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    32.
    发明专利
    未知

    公开(公告)号：DE3829850A1

    公开(公告)日：1990-03-15

    申请号：DE3829850

    申请日：1988-09-02

    Applicant: BASF AG

    Inventor： PAUST JOACHIM DR ,  ERNST HANSGEORG DR

    IPC: C07D239/42

    Abstract: In an improved process for the preparation of 2-n-propyl-4-amino-5-methoxymethyl-pyrimidine of the formula I I by reacting butyramidine II II with alpha -methoxymethyl- beta -methoxyacrylonitrile III III the butyramidine II is reacted with a 0.4-5 molar excess of alpha -methoxymethyl- beta -methoxyacrylonitrile III at from -10 DEG to +20 DEG C.

    PROCESS FOR THE PREPARATION OF ALPHA-TOCOPHEROL
    34.
    发明专利
    PROCESS FOR THE PREPARATION OF ALPHA-TOCOPHEROL 未知

    公开(公告)号：DE3465992D1

    公开(公告)日：1987-10-15

    申请号：DE3465992

    申请日：1984-03-07

    Applicant: BASF AG

    Inventor： ERNST HANSGEORG DR ,  GEHRKEN HENNING-PETER DR ,  PAUST JOACHIM DR

    IPC: C07D317/60 ,  B01J31/16 ,  C07B61/00 ,  C07D311/72

    Abstract: A process for the preparation of alpha -tocopherol of the formula I (I) by reacting a chroman derivative with a C14-Grignard reagent using a di-alkali metal tetrahalocuprate catalyst in a Schlosser-Fouquet reaction, wherein a chroman derivative of the general formula II (II) where Y is a leaving group, especially Br, is used and is reacted, at from -70 DEG to 0 DEG C., first with a solution of about 1 equivalent of a Grignard compound of the general formula III X-Mg-R (III) where X is Cl, Br or I and R is straight-chain or branched alkyl of 1 to 14 carbon atoms, preferably methyl, ethyl or and then with a solution of a Grignard reagent of the formula IIIa (IIIa) in an ether solvent and a solution of a di-alkali metal tetrahalocuprate in an ether solvent. The novel process simplifies the preparation of 2RS,4'RS,8'RS-, 2R,4'RS,8'RS- or 2R,4'R,8'R- alpha -tocopherol by reacting a chroman structural unit, containing a C2 side-chain in the 2-position, with the corresponding C14-Grignard compound.

    35.
    发明专利
    未知

    公开(公告)号：DE3417944A1

    公开(公告)日：1985-11-21

    申请号：DE3417944

    申请日：1984-05-15

    Applicant: BASF AG

    Inventor： ERNST HANSGEORG DR ,  ECKHARDT HEINZ DR ,  PAUST JOACHIM DR

    IPC: C07C67/00 ,  C07C241/00 ,  C07C245/08 ,  C07D475/14

    Abstract: An improved process for the preparation of riboflavin by condensation of a 4,5-dimethyl-N-(D)-ribityl-2-phenylazoaniline derivative with barbituric acid in the presence of an acidic condensing agent in an organic solvent, wherein a 4,5-dimethyl-N-(D)-ribityl-2-(o-alkoxyphenylazo)-aniline of the formula IIa where R is alkyl of 1 to 4 carbon atoms, in particular methyl, is reacted with barbituric acid, as well as the novel intermediates of the formula IIa.

    36.
    发明专利
    未知

    公开(公告)号：DE3309159A1

    公开(公告)日：1984-09-20

    申请号：DE3309159

    申请日：1983-03-15

    Applicant: BASF AG

    Inventor： GEHRKEN HENNING-PETER DR ,  ERNST HANSGEORG DR ,  PAUST JOACHIM DR

    IPC: C07D311/58 ,  C07D311/72

    Abstract: Novel optically active chroman derivatives of the general formulae Ia and Ib (Ia) (Ib) where R1, R2, R3 and R4 are each hydrogen or alkyl and X is -OH, -O-CO-alkyl, -O-alkyl, -O-tosyl, -O-mesyl, -O-benzenesulfonyl, Cl, Br or I, are prepared by a process in which (a) the racemate of the formula I' (I') is esterified in the side chain with a carboxylic acid and then acylated with an optically active carboxylic acid halide of the general formula III (III) or with the corresponding carboxylic anhydride, to give a chroman derivative IV (IV) or (b) the racemate I' is esterified in the side chain with the carboxylic acid from which III is derived, and, if required, the resulting ester is acylated with a carboxylic acid halide to give IV' (IV') the resulting mixture IV or IV', which consists of two diastereomers, is resolved by fractional crystallization, the diastereomers are hydrolyzed to the alcohols Ia and Ib and, if desired, these are converted to the other compounds Ia and Ib in a conventional manner. Useful optically active chroman derivatives Ia and Ib and diastereomeric chromanyl esters IV and IV' are also claimed.

    38.
    发明专利
    未知

    公开(公告)号：DK1078916T3

    公开(公告)日：2003-01-06

    申请号：DK00115618

    申请日：2000-07-20

    Applicant: BASF AG

    Inventor： PAUST JOACHIM DR ,  ERNST HANSGEORG DR ,  KACZMAREK REINHARD DR ,  JAEDICKE HAGEN DR

    IPC: C07B61/00 ,  C07C231/08 ,  C07C233/18 ,  C07C233/47 ,  C07C233/69 ,  C07C233/83

    Abstract: Preparation of N-acyl derivatives (I) using readily available starting materials. N-acyl derivatives of formula R -C(O)N(H)C(R )X (I) are prepared by reacting, in the presence of a compound of formula R -COOH (II), a carbonic acid amide of formula R -CONH2 (III) and a glyoxalmonoacetal derivative of formula R C(O)C(OR )OR (IV). R , R = H or optionally substituted alkyl or aryl; R ,R = 1 - 12C alkyl; and X = CH(OR ) or COOR . An Independent claim is also included for a compound of formula R -C(O)N(H)C(R )C(OR )OR (V).

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