公开(公告)号：JP2009106290A

公开(公告)日：2009-05-21

申请号：JP2008290560

申请日：2008-11-13

Applicant: Abbott Lab ,  Childrens Medical Center Corp ,  アボット・ラボラトリーズAbbott Laboratories ,  ザ・チルドレンズ・メデイカル・センター・コーポレイシヨン

Inventor： DAVIDSON DONALD J ,  WANG JIEYI ,  GUBBINS EARL J ,  CAO YIHAI ,  FOLKMAN JUDAH M ,  O'REILLY MICHAEL S

IPC: C12N15/09 ,  A61K38/00 ,  A61K48/00 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K14/745 ,  C12N5/10 ,  C12N9/68 ,  C12P21/02 ,  C12P21/06

CPC classification number: C12N9/6435 ,  A61K38/00 ,  A61K48/00 ,  C12Y304/21007

Abstract: PROBLEM TO BE SOLVED: To provide a compound useful for the treatment of angiogenic diseases of mammals, especially safe in therapeutic use, and usable as an antiangiogenic agent exhibiting selective toxicity to pathological symptoms e.g. by the selective inhibition of the proliferation of endothelial cells without or scarcely developing toxicity to normal (non-cancer) cells. SOLUTION: Mammalian kringle 5 fragments and kringle 5 fusion proteins are disclosed as compounds for treating angiogenic diseases. Methods and compounds for inhibiting angiogenic diseases are also disclosed. The kringle fragment is expressed by structure formula A-B-C-X-Y (in the formula, A is absent or a nitrogen-protective group; Y is absent or a carboxylic acid protective group; B is a natural amino acid residue; C is expressed by formula R 1 -R 2 -R 3 -R 4 (the groups are lysyl, leucyl or arginyl, tyrosyl, etc., and aspartyl, respectively); and X is absent or a natural amino acid residue or the like). COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 待解决的问题：提供可用于治疗哺乳动物的血管生成疾病的化合物，特别是在治疗用途中安全，并且可用作对病理学症状具有选择性毒性的抗血管生成剂。 通过选择性抑制内皮细胞的增殖而没有或几乎不发展对正常（非癌症）细胞的毒性。 解决方案：公开了哺乳动物kringle 5片段和kringle 5融合蛋白作为治疗血管生成疾病的化合物。 还公开了用于抑制血管生成疾病的方法和化合物。 三环片段由结构式ABCXY表示（在该式中，A不存在或氮保护基; Y不存在或羧酸保护基; B为天然氨基酸残基; C由式R 1 -R 2 -R 3 -R 4 （这些基团是赖氨酰，亮氨酰或精氨酰，酪氨酰等 ，和天冬氨酰基）; X不存在或天然氨基酸残基等）。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：WO2008002956A3

公开(公告)日：2008-07-03

申请号：PCT/US2007072185

申请日：2007-06-27

Applicant: ABBOTT LAB ,  FAGHIH RAMIN ,  GFESSER GREGORY A ,  LYNCH CHRISTOPHER L ,  GOPALAKRISHNAN MURALI ,  GOPALAKRISHNAN SUJATHA ,  MALYSZ JOHN ,  GUBBINS EARL J ,  EL KOUHEN RACHID ,  LI JINHE ,  SARRIS KATHY A ,  MICHMERHUIZEN MELISSA J ,  WANG YING

Inventor： FAGHIH RAMIN ,  GFESSER GREGORY A ,  LYNCH CHRISTOPHER L ,  GOPALAKRISHNAN MURALI ,  GOPALAKRISHNAN SUJATHA ,  MALYSZ JOHN ,  GUBBINS EARL J ,  EL KOUHEN RACHID ,  LI JINHE ,  SARRIS KATHY A ,  MICHMERHUIZEN MELISSA J ,  WANG YING

IPC: C07D417/04 ,  A61K31/422 ,  A61K31/427 ,  C07D413/04 ,  C07D417/14

CPC classification number: C07D417/04 ,  C07D413/04 ,  C07D417/14

Abstract: The invention relates to compounds of formula I selected from compounds. The compounds of formula (I) in treating conditions and disorders that are regulated by the nicotinic acetylcholine receptors.

