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    33.
    发明专利
    未知

    公开(公告)号：DE50303744D1

    公开(公告)日：2006-07-20

    申请号：DE50303744

    申请日：2003-11-17

    Applicant: BASF AG

    Inventor： MAIER ULRIKE ,  KLATT MARTIN JOCHEN

    IPC: C07D339/04 ,  A61K31/385 ,  A61P5/50

    Abstract: The invention relates to a process for purifying lipoic acid, which comprises adding to a solution of lipoic acid at least 0.1 times the amount of an adsorbent, based on the mass of lipoic acid to be purified, and subsequently removing the adsorbent. It is possible in this way to provide racemic or nonracemic lipoic acid with an oligomer content below 1% by weight, for example from 0.1 to 1% by weight.

    34.
    发明专利
    未知

    公开(公告)号：DE10255242A9

    公开(公告)日：2004-12-23

    申请号：DE10255242

    申请日：2002-11-26

    Applicant: BASF AG

    Inventor： MAIER ULRIKE ,  KLATT MARTIN JOCHEN

    IPC: A61P5/50 ,  C07D339/04 ,  B01J20/10 ,  A23L1/30 ,  A61K31/385

    Abstract: The invention relates to a process for purifying lipoic acid, which comprises adding to a solution of lipoic acid at least 0.1 times the amount of an adsorbent, based on the mass of lipoic acid to be purified, and subsequently removing the adsorbent. It is possible in this way to provide racemic or nonracemic lipoic acid with an oligomer content below 1% by weight, for example from 0.1 to 1% by weight.

    35.
    发明专利
    未知

    公开(公告)号：AT240932T

    公开(公告)日：2003-06-15

    申请号：AT99118428

    申请日：1999-09-17

    Applicant: BASF AG

    Inventor： STUERMER RAINER ,  KLATT MARTIN JOCHEN ,  BOERMER ARMIN ,  HOLZ JENS ,  VOSS GUDRUN

    IPC: B01J31/24 ,  C07B53/00 ,  C07B61/00 ,  C07C67/297 ,  C07C67/31 ,  C07C69/67 ,  C07C69/675 ,  C07C69/732

    Abstract: Enantiomerically pure beta -hydroxyesters (I) are prepared by asymmetric hydrogenation of a beta -hydroxyester (II) over a ruthenium complex catalyst (III) containing an optically active bidentate bis-phospholane ligand. Preparation of enantiomerically pure beta -hydroxyesters (I) involves reacting a beta -hydroxyester (II) with hydrogen in presence of a ruthenium complex catalyst of formula (III): LRuX2 (III) X = halo, acetate, allyl, methallyl, 2-phenylallyl, perchlorate, trifluoroacetate, tetrafluoroborate, hexafluoroantimonate, hexafluorophosphate, hexafluoroarsenate or trichloroacetate; L = bidentate bis-phospholane ligand of formula (A) : Y = bridging group providing 1-5C between the two P atoms; R1 = H, 1-6C alkyl, aryl, alkaryl or Si(R2)3; R2 = alkyl or aryl; m = 0 and R3 = OR4; or m = 1 and R3 = H; R4 = as R1.

    METHOD FOR PRODUCING LIPOIC ACID AND DIHYDROLIPOIC ACID
    36.
    发明专利
    METHOD FOR PRODUCING LIPOIC ACID AND DIHYDROLIPOIC ACID 未知

    公开(公告)号：CA2417842A1

    公开(公告)日：2003-01-30

    申请号：CA2417842

    申请日：2001-07-24

    Applicant: BASF AG

    Inventor： PAUST JOACHIM ,  KLATT MARTIN JOCHEN ,  NIEBEL MARKUS

    IPC: A61K31/20 ,  A61P3/10 ,  C07B53/00 ,  C07C303/38 ,  C07C309/66 ,  C07C319/08 ,  C07C319/18 ,  C07C319/28 ,  C07C321/04 ,  C07C323/52 ,  C07D339/04

    Abstract: The invention relates to a method for producing R-lipoic acid and S-lipoic acid comprising a step selected from the following: (a) distillation of dihydrolipoic acid, (b) reaction of (2) or the stereoisomer thereof, wherein Ms represents SO2-R', and R and R' independently mean C1-C6-alkyl, C3-C8- cycloalkyl, C3-C8-cycloalkylalkyl, aryl or aralkyl, with sodium sulphide and sulphur in ethanol and reaction with a complex hydride, (c) extraction of a protic solution of R dihydrolipoic acid or S-dihydrolipoic acid with an organic solvent at a pH value of 9 -10, or (d) extraction of R-dihydrolipoic acid or S-dihydrolipoic acid with an organic solvent from a protic solution at a pH value of 4 - 5, or a combination of individual or several steps (a) - (d). The invention also relates to a method for producing dihydrolipoic acid and the compound 1,6,8 octane triol.

    METHOD FOR PRODUCING LIPOIC ACID AND DIHYDROLIPOIC ACID
    38.
    发明专利
    METHOD FOR PRODUCING LIPOIC ACID AND DIHYDROLIPOIC ACID 未知

    公开(公告)号：CA2430073A1

    公开(公告)日：2002-06-06

    申请号：CA2430073

    申请日：2001-11-29

    Applicant: BASF AG

    Inventor： NIEBEL MARKUS ,  KLATT MARTIN JOCHEN ,  PAUST JOACHIM

    IPC: C07D339/04

    Abstract: The invention relates to a method for producing R- and S-lipoic acid and R- dihydrolipoic acid comprising the following steps: (a) reaction of the compound of formula (2) with sodium sulphide and sulphur in methanol, whereby Ms represents SO2R', and R and R' independently of one another represent C1-C6 alkyl, C3-C8-cycloalkyl, C3-C8-cycloalkylalkyl, aryl or aralkyl. The invention relates in particular to methods for producing pure R- or S-dihydrolipoic acid, which is either used directly or processed further to obtain R- and S- lipoic acid. The method is also used to produce medicaments. The invention also relates to a solution of sodium sulphide-trihydrate and sulphur in methanol, whereby the sulphur is present as a molar surplus in relation to the sodium sulphide-trihydrate, and to a kit that comprises the inventive solution.

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