公开(公告)号：WO9427698A3

公开(公告)日：1996-10-10

申请号：PCT/US9305735

申请日：1993-06-15

Applicant: BAXTER INT

Inventor： LAKE WILLIAM C ,  GIESLER RICHARD ,  VAN EPPS DENNIS ,  CHAPMAN JOHN R ,  MARTINSON JEFFREY A ,  ELLIS DALE R ,  AONO FREDERICK ,  BISCHOF DANIEL F

IPC: G01N33/48 ,  A61K35/14 ,  A61K35/24 ,  A61M1/36 ,  B03B5/28 ,  C12M1/00 ,  C12N5/00 ,  C12N5/06 ,  C12Q1/02 ,  C12Q1/24 ,  G01N33/49 ,  G01N33/50 ,  G01N33/53 ,  G01N33/569 ,  B01D

CPC classification number: G01N33/56972 ,  A61M1/3618 ,  A61M1/362 ,  A61M1/3696 ,  C12Q1/24 ,  G01N33/5005 ,  G01N33/569

Abstract: A method combining the techniques of immunoaffinity separation and continuous flow centrifugal separation is provided for selective separation of a nucleated heterogeneous cell population from a heterogeneous cell mixture. The heterogeneous cell mixture is intimately contacted to promote binding thereto by particles having attached a substance that actively binds to a specific desired type of cell out of the cell mixture. The particles are selected so that the sedimentation velocity of the particle/cell conjugate differs sufficiently from those of other cells in the cell mixture to allow its separation by means of a continuous flow cell separator. The method rapidly processes large volumes of cell mixture with the high accuracy expected of immunoaffinity separation and can be used to separate, for example, various types of leukocytes from whole blood, bone marrow concentrate, or a peripheral blood stem cell concentrate; or precursors of lymphokine activated killer cells, tumor infiltrating lymphocyte cells, or activated killer monocytes from lymphocyte or monocyte cell concentrates or from a tissue cell preparation.

公开(公告)号：EP1003609A4

公开(公告)日：2004-12-15

申请号：EP98934139

申请日：1998-06-22

Applicant: BAXTER INT

Inventor： MIN KYUNGYOON ,  BROWN RICHARD I ,  BISCHOF DANIEL F ,  CORK WILLIAM H ,  CANTU ROBERT J

IPC: A61M1/02 ,  A61M1/36 ,  B01D21/26 ,  B04B5/04 ,  B04B11/02 ,  B04B13/00 ,  B04B11/04

CPC classification number: B01D21/302 ,  A61M1/3696 ,  B01D21/262 ,  B01D2221/10 ,  B04B5/0442 ,  B04B13/00 ,  B04B2005/045

Abstract: A blood separation system operates in a first mode to convey whole blood into the inlet region (48) of a blood processing chamber (38) for centrifugal separation into packed red blood cells, a plasma constituent, and an interface, which carries mononuclear cells, between the packed red blood cells and the plasma constituent. The system removes packed red blood cells and the plasma constituent from the chamber (38), while maintaining the interface within the chamber (38). The system operates in a second mode to remove the interface from the chamber (38) by conveying packed red blood cells into the inlet region (48). An outlet path (46) conveys the removed interface from the chamber (38). The outlet path (46) includes a first sensing element (OS) to locate mononuclear cells in the removed interface and provide a sensed output upon locating mononuclear cells.

公开(公告)号：WO2006049965A3

公开(公告)日：2006-10-05

申请号：PCT/US2005038426

申请日：2005-10-24

Applicant: BAXTER INT ,  LYNN DANIEL ,  SERVI LAWRENCE J JR ,  ARIAGNO SCOTT ,  ELLIS DALE ,  LING MICHAEL T K ,  BISCHOF DANIEL F ,  FAN SUCHUAN C ,  SADIK ADEL

Inventor： LYNN DANIEL ,  SERVI LAWRENCE J JR ,  ARIAGNO SCOTT ,  ELLIS DALE ,  LING MICHAEL T K ,  BISCHOF DANIEL F ,  FAN SUCHUAN C ,  SADIK ADEL

IPC: A61M5/32

CPC classification number: A61M5/3213

Abstract: Medical needle assemblies and needle covers for medical needles are disclosed. The needle covers include a relatively rigid outer surface and more resilient inner surface. The needle covers protect the needle from damage, allow for effective sterilization of the assembly, provide a sterile barrier, and evidence of product tampering.

