公开(公告)号：PL175485B1

公开(公告)日：1999-01-29

申请号：PL30148593

申请日：1993-12-14

Applicant: BASF AG

Inventor： UNGER LILIANE ,  STEINER GERD ,  BEHL BERTHOLD ,  TESCHENDORF HANS-JUERGEN ,  MUNSCHAUER RAINER

IPC: C07D403/02

公开(公告)号：MX9805499A

公开(公告)日：1998-11-30

申请号：MX9805499

申请日：1998-07-07

Applicant: BASF AG

Inventor： TREIBER HANS-JOERG ,  BLANK STEFAN ,  STARCK DOROTHEA ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN

IPC: A61K31/00 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4433 ,  A61K31/4439 ,  C07D243/08 ,  A61K31/505 ,  A61K31/506 ,  A61K31/55 ,  A61K31/551 ,  A61K31/5513 ,  A61P25/18 ,  A61P43/00 ,  C07D213/73 ,  C07D223/04 ,  C07D245/02 ,  C07D401/04 ,  C07D401/14 ,  C07D403/02 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

Abstract: La presente invencion se refiere a compuestos de azacicloheptano y diazacicloheptano y ciclooctano de la siguiente formula (I) Ar1-A-B-Ar2 donde Ar1; A; B y Ar2 tienen los significados proporcionados en la descripcion. Los compuestos de conformidad con la presente invencion poseen una alta afinidad con los receptores de dopamina D3 y pueden por consiguiente emplearse para el tratamiento de enfermedades que reaccionan con ligandos de dopamina D3.

公开(公告)号：ES2120445T3

公开(公告)日：1998-11-01

申请号：ES92909823

申请日：1992-05-08

Applicant: BASF AG

Inventor： RENDENBACH-MUELLER BEATRICE ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN

IPC: A61K31/435 ,  A61K31/425 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/495 ,  A61K31/496 ,  A61P9/12 ,  A61P25/16 ,  A61P25/18 ,  C07D277/20 ,  C07D277/40 ,  C07D277/54 ,  C07D417/12 ,  C07D417/14

Abstract: PCT No. PCT/EP92/01004 Sec. 371 Date Dec. 13, 1993 Sec. 102(e) Date Dec. 13, 1993 PCT Filed May 8, 1992 PCT Pub. No. WO92/22540 PCT Pub. Date Dec. 23, 1992.Aminoalkyl-substituted 5-mercaptothiazoles of the formula where R1, n and A have the meanings stated in the description, and the preparation thereof are described. The compounds are suitable for controlling diseases.

公开(公告)号：HUT77772A

公开(公告)日：1998-08-28

申请号：HU9700329

申请日：1995-07-21

Applicant: BASF AG

Inventor： HOEGER THOMAS ,  MUNSCHAUER RAINER ,  STEINER GERD ,  TESCHENDORF HANS-JUERGEN ,  UNGER LILIANE

IPC: C07D401/06 ,  A61K31/40 ,  A61K31/415 ,  A61K31/47 ,  A61K31/505 ,  A61P25/18 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D513/04

Abstract: PCT No. PCT/EP95/02893 Sec. 371 Date Sep. 18, 1997 Sec. 102(e) Date Sep. 18, 1997 PCT Filed Jul. 21, 1995 PCT Pub. No. WO96/04272 PCT Pub. Date Feb. 15, 1996N-substitued 3-azabicyclo[3.2.0]heptane derivatives of formula (I) in which R1, R2, A, X, Y and Z have the meanings given in the description, their method of preparation and their use as pharmacological agents.

公开(公告)号：HUT77608A

公开(公告)日：1998-06-29

申请号：HU9700111

申请日：1995-07-14

Applicant: BASF AG

Inventor： BACH ALFRED ,  HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  RENDENBACH-MUELLER BEATRICE ,  TESCHENDORF HANS-JUERGEN ,  UNGER LILIANE ,  WICKE KARSTEN

IPC: C07D233/84 ,  A61K31/33 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/445 ,  A61K31/495 ,  A61K31/496 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D213/56 ,  C07D213/64 ,  C07D213/65 ,  C07D213/70 ,  C07D213/73 ,  C07D213/79 ,  C07D213/81 ,  C07D233/90 ,  C07D307/79 ,  C07D333/24 ,  C07D333/28 ,  C07D333/38 ,  C07D471/18 ,  A61K31/505 ,  A61K31/52 ,  A61K31/53

Abstract: PCT No. PCT/EP95/02782 Sec. 371 Date Jan. 14, 1997 Sec. 102(e) Date Jan. 14, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02246 PCT Pub. Date Feb. 1, 1996The present invention relate to the use of heterocyclic compounds of the following formula:Het-A-B-Arwhere Het, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.

