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公开(公告)号：WO0067734A3
公开(公告)日：2002-06-20
申请号：PCT/EP0003967
申请日：2000-05-03
Applicant: BASF AG , LUBISCH WILFRIED , SADOWSKI JENS , KOCK MICHAEL , HOEGER THOMAS
Inventor： LUBISCH WILFRIED , SADOWSKI JENS , KOCK MICHAEL , HOEGER THOMAS
IPC: C07D237/32 , A61K31/502 , A61P1/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P17/02 , A61P19/02 , A61P25/00 , A61P25/08 , A61P25/10 , A61P25/12 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/04 , A61P37/00 , A61P41/00 , A61P43/00 , C07D401/12 , C07D403/12 , A61K31/495
CPC classification number: A61K31/502
Abstract: The invention relates to the use of phthalazine derivatives as inhibitors of the enzyme poly(ADP-ribose)polymerase or PARP (EC 2.4.2.30), and to their use as inhibitors of PARP-homologous enzymes. These phthalazine derivatives also exhibit, in particular, a selective inhibition of the PARP-homologous enzymes. The inventive phthalazine derivatives are used for producing medicaments used in the treatment of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, stroke, cerebral trauma, epilepsy, damages to the kidney, cardiovascular diseases, tumors, rheumatic diseases, diabetes mellitus, etc.
Abstract translation: 本发明涉及使用酞嗪衍生物作为酶聚聚合酶或（ADP-核糖）的PARP抑制剂（EC 2.4.2.30），如PARP-同源酶的抑制剂，并且特别在使用中，这些酞嗪衍生物也显示出选择性抑制 的PARP-同源酶。 在使用用于制造药物的神经变性疾病如阿尔茨海默氏病，帕金森氏病，中风，脑外伤，癫痫症，肾损伤，心血管疾病，肿瘤，风湿性疾病，糖尿病等的治疗
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公开(公告)号：WO0061551A3
公开(公告)日：2000-12-28
申请号：PCT/EP0002746
申请日：2000-03-29
Applicant: BASF AG , ZECHEL JOHANN CHRISTIAN , KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , SADOWSKI JENS , HORNBERGER WILFRIED
Inventor： ZECHEL JOHANN-CHRISTIAN , KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , SADOWSKI JENS , HORNBERGER WILFRIED
IPC: C07D239/36 , A61K31/505 , A61K45/00 , A61K45/06 , A61P3/14 , A61P7/02 , A61P9/10 , A61P9/12 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , C07D239/34 , C07D239/60 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D239/46 , C07D403/04
CPC classification number: C07D405/14 , A61K45/06 , C07D239/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D409/14 , C07D417/12 , C07D417/14
Abstract: The invention relates to novel compounds that bind to integrin receptor ligands. The invention also relates to the production thereof, to their use as integrin receptor ligands and to their use for treating diseases, to pharmaceutical preparations that contain said compounds and to pharmaceutical preparations that contain at least one additional active compound.
Abstract translation: 本发明涉及一种结合于整联蛋白受体的新的化合物，它们的制备，它们作为整联的使用和用于治疗疾病的，含有这些化合物和含有至少一种其他活性化合物的药物制剂的药物制剂。
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公开(公告)号：WO0110847A8
公开(公告)日：2001-12-06
申请号：PCT/EP0007440
申请日：2000-08-01
Applicant: BASF AG , KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , HOLZENKAMP UTA , MACK HELMUT , SADOWSKI JENS , HORNBERGER WILFRIED , LAUX VOLKER
Inventor： KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , HOLZENKAMP UTA , MACK HELMUT , SADOWSKI JENS , HORNBERGER WILFRIED , LAUX VOLKER
IPC: A61K31/4402 , A61K31/55 , A61K31/5513 , A61P3/14 , A61P5/18 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D213/74 , C07D223/20 , C07D243/38 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14 , C07D213/73 , C07D491/04
CPC classification number: C07D401/06 , C07D223/20 , C07D243/38 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14
Abstract: The invention relates to novel compounds of formula (I) which bind to integrin receptors, wherein G and L have the following meaning: L is a structural element of formula IL, wherein T represents a COOH group or a radical that can be hydrolyzed to obtain COOH and U- represents (XL)a-(CRL RL )b-, -CRL =CRL -, ethylene or =CRL -, wherein a is 0 or 1; b is 0, 1 or 2; XL represents CRL RL , NRL , oxygen or sulfur and G is a structural element of formula IG, wherein the insertion of structural element G can occur in both orientations and XO represents nitrogen or CRG . The invention also relates to the production of said compounds and to their use as medicaments.