Abstract translation: 公开了用于医​​用针的医用针组件和针盖。 针罩包括相对刚性的外表面和更具弹性的内表面。 针盖可以保护针头免受损伤，允许组装的有效灭菌，提供无菌屏障，以及产品篡改的证据。

公开(公告)号：WO2006039251A3

公开(公告)日：2006-08-03

申请号：PCT/US2005034504

申请日：2005-09-27

Applicant: BAXTER INT ,  MATHIAS JEAN-MARIE ,  BLICKHAN BRYAN J ,  HALDIMAN STEPHANIE ,  SERVI LAWRENCE J JR ,  BERNES JEAN-CLAUDE ,  BISCHOF DANIEL F

Inventor： MATHIAS JEAN-MARIE ,  BLICKHAN BRYAN J ,  HALDIMAN STEPHANIE ,  SERVI LAWRENCE J JR ,  BERNES JEAN-CLAUDE ,  BISCHOF DANIEL F

IPC: A61B5/15 ,  A61J1/14 ,  A61M1/02

CPC classification number: A61M1/0236 ,  A61B5/15 ,  A61B5/15003 ,  A61B5/150366 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150717 ,  A61B5/150755 ,  A61B5/150992 ,  A61B5/1545 ,  A61J1/12 ,  A61M1/0209

Abstract: Methods and apparatus for collecting blood samples in vacuum sample tubes are disclosed. The samples, including the initial blood sample, are substantially free of excess air. Disclosed is also a biological fluid sampling system (18) comprising: a plastic container (42) including an interior chamber (54); a sample access site (68) external to and spaced from said container by y preselected distance; an internal flow path (43) communicating with said access site and extending substantially into said interior chamber, said internal flow path providing the only path for blood flow into and from said chamber.

Abstract translation: 公开了用于在真空样品管中收集血样的方法和装置。 包括初始血液样本在内的样品基本上没有多余的空气。 公开了一种生物流体采样系统（18），包括：包括内部腔室（54）的塑料容器（42）; y预选距离在所述容器外部和与所述容器隔开的样品进入位置（68）; 与所述进入位置连通并且基本上延伸到所述内部腔室中的内部流动路径（43），所述内部流动路径提供用于血液流入和流出所述腔室的唯一途径。

公开(公告)号：WO03049784A2

公开(公告)日：2003-06-19

申请号：PCT/US0237508

申请日：2002-11-22

Applicant: BAXTER INT

Inventor： BISCHOF DANIEL F ,  LO YING-CHENG ,  LYNN DANIEL ,  BLICKHAN BRYAN J

IPC: A61J1/05 ,  A01N1/02 ,  A61K35/14 ,  A61M1/02 ,  A61M1/36 ,  A61P7/04 ,  A61M

CPC classification number: A61M1/3681 ,  A01N1/02 ,  A01N1/0215 ,  A01N1/0263 ,  A61M1/0222 ,  A61M1/0231 ,  A61M1/0272 ,  A61M1/0281 ,  A61M1/3683

Abstract: Systems and methods for manually process blood and blood components in sterile, closed environments, which further condition the blood components for subsequent pathogen inactivation processes. The systems and methods mate the manual collection of random donor platelet units with the creation of larger therapeutic doses of platelets targeted to undergo pathogen inactivation prior to long term storage and/or transfusion.

Abstract translation: 在无菌，封闭环境中手动处理血液和血液成分的系统和方法，其进一步调节血液成分以用于随后的病原体灭活过程。 系统和方法将随机供体血小板单元的手动收集与在长期储存和/或输血之前进行病原体灭活的较大治疗剂量的血小板相匹配。

公开(公告)号：EP0653062A4

公开(公告)日：1997-12-03

申请号：EP93915369

申请日：1993-06-15

Applicant: BAXTER INT

Inventor： LAKE WILLIAM C ,  GIESLER RICHARD ,  VAN EPPS DENNIS ,  CHAPMAN JOHN R ,  MARTINSON JEFFREY A ,  ELLIS DALE R ,  AONO FREDERICK ,  BISCHOF DANIEL F

IPC: G01N33/48 ,  A61K35/14 ,  A61K35/24 ,  A61M1/36 ,  B03B5/28 ,  C12M1/00 ,  C12N5/00 ,  C12N5/06 ,  C12Q1/02 ,  C12Q1/24 ,  G01N33/49 ,  G01N33/50 ,  G01N33/53 ,  G01N33/569

CPC classification number: G01N33/56972 ,  A61M1/3618 ,  A61M1/362 ,  A61M1/3696 ,  C12Q1/24 ,  G01N33/5005 ,  G01N33/569

公开(公告)号：EP0540734A4

公开(公告)日：1994-07-13

申请号：EP92917334

申请日：1992-04-27

Applicant: BAXTER INT

Inventor： GOLDHABER RICHARD ,  BISCHOF DANIEL F ,  JOHNSON KENNETH M

IPC: A61J3/00 ,  A61J1/05 ,  A61J1/10 ,  A61M1/02 ,  A61M1/36 ,  B01D37/00

CPC classification number: A61M1/0231 ,  A61M1/0222 ,  A61M1/3643 ,  A61M1/3644 ,  A61M2202/0429 ,  A61M2202/0439 ,  A61M2202/0042 ,  A61M2202/005

Abstract: Systems and methods of collecting blood cells use a first container (16) connected to at least three transfer containers (18, 26, 34). A filtration system (10) is provided with one transfer container (34), which ultimately serves as the storage container for red blood cells free of white blood cells. The two other transfer containers (18, 26) are connected to each other, one (18) of which is empty and one (26) or which contains an additive solution (5) for storage of red blood cells. The empty transfer container (18) is used for storage of platelet concentrate, while the container (26) that originally contained the additive solution is ultimately used to store the platelet-poor plasma component. A portion of the additive solution (5) may be separately passed through the filtration system (10) after filtration of the red cells to flush additional red blood cells from the filtration device (40).