公开(公告)号：BR9508296A

公开(公告)日：1998-05-19

申请号：BR9508296

申请日：1995-07-14

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  RENDENDACH-MULLER BEATRICE ,  LANSKY ANNEGRET ,  WICKE CARSTEN ,  TESCHENDORF HANS-JUERGEN ,  BACH ALFRED ,  UNGER LILIANE

IPC: C07D233/84 ,  A61K31/33 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/445 ,  A61K31/495 ,  A61K31/496 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D213/56 ,  C07D213/64 ,  C07D213/65 ,  C07D213/70 ,  C07D213/73 ,  C07D213/79 ,  C07D213/81 ,  C07D233/90 ,  C07D307/79 ,  C07D333/24 ,  C07D333/28 ,  C07D333/38 ,  C07D471/18

Abstract: PCT No. PCT/EP95/02782 Sec. 371 Date Jan. 14, 1997 Sec. 102(e) Date Jan. 14, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02246 PCT Pub. Date Feb. 1, 1996The present invention relate to the use of heterocyclic compounds of the following formula:Het-A-B-Arwhere Het, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.

公开(公告)号：HUT77128A

公开(公告)日：1998-03-02

申请号：HU9700109

申请日：1995-07-14

Applicant: BASF AG

Inventor： BIALOJAN SIEGFRIED ,  DRESCHER KARLA ,  HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  MUNSCHAUER RAINER ,  TESCHENDORF HANS-JUERGEN ,  UNGER LILIANE ,  WICKE KARSTEN

IPC: C07D249/08 ,  A61K31/41 ,  A61K31/435 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/505 ,  A61K31/53 ,  A61P1/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D249/12 ,  C07D249/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  A61K31/495

Abstract: PCT No. PCT/EP95/02781 Sec. 371 Date Jan. 14, 1997 Sec. 102(e) Date Jan. 14, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02520 PCT Pub. Date Feb. 1, 1996The present invention relates to triazole compounds of the following formula: where R1, R2, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.

公开(公告)号：SI9520086A

公开(公告)日：1997-08-31

申请号：SI9520086

申请日：1995-07-22

Applicant: BASF AG

Inventor： STEINER GERD ,  MUNSCHAUER RAINER ,  HOEGER THOMAS ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN

IPC: A61K31/40 ,  A61K31/403 ,  A61P25/18 ,  A61P43/00 ,  C07D409/12 ,  C07D209/44 ,  C07D209/52 ,  C07D209/90 ,  C07D209/92 ,  C07D403/06

Abstract: PCT No. PCT/EP95/02912 Sec. 371 Date Feb. 3, 1997 Sec. 102(e) Date Feb. 3, 1997 PCT Filed Jul. 22, 1995 PCT Pub. No. WO96/04245 PCT Pub. Date Feb. 15, 1996A compound of the formula in which A, R1 and n have the meanings stated in the description are described. The novel compounds are suitable for controlling diseases.

公开(公告)号：PL318459A1

公开(公告)日：1997-06-09

申请号：PL31845995

申请日：1995-07-22

Applicant: BASF AG

Inventor： STEINER GERD ,  MUNSCHAUER RAINER ,  HOEGER THOMAS ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN

IPC: A61K31/40 ,  A61K31/403 ,  A61P25/18 ,  A61P43/00 ,  C07D409/12 ,  C07D209/44 ,  C07D209/52 ,  C07D209/90 ,  C07D209/92 ,  C07D403/06

Abstract: PCT No. PCT/EP95/02912 Sec. 371 Date Feb. 3, 1997 Sec. 102(e) Date Feb. 3, 1997 PCT Filed Jul. 22, 1995 PCT Pub. No. WO96/04245 PCT Pub. Date Feb. 15, 1996A compound of the formula in which A, R1 and n have the meanings stated in the description are described. The novel compounds are suitable for controlling diseases.

公开(公告)号：HUT75315A

公开(公告)日：1997-05-28

申请号：HU9601511

申请日：1994-11-26

Applicant: BASF AG

Inventor： HOEGER THOMAS ,  MUNSHAUER RAINER ,  STEINER GERD ,  TESCHENDORF HANS-JUERGEN ,  UNGER LILIANE

IPC: C07D401/04 ,  A61K31/40 ,  A61K31/403 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/505 ,  A61P25/00 ,  A61P25/02 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  A61P43/00 ,  C07D209/02 ,  C07D209/46 ,  C07D209/52 ,  C07D209/90 ,  C07D209/96 ,  C07D403/04 ,  C07D403/06 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07D413/06 ,  C07D409/14

Abstract: PCT No. PCT/EP94/03910 Sec. 371 Date Apr. 19, 1996 Sec. 102(e) Date Apr. 19, 1996 PCT Filed Nov. 26, 1994 PCT Pub. No. WO95/15312 PCT Pub. Date Jun. 8, 1995Compounds of the formula I I where the substituents have the meanings given in the description, and their preparation are described. The novel compounds are suitable for the control of diseases.