Abstract translation: 本发明涉及选自化合物的式I化合物。 式（I）化合物在治疗由烟碱乙酰胆碱受体调节的病症和病症中。

公开(公告)号：WO2009003074A9

公开(公告)日：2010-10-28

申请号：PCT/US2008068264

申请日：2008-06-26

Applicant: ABBOTT LAB ,  GOPALAKRISHNAN MURALI ,  LI JINHE ,  CASSAR STEVEN C ,  MALYSZ JOHN ,  ANDERSON DAVID J ,  GUBBINS EARL J ,  BERTRAND DANIEL C

Inventor： GOPALAKRISHNAN MURALI ,  LI JINHE ,  CASSAR STEVEN C ,  MALYSZ JOHN ,  ANDERSON DAVID J ,  GUBBINS EARL J ,  BERTRAND DANIEL C

IPC: C07K14/435

CPC classification number: C07K14/723 ,  C07K14/70571 ,  G01N33/566 ,  G01N2500/04

Abstract: The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of a7 nicotinic acetylcholine receptors.

Abstract translation: 本发明描述了新的胆碱能/ 5-羟色胺能受体嵌合受体，并且提供适合于筛选配体的方法和组合物，所述配体如α7烟碱乙酰胆碱受体的激动剂，拮抗剂和变构调节剂。

公开(公告)号：WO2009003074A2

公开(公告)日：2008-12-31

申请号：PCT/US2008068264

申请日：2008-06-26

Applicant: ABBOTT LAB ,  GOPALAKRISHNAN MURALI ,  LI JINHE ,  CASSAR STEVEN C ,  MALYSZ JOHN ,  ANDERSON DAVID J ,  GUBBINS EARL J ,  BERTRAND DANIEL C

Inventor： GOPALAKRISHNAN MURALI ,  LI JINHE ,  CASSAR STEVEN C ,  MALYSZ JOHN ,  ANDERSON DAVID J ,  GUBBINS EARL J ,  BERTRAND DANIEL C

IPC: C07K14/435

CPC classification number: C07K14/723 ,  C07K14/70571 ,  G01N33/566 ,  G01N2500/04

Abstract: The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of a7 nicotinic acetylcholine receptors.

Abstract translation: 本发明描述了新的胆碱能/ 5-羟色胺能受体嵌合受体，并且提供适合于筛选配体的方法和组合物，所述配体如α7烟碱乙酰胆碱受体的激动剂，拮抗剂和变构调节剂。

公开(公告)号：WO2009003074A8

公开(公告)日：2009-07-16

申请号：PCT/US2008068264

申请日：2008-06-26

Applicant: ABBOTT LAB ,  GOPALAKRISHNAN MURALI ,  LI JINHE ,  CASSAR STEVEN C ,  MALYSZ JOHN ,  ANDERSON DAVID J ,  GUBBINS EARL J ,  BERTRAND DANIEL C

Inventor： GOPALAKRISHNAN MURALI ,  LI JINHE ,  CASSAR STEVEN C ,  MALYSZ JOHN ,  ANDERSON DAVID J ,  GUBBINS EARL J ,  BERTRAND DANIEL C

IPC: C07K14/435

CPC classification number: C07K14/723 ,  C07K14/70571 ,  G01N33/566 ,  G01N2500/04

Abstract: The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of a7 nicotinic acetylcholine receptors.

Abstract translation: 本发明描述了新的胆碱能/ 5-羟色胺能受体嵌合受体，并且提供适合于筛选配体的方法和组合物，所述配体如α7烟碱乙酰胆碱受体的激动剂，拮抗剂和变构调节剂。

公开(公告)号：WO9741824A2

公开(公告)日：1997-11-13

申请号：PCT/US9707700

申请日：1997-05-05

Applicant: ABBOTT LAB

Inventor： DAVIDSON DONALD J ,  WANG JIEYI ,  GUBBINS EARL J

IPC: C12N15/09 ,  A61K20060101 ,  A61K35/14 ,  A61K38/00 ,  A61K38/04 ,  A61K38/48 ,  A61K39/00 ,  A61K45/00 ,  A61K48/00 ,  A61K101/00 ,  A61P1/04 ,  A61P15/18 ,  A61P17/06 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K1/00 ,  C07K14/00 ,  C07K14/47 ,  C07K14/515 ,  C07K19/00 ,  C12N20060101 ,  C12N9/68 ,  C12N15/02 ,  C12N15/57 ,  C12P21/06 ,  A61K

CPC classification number: C12N9/6435 ,  A61K38/00 ,  A61K48/00 ,  C12Y304/21007

Abstract: Mammalian kringle (5) fragments and kringle (5) fusion proteins are disclosed as compounds for treating angiogenic diseases. Methods and compositions for inhibiting angiogenic diseases are also disclosed.

