公开(公告)号：CA2372704A1

公开(公告)日：2000-11-16

申请号：CA2372704

申请日：2000-05-03

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  SADOWSKI JENS ,  HOGER THOMAS ,  KOCK MICHAEL

IPC: C07D237/32 ,  A61K31/502 ,  A61P1/10 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P17/02 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/10 ,  A61P25/12 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  A61P41/00 ,  A61P43/00 ,  C07D401/12 ,  C07D403/12 ,  A61K31/00

Abstract: The invention relates to the use of phthalazine derivatives as inhibitors of the enzyme poly(ADP-ribose)polymerase or PARP (EC 2.4.2.30), and to their us e as inhibitors of PARP-homologous enzymes. These phthalazine derivatives also exhibit, in particular, a selective inhibition of the PARP-homologous enzyme s.

公开(公告)号：AU3965900A

公开(公告)日：2000-11-10

申请号：AU3965900

申请日：2000-04-11

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  KOCK MICHAEL ,  HOGER THOMAS ,  GRANDEL ROLAND ,  SCHULT SABINE ,  MULLER REINHOLD

IPC: C07D235/08 ,  A61K31/4184 ,  A61K31/4427 ,  A61K31/4523 ,  A61K31/496 ,  A61K31/551 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D235/10 ,  C07D235/12 ,  C07D235/14 ,  C07D235/16 ,  C07D401/08 ,  C07D403/08 ,  C07D235/06

Abstract: Compounds of the formula I or IIand their tautomeric forms, possible enantiomeric and diastereomeric forms, possible cistrans isomers on the rings in A and prodrugs thereof, pharmaceutical compositions containing these compounds and methods of treating neurodegenerative diseases or neuronal damage with these compounds.

公开(公告)号：AU3034300A

公开(公告)日：2000-06-19

申请号：AU3034300

申请日：1999-11-23

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  KOCK MICHAEL ,  HOGER THOMAS ,  SCHULT SABINE ,  GRANDEL ROLAND ,  MULLER REINHOLD

IPC: A61K20060101 ,  A61K31/4184 ,  A61K31/454 ,  A61K31/496 ,  A61P20060101 ,  A61P3/12 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P17/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07D20060101 ,  C07D235/30 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04

Abstract: Compounds of the formula Ia or IB where A is a saturated or monounsaturated heterocyclic, 4 - to 8-membered ring which contains one or two nitrogen atoms, and their tautomeric forms, possible enantiomeric and diastereomeric forms, their prodrugs and possible physiologically tolerated salts are useful as inhibitors of the enzyme poly(ADP-ribose)polymerase.

公开(公告)号：CA2352554A1

公开(公告)日：2000-06-08

申请号：CA2352554

申请日：1999-11-23

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  KOCK MICHAEL ,  SCHULT SABINE ,  MULLER REINHOLD ,  GRANDEL ROLAND ,  HOGER THOMAS

IPC: A61K20060101 ,  A61K31/4184 ,  A61K31/454 ,  A61K31/496 ,  A61P20060101 ,  A61P3/12 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P17/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07D20060101 ,  C07D235/30 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04

Abstract: The invention relates to compounds of general formula (1a) or (1b) wherein R 1 and R4 are hydrogen or defined substituents, A is a saturated or monoethenoi d heterocyclic ring with 4 to 8 members which contains one or two nitrogen atoms, wherein additionally one oxygen or sulfur atom can be present. Said ring can be further substituted. The invention also relates to their tautome r forms, possible enantiomer and diastereomer forms, their prodrugs, as well a s possible physiologically acceptable salts. The invention also relates to the use of said compounds for treating diseases related to a pathologically increased activity of PARP.

公开(公告)号：CA2349227A1

公开(公告)日：2000-05-11

申请号：CA2349227

申请日：1999-10-28

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  KOCK MICHAEL ,  HOGER THOMAS

IPC: G01N33/53 ,  A61K31/00 ,  A61K31/4184 ,  A61K31/4427 ,  A61K31/454 ,  A61K31/496 ,  A61K31/55 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P25/08 ,  A61P25/10 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07C237/30 ,  C07D235/18 ,  C07D401/10 ,  C07D403/10 ,  C07D521/00 ,  C12Q1/48 ,  G01N33/00 ,  G01N33/15 ,  G01N33/573 ,  G01N33/577

Abstract: The invention relates to novel 2-phenylbenzimidazoles of general formula (I) or (II), wherein the radicals have the meanings cited in the description, an d to their tautomeric forms, possible enantiomeric and diastereomeric forms, t o their prodrugs, and to possible physiologically compatible salts. The invention also relates to the production of said compounds and to their use.

