公开(公告)号：ES2259703T3

公开(公告)日：2006-10-16

申请号：ES02719954

申请日：2002-02-28

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROGER BURKHARD ,  SCHRODER HARTWIG ,  ZELDER OSKAR

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/10 ,  C12N15/54 ,  C12N15/77 ,  C12R1/13

Abstract: Vector de tipo plásmido, que no se replica en las cepas bacterias del género Brevibacterium o Corynebacterium, con los componentes siguientes: a) un origen de replicación para E. coli, b) uno o varios marcadores genéticos, c) opcionalmente un fragmento de secuencia, que posibilita la transferencia del DNA mediante conjugación (mob), d) un fragmento de secuencia, que es homólogo a las secuencias de las cepas bacterianas del género Brevibacterium o Corynebacterium y que proporcionan una recombinación homóloga en estas cepas bacterianas, e) el gen sacB procedente de B. amyloliquefaciens bajo el control de un promotor.

公开(公告)号：NO20062685L

公开(公告)日：2006-09-14

申请号：NO20062685

申请日：2006-06-09

Applicant: BASF AG

Inventor： KROGER BURKHARD ,  ZELDER OSKAR ,  SCHRODER HARTWIG ,  HAFNER STEFAN ,  KIEFER PATRICK ,  WITTMANN CHRISTOPH ,  KLOPPROGGE CORINNA ,  HEINZLE ELMAR

IPC: C12P13/08 ,  C12N9/04

Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., lactate dehydrogenase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of the expression of lactate dehydrogenase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.

公开(公告)号：NO20062685A

公开(公告)日：2006-09-14

申请号：NO20062685

申请日：2006-06-09

Applicant: BASF AG

Inventor： KROGER BURKHARD ,  ZELDER OSKAR ,  SCHRODER HARTWIG ,  HAFNER STEFAN ,  KIEFER PATRICK ,  WITTMANN CHRISTOPH ,  KLOPPROGGE CORINNA ,  HEINZLE ELMAR

IPC: C12P13/08 ,  C12N9/04

CPC classification number: C12N9/0006 ,  C12P13/08

公开(公告)号：AU2006200807A1

公开(公告)日：2006-03-23

申请号：AU2006200807

申请日：2006-02-24

Applicant: BASF AG

Inventor： HABERHAUER GREGOR ,  SCHRODER HARTWIG ,  POMPEJUS MARKUS ,  ZELDER OSKAR ,  KROGER BURKHARD

IPC: C12N15/31 ,  C07K14/34 ,  C12N1/21 ,  C12N9/90 ,  C12N15/61 ,  C12P13/08 ,  C12Q1/68

公开(公告)号：AU783706B2

公开(公告)日：2005-11-24

申请号：AU5420500

申请日：2000-06-23

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROGER BURKHARD ,  SCHRODER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: C12N15/09 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/21 ,  C12N9/00 ,  C12N9/02 ,  C12N9/18 ,  C12N15/31 ,  C12N15/52 ,  C12P20060101 ,  C12P13/04 ,  C12P21/02 ,  C12Q20060101 ,  C12R1/15

Abstract: Isolated nucleic acid molecules, designated HA nucleic acid molecules, which encode novel HA proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HA nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated HA proteins, mutated HA proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of HA genes in this organism.

公开(公告)号：AU2003229691A8

公开(公告)日：2003-10-27

申请号：AU2003229691

申请日：2003-04-16

Applicant: BASF AG

Inventor： HAFNER STEFAN ,  KLOPPROGGE CORINNA ,  SCHRODER HARTWIG ,  ZELDER OSKAR ,  KROGER BURKHARD

IPC: A23K1/00 ,  A23K1/16 ,  C12N1/15 ,  C12N9/10 ,  C12N15/09 ,  C12P11/00 ,  C12P13/12 ,  C12R1/15 ,  C12N15/63

Abstract: The invention relates to methods for the fermentative production of sulfur-containing fine chemicals, in particular L-methionine, by using bacteria which express a nucleotide sequence coding for a methionine synthase (metH) gene.

公开(公告)号：AU2002365499A1

公开(公告)日：2003-06-10

申请号：AU2002365499

申请日：2002-10-31

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  SCHRODER HARTWIG ,  KROGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR ,  ZELDER OSKAR

IPC: C12N15/11 ,  C07K14/34 ,  C12N1/21 ,  C12N15/63 ,  C12P13/08

Abstract: Isolated nucleic acid (I) that encodes particular protein sequences (II) that have, at specific positions, an amino acid alteration. Independent claims are also included for: (1) Vector that contains at least one (I); (2) Host cell transfected with at least one vector of (1); and (3) Method for preparing fine chemicals by culturing cells of (2).

公开(公告)号：AU2002346807A1

公开(公告)日：2003-05-19

申请号：AU2002346807

申请日：2002-10-31

Applicant: BASF AG

Inventor： SCHRODER HARTWIG ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  POMPEJUS MARKUS ,  KROGER BURKHARD ,  HABERHAUER GREGOR

IPC: C12N1/21 ,  C12N15/52 ,  C12N15/77 ,  C12P13/08 ,  C12N15/01 ,  C12N9/00 ,  C12R1/15 ,  C07K14/34

Abstract: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.

公开(公告)号：AU2002251038A1

公开(公告)日：2002-09-19

申请号：AU2002251038

申请日：2002-02-28

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  KROGER BURKHARD ,  POMPEJUS MARKUS ,  SCHRODER HARTWIG

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/10 ,  C12N15/54 ,  C12N15/77 ,  C12R1/13 ,  C12N15/90

Abstract: The invention relates to a novel method for modifying the genome of Gram-positive bacteria, to these bacteria and to novel vectors. The invention particularly relates to a method for modifying corynebacteria or brevibacteria with the aid of a novel marker gene which has a conditionally negatively dominant action in the bacteria.

公开(公告)号：ID27819A

公开(公告)日：2001-04-26

申请号：ID20002542

申请日：1999-06-04

Applicant: BASF AG

Inventor： KOCK MICHAEL ,  HOGER THOMAS ,  KROGER BURKHARD ,  OTTERBACH BERND ,  LUBISCH WILFRIED ,  LEMAIRE HANS GEORG

IPC: A01K67/027 ,  A61K38/00 ,  A61K38/45 ,  A61K48/00 ,  A61K49/00 ,  A61P43/00 ,  C07K14/455 ,  C12N1/15 ,  C12N1/19 ,  C12N5/10 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12Q1/68 ,  G01N33/53 ,  C12N15/10 ,  A61K31/70

Abstract: The invention relates to poly(ADP-ribose)polymerase (PARP) homologs which have an amino acid sequence which has a) a functional NAD+ binding domain and b) no zinc finger sequence motif of the general formula CX2CXmHX2C in which m is an integral value from 28 or 30, and the X radicals are, independently of one another, any amino acid; and the functional equivalents thereof; nucleic acids coding therefor; antibodies with specificity for the novel protein; pharmaceutical and gene therapy compositions which comprise products according to the invention; methods for the analytical determination of the proteins and nucleic acids according to the invention; methods for identifying effectors or binding partners of the proteins according to the invention; novel PARP effectors; and methods for determining the activity of such effectors.