公开(公告)号：CZ342698A3

公开(公告)日：1999-05-12

申请号：CZ342698

申请日：1997-05-05

Applicant: ABBOTT LAB

Inventor： DAVIDSON DONALD J ,  WANG JIEYI ,  GUBBINS EARL J

IPC: C12N15/09 ,  A61K20060101 ,  A61K35/14 ,  A61K38/00 ,  A61K38/04 ,  A61K38/48 ,  A61K39/00 ,  A61K45/00 ,  A61K48/00 ,  A61K101/00 ,  A61P1/04 ,  A61P15/18 ,  A61P17/06 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K1/00 ,  C07K14/00 ,  C07K14/47 ,  C07K14/515 ,  C07K19/00 ,  C12N20060101 ,  C12N9/68 ,  C12N15/02 ,  C12N15/57 ,  C12P21/06

Abstract: Compounds of formulae (I) and (II), and their salts, esters and prodrugs, are new: A-B-C-X-Y (I); A-B1-C1-X1-Y (II); A = absent or a nitrogen-protecting group; Y = absent or a carboxy-protecting group; B = absent or 1-197 naturally occurring amino acids (aa) corresponding to residues 334-530 of the 791 aa human plasminogen (hPA) sequence given in the specification; C = Lys-R2-R3-Asp; R2 = Leu or Arg; R3 = Tyr, 3-iodotyrosinyl (ITyr) or Phe; X = absent or is 1-12 naturally occurring aa corresponding to residues 535-546 of hP and its homologues or analogues; B1 = absent or is 1-176 aa corresponding to residues 334-513 of hP; C1 = the 514-523 aa sequence of hP; X1 = absent or is 1-10 aa corresponding to residues 524-533 of hP.

公开(公告)号：CA2253243A1

公开(公告)日：1997-11-13

申请号：CA2253243

申请日：1997-05-05

Applicant: ABBOTT LAB

Inventor： WANG JIEYI ,  GUBBINS EARL J ,  DAVIDSON DONALD J

IPC: A61K38/00 ,  A61K48/00 ,  C12N9/68 ,  C12N15/57 ,  C07K7/06 ,  C12P21/06 ,  A61K35/12 ,  A61K38/48 ,  A61K47/48 ,  C12N15/62 ,  C12N9/96

Abstract: Mammalian kringle (5) fragments of plasminogen and kringle (5) fusion proteins are disclosed as compounds for treating angiogenic diseases. Methods and compositions for inhibiting angiogenic diseases are also disclosed.