公开(公告)号：NZ290426A

公开(公告)日：1998-02-26

申请号：NZ29042695

申请日：1995-07-21

Applicant: BASF AG

Inventor： STEINER GERD ,  MUNSCHAUER RAINER ,  HOGER THOMAS ,  UNGER LILIANE ,  TESCHENDORF HANS-JURGEN

IPC: C07D401/06 ,  A61K31/40 ,  A61K31/415 ,  A61K31/47 ,  A61K31/505 ,  A61P25/18 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D513/04

Abstract: PCT No. PCT/EP95/02893 Sec. 371 Date Sep. 18, 1997 Sec. 102(e) Date Sep. 18, 1997 PCT Filed Jul. 21, 1995 PCT Pub. No. WO96/04272 PCT Pub. Date Feb. 15, 1996N-substitued 3-azabicyclo[3.2.0]heptane derivatives of formula (I) in which R1, R2, A, X, Y and Z have the meanings given in the description, their method of preparation and their use as pharmacological agents.

公开(公告)号：AU680583B2

公开(公告)日：1997-07-31

申请号：AU1240395

申请日：1994-11-26

Applicant: BASF AG

Inventor： STEINER GERD ,  MUNSCHAUER RAINER ,  UNGER LILIANE ,  TESCHENDORF HANS-JURGEN ,  HOGER THOMAS

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61P21/02 ,  A61P25/08 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D209/14 ,  C07D209/18 ,  C07D209/44 ,  C07D209/52 ,  C07D487/04 ,  C07D491/048 ,  C07D497/04

Abstract: PCT No. PCT/EP94/03913 Sec. 371 Date Jun. 6, 1996 Sec. 102(e) Date Jun. 6, 1996 PCT Filed Nov. 26, 1994 PCT Pub. No. WO95/15327 PCT Pub. Date Jun. 8, 1995Compounds of the formula I I where B, R1, R2, n and A have the meanings given in the description, and their preparation are described. The novel compounds are suitable for the control of diseases.

公开(公告)号：SK285529B6

公开(公告)日：2007-03-01

申请号：SK7142001

申请日：1999-11-23

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  KOCK MICHAEL ,  HOGER THOMAS ,  SCHULT SABINE ,  GRANDEL ROLAND ,  MULLER REINHOLD

IPC: C07D235/00 ,  A61K20060101 ,  A61K31/00 ,  A61K31/4184 ,  A61K31/454 ,  A61K31/496 ,  A61P20060101 ,  A61P3/12 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P17/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07D20060101 ,  C07D235/30 ,  C07D401/00 ,  C07D401/04 ,  C07D401/14 ,  C07D403/00 ,  C07D403/04

Abstract: The invention relates to compounds of the general formula (Ia) or (Ib), wherein A is a saturated or monounsaturated heterocyclic ring with 4 to 8 members which contains one or two nitrogen atoms, and their tautomeric forms, possible enantiomeric and diastereomeric forms, as well as possible physiologically acceptable salts and their use for treating diseases related to a pathologically increased activity of PARP.

公开(公告)号：PL354118A1

公开(公告)日：2003-12-29

申请号：PL35411800

申请日：2000-09-15

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  KOCK MICHAEL ,  HOGER THOMAS ,  GRANDEL ROLAND ,  MULLER REINHOLD ,  SCHULT SABINE

IPC: A61K31/5517 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P11/00 ,  A61P13/12 ,  A61P17/02 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/10 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/04 ,  A61P37/02 ,  A61P43/00 ,  C07D487/06 ,  C07D519/00 ,  C07D487/00

公开(公告)号：NZ510042A

公开(公告)日：2003-08-29

申请号：NZ51004299

申请日：1999-07-20

Applicant: BASF AG

Inventor： JUCHELKA FRIEDER ,  STEINER GERD ,  HOGER THOMAS ,  UNGER LILIANE ,  TESCHENDORF HANS-JORGEN

IPC: A61K31/425 ,  A61K31/428 ,  A61P25/00 ,  C07D417/06

Abstract: An N substituted 3 azabicyclo[3.2.0]heptane derivative or a salt thereof useful as a neuroleptic, antidepressant, sedative or hypnotic has the formula (I) wherein: R1 is F or Cl; R2 and R3 are independently H or alkyl and R4 is Cl, CH3, NO2 or NH2.