40 중량% 및감귤류과피분말또는이의추출물 10 내지 50 중량%를포함하는심장순환기질환예방및 건강증진에유용한양념조성물에관한것으로, 이를음식에첨가함으로써간질환, 암, 심장순환기질환등의성인병예방및 건강증진효과를얻을수 있다.
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公开(公告)号：KR1019990030752A
公开(公告)日：1999-05-06
申请号：KR1019970051150
申请日：1997-10-06
Applicant: 한국과학기술연구원
IPC: C12N15/06 , A01K67/027 , C12N15/51
Abstract: 본 발명은 인체 B형 간염 바이러스(HBV)의 X 단백질 유전자를 형질전환 시켜 간암생쥐를 생산하는 방법에 관한 것으로 형질전환체 간암생쥐는 즉시 사망하지 않으며 번식성이 있고 후대에도 암이 발생되어 인체간암을 연구하는 질환 모델 동물로 사용할 수 있는 기술을 제공한다.
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