公开(公告)号：ZA200200816B

公开(公告)日：2004-10-27

申请号：ZA200200816

申请日：2002-01-30

Applicant: BASF AG

Inventor： HABERHAUER GREGOR ,  KROEGER BURKHARD ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  ZELDER OSKAR

IPC: C12N20060101 ,  C12P20060101 ,  C12N ,  C12P

公开(公告)号：BR0214056A

公开(公告)日：2004-10-13

申请号：BR0214056

申请日：2002-11-11

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  POMPEJUS MARKUS ,  SCHRÖDER HARTWIG ,  KRÖGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

IPC: C12N1/21 ,  C12N9/04 ,  C12N15/53 ,  C12P13/08

Abstract: Isolated nucleic acid (I) that encodes a glucose-6-phosphate dehydrogenase (II) from Corynebacterium glutamicumin which Ala at position 243 has been replaced by some other amino acid, specifically Thr, is new. Independent claims are also included for the following: (1) Vector (V) that contains (I); (2) Host cell (C) transfected with (V); and (3) Preparing fine chemicals by culturing (C).

公开(公告)号：BR0213773A

公开(公告)日：2004-10-13

申请号：BR0213773

申请日：2002-10-31

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  POMPEJUS MARKUS ,  DER HARTWIG SCHR ,  GER BURKHARD KR ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

IPC: C12N1/21 ,  C12N9/00 ,  C12P13/08 ,  C12N15/52

Abstract: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.

公开(公告)号：HU0301136A2

公开(公告)日：2003-08-28

申请号：HU0301136

申请日：2000-06-23

Applicant: BASF AG

Inventor： HABERHAUER GREGOR ,  KROEGER BURKHARD ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  ZELDER OSKAR

IPC: C12N15/31

Abstract: An isolated nucleic acid (I) from Corynebacterium glutamicum encoding a sugar metabolism and oxidative phosphorylation (SMP) protein, or a portion of it, providing that the nucleic acid does not consist of any of the F-designated genes, given in the specification, is new. Independent claims are also included for the following: (1) an isolated C. glutamicum nucleic acid that comprises one of 391 sequences (A), given in the specification, or a portion of it, providing the nucleic acid does not consist of any of the F-designated genes; (2) an isolated nucleic acid which encodes a polypeptide with one of 391 sequences (B), given in the specification, providing the nucleic acid does not consist of any of the F-designated genes; (3) an isolated nucleic acid which encodes a naturally occurring allelic variant of a polypeptide with a sequence of (B), providing that the nucleic acid does not consist of any of the F-designated genes; (4) an isolated nucleic acid comprising a nucleotide which is 50 % homologous to a nucleotide sequence of (A) or a portion of it, providing the nucleic acid does not consist of any of the F-designated genes; (5) an isolated nucleic acid comprising a fragment of 15 nucleotides of a nucleic acid with a sequence of (A), providing the nucleic acid does not consist of any of the F-designated genes; (6) an isolated nucleic acid which hybridizes (I) or (1) - (5) under stringent conditions; (7) an isolated nucleic acid comprising (I) or (1) - (6) or a portion of them and a nucleotide sequence encoding a heterologous polypeptide; (8) a vector comprising (I) or (1) - (7); (9) a host cell transfected with (8); (10) producing a polypeptide comprising culturing (9); (11) an isolated SMP polypeptide from C. glutamicum, or a portion of it; (12) an isolated polypeptide comprising an amino acid sequence of (B), providing that the sequence is not encoded by any of the F-designated genes; (13) an isolated polypeptide which is encoded by a nucleic acid comprising a nucleotide sequence that is 50 % homologous to a sequence of (A), providing that the nucleic acid does not consist of any of the F-designated nucleic acids; (14) an isolated polypeptide comprising an amino acid sequence which is 50 % homologous to a sequence of (B), providing the sequence is not encoded by any of the F-designated genes; (15) producing a fine chemical comprising culturing a cell containing (8); (16) producing a fine chemical comprising culturing a cell whose genomic DNA has been altered by the inclusion of (I) or (1) - (7); (17) diagnosing for the presence or activity of C. diphtheriae in a subject comprising detecting the presence of one of (A) or (B), providing the sequences are not or are not encoded by any of the F-designated sequences; (18) a host cell comprising a nucleic acid of (A), where the nucleic acid has been disrupted; (19) a host cell comprising a nucleic acid of (A), where the nucleic acid comprises a nucleic acid modification; and (20) a host comprising a nucleic acid of (A), where the regulatory region is modified relative to the wild-type regulatory region of the molecule.