Abstract translation: 本发明涉及式（I）的化合物BGL（I）其中G和L具有以下含义：L式IL -UT（IL），其中T是基团COOH或水解性与COOH和-U-自由基的结构元件 - （XL ）α-（CRL <1> RL <2>）b -CRL <1> CRL <1> CRL <2> - ，亚乙炔基或= CRL <1> - 表示，其中a是0或1，b 0,1或2 XL CRL <3> RL <4> NRL <5>，氧或硫，G是式LG（IG）的结构元件的结构元件G能够以两个方向和XG进行的，其中，所述安装是氮或CRG < 1与整联蛋白受体结合，它们的产生和它们作为药物的用途。
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公开(公告)号：WO0110847A3
公开(公告)日：2001-11-01
申请号：PCT/EP0007440
申请日：2000-08-01
Applicant: BASF AG , KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , HOLZENKAMP UTA , MACK HELMUT , SADOWSKI JENS , HORNBERGER WILFRIED , LAUX VOLKER
Inventor： KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , HOLZENKAMP UTA , MACK HELMUT , SADOWSKI JENS , HORNBERGER WILFRIED , LAUX VOLKER
IPC: A61K31/4402 , A61K31/55 , A61K31/5513 , A61P3/14 , A61P5/18 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D213/74 , C07D223/20 , C07D243/38 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14 , C07D213/73 , C07D491/04
CPC classification number: C07D401/06 , C07D223/20 , C07D243/38 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14
Abstract: The invention relates to novel compounds of formula (I) which bind to integrin receptors, wherein G and L have the following meaning: L is a structural element of formula IL, wherein T represents a COOH group or a radical that can be hydrolyzed to obtain COOH and U- represents (XL)a-(CRL RL )b-, -CRL =CRL -, ethylene or =CRL -, wherein a is 0 or 1; b is 0, 1 or 2; XL represents CRL RL , NRL , oxygen or sulfur and G is a structural element of formula IG, wherein the insertion of structural element G can occur in both orientations and XO represents nitrogen or CRG . The invention also relates to the production of said compounds and to their use as medicaments.
Abstract translation: 本发明涉及式（I）的化合物BGL（I）其中G和L具有以下含义：L式IL -UT（IL），其中T是基团COOH或水解性与COOH和-U-自由基的结构元件 - （XL ）α-（CRL <1> RL <2>）b -CRL <1> CRL <1> CRL <2> - ，亚乙炔基或= CRL <1> - 表示，其中a是0或1，b 0,1或2 XL CRL <3> RL <4> NRL <5>，氧或硫，G是式LG（IG）的结构元件的结构元件G能够以两个方向和XG进行的，其中，所述安装是氮或CRG < 1>结合至整联蛋白受体，它们的制备和它们作为药物的用途。
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公开(公告)号：PL352150A1
公开(公告)日：2003-07-28
申请号：PL35215000
申请日：2000-05-03
Applicant: BASF AG
Inventor： LUBISCH WILFRIED , SADOWSKI JENS , KOCK MICHAEL , HOEGER THOMAS
IPC: C07D237/32 , A61K31/502 , A61P1/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P17/02 , A61P19/02 , A61P25/00 , A61P25/08 , A61P25/10 , A61P25/12 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/04 , A61P37/00 , A61P41/00 , A61P43/00 , C07D401/12 , C07D403/12 , A61K31/495
Abstract: The present invention relates to the use of phthalazine derivatives as inhibitors of the enzyme poly(ADP-ribose) polymerase or PARP (EC 2.4.2.30), to the use as inhibitors of PARP-homologous enzymes and, in particular, these phthalazine derivatives also show a selective inhibition of PARP-homologous enzymes.
