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公开(公告)号：CA2221731C
公开(公告)日：2006-10-17
申请号：CA2221731
申请日：1996-05-22
Applicant: BAXTER INT
Inventor： MIN KYUNGYOON , BROWN RICHARD I
IPC: A61K35/14 , B04B5/00 , A61M1/02 , A61M1/30 , A61M1/36 , B01D17/02 , B01D21/24 , B01D21/26 , B04B5/04 , B04B7/08 , B04B13/00
Abstract: Systems and methods for separating mono nuclear cells from whole blood rotat e a separation compartment (38) about a rotational axis. Whole blood is introduced from an inlet region (74) into a first regio n (76) of the chamber during its rotation to separte the whole blood into a plasma constituent, red blood cells and interphase between the red blood cells and the plasma constituent. The interface contains mono nuclear cells. While conveying whole blood into the first region, the plasma constituent is collected in the first region, while collecting the red blood cells in a second region of the chamber spaced away from the inlet region. Red blood cells are than conveyed into the second region (78) in a back flow direction toward the inlet region. Whi le conveying red blood cells into the second region, the mono nuclear cells are collected in the first region.
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公开(公告)号：NO20052461L
公开(公告)日：2005-05-23
申请号：NO20052461
申请日：2005-05-23
Applicant: BAXTER INT
Inventor： BROWN RICHARD I , MORIARITY JULIE , MIN KYUNGYOON
Abstract: Blood separation systems and methods introduce blood into an annular separation channel between a low-G wall and a high-G wall while rotating the separation channel about an axis, for separation of the blood into blood components. The annular separation channel has an annular boundary wall. The systems and methods direct a first blood component into a constricted channel along the low-G wall. The systems and methods remove the first blood component through a first path that communicates with the separation channel through an opening that adjoins the constricted channel adjacent the low-G wall. The systems and methods direct a second blood component along a surface that extends generally in an axial direction along the high-G wall toward the annular boundary wall. The systems and methods collect the second blood component through a second path that communicates with the separation channel through an opening that adjoins the surface adjacent the high-G wall axially spaced from the annular boundary wall.
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公开(公告)号：AU2003282971A1
公开(公告)日：2004-05-13
申请号：AU2003282971
申请日：2003-10-21
Applicant: BAXTER INT
Inventor： MIN KYUNGYOON , BROWN RICHARD I , MORIARITY JULIE
Abstract: Blood separation systems and methods introduce blood into an annular separation channel between a low-G wall and a high-G wall while rotating the separation channel about an axis, for separation of the blood into blood components. The annular separation channel has an annular boundary wall. The systems and methods direct a first blood component into a constricted channel along the low-G wall. The systems and methods remove the first blood component through a first path that communicates with the separation channel through an opening that adjoins the constricted channel adjacent the low-G wall. The systems and methods direct a second blood component along a surface that extends generally in an axial direction along the high-G wall toward the annular boundary wall. The systems and methods collect the second blood component through a second path that communicates with the separation channel through an opening that adjoins the surface adjacent the high-G wall axially spaced from the annular boundary wall.
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公开(公告)号：ES2194101T3
公开(公告)日：2003-11-16
申请号：ES96916696
申请日：1996-05-22
Applicant: BAXTER INT
Inventor： BROWN RICHARD I , MIN KYUNGYOON
IPC: A61K35/14 , A61M1/02 , A61M1/30 , A61M1/36 , B01D17/02 , B01D21/24 , B01D21/26 , B04B5/04 , B04B7/08 , B04B13/00
Abstract: A blood separation system for separating mono nuclear cells from whole blood is described. The system comprises a chamber (12) that is rotatable about a rotational axis (28). The chamber comprises first and second spaced apart walls (24, 26) that form a separation zone having a high-G side and a low-G side which is located closer to the rotational axis than the high-G side. The chamber also includes an inlet region (74) where whole blood enters the separation zone for separation into red blood cells (96), a plasma constituent carrying platelets (98), and an interface (58) carrying mono nuclear cells between the red blood cells and the plasma constituent. A plasma constituent collection region (76) is also provided in the chamber where the plasma constituent is collected for removal from the chamber. An outlet path (46, 206) communicates with the plasma constituent collection region (76) and provides for removal of the interface (58) from the chamber. The system is operated under the control of a controller (134) that is operable in first and second modes. In the first mode, whole blood is conveyed into the inlet region while red blood cells and the plasma constituent are removed from the chamber and while the interface (58) is maintained at a set location within the chamber. In the second mode, the controller operates to move the interface from the set location for removal from the chamber via the outlet path. Finally, the system is equipped with a sensing element (226) for detecting mono nuclear cells in the interface in the outlet path. A method of separating mono nuclear cells from whole blood is also described.
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公开(公告)号：BR0204452A
公开(公告)日：2003-03-11
申请号：BR0204452
申请日：2002-02-13
Applicant: BAXTER INT
Inventor： BROWN RICHARD I , MIN KYUNGYOON , VISHNOI ROHIT , THOM SANDRA , FARRELL LIAM , WESTBERG TOM
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Patent Agency Ranking
公开(公告)号：CA2418477A1
公开(公告)日：2002-12-12
申请号：CA2418477
申请日：2002-06-04
Applicant: BAXTER INT
Inventor： BROWN RICHARD I , MIN KYUNGYOON
IPC: G01N1/10 , A61M1/36 , B04B5/04 , C02F1/34 , C02F1/38 , C12M1/26 , C12M1/34 , C12N1/02 , G01N1/36 , B01D21/26
Abstract: Methods and apparatus for concentrating and recovering pathogens from a flui d other than blood are disclosed. The method includes concentrating the pathogens contained in the fluid by continuously feeding the fluid through o ne or more flexible chamber(s) and subjecting the chamber(s) to centrifugal forces. The concentrated pathogens may be re-suspended by shaking the chamber(s).
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公开(公告)号：CA2407961A1
公开(公告)日：2002-09-12
申请号：CA2407961
申请日：2002-02-13
Applicant: BAXTER INT
Inventor： WESTBERG TOM , MIN KYUNGYOON , VISHNOI ROHIT , BROWN RICHARD I
Abstract: Automated systems (10) and methods for withdrawing a selected compound from blood are disclosed. The systems and methods utilize a disposable fluid circuit (50) mounted on a re-usable hardware component or module (12). The system withdraws blood from a donor or patient, separates the blood into two or more components and further combines the separated component with a solve nt so as to remove a compound from the blood component.
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公开(公告)号：CA2407947A1
公开(公告)日：2002-09-12
申请号：CA2407947
申请日：2002-02-13
Applicant: BAXTER INT
Inventor： MIN KYUNGYOON , BROWN RICHARD I , FARRELL LIAM , VISHNOI ROHIT , THOM SANDRA , WESTBERG TOM
Abstract: Automated systems and method for processing blood and other fluids are disclosed. The systems and methods utilize a disposable fluid circuit select ed from one of two or more circuits. The circuits are mounted on a re-usable hardware component or module. The system includes a programmable controller including programs for use with the fluid circuits.
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公开(公告)号：BR9810649A
公开(公告)日：2000-10-03
申请号：BR9810649
申请日：1998-06-22
Applicant: BAXTER INT
Inventor： MIN KYUNGYOON , BROWN RICHARD I , BISCHOF DANIEL F , CORK WILLIAM H , CANTU ROBERT J
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公开(公告)号：AU714650B2
公开(公告)日：2000-01-06
申请号：AU9701498
申请日：1998-12-09
Applicant: BAXTER INT
Inventor： BROWN RICHARD I , MIN KYUNGYOON
IPC: B01D21/26
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