Abstract translation: 公开了哺乳动物kringle（5）片段和kringle（5）融合蛋白作为治疗血管生成疾病的化合物。 还公开了用于抑制血管生成疾病的方法和组合物。

公开(公告)号：MX2008016336A

公开(公告)日：2009-01-16

申请号：MX2008016336

申请日：2007-06-27

Applicant: ABBOTT LAB

Inventor： FAGHIH RAMIN ,  GFESSER GREGORY A ,  LYNCH CHRISTOPHER L ,  GOPALAKRISHNAN MURALI ,  GOPALAKRISHNAN SUJATHA ,  MALYSZ JOHN ,  GUBBINS EARL J ,  KOUHEN RACHID EL ,  LI JINHE ,  SARRIS KATHY A ,  MICHMERHUIZEN MELISSA J ,  WANG YING

IPC: C07D417/04 ,  A61K31/422 ,  A61K31/427 ,  C07D413/04 ,  C07D417/14

Abstract: La invención se refiere a una serie de derivados de tiazolina y oxazolina, composiciones de los mismos, y métodos para tratar condiciones y trastornos utilizando dichos compuestos.

公开(公告)号：DK0910571T3

公开(公告)日：2005-10-31

申请号：DK97925478

申请日：1997-05-05

Applicant: ABBOTT LAB

Inventor： DAVIDSON DONALD J ,  WANG JIEYI ,  GUBBINS EARL J

IPC: C12N15/09 ,  A61K20060101 ,  A61K35/14 ,  A61K38/00 ,  A61K38/04 ,  A61K38/48 ,  A61K39/00 ,  A61K45/00 ,  A61K48/00 ,  A61K101/00 ,  A61P1/04 ,  A61P15/18 ,  A61P17/06 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K1/00 ,  C07K14/00 ,  C07K14/47 ,  C07K14/515 ,  C07K19/00 ,  C12N20060101 ,  C12N9/68 ,  C12N15/02 ,  C12N15/57 ,  C12P21/06

Abstract: Compounds of formulae (I) and (II), and their salts, esters and prodrugs, are new: A-B-C-X-Y (I); A-B1-C1-X1-Y (II); A = absent or a nitrogen-protecting group; Y = absent or a carboxy-protecting group; B = absent or 1-197 naturally occurring amino acids (aa) corresponding to residues 334-530 of the 791 aa human plasminogen (hPA) sequence given in the specification; C = Lys-R2-R3-Asp; R2 = Leu or Arg; R3 = Tyr, 3-iodotyrosinyl (ITyr) or Phe; X = absent or is 1-12 naturally occurring aa corresponding to residues 535-546 of hP and its homologues or analogues; B1 = absent or is 1-176 aa corresponding to residues 334-513 of hP; C1 = the 514-523 aa sequence of hP; X1 = absent or is 1-10 aa corresponding to residues 524-533 of hP.

公开(公告)号：BRPI0712667A2

公开(公告)日：2012-09-04

申请号：BRPI0712667

申请日：2007-06-27

Applicant: ABBOTT LAB

Inventor： FAGHIH RAMIN ,  GFESSER GREGORY A ,  LYNCH CHRISTOPHER L ,  GOPALAKRISHNAN MURALI ,  GOPALAKRISHNAN SUJATHA ,  MALYSZ JOHN ,  GUBBINS EARL J ,  EL KOUHEN RACHID ,  LI JINHE

IPC: C07D207/34 ,  A61K31/402 ,  A61P25/00 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10

Abstract: The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：CA2253243C

公开(公告)日：2010-04-06

申请号：CA2253243

申请日：1997-05-05

Applicant: ABBOTT LAB ,  CHILDRENS MEDICAL CENTER

Inventor： DAVIDSON DONALD J ,  WANG JIEYI ,  GUBBINS EARL J ,  CAO YIHAI ,  FOLKMAN M JUDAH ,  O'REILLY MICHAEL S

IPC: C12N15/57 ,  A61K35/12 ,  A61K38/00 ,  A61K38/48 ,  A61K47/48 ,  A61K48/00 ,  C07K7/06 ,  C12N9/68 ,  C12N9/96 ,  C12N15/62 ,  C12P21/06

Abstract: Mammalian kringle (5) fragments of plasminogen and kringle (5) fusion proteins are disclosed as compounds for treating angiogenic diseases. Methods and compositions for inhibiting angiogenic diseases are also disclosed.