公开(公告)号：AU2002365499A1

公开(公告)日：2003-06-10

申请号：AU2002365499

申请日：2002-10-31

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  SCHRODER HARTWIG ,  KROGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR ,  ZELDER OSKAR

IPC: C12N15/11 ,  C07K14/34 ,  C12N1/21 ,  C12N15/63 ,  C12P13/08

Abstract: Isolated nucleic acid (I) that encodes particular protein sequences (II) that have, at specific positions, an amino acid alteration. Independent claims are also included for: (1) Vector that contains at least one (I); (2) Host cell transfected with at least one vector of (1); and (3) Method for preparing fine chemicals by culturing cells of (2).

公开(公告)号：DE10154245A1

公开(公告)日：2003-06-05

申请号：DE10154245

申请日：2001-11-05

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  KROEGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

IPC: C07H21/04 ,  C07K14/34 ,  C12N1/21 ,  C12N9/12 ,  C12N9/16 ,  C12N9/90 ,  C12N15/31 ,  C12P13/08 ,  C12R1/15 ,  C12N15/11 ,  C12N15/77 ,  C12P13/04

Abstract: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.

公开(公告)号：DE10155505A1

公开(公告)日：2003-05-22

申请号：DE10155505

申请日：2001-11-13

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  KROEGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

IPC: C12N1/21 ,  C12N9/04 ,  C12N15/53

Abstract: The invention relates to an isolated nucleic acid molecule coding for a polypeptide comprising the amino acid sequence which is respectively referred to in table 1/column 2. Said nucleic acid molecule which is in the amino acid position indicated in table 1/column 4 codes for a different proteinogenous amino acid to the one which is indicated on the same line in table 1/column 5.

公开(公告)号：AU2002346807A1

公开(公告)日：2003-05-19

申请号：AU2002346807

申请日：2002-10-31

Applicant: BASF AG

Inventor： SCHRODER HARTWIG ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  POMPEJUS MARKUS ,  KROGER BURKHARD ,  HABERHAUER GREGOR

IPC: C12N1/21 ,  C12N15/52 ,  C12N15/77 ,  C12P13/08 ,  C12N15/01 ,  C12N9/00 ,  C12R1/15 ,  C07K14/34

Abstract: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.

公开(公告)号：DE10154292A1

公开(公告)日：2003-05-15

申请号：DE10154292

申请日：2001-11-05

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  KROEGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

IPC: C12N1/21 ,  C12N15/52 ,  C12N15/77 ,  C12P13/08 ,  C12N15/11 ,  C12P13/04

Abstract: The invention relates to novel nucleic acid molecules, the use thereof in the construction of bio-engineering improved microorganisms and methods for the production of fine chemicals, especially amino acids with the aid of said bio-engineered improved microorganisms.

公开(公告)号：DE10154246A1

公开(公告)日：2003-05-08

申请号：DE10154246

申请日：2001-11-05

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  POMPEJUS MARKUS ,  SCHROEDER HARTWIG ,  KROEGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR

IPC: C12N1/21 ,  C12N15/52 ,  C12P13/04 ,  C12N15/11 ,  C12N15/77 ,  C12P13/08

Abstract: The invention concerns novel nucleic acid molecules, the use of said molecules for producing by recombination genetically improved micro-organisms, and a method for preparing fine chemical products, in particular amino acids, using said genetically improved micro-organisms.