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Patent Agency Ranking
公开(公告)号：CZ20013678A3
公开(公告)日：2002-07-17
申请号：CZ20013678
申请日：2000-03-29
Applicant: BASF AG
Inventor： ZECHEL JOHANN-CHRISTIAN , KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH AMULF , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , SADOWSKI JENS , HORNBERGER WILFRIED
IPC: C07D239/36 , A61K31/505 , A61K45/00 , A61K45/06 , A61P3/14 , A61P7/02 , A61P9/10 , A61P9/12 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , C07D239/34 , C07D239/60 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D239/32 , C07D239/70 , C07D239/46 , A61K31/506 , A61K31/541 , A61K31/517 , A61P9/00 , A61P7/00 , A61P19/00 , A61P31/00
Abstract: The invention relates to novel compounds which bind to integrin receptors, to their preparation, to their use as integrin receptor ligands and for treating diseases, to pharmaceutical preparations comprising these compounds, and to pharmaceutical preparations comprising at least one other active compound.
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公开(公告)号：NO20015462A
公开(公告)日：2001-11-08
申请号：NO20015462
申请日：2001-11-08
Applicant: BASF AG
Inventor： LUBISCH WILFRIED , SADOWSKI JENS , KOCK MICHAEL , HOEGER THOMAS
IPC: C07D237/32 , A61K31/502 , A61P1/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P17/02 , A61P19/02 , A61P25/00 , A61P25/08 , A61P25/10 , A61P25/12 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/04 , A61P37/00 , A61P41/00 , A61P43/00 , C07D401/12 , C07D403/12
CPC classification number: A61K31/502
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公开(公告)号：CA2379977A1
公开(公告)日：2001-02-15
申请号：CA2379977
申请日：2000-08-01
Applicant: BASF AG
Inventor： HORNBERGER WILFRIED , LANGE UDO , GENESTE HERVE , KLING ANDREAS , SUBKOWSKI THOMAS , HOLZENKAMP UTA , MACK HELMUT , GRAEF CLAUDIA ISABELLA , LAUTERBACH ARNULF , LAUX VOLKER , SADOWSKI JENS
IPC: A61K31/4402 , A61K31/55 , A61K31/5513 , A61P3/14 , A61P5/18 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D213/74 , C07D223/20 , C07D243/38 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14 , C07D221/00 , C07D223/00 , C07D233/00 , C07D333/00 , C07D491/04 , C07D213/73
Abstract: The invention relates to novel compounds of formula (I) which bind to integr in receptors, wherein G and L have the following meaning: L is a structural element of formula IL, wherein T represents a COOH group or a radical that c an be hydrolyzed to obtain COOH and U- represents (XL)a-(CRL1RL2)b-, -CRL1=CRL2 -, ethylene or =CRL1-, wherein a is 0 or 1; b is 0, 1 or 2; XL represents CRL3RL4, NRL5, oxygen or sulfur and G is a structural element of formula IG, wherein the insertion of structural element G can occur in both orientations and XO represents nitrogen or CRG1. The invention also relates to the production of said compounds and to their use as medicaments.
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公开(公告)号：ZA200108035B
公开(公告)日：2002-10-21
申请号：ZA200108035
申请日：2001-10-01
Applicant: BASF AG
Inventor： ZECHEL JOHANN-CHRISTIAN , KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , ISABELLA GRAEF CLAUDIA , SUBKOWSKI THOMAS , SADOWSKI JENS , HORNBERGER WILFRIED
IPC: C07D239/38 , A61K31/505 , A61K31/513 , A61P9/02 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/08 , A61P35/00 , A61P43/00 , C07D239/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D
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公开(公告)号：TR200102944T2
公开(公告)日：2002-08-21
申请号：TR200102944
申请日：2000-03-29
Applicant: BASF AG
Inventor： ZECHEL JOHANN CHRISTIAN , KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA ISABELA , SUBKOWSKI THOMAS , SADOWSKI JENS , HORNBERGER WILFRIED
IPC: A61K31/505 , A61K45/00 , A61K45/06 , A61P3/14 , A61P7/02 , C07D239/36 , A61P9/10 , A61P9/12 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , C07D239/34 , C07D239/60 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , A61K5 , A61P10 , C07D12 , C07D46
Abstract: The invention relates to novel compounds which bind to integrin receptors, to their preparation, to their use as integrin receptor ligands and for treating diseases, to pharmaceutical preparations comprising these compounds, and to pharmaceutical preparations comprising at least one other active compound.
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