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    (알)-(-)-무스콘의 입체선택적 제조 방법
    31.
    发明授权
    (알)-(-)-무스콘의 입체선택적 제조 방법 失效
    （Al） - （ - ） - Muscons的立体选择性制备方法

    公开(公告)号：KR100340760B1

    公开(公告)日：2002-06-20

    申请号：KR1020000023417

    申请日：2000-05-02

    Applicant: 우리켐테크(주) ,  한국과학기술원

    Inventor： 김용해 ,  최용현 ,  김권

    IPC: C07B55/00

    Abstract: 본 발명은 4-(시스-2,6-다이메틸피페리딘)-(R)-다이나프토다이옥사포스페핀(Ⅰ), 4-(R,R-2,5-다이페닐피롤리딘)-(R)-다이나프토다이옥사포스페핀(Ⅱ)을 구리(Ⅱ)트리플레이트와 반응시켜 구리와 복합체를 형성하고, 이를 키랄 촉매로 사용하여 다이메틸징크를 2-시클로펜타데세논과 1,4-첨가반응시켜 고 광학순도, 고 수율로 (R)-(-)-무스콘(
    l -muscone)을 입체선택적으로 제조하는 방법을 제공하는 것이다.

    독시플루리딘의제조방법
    32.
    发明公开
    독시플루리딘의제조방법 失效
    DOXIFLURIDINE的制造方法

    公开(公告)号：KR1020000033947A

    公开(公告)日：2000-06-15

    申请号：KR1019980051031

    申请日：1998-11-26

    Applicant: 한국과학기술원

    Inventor： 김용해 ,  임진수

    IPC: C07D405/04

    Abstract: PURPOSE: A manufacturing method of doxifluridine is provided which is not harmful to worker and produces doxifluridine in higher production yields than 70% CONSTITUTION: 2',3'-acetyl-5-fluorouridine(III) is methylated with 1-3 mol of methanesulfonyl chloride, based on the amount of compound (III), at 0-50°C to synthesize 2',3'-acetyl-5'-methl-5-fluorouridine(IV), then 2-7 mol of metal zinc and sodium iodide, based on the amount of compound (IV), react with 2',3'-acetyl-5'-methl-5-fluorouridine(IV) at 50-110°C to synthesize 2',3'-acetyl-5'-dioxy-5-fluorouridine(VI). The protection of 2',3'-acetyl-5'-dioxy-5-fluorouridine is removed by using acetic acid or trifluoroacetic acid as solvent, and ultrasound to produce doxifluridine(I).

    Abstract translation: 目的：提供杜氏氟里定的制造方法，其对工作者无害，并且以高于70％的生产产率产生多西菌定：2'，3'-乙酰基-5-氟尿苷（III）与1-3mol甲磺酰基甲基化 氯化物，基于化合物（III）的量，在0-50℃下合成2'，3'-乙酰基-5'-甲基-5-氟尿苷（IV），然后加入2-7mol金属锌和钠 碘化物基于化合物（IV）的量在50-110℃与2'，3'-乙酰基-5'-甲基-5-氟尿苷（IV）反应，合成2'，3'-乙酰基-5 “-dioxy -5-氟尿苷（VI）。 通过使用乙酸或三氟乙酸作为溶剂，除去2'，3'-乙酰基-5'-二氧-5-氟尿苷的保护，超声波产生多西氟利酸（I）。

    비고리 퓨린유도체의 제조방법
    36.
    发明授权
    비고리 퓨린유도체의 제조방법 失效
    制备ACYCLIC衍生物的方法

    公开(公告)号：KR1019910000441B1

    公开(公告)日：1991-01-25

    申请号：KR1019880013575

    申请日：1988-10-18

    Applicant: 한국과학기술원

    Inventor： 김용해 ,  김중영

    IPC: C07D473/02

    Abstract: A process for preparing acyclic purine derivs. of formula (I) comprises an alkylation reaction of a cpd. of formula (II) with 2- acetoxyethyl acetoxymethylether or chloromethyl-1,3-di-o-benzylglycerol in the presence of cesium iodide and acetonitrile. In the formulas, Z=2-acetoxyethoxymethyl or 1,3-di-o- benzylpropoxymethyl; X= -SH, -NH2 or -H; and Y= -SH, -OH or NH2. (I) have antiviral, anticancer and anti-bacterial activity.

    Abstract translation: 制备无环嘌呤衍生物的方法。 式（I）的烷基化反应包括cpd的烷基化反应。 式（II）的化合物与2-乙酰氧基乙基乙酰氧基甲基醚或氯甲基-1,3-二-O-苄基甘油在碘化铯和乙腈存在下反应。 式中，Z = 2-乙酰氧基乙氧基甲基或1,3-二邻 - 苄基丙氧基甲基; X = -SH，-NH 2或-H; 和Y = -SH，-OH或NH 2。 （I）具有抗病毒，抗癌和抗菌活性。

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