Abstract translation: 收集血细胞的系统和方法使用连接至少三个转运容器的第一容器。 过滤系统设置有一个转运容器，其最终用作不含白细胞的红细胞的储存容器。 另外两个转移容器彼此连接，其中一个是空的，其中一个包含用于储存红细胞的添加剂溶液。 空转移容器用于储存血小板浓缩物，而最初含有添加剂溶液的容器最终用于储存贫血小板血浆成分。 过滤红细胞后，一部分添加剂溶液可以分开通过过滤系统，以从过滤装置冲洗另外的红细胞。

公开(公告)号：EP1058563A4

公开(公告)日：2002-03-20

申请号：EP98957791

申请日：1998-11-11

Applicant: BAXTER INT

Inventor： BISCHOF DANIEL F ,  LIKENS MATTHEW E ,  GOLDHABER RICHARD P ,  DENIEGA JOSE C ,  DUFF DANIEL H

IPC: A61M1/34 ,  A61K35/14 ,  A61M1/02 ,  A61M1/26 ,  A61M1/30 ,  B01D17/02 ,  B01D21/00 ,  B01D21/24 ,  B01D21/26 ,  B01D21/28 ,  B01D21/30 ,  B01D61/00 ,  B01D61/14 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D61/08 ,  B01D61/22

CPC classification number: B01D21/2405 ,  A61M1/265 ,  A61M1/30 ,  A61M1/303 ,  A61M1/306 ,  A61M1/308 ,  A61M1/309 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/3496 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3393 ,  A61M2209/082 ,  B01D17/0217 ,  B01D17/085 ,  B01D21/0012 ,  B01D21/26 ,  B01D2221/10

Abstract: Blood separation systems and methods draw whole blood from a blood donor selected from a population of blood donors. The whole blood of the selected blood donor has a known hematocrit value that varies within the population of blood donors according to morphology of the selected blood donor. The systems and methods operate a pump in the inlet line to convey a volume of whole blood from the donor at a commanded flow rate for processing into plasma constituent and concentrated red blood cells. The systems and methods set the commanded flow rate to vary the volume of whole blood conveyed over time as a function of the known hematocrit value of the selected donor. The systems and methods obtain, after processing the whole blood volume, a targeted volume of concentrated red blood cells, which is substantially constant for the population of blood donors despite variances in known hematocrit values among the donors.

公开(公告)号：EP0809433A4

公开(公告)日：2001-01-10

申请号：EP96941472

申请日：1996-11-26

Applicant: BAXTER INT

Inventor： SUN CHONG-SON ,  CHAPMAN JOHN ,  BISCHOF DANIEL F

IPC: A61K35/14 ,  A61L2/00 ,  A61M1/02 ,  A61M1/36 ,  B01J19/12 ,  A01N1/02 ,  A61B19/00 ,  A61M37/00

CPC classification number: A61K35/16 ,  A61L2/0011 ,  A61L2/0017 ,  A61L2/08 ,  A61M1/0218 ,  A61M1/3633 ,  A61M1/3679 ,  A61M1/3681 ,  A61M1/3683 ,  A61M2202/0439 ,  B01J19/122 ,  A61M2202/0057

Abstract: Systems and methods treat plasma carrying contaminants and leukocytes that are capable of entraining contaminants. The systems and methods separate leukocytes from the plasma by filtration, thereby removing contaminants entrained within leukocytes. The systems and methods also add to the plasma a photoactive material and emit radiation at a selected wavelength into the plasma to activate the photoactive material and thereby eradicate the contaminant that is free of entrainment by leukocytes.

公开(公告)号：EP1450892A4

公开(公告)日：2005-11-30

申请号：EP02804701

申请日：2002-11-22

Applicant: BAXTER INT

Inventor： BISCHOF DANIEL F ,  LO YING-CHENG ,  LYNN DANIEL ,  BLICKHAN BRYAN J

IPC: A61J1/05 ,  A01N1/02 ,  A61K35/14 ,  A61M1/02 ,  A61M1/36 ,  A61P7/04 ,  A61M37/00 ,  A61B19/00 ,  B01D33/00 ,  C02F1/38

CPC classification number: A61M1/3681 ,  A01N1/02 ,  A01N1/0215 ,  A01N1/0263 ,  A61M1/0222 ,  A61M1/0231 ,  A61M1/0272 ,  A61M1/0281 ,  A